Luis De La Torre-Ubieta
Assistant Professor-in-Residence, Psychiatry and Biobehavioral Sciences, University of California Los Angeles
Affiliations
Biography:
Dr. de la Torre-Ubieta performed his undergraduate studies at the University of Puerto Rico and obtained his doctoral degree in Neurobiology from Harvard University studying cell-intrinsic mechanisms regulating neuronal morphogenesis. He then went on to pursue postdoctoral studies at UCLA in the Geschwind laboratory where he employed computational and molecular approaches to study human cortical neurogenesis. His work focused on developing and characterizing in vitro models of human brain development and elucidating signaling and gene-regulatory mechanisms operating in the developing human neocortex. His research has been funded through individual awards by the NIH, CIRM, and the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, and is an Albert J. Ryan Foundation Fellow. Prof. de la Torre-Ubieta is also an avid microscopist and received a Wellcome Trust Image Award for his work imaging cleared mouse brains.
Publications
- de la Torre-Ubieta L. Defining the evolutionary and gene regulatory logic of vertebrate neuronal diversity.. Neuron, 2022.
- Ayg?n N, Elwell AL, Liang D, Lafferty MJ, Cheek KE, Courtney KP, Mory J, Hadden-Ford E, Krupa O, de la Torre-Ubieta L, Geschwind DH, Love MI, Stein JL. Brain-trait-associated variants impact cell-type-specific gene regulation during neurogenesis.. American journal of human genetics, 2021.
- Liang D, Elwell AL, Ayg?n N, Krupa O, Wolter JM, Kyere FA, Lafferty MJ, Cheek KE, Courtney KP, Yusupova M, Garrett ME, Ashley-Koch A, Crawford GE, Love MI, de la Torre-Ubieta L, Geschwind DH, Stein JL. Cell-type-specific effects of genetic variation on chromatin accessibility during human neuronal differentiation.. Nature neuroscience, 2021.
- Kim M, Haney JR, Zhang P, Hernandez LM, Wang LK, Perez-Cano L, Loohuis LMO, de la Torre-Ubieta L, Gandal MJ. Brain gene co-expression networks link complement signaling with convergent synaptic pathology in schizophrenia.. Nature neuroscience, 2021.
- Seidlitz J, Nadig A, Liu S, Bethlehem RAI, V?rtes PE, Morgan SE, V?a F, Romero-Garcia R, Lalonde FM, Clasen LS, Blumenthal JD, Paquola C, Bernhardt B, Wagstyl K, Polioudakis D, de la Torre-Ubieta L, Geschwind DH, Han JC, Lee NR, Murphy DG, Bullmore ET, Raznahan A. Author Correction: Transcriptomic and cellular decoding of regional brain vulnerability to neurogenetic disorders.. Nature communications, 2020.
- Hernandez LM, Kim M, Hoftman GD, Haney JR, de la Torre-Ubieta L, Pasaniuc B, Gandal MJ. Transcriptomic Insight Into the Polygenic Mechanisms Underlying Psychiatric Disorders.. Biological psychiatry, 2020.
- Walker RL, Ramaswami G, Hartl C, Mancuso N, Gandal MJ, de la Torre-Ubieta L, Pasaniuc B, Stein JL, Geschwind DH. Genetic Control of Expression and Splicing in Developing Human Brain Informs Disease Mechanisms.. Cell, 2019.
- Polioudakis D, de la Torre-Ubieta L, Langerman J, Elkins AG, Shi X, Stein JL, Vuong CK, Nichterwitz S, Gevorgian M, Opland CK, Lu D, Connell W, Ruzzo EK, Lowe JK, Hadzic T, Hinz FI, Sabri S, Lowry WE, Gerstein MB, Plath K, Geschwind DH. A Single-Cell Transcriptomic Atlas of Human Neocortical Development during Mid-gestation.. Neuron, 2019.
- de la Torre-Ubieta L, Stein JL, Won H, Opland CK, Liang D, Lu D, Geschwind DH. The Dynamic Landscape of Open Chromatin during Human Cortical Neurogenesis.. Cell, 2018.
- Watanabe M, Buth JE, Vishlaghi N, de la Torre-Ubieta L, Taxidis J, Khakh BS, Coppola G, Pearson CA, Yamauchi K, Gong D, Dai X, Damoiseaux R, Aliyari R, Liebscher S, Schenke-Layland K, Caneda C, Huang EJ, Zhang Y, Cheng G, Geschwind DH, Golshani P, Sun R, Novitch BG. Self-Organized Cerebral Organoids with Human-Specific Features Predict Effective Drugs to Combat Zika Virus Infection.. Cell reports, 2017.
- Won H, de la Torre-Ubieta L, Stein JL, Parikshak NN, Huang J, Opland CK, Gandal MJ, Sutton GJ, Hormozdiari F, Lu D, Lee C, Eskin E, Voineagu I, Ernst J, Geschwind DH. Chromosome conformation elucidates regulatory relationships in developing human brain.. Nature, 2016.
- de la Torre-Ubieta L, Won H, Stein JL, Geschwind DH. Advancing the understanding of autism disease mechanisms through genetics.. Nature medicine, 2016.
- Stein JL, de la Torre-Ubieta L, Tian Y, Parikshak NN, Hern?ndez IA, Marchetto MC, Baker DK, Lu D, Hinman CR, Lowe JK, Wexler EM, Muotri AR, Gage FH, Kosik KS, Geschwind DH. A quantitative framework to evaluate modeling of cortical development by neural stem cells.. Neuron, 2014.