M. Carrie Miceli

M Carrie Miceli

Professor, MIMG, University of California Los Angeles

UC Profile

Education and Training

Stanford University Medical CenterPostdoc1993Immunology
Duke University Medical CenterPhD1988Immunology
UCSDBA1983Biochemistry and Cell Biology

Publications

  1. Scripture-Adams DD, Chesmore, K.N., Barthélémy, F Wang RT, Nieves-Rodriguez S, Wang DW, Mokhonova EI, Douine ED, Wan J, Little I, Rabichow LN, * Nelson SF, and * Miceli MC *denotes equal contributions. Single nuclei transcriptomics of muscle reveals intra-muscular cell dynamics linked to dystrophin loss and rescue. Communications Biology, 2022.
  2. Barthélémy F*, Santoso JW*, Rabichow L, Jin R, Little I, Nelson SF, McCain ML*, Miceli MC* . Modeling Patient-Specific Muscular Dystrophy Phenotypes and Therapeutic Responses in Reprogrammed Myotubes Engineered on Micromolded Gelatin Hydrogels. Front Cell Dev Biol , 2022.
  3. Bishop et al.. Immuno-mass spectrometry imaging of skeletal muscle dystrophin. Scientific Reports , 2021.
  4. Barthélémy, F, Woods, Nieves -Rodriguez, Wang, R, Wanagat, *Miceli, MC, *Nelson, S.F. 62(6):688-698, 2020. *joint senior authors. . A Well Tolerated Core Needle Biopsy Process for Children and Adults. Muscle and Nerve, 2020.
  5. Barthélémy, F, Wang, RT, Hsu, C, Douine, ED. Nelson, SF and Miceli, M.C. . Targeting RyR activity boosts antisense exon 44 and 45 skipping in human DMD skeletal or cardiac muscle culture models. Molecular Therapy, Nucleic Acids, 2019.
  6. Gibbs, EM, Barthélémy, F. Douine ED , Hardiman, N, Shieh, PB, Khanlou, N, Crosbie-Watson, RHC*, Nelson, SF* and Miceli, MC*.. *denotes equal contribution. Large in-frame 5’deletions in DMD associated with mild Duchenne Muscular Dystrophy: two case reports and a review of the literature. , 2019.
  7. Wang, RT*, Barthelemy, F*. Martin, ED, Douine, D, Eskin, A. Lucas, Lavigne, JA. L Peay, H., Khanlou, N, Cantor, RM. Cantor, Miceli. M.C.*, Nelson SF* equal contributions. DMD Genotype Correlations from the Duchenne Registry: endogenous exon skipping, is a factor in prolonged ambulation for individuals with a defined mutation sub-type. Human Mutation, 2018.
  8. Wang, DW, Mokhonova, EI, Kendall, GC, Becerra, D., Naeini, Y, Spencer, MJ, Cantor, R. Nelson, SF*, Miceli, MC* . (2018 Vol. June 11: 180-191 *. Miceli and Nelson share senior authorship. Repurposing Dantrolene for Long-term Combination Therapy to Potentiate Antisense-Mediated DMD Exon Skipping in the mdx mouse. Molecular Therapy: Nucleic Acids, 2018.
  9. Miceli MC, Nelson SF. The case for eteplirsen: Paving the way for precision medicine.. Molecular genetics and metabolism, 2016.
  10. Young CS, Hicks MR, Ermolova NV, Nakano H, Jan M, Younesi S, Karumbayaram S, Kumagai-Cresse C, Wang D, Zack JA, Kohn DB, Nakano A, Nelson SF, Miceli MC, Spencer MJ, Pyle AD. Apr 7;18(4):533-40 PMID: 26877224; PMCID: PMC4826286 (Journal cover). A Single CRISPR-Cas9 Deletion Strategy that Targets the Majority of DMD Patients Restores Dystrophin Function in hiPSC-Derived Muscle Cells. Cell Stem Cell, 2016.
  11. Capote J, Kramerova I, Martinez L, Vetrone S, Barton ER, Sweeney HL, Miceli MC, Spencer, MJ. . Osteopontin Ablation Ameliorates Muscular Dystrophy by shifting macrophages to a pro-regenerative phenotype. Journal of Cell Biology, 2016.
  12. Silva, O, Crocetti, J, Humphries, J, Burkhardt, J and M. C. Miceli (2015). . Discs Large Homolog 1 splice variants regulate p38 dependent and Independent Effector Functions in CD8+ T cells. PLOS One, 2015.
  13. Crocetti J*, Silva O*, Humphries LA, Tibbs MD, Miceli MC. *denotes equal contributions. Selective phosphorylation of the Dlg1AB variant is critical for TCR-induced p38 activation and induction of proinflammatory cytokines in CD8+ T cells. Journal of Immunology, 2014.
  14. Kendall GC*, Mokhonova E*, Moran M, Sejbuk NE, Wang DW, Silva O, Wang RT, Martinez Lu, Damoiseaux R, Spencer MJ *, Nelson SF*,† Miceli MC*,†. equal contributions.. . Dantrolene Enhances Antisense-Mediated Exon Skipping in Human and Mouse Models of Duchenne Muscular Dystrophy. Science Translational Medicine , 2012.
  15. Humphries, L.A., Shaffer, M.H., Sacirbegovic, F., Tomassian, T., McMahon, K.-A., Humbert, P.O., Silva, O., Round, J.L., Takamiya, K., Huganir, R.L., Burkhardt, J.K., Russell, S.M., Miceli, M.C. . Characterization of in vivo Dlg1 deletion on T cell development and function. PLoS ONE, 2012.
  16. Tomassian, T, Humphries, L., Lui, S.D., Silva, O. Brooks, D., Miceli, M.C. . Caveolin-1 orchestrates synaptic polarity, signal specificity and function in CD8 T cells. J Immunology , 2011.
  17. Liu S.D., Lee, S., La Cava, A., Motran, C.C., Hahn*, B.H., Miceli*, M.C. . Galectin-1-induced down-regulation of T lymphocyte activation protects (NZB x NZW) F1 mice from lupus-like disease. Lupus, 2011.
  18. Liu S.D., Lee, S., La Cava, A., Motran, C.C., Hahn*, B.H., Miceli*, M.C. . Galectin-1-induced down-regulation of T lymphocyte activation protects (NZB x NZW) F1 mice from lupus-like disease. Lupus, 2011.
  19. 27. Liu, S.D., Tomassian, T., Miceli, M.C. ., 182 (9):5283-5295, 2009. Galectin-1 tunes TCR binding and signal transduction to regulate CD8 burst size. Journal of Immunology, 2009.
  20. Vetrone, S.A., Montecino-Rodriguez, E., Kudryashova, E., Kramerova, I., Hoffman, E.P., Liu, S.D., Miceli, M.C., Spencer M.J. . Osteopontin promotes fibrosis in Mdx muscle through modulation of immune cell subsets and intramuscular TGFbeta. Journal of Clinical Investigation, 119 (6):1583-1594, 2009., 2009.
  21. Liu, S.D, Chung, C.D, Tomassian, T, Pang, M, Baum, L.G, Miceli, M.C. E. , 112 (1):120-130, 2008. Endogenous galectin-1 functions to enforce class I restricted TCR functional fate decisions in thymocytes. Blood, 2008.
  22. Motran, C. Molinder K.M., Liu S.D., Poirer, F., Miceli, M.C. . Galectin-1 functions as a Th2 cytokine that selectively induces Th1 apoptosis and promotes Th2 function. European Journal of Immunology, 2008.
  23. Round, JL, Humphries, LA, Tomassian, T, Mittelstadt, P, Zhang M, Miceli, M.C. , 8:154, 2007. Scaffold protein Dlgh1 coordinates alternative p38 kinase activation, directing T cell receptor signals toward NFAT but not NF-kB transcription factors. Nature Immunology, 2007.
  24. Zhang, M., Moran, M., Round, J., Low, T., Patel, V., Tomassian, T., Hernandez, J.D., Miceli M.C. . CD45 signals outside of lipid rafts to promote synaptic raft clustering, Erk activation and IL-2 production. Journal of Immunology, 2005.
  25. Round, J.L., Tomassian, T., Zhang, M., Patel, P., Schoenberger, S.P., Miceli, M.C. . Dlgh1 coordinates actin polymerization, synaptic TCR and lipid raft aggregation and effector function in T lymphocytes. 23. Round, J.L., Tomassian, T., Zhang, M., Patel, P., Schoenberger, S.P., Miceli, M.C. Journal of Experimental Medicine , 2005.
  26. Miceli MC, Moran M, Chung CD, Patel VP, Low T, Zinnanti W. Co-stimulation and counter-stimulation: lipid raft clustering controls TCR signaling and functional outcomes.. Seminars in immunology, 2001.
  27. Patel, V., Moran, M., Low, T., Miceli, M.C. . A molecular framework for two step T cell signaling: Lck SH3 domain mutations discriminate two distinctly regulated lipid raft reorganization events. Journal of Immunology, 2001.
  28. Tomassian, T, Humphries, L., Lui, S.D., Silva, O. Brooks, D., Miceli, M.C. . Caveolin-1 orchestrates synaptic polarity, signal specificity and function in CD8 T cells. J Immunol. Journal of Immunology, 2001.
  29. Chung, C.D., Patel, V.P., Moran, M., Lewis L.A., Miceli, M.C. . Galectin-1 induces partial beta chain phosphorylation and antagonizes processive TCR signal transduction. Journal of Immunology, 2000.
  30. Vespa, G.N.R, Kozak, K., Lewis, L., Moran, M., Ngyen J.T., Baum, L.G., Miceli, M.C. . Galectin-1 specifically modulates TCR signals to enhance TCR apoptosis, but inhibit proliferation and IL-2 production. Journal of Immunology, 1999.
  31. Vespa, G.N.R, Kozak, K., Lewis, L., Moran, M., Ngyen J.T., Baum, L.G., Miceli, M.C. Galectin-1 specifically modulates TCR signals to enhance TCR apoptosis, but inhibit proliferation and IL-2 production. . TCR-Induced IL-2 production and apoptosis have different requirements for Lck activities. Journal of Immunology, 1999.
  32. Moran, M., Miceli MC. Engagement of GPI-anchored T cell CD48 contributes to TCR signals and cytoskeletal reorganization: A role for lipid rafts in T cell activation. Immunity, 9:787-796, 1998, 1998.
  33. Chung, C.D., Lewis, L.A., Miceli, M.C. . , 159:1758-1766, 1997. TCR-Induced IL-2 production and apoptosis have different requirements for Lck activities. Journal of Immunology, 1997.
  34. Lewis, L.A., Chung, C.D., Chen, J., Parnes, J.R., Moran, M.M., Patel, V.P., Miceli, M.C. . The Lck SH2 phosphotyrosine binding site is critical for efficient TCR-induced processive tyrosine phosphorylation of the beta chain and IL-2 production. Journal of Immunology, 1997.
  35. Miceli, M.C., von Hoegen, P., Parnes, J.R. . USA, 88:2623-2627, 1991. Adhesion versus coreceptor functions of CD4 and CD8: Role of the cytoplasmic tail in coreceptor activity. Proceedings of the National Academy of Sciences,, 1991.
  36. Abraham, N., Miceli, M.C., Parnes, J.R., Veillette, A. . Enhancement of T cell responsiveness by the lymphocyte-specific tyrosine protein kinase p56lck. Nature, 1991.
  37. Miceli, MC, Finn, OJ. . T cell receptor beta chain selection in human allograft rejection. J Immunol, 142:81-88, 1989. Journal of Immunoly, 142:81-88, 1989, 1989.