Maureen An-Ping Su
Professor, MIMG, University of California Los Angeles
Professor, Pediatrics, University of California Los Angeles
MASu@mednet.ucla.edu
3108256244
As a physician scientist, Maureen A. Su, MD, cares for pediatric patients with autoimmune endocrinopathies and leads an immunology research group focused on autoimmunity, anti-cancer immunity, and sex differences in immunity. She is a Professor of Pediatrics and Microbiology Immunology and Medical Genetics (MIMG) and serves as Associate Director of the UCLA/Caltech Medical Scientist Training Program (MSTP).
Affiliations
Member, Immunity, Microbes & Molecular Pathogenesis GPB Home Area
Biography:
Maureen A. Su, MD, is a Professor of Microbiology/Immunology and Medical Genetics at University of California, Los Angeles (UCLA). Dr. Su received her combined bachelor’s and master’s degrees from Harvard College and her M.D. degree from Harvard Medical School. She completed her pediatrics residency and fellowship in endocrinology at the University of California, San Francisco (UCSF). After 8 years on faculty in the Department of Pediatrics and Microbiology/Immunology at University of North Carolina at Chapel Hill (UNC-CH), she moved to UCLA in 2018.
As a physician-scientist, her long-term goal is to understand what causes autoimmune diseases with the goal of developing therapeutics to prevent and treat the underlying immune condition. Her work has focused on understanding Autoimmune Polyendocrinopathy Syndrome (APS1), autoimmunity against the peripheral nervous system (GBS/CIDP), and Type 1 Diabetes (T1D). Using knowledge gained from studying autoimmunity, she is developing ways to harness the autoimmune response to fight off cancer. She was elected to the Council of the Society for Pediatric Research (SPR) and is a member of the American Society of Clinical Investigation (ASCI).
Awards and Honors
- GBS/CIDP Foundation, Global Medical Advisory Board, 2021-pres.
- NIH NICHD, Pediatric Scientist Development Program, 2005-2008.
- Undergraduate Research Mentor Award, UCLA, 2022.
- American Society of Clinical Investigation, Elected Member, 2019-pres.
- Phi Beta Kappa, Harvard College, 1994.
- NIH Study Section, Standing Member, 2021-2028.
- Jefferson Pilot Award, UNC Chapel Hill, 2014.
- UCSF External Advisor, Endocrine T32, 2020-pres.
- APS 1 Foundation, Medical Advisory Board, 2021-pres.
- GBS/CIDP Foundation, Benson Research Award, 2022.
- Summa Cum Laude, Harvard College, 1995.
- Yang Family Biomedical Research Award, UNC Chapel Hill, 2014.
- Vanderbilt External Advisor, Cancer Biology T32, 2020-pres.
- Doris Duke Foundation, Clinical Scientist Development Program, 2012-2015.
- Society of Pediatric Research, Elected Council Member, 2016-2019.
Publications
- Cheng MI, Li JH, Riggan L, Chen B, Tafti RY, Chin S, Ma F, Pellegrini M, Hrncir H, Arnold AP, O'Sullivan TE, Su MA. The X-linked epigenetic regulator UTX controls NK cell-intrinsic sex differences.. Nature immunology, 2023.
- Valenzise M, Foti Randazzese S, Toscano F, Lombardo F, Salzano G, Pajno C, Wasniewska M, Cascio A, Su MA. Mild COVID-19 in an APECED Patient with Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) and High Titer of Type 1 IFN-Abs: A Case Report.. Pathogens (Basel, Switzerland), 2023.
- Lizhong Ding, Lu Sun, Melissa T. Bu, Yanjun Zhang, Lauren N. Scott, Robert M. Prins, Maureen A. Su, Melissa G. Lechner, Willy Hugo . Antigen presentation by clonally diverse CXCR5+ B cells to CD4 and CD8 T cells is associated with durable response to immune checkpoint inhibitors. bioRxiv, 2023.
- Melissa G. Lechner, Zikang Zhou, Aline T. Hoang, Nicole Huang, Jessica Ortega, Lauren N. Scott, Ho-Chung Chen, Anushi Y. Patel, Rana Yakhshi-Tafti, Kristy Kim, Willy Hugo, Pouyan Famini, Alexandra Drakaki, Antoni Ribas, Trevor E. Angell, Maureen A. Su. Clonally-Expanded, Thyrotoxic Autoimmune Mediator CD8+ T cells Driven by IL21 Contribute to Checkpoint Inhibitor Thyroiditis. (2022): 2022.12.18.517398. Web. 06 Feb. 2023. bioRxiv, 2023.
- Quandt Z, Kim S, Villanueva-Meyer J, Coupe C, Young A, Kang JH, Yazdany J, Schmajuk G, Rush S, Ziv E, Perdigoto AL, Herold K, Lechner MG, Su MA, Tyrrell JB, Bluestone J, Anderson M, Masharani U. Spectrum of Clinical Presentations, Imaging Findings, and HLA Types in Immune Checkpoint Inhibitor-Induced Hypophysitis.. Journal of the Endocrine Society, 2023.
- Lechner MG, Cheng MI, Patel AY, Hoang AT, Yakobian N, Astourian M, Pioso MS, Rodriguez ED, McCarthy EC, Hugo W, Angell TE, Drakaki A, Ribas A, Su MA. Inhibition of IL-17A Protects against Thyroid Immune-Related Adverse Events while Preserving Checkpoint Inhibitor Antitumor Efficacy.. Journal of immunology (Baltimore, Md. : 1950), 2022.
- Dasgupta A, Tsay E, Federman N, Lechner MG, Su MA. Polyendocrine Autoimmunity and Diabetic Ketoacidosis Following Anti-PD-1 and Interferon α.. Pediatrics, 2022.
- Wang Y, Guo L, Yin X, McCarthy EC, Cheng MI, Hoang AT, Chen HC, Patel AY, Allard Trout D, Xu E, Yakobian N, Hugo W, Howard JF, Sheu KM, Hoffmann A, Lechner MG, Su MA. Pathogenic TNF-α drives peripheral nerve inflammation in an Aire-deficient model of autoimmunity.. Proceedings of the National Academy of Sciences of the United States of America, 2022.
- Wilkinson NM, Chen HC, Lechner MG, Su MA. Sex Differences in Immunity.. Annual review of immunology, 2022.
- Chou WC, Guo Z, Guo H, Chen L, Zhang G, Liang K, Xie L, Tan X, Gibson SA, Rampanelli E, Wang Y, Montgomery SA, Brickey WJ, Deng M, Freeman L, Zhang S, Su MA, Chen X, Wan YY, Ting JP. AIM2 in regulatory T cells restrains autoimmune diseases.. Nature, 2021.
- Kathuria-Prakash N, Mosaferi T, Xie M, Antrim L, Angell TE, In GK, Su MA, Lechner MG. COVID-19 Outcomes of Patients With Differentiated Thyroid Cancer: A Multicenter Los Angeles Cohort Study.. Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists, 2021.
- Wolbert J, Cheng MI, Meyer zu Horste G, Su MA. Deciphering immune mechanisms in chronic inflammatory demyelinating polyneuropathies.. JCI insight, 2020.
- Hwang BJ, Zhang Y, Brozowski JM, Liu Z, Burette S, Lough K, Smith CC, Shan Y, Chen J, Li N, Williams S, Su M, Googe P, Thomas NE, Liu Z. The dysfunction of BP180/collagen XVII in keratinocytes promotes melanoma progression.. Oncogene, 2019.
- Su MA, Anderson MS. Pulling RANK on Cancer: Blocking Aire-Mediated Central Tolerance to Enhance Immunotherapy.. Cancer immunology research, 2019.
- Brown MA, Su MA. An Inconvenient Variable: Sex Hormones and Their Impact on T Cell Responses.. Journal of immunology (Baltimore, Md. : 1950), 2019.
- Liu C, He H, Li X, Su MA, Cao Y. Correction: Dynamic metrics-based biomarkers to predict responders to anti-PD-1 immunotherapy.. British journal of cancer, 2019.
- Liu C, He H, Li X, Su MA, Cao Y. Dynamic metrics-based biomarkers to predict responders to anti-PD-1 immunotherapy.. British journal of cancer, 2018.
- Allard DE, Wang Y, Li JJ, Conley B, Xu EW, Sailer D, Kimpston C, Notini R, Smith CJ, Koseoglu E, Starmer J, Zeng XL, Howard JF, Hoke A, Scherer SS, Su MA. Schwann cell-derived periostin promotes autoimmune peripheral polyneuropathy via macrophage recruitment.. The Journal of clinical investigation, 2018.
- Zhang Y, Hwang BJ, Liu Z, Li N, Lough K, Williams SE, Chen J, Burette SW, Diaz LA, Su MA, Xiao S, Liu Z. BP180 dysfunction triggers spontaneous skin inflammation in mice.. Proceedings of the National Academy of Sciences of the United States of America, 2018.
- Smith CJ, Allard DE, Wang Y, Howard JF, Montgomery SA, Su MA. IL-10 Paradoxically Promotes Autoimmune Neuropathy through S1PR1-Dependent CD4+ T Cell Migration.. Journal of immunology (Baltimore, Md. : 1950), 2018.
- Bakhru P, Zhu ML, Wang HH, Hong LK, Khan I, Mouchess M, Gulati AS, Starmer J, Hou Y, Sailer D, Lee S, Zhao F, Kirkwood JM, Moschos S, Fong L, Anderson MS, Su MA. Combination central tolerance and peripheral checkpoint blockade unleashes antimelanoma immunity.. JCI insight, 2017.
- Valenzise M, Aversa T, Salzano G, Zirilli G, De Luca F, Su M. Novel insight into Chronic Inflammatory Demyelinating Polineuropathy in APECED syndrome: molecular mechanisms and clinical implications in children.. Italian journal of pediatrics, 2017.
- Thrasher BJ, Hong LK, Whitmire JK, Su MA. Epigenetic Dysfunction in Turner Syndrome Immune Cells.. Current allergy and asthma reports, 2016.
- Zhu ML, Bakhru P, Conley B, Nelson JS, Free M, Martin A, Starmer J, Wilson EM, Su MA. Sex bias in CNS autoimmune disease mediated by androgen control of autoimmune regulator.. Nature communications, 2016.
- Bakhru P, Su MA. Estrogen turns down "the AIRE".. The Journal of clinical investigation, 2016.
- Anderson MS, Su MA. AIRE expands: new roles in immune tolerance and beyond.. Nature reviews. Immunology, 2016.
- Cook KD, Shpargel KB, Starmer J, Whitfield-Larry F, Conley B, Allard DE, Rager JE, Fry RC, Davenport ML, Magnuson T, Whitmire JK, Su MA. T Follicular Helper Cell-Dependent Clearance of a Persistent Virus Infection Requires T Cell Expression of the Histone Demethylase UTX.. Immunity, 2015.
- Su MA, Anderson MS. Breaking through the central tolerance ceiling to unleash anticancer immune responses.. Oncoimmunology, 2014.
- Khan IS, Mouchess ML, Zhu ML, Conley B, Fasano KJ, Hou Y, Fong L, Su MA, Anderson MS. Enhancement of an anti-tumor immune response by transient blockade of central T cell tolerance.. The Journal of experimental medicine, 2014.
- Whitfield-Larry F, Felton J, Buse J, Su MA. Myeloid-derived suppressor cells are increased in frequency but not maximally suppressive in peripheral blood of Type 1 Diabetes Mellitus patients.. Clinical immunology (Orlando, Fla.), 2014.
- Waterfield M, Khan IS, Cortez JT, Fan U, Metzger T, Greer A, Fasano K, Martinez-Llordella M, Pollack JL, Erle DJ, Su M, Anderson MS. The transcriptional regulator Aire coopts the repressive ATF7ip-MBD1 complex for the induction of immunotolerance.. Nature immunology, 2014.
- Free ME, Su MA. Reply: To PMID 23553415.. Arthritis and rheumatism, 2013.
- Sarantopoulos S, Su MA. BAFF-ling autoantibodies.. The Journal of clinical investigation, 2013.
- Misumi I, Alirezaei M, Eam B, Su MA, Whitton JL, Whitmire JK. Differential T cell responses to residual viral antigen prolong CD4+ T cell contraction following the resolution of infection.. Journal of immunology (Baltimore, Md. : 1950), 2013.
- Free ME, Bunch DO, McGregor JA, Jones BE, Berg EA, Hogan SL, Hu Y, Preston GA, Jennette JC, Falk RJ, Su MA. Patients with antineutrophil cytoplasmic antibody-associated vasculitis have defective Treg cell function exacerbated by the presence of a suppression-resistant effector cell population.. Arthritis and rheumatism, 2013.
- Zeng XL, Nagavalli A, Smith CJ, Howard JF, Su MA. Divergent effects of T cell costimulation and inflammatory cytokine production on autoimmune peripheral neuropathy provoked by Aire deficiency.. Journal of immunology (Baltimore, Md. : 1950), 2013.
- Zhu ML, Nagavalli A, Su MA. Aire deficiency promotes TRP-1-specific immune rejection of melanoma.. Cancer research, 2013.
- Su MA, Davini D, Cheng P, Giang K, Fan U, DeVoss JJ, Johannes KP, Taylor L, Shum AK, Valenzise M, Meloni A, Bour-Jordan H, Anderson MS. Defective autoimmune regulator-dependent central tolerance to myelin protein zero is linked to autoimmune peripheral neuropathy.. Journal of immunology (Baltimore, Md. : 1950), 2012.
- Wang Y, Su MA, Wan YY. An essential role of the transcription factor GATA-3 for the function of regulatory T cells.. Immunity, 2011.
- Anderson MS, Su MA. Aire and T cell development.. Current opinion in immunology, 2010.
- Su MA, Anderson MS. Monogenic autoimmune diseases: insights into self-tolerance.. Pediatric research, 2009.
- Louvet C, Kabre BG, Davini DW, Martinier N, Su MA, DeVoss JJ, Rosenthal WL, Anderson MS, Bour-Jordan H, Bluestone JA. A novel myelin P0-specific T cell receptor transgenic mouse develops a fulminant autoimmune peripheral neuropathy.. The Journal of experimental medicine, 2009.
- Su MA, Stenerson M, Liu W, Putnam A, Conte F, Bluestone JA, Anderson MS. The role of X-linked FOXP3 in the autoimmune susceptibility of Turner Syndrome patients.. Clinical immunology (Orlando, Fla.), 2009.
- Gardner JM, Devoss JJ, Friedman RS, Wong DJ, Tan YX, Zhou X, Johannes KP, Su MA, Chang HY, Krummel MF, Anderson MS. Deletional tolerance mediated by extrathymic Aire-expressing cells.. Science (New York, N.Y.), 2008.
- Su MA, Giang K, Zumer K, Jiang H, Oven I, Rinn JL, Devoss JJ, Johannes KP, Lu W, Gardner J, Chang A, Bubulya P, Chang HY, Peterlin BM, Anderson MS. Mechanisms of an autoimmunity syndrome in mice caused by a dominant mutation in Aire.. The Journal of clinical investigation, 2008.
- Zhang L, Barker JM, Babu S, Su M, Stenerson M, Cheng M, Shum A, Zamir E, Badolato R, Law A, Eisenbarth GS, Anderson MS. A robust immunoassay for anti-interferon autoantibodies that is highly specific for patients with autoimmune polyglandular syndrome type 1.. Clinical immunology (Orlando, Fla.), 2007.
- Sipe WE, Su M, Posselt A, Kim GE, Quiros JA, Rosenthal P. Propylthiouracil-associated liver failure presenting as probable autoimmune hepatitis in a child with Graves' disease.. Pediatric transplantation, 2006.
- Su MA, Anderson MS. Aire: an update.. Current opinion in immunology, 2004.