Megan McEvoy

Megan Marie McEvoy

Professor, Institute for Society And Genetics, University of California Los Angeles

Professor, MIMG, University of California Los Angeles


  1. Hausrath AC, McEvoy MM. Structural Analyses of the Multicopper Site of CopG Support a Role as a Redox Enzyme.. Advances in experimental medicine and biology, 2023.
  2. Shafer CM, Tseng A, Allard P, McEvoy MM. Strength of Cu-efflux response in Escherichia coli coordinates metal resistance in Caenorhabditis elegans and contributes to the severity of environmental toxicity.. The Journal of biological chemistry, 2021.
  3. Gomez-Lugo JJ, Santos BD, Perez-Perez DA, Montfort-Gardeazabal JM, McEvoy MM, Zarate X. Expression and Purification of Recombinant Proteins in Escherichia coli Tagged with the Metal-Binding Proteins SmbP and CusF3H.. Methods in molecular biology (Clifton, N.J.), 2021.
  4. Hausrath AC, Ramirez NA, Ly AT, McEvoy MM. The bacterial copper resistance protein CopG contains a cysteine-bridged tetranuclear copper cluster.. The Journal of biological chemistry, 2020.
  5. Górecki K, McEvoy MM. Phylogenetic analysis reveals an ancient gene duplication as the origin of the MdtABC efflux pump.. PloS one, 2020.
  6. Bazzi W, Abou Fayad AG, Nasser A, Haraoui LP, Dewachi O, Abou-Sitta G, Nguyen VK, Abara A, Karah N, Landecker H, Knapp C, McEvoy MM, Zaman MH, Higgins PG, Matar GM. Heavy Metal Toxicity in Armed Conflicts Potentiates AMR in A. baumannii by Selecting for Antibiotic and Heavy Metal Co-resistance Mechanisms.. Frontiers in microbiology, 2020.
  7. Affandi T, McEvoy MM. Mechanism of metal ion-induced activation of a two-component sensor kinase.. The Biochemical journal, 2019.
  8. Santiago AG, Chen TY, Genova LA, Jung W, George Thompson AM, McEvoy MM, Chen P. Adaptor protein mediates dynamic pump assembly for bacterial metal efflux.. Proceedings of the National Academy of Sciences of the United States of America, 2017.
  9. Affandi T, Issaian AV, McEvoy MM. The Structure of the Periplasmic Sensor Domain of the Histidine Kinase CusS Shows Unusual Metal Ion Coordination at the Dimeric Interface.. Biochemistry, 2016.
  10. Cantu-Bustos JE, Vargas-Cortez T, Morones-Ramirez JR, Balderas-Renteria I, Galbraith DW, McEvoy MM, Zarate X. Expression and purification of recombinant proteins in Escherichia coli tagged with the metal-binding protein CusF.. Protein expression and purification, 2016.
  11. Chacón KN, Mealman TD, McEvoy MM, Blackburn NJ. Tracking metal ions through a Cu/Ag efflux pump assigns the functional roles of the periplasmic proteins.. Proceedings of the National Academy of Sciences of the United States of America, 2014.
  12. Gudipaty SA, McEvoy MM. The histidine kinase CusS senses silver ions through direct binding by its sensor domain.. Biochimica et biophysica acta, 2014.
  13. Padilla-Benavides T, George Thompson AM, McEvoy MM, Argüello JM. Mechanism of ATPase-mediated Cu+ export and delivery to periplasmic chaperones: the interaction of Escherichia coli CopA and CusF.. The Journal of biological chemistry, 2014.
  14. Jayakanthan S, Roberts SA, Weichsel A, Argüello JM, McEvoy MM. Conformations of the apo-, substrate-bound and phosphate-bound ATP-binding domain of the Cu(II) ATPase CopB illustrate coupling of domain movement to the catalytic cycle.. Bioscience reports, 2012.
  15. Mealman TD, Zhou M, Affandi T, Chacón KN, Aranguren ME, Blackburn NJ, Wysocki VH, McEvoy MM. N-terminal region of CusB is sufficient for metal binding and metal transfer with the metallochaperone CusF.. Biochemistry, 2012.
  16. Gudipaty SA, Larsen AS, Rensing C, McEvoy MM. Regulation of Cu(I)/Ag(I) efflux genes in Escherichia coli by the sensor kinase CusS.. FEMS microbiology letters, 2012.
  17. Mealman TD, Blackburn NJ, McEvoy MM. Metal export by CusCFBA, the periplasmic Cu(I)/Ag(I) transport system of Escherichia coli.. Current topics in membranes, 2012.
  18. Kim EH, Nies DH, McEvoy MM, Rensing C. Switch or funnel: how RND-type transport systems control periplasmic metal homeostasis.. Journal of bacteriology, 2011.
  19. McEvoy MM, Rensing C. Biometals 2010 (Tucson, Arizona, USA).. Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine, 2011.
  20. Mealman TD, Bagai I, Singh P, Goodlett DR, Rensing C, Zhou H, Wysocki VH, McEvoy MM. Interactions between CusF and CusB identified by NMR spectroscopy and chemical cross-linking coupled to mass spectrometry.. Biochemistry, 2011.
  21. Conroy O, Kim EH, McEvoy MM, Rensing C. Differing ability to transport nonmetal substrates by two RND-type metal exporters.. FEMS microbiology letters, 2010.
  22. Kim EH, Rensing C, McEvoy MM. Chaperone-mediated copper handling in the periplasm.. Natural product reports, 2010.
  23. Kim EH, Charpentier X, Torres-Urquidy O, McEvoy MM, Rensing C. The metal efflux island of Legionella pneumophila is not required for survival in macrophages and amoebas.. FEMS microbiology letters, 2009.
  24. Quaranta D, McEvoy MM, Rensing C. Site-directed mutagenesis identifies a molecular switch involved in copper sensing by the histidine kinase CinS in Pseudomonas putida KT2440.. Journal of bacteriology, 2009.
  25. Loftin IR, Blackburn NJ, McEvoy MM. Tryptophan Cu(I)-pi interaction fine-tunes the metal binding properties of the bacterial metallochaperone CusF.. Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry, 2009.
  26. Bagai I, Rensing C, Blackburn NJ, McEvoy MM. Direct metal transfer between periplasmic proteins identifies a bacterial copper chaperone.. Biochemistry, 2008.
  27. Loftin IR, Franke S, Blackburn NJ, McEvoy MM. Unusual Cu(I)/Ag(I) coordination of Escherichia coli CusF as revealed by atomic resolution crystallography and X-ray absorption spectroscopy.. Protein science : a publication of the Protein Society, 2007.
  28. Bagai I, Liu W, Rensing C, Blackburn NJ, McEvoy MM. Substrate-linked conformational change in the periplasmic component of a Cu(I)/Ag(I) efflux system.. The Journal of biological chemistry, 2007.
  29. Kittleson JT, Loftin IR, Hausrath AC, Engelhardt KP, Rensing C, McEvoy MM. Periplasmic metal-resistance protein CusF exhibits high affinity and specificity for both CuI and AgI.. Biochemistry, 2006.
  30. Loftin IR, Franke S, Roberts SA, Weichsel A, Héroux A, Montfort WR, Rensing C, McEvoy MM. A novel copper-binding fold for the periplasmic copper resistance protein CusF.. Biochemistry, 2005.
  31. Astashkin AV, Raitsimring AM, Walker FA, Rensing C, McEvoy MM. Characterization of the copper(II) binding site in the pink copper binding protein CusF by electron paramagnetic resonance spectroscopy.. Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry, 2005.
  32. Dyer CM, Quillin ML, Campos A, Lu J, McEvoy MM, Hausrath AC, Westbrook EM, Matsumura P, Matthews BW, Dahlquist FW. Structure of the constitutively active double mutant CheYD13K Y106W alone and in complex with a FliM peptide.. Journal of molecular biology, 2004.