Education and Training
Stanford University Medical Center | Postdoc | 1993 | Immunology |
Duke University Medical Center | PhD | 1988 | Immunology |
UCSD | BA | 1983 | Biochemistry and Cell Biology |
Publications
- Scripture-Adams DD, Chesmore, K.N., Barthélémy, F Wang RT, Nieves-Rodriguez S, Wang DW, Mokhonova EI, Douine ED, Wan J, Little I, Rabichow LN, * Nelson SF, and * Miceli MC *denotes equal contributions. Single nuclei transcriptomics of muscle reveals intra-muscular cell dynamics linked to dystrophin loss and rescue. Communications Biology, 2022.
- Barthélémy F*, Santoso JW*, Rabichow L, Jin R, Little I, Nelson SF, McCain ML*, Miceli MC* . Modeling Patient-Specific Muscular Dystrophy Phenotypes and Therapeutic Responses in Reprogrammed Myotubes Engineered on Micromolded Gelatin Hydrogels. Front Cell Dev Biol , 2022.
- Bishop et al.. Immuno-mass spectrometry imaging of skeletal muscle dystrophin. Scientific Reports , 2021.
- Barthélémy, F, Woods, Nieves -Rodriguez, Wang, R, Wanagat, *Miceli, MC, *Nelson, S.F. 62(6):688-698, 2020. *joint senior authors. . A Well Tolerated Core Needle Biopsy Process for Children and Adults. Muscle and Nerve, 2020.
- Barthélémy, F, Wang, RT, Hsu, C, Douine, ED. Nelson, SF and Miceli, M.C. . Targeting RyR activity boosts antisense exon 44 and 45 skipping in human DMD skeletal or cardiac muscle culture models. Molecular Therapy, Nucleic Acids, 2019.
- Gibbs, EM, Barthélémy, F. Douine ED , Hardiman, N, Shieh, PB, Khanlou, N, Crosbie-Watson, RHC*, Nelson, SF* and Miceli, MC*.. *denotes equal contribution. Large in-frame 5’deletions in DMD associated with mild Duchenne Muscular Dystrophy: two case reports and a review of the literature. , 2019.
- Wang, RT*, Barthelemy, F*. Martin, ED, Douine, D, Eskin, A. Lucas, Lavigne, JA. L Peay, H., Khanlou, N, Cantor, RM. Cantor, Miceli. M.C.*, Nelson SF* equal contributions. DMD Genotype Correlations from the Duchenne Registry: endogenous exon skipping, is a factor in prolonged ambulation for individuals with a defined mutation sub-type. Human Mutation, 2018.
- Wang, DW, Mokhonova, EI, Kendall, GC, Becerra, D., Naeini, Y, Spencer, MJ, Cantor, R. Nelson, SF*, Miceli, MC* . (2018 Vol. June 11: 180-191 *. Miceli and Nelson share senior authorship. Repurposing Dantrolene for Long-term Combination Therapy to Potentiate Antisense-Mediated DMD Exon Skipping in the mdx mouse. Molecular Therapy: Nucleic Acids, 2018.
- Miceli MC, Nelson SF. The case for eteplirsen: Paving the way for precision medicine.. Molecular genetics and metabolism, 2016.
- Young CS, Hicks MR, Ermolova NV, Nakano H, Jan M, Younesi S, Karumbayaram S, Kumagai-Cresse C, Wang D, Zack JA, Kohn DB, Nakano A, Nelson SF, Miceli MC, Spencer MJ, Pyle AD. Apr 7;18(4):533-40 PMID: 26877224; PMCID: PMC4826286 (Journal cover). A Single CRISPR-Cas9 Deletion Strategy that Targets the Majority of DMD Patients Restores Dystrophin Function in hiPSC-Derived Muscle Cells. Cell Stem Cell, 2016.
- Capote J, Kramerova I, Martinez L, Vetrone S, Barton ER, Sweeney HL, Miceli MC, Spencer, MJ. . Osteopontin Ablation Ameliorates Muscular Dystrophy by shifting macrophages to a pro-regenerative phenotype. Journal of Cell Biology, 2016.
- Silva, O, Crocetti, J, Humphries, J, Burkhardt, J and M. C. Miceli (2015). . Discs Large Homolog 1 splice variants regulate p38 dependent and Independent Effector Functions in CD8+ T cells. PLOS One, 2015.
- Crocetti J*, Silva O*, Humphries LA, Tibbs MD, Miceli MC. *denotes equal contributions. Selective phosphorylation of the Dlg1AB variant is critical for TCR-induced p38 activation and induction of proinflammatory cytokines in CD8+ T cells. Journal of Immunology, 2014.
- Kendall GC*, Mokhonova E*, Moran M, Sejbuk NE, Wang DW, Silva O, Wang RT, Martinez Lu, Damoiseaux R, Spencer MJ *, Nelson SF*,† Miceli MC*,†. equal contributions.. . Dantrolene Enhances Antisense-Mediated Exon Skipping in Human and Mouse Models of Duchenne Muscular Dystrophy. Science Translational Medicine , 2012.
- Humphries, L.A., Shaffer, M.H., Sacirbegovic, F., Tomassian, T., McMahon, K.-A., Humbert, P.O., Silva, O., Round, J.L., Takamiya, K., Huganir, R.L., Burkhardt, J.K., Russell, S.M., Miceli, M.C. . Characterization of in vivo Dlg1 deletion on T cell development and function. PLoS ONE, 2012.
- Tomassian, T, Humphries, L., Lui, S.D., Silva, O. Brooks, D., Miceli, M.C. . Caveolin-1 orchestrates synaptic polarity, signal specificity and function in CD8 T cells. J Immunology , 2011.
- Liu S.D., Lee, S., La Cava, A., Motran, C.C., Hahn*, B.H., Miceli*, M.C. . Galectin-1-induced down-regulation of T lymphocyte activation protects (NZB x NZW) F1 mice from lupus-like disease. Lupus, 2011.
- Liu S.D., Lee, S., La Cava, A., Motran, C.C., Hahn*, B.H., Miceli*, M.C. . Galectin-1-induced down-regulation of T lymphocyte activation protects (NZB x NZW) F1 mice from lupus-like disease. Lupus, 2011.
- 27. Liu, S.D., Tomassian, T., Miceli, M.C. ., 182 (9):5283-5295, 2009. Galectin-1 tunes TCR binding and signal transduction to regulate CD8 burst size. Journal of Immunology, 2009.
- Vetrone, S.A., Montecino-Rodriguez, E., Kudryashova, E., Kramerova, I., Hoffman, E.P., Liu, S.D., Miceli, M.C., Spencer M.J. . Osteopontin promotes fibrosis in Mdx muscle through modulation of immune cell subsets and intramuscular TGFbeta. Journal of Clinical Investigation, 119 (6):1583-1594, 2009., 2009.
- Liu, S.D, Chung, C.D, Tomassian, T, Pang, M, Baum, L.G, Miceli, M.C. E. , 112 (1):120-130, 2008. Endogenous galectin-1 functions to enforce class I restricted TCR functional fate decisions in thymocytes. Blood, 2008.
- Motran, C. Molinder K.M., Liu S.D., Poirer, F., Miceli, M.C. . Galectin-1 functions as a Th2 cytokine that selectively induces Th1 apoptosis and promotes Th2 function. European Journal of Immunology, 2008.
- Round, JL, Humphries, LA, Tomassian, T, Mittelstadt, P, Zhang M, Miceli, M.C. , 8:154, 2007. Scaffold protein Dlgh1 coordinates alternative p38 kinase activation, directing T cell receptor signals toward NFAT but not NF-kB transcription factors. Nature Immunology, 2007.
- Zhang, M., Moran, M., Round, J., Low, T., Patel, V., Tomassian, T., Hernandez, J.D., Miceli M.C. . CD45 signals outside of lipid rafts to promote synaptic raft clustering, Erk activation and IL-2 production. Journal of Immunology, 2005.
- Round, J.L., Tomassian, T., Zhang, M., Patel, P., Schoenberger, S.P., Miceli, M.C. . Dlgh1 coordinates actin polymerization, synaptic TCR and lipid raft aggregation and effector function in T lymphocytes. 23. Round, J.L., Tomassian, T., Zhang, M., Patel, P., Schoenberger, S.P., Miceli, M.C. Journal of Experimental Medicine , 2005.
- Miceli MC, Moran M, Chung CD, Patel VP, Low T, Zinnanti W. Co-stimulation and counter-stimulation: lipid raft clustering controls TCR signaling and functional outcomes.. Seminars in immunology, 2001.
- Patel, V., Moran, M., Low, T., Miceli, M.C. . A molecular framework for two step T cell signaling: Lck SH3 domain mutations discriminate two distinctly regulated lipid raft reorganization events. Journal of Immunology, 2001.
- Tomassian, T, Humphries, L., Lui, S.D., Silva, O. Brooks, D., Miceli, M.C. . Caveolin-1 orchestrates synaptic polarity, signal specificity and function in CD8 T cells. J Immunol. Journal of Immunology, 2001.
- Chung, C.D., Patel, V.P., Moran, M., Lewis L.A., Miceli, M.C. . Galectin-1 induces partial beta chain phosphorylation and antagonizes processive TCR signal transduction. Journal of Immunology, 2000.
- Vespa, G.N.R, Kozak, K., Lewis, L., Moran, M., Ngyen J.T., Baum, L.G., Miceli, M.C. . Galectin-1 specifically modulates TCR signals to enhance TCR apoptosis, but inhibit proliferation and IL-2 production. Journal of Immunology, 1999.
- Vespa, G.N.R, Kozak, K., Lewis, L., Moran, M., Ngyen J.T., Baum, L.G., Miceli, M.C. Galectin-1 specifically modulates TCR signals to enhance TCR apoptosis, but inhibit proliferation and IL-2 production. . TCR-Induced IL-2 production and apoptosis have different requirements for Lck activities. Journal of Immunology, 1999.
- Moran, M., Miceli MC. Engagement of GPI-anchored T cell CD48 contributes to TCR signals and cytoskeletal reorganization: A role for lipid rafts in T cell activation. Immunity, 9:787-796, 1998, 1998.
- Chung, C.D., Lewis, L.A., Miceli, M.C. . , 159:1758-1766, 1997. TCR-Induced IL-2 production and apoptosis have different requirements for Lck activities. Journal of Immunology, 1997.
- Lewis, L.A., Chung, C.D., Chen, J., Parnes, J.R., Moran, M.M., Patel, V.P., Miceli, M.C. . The Lck SH2 phosphotyrosine binding site is critical for efficient TCR-induced processive tyrosine phosphorylation of the beta chain and IL-2 production. Journal of Immunology, 1997.
- Miceli, M.C., von Hoegen, P., Parnes, J.R. . USA, 88:2623-2627, 1991. Adhesion versus coreceptor functions of CD4 and CD8: Role of the cytoplasmic tail in coreceptor activity. Proceedings of the National Academy of Sciences,, 1991.
- Abraham, N., Miceli, M.C., Parnes, J.R., Veillette, A. . Enhancement of T cell responsiveness by the lymphocyte-specific tyrosine protein kinase p56lck. Nature, 1991.
- Miceli, MC, Finn, OJ. . T cell receptor beta chain selection in human allograft rejection. J Immunol, 142:81-88, 1989. Journal of Immunoly, 142:81-88, 1989, 1989.