Michela Ottolia

Michela Ottolia

Professor-in-Residence, Anesthesiology, University of California Los Angeles

UC Profile

Publications

  1. Xue J, Zeng W, John S, Attiq N, Ottolia M, Jiang Y. Structural mechanisms of PIP2 activation and SEA0400 inhibition in human cardiac sodium-calcium exchanger NCX1.. bioRxiv : the preprint server for biology, 2024.
  2. Maltsev AV, Barlas YZ, Hazan A, Zhang R, Ottolia M, Goldhaber JI. Dual network structure of the AV node.. ArXiv, 2024.
  3. Scranton K, John S, Angelini M, Steccanella F, Umar S, Zhang R, Goldhaber JI, Olcese R, Ottolia M. Cardiac function is regulated by the sodium-dependent inhibition of the sodium-calcium exchanger NCX1.. Nature communications, 2024.
  4. Xue J, Zeng W, Han Y, John S, Ottolia M, Jiang Y. Structural mechanisms of the human cardiac sodium-calcium exchanger NCX1.. Nature communications, 2023.
  5. Nilsson M, Lindström SH, Kaneko M, Wang K, Minguez-Viñas T, Angelini M, Steccanella F, Holder D, Ottolia M, Olcese R, Pantazis A. An epilepsy-associated KV1.2 charge-transfer-center mutation impairs KV1.2 and KV1.4 trafficking.. Proceedings of the National Academy of Sciences of the United States of America, 2022.
  6. Ottolia M, John S, Hazan A, Goldhaber JI. The Cardiac Na+ -Ca2+ Exchanger: From Structure to Function.. Comprehensive Physiology, 2021.
  7. Angelini M, Pezhouman A, Savalli N, Chang MG, Steccanella F, Scranton K, Calmettes G, Ottolia M, Pantazis A, Karagueuzian HS, Weiss JN, Olcese R. Suppression of ventricular arrhythmias by targeting late L-type Ca2+ current.. The Journal of general physiology, 2021.
  8. Lotteau S, Zhang R, Hazan A, Grabar C, Gonzalez D, Aynaszyan S, Philipson KD, Ottolia M, Goldhaber JI. Acute Genetic Ablation of Cardiac Sodium/Calcium Exchange in Adult Mice: Implications for Cardiomyocyte Calcium Regulation, Cardioprotection, and Arrhythmia.. Journal of the American Heart Association, 2021.
  9. Zyrianova T, Lopez B, Liao A, Gu C, Wong L, Ottolia M, Olcese R, Schwingshackl A. BK Channels Regulate LPS-induced CCL-2 Release from Human Pulmonary Endothelial Cells.. American journal of respiratory cell and molecular biology, 2021.
  10. Yue X, Hazan A, Lotteau S, Zhang R, Torrente AG, Philipson KD, Ottolia M, Goldhaber JI. Na/Ca exchange in the atrium: Role in sinoatrial node pacemaking and excitation-contraction coupling.. Cell calcium, 2020.
  11. Scranton K, John S, Escobar A, Goldhaber JI, Ottolia M. Modulation of the cardiac Na+-Ca2+ exchanger by cytoplasmic protons: Molecular mechanisms and physiological implications.. Cell calcium, 2019.
  12. John S, Kim B, Olcese R, Goldhaber JI, Ottolia M. Molecular determinants of pH regulation in the cardiac Na+-Ca2+ exchanger.. The Journal of general physiology, 2018.
  13. Shattock MJ, Ottolia M, Bers DM, Blaustein MP, Boguslavskyi A, Bossuyt J, Bridge JH, Chen-Izu Y, Clancy CE, Edwards A, Goldhaber J, Kaplan J, Lingrel JB, Pavlovic D, Philipson K, Sipido KR, Xie ZJ. Na+/Ca2+ exchange and Na+/K+-ATPase in the heart.. The Journal of physiology, 2015.
  14. Ottolia M, Torres N, Bridge JH, Philipson KD, Goldhaber JI. Na/Ca exchange and contraction of the heart.. Journal of molecular and cellular cardiology, 2013.
  15. John SA, Liao J, Jiang Y, Ottolia M. The cardiac Na+-Ca2+ exchanger has two cytoplasmic ion permeation pathways.. Proceedings of the National Academy of Sciences of the United States of America, 2013.
  16. Nicoll DA, Ottolia M, Goldhaber JI, Philipson KD. 20 years from NCX purification and cloning: milestones.. Advances in experimental medicine and biology, 2013.
  17. Ottolia M, Philipson KD. NCX1: mechanism of transport.. Advances in experimental medicine and biology, 2013.
  18. John SA, Ribalet B, Weiss JN, Philipson KD, Ottolia M. Ca2+-dependent structural rearrangements within Na+-Ca2+ exchanger dimers.. Proceedings of the National Academy of Sciences of the United States of America, 2011.
  19. Ottolia M, Nicoll DA, John S, Philipson KD. Interactions between Ca2+ binding domains of the Na+-Ca2+ exchanger and secondary regulation.. Channels (Austin, Tex.), 2010.
  20. Ottolia M, Nicoll DA, Philipson KD. Roles of two Ca2+-binding domains in regulation of the cardiac Na+-Ca2+ exchanger.. The Journal of biological chemistry, 2009.
  21. Chaptal V, Ottolia M, Mercado-Besserer G, Nicoll DA, Philipson KD, Abramson J. Structure and functional analysis of a Ca2+ sensor mutant of the Na+/Ca2+ exchanger.. The Journal of biological chemistry, 2009.
  22. Xie Y, Ottolia M, John SA, Chen JN, Philipson KD. Conformational changes of a Ca2+-binding domain of the Na+/Ca2+ exchanger monitored by FRET in transgenic zebrafish heart.. American journal of physiology. Cell physiology, 2008.
  23. Chaptal V, Besserer GM, Ottolia M, Nicoll DA, Cascio D, Philipson KD, Abramson J. How does regulatory Ca2+ regulate the Na+-Ca2+ exchanger?. Channels (Austin, Tex.), 2008.
  24. Yusifov T, Savalli N, Gandhi CS, Ottolia M, Olcese R. The RCK2 domain of the human BKCa channel is a calcium sensor.. Proceedings of the National Academy of Sciences of the United States of America, 2007.
  25. John SA, Ottolia M, Weiss JN, Ribalet B. Dynamic modulation of intracellular glucose imaged in single cells using a FRET-based glucose nanosensor.. Pflugers Archiv : European journal of physiology, 2007.
  26. Besserer GM, Ottolia M, Nicoll DA, Chaptal V, Cascio D, Philipson KD, Abramson J. The second Ca2+-binding domain of the Na+ Ca2+ exchanger is essential for regulation: crystal structures and mutational analysis.. Proceedings of the National Academy of Sciences of the United States of America, 2007.
  27. Ottolia M, John S, Xie Y, Ren X, Philipson KD. Shedding light on the Na+/Ca2+ exchanger.. Annals of the New York Academy of Sciences, 2007.
  28. Nicoll DA, Ren X, Ottolia M, Phillips M, Paredes AR, Abramson J, Philipson KD. What we know about the structure of NCX1 and how it relates to its function.. Annals of the New York Academy of Sciences, 2007.
  29. Ottolia M, Philipson KD, John S. Xenopus oocyte plasma membrane sheets for FRET analysis.. American journal of physiology. Cell physiology, 2006.
  30. Ottolia M, John S, Ren X, Philipson KD. Fluorescent Na+-Ca+ exchangers: electrophysiological and optical characterization.. The Journal of biological chemistry, 2006.
  31. Ottolia M, Nicoll DA, Philipson KD. Mutational analysis of the alpha-1 repeat of the cardiac Na(+)-Ca2+ exchanger.. The Journal of biological chemistry, 2004.
  32. Ottolia M, Philipson KD, John S. Conformational changes of the Ca(2+) regulatory site of the Na(+)-Ca(2+) exchanger detected by FRET.. Biophysical journal, 2004.
  33. Ottolia M, Schumann S, Nicoll DA, Philipson KD. Activation of the cardiac Na+/Ca2+ exchanger by DEPC.. Annals of the New York Academy of Sciences, 2002.
  34. Philipson KD, Nicoll DA, Ottolia M, Quednau BD, Reuter H, John S, Qiu Z. The Na+/Ca2+ exchange molecule: an overview.. Annals of the New York Academy of Sciences, 2002.
  35. Nicoll DA, Ottolia M, Philipson KD. Toward a topological model of the NCX1 exchanger.. Annals of the New York Academy of Sciences, 2002.
  36. Ottolia M, John S, Qiu Z, Philipson KD. Split Na+-Ca2+ exchangers. Implications for function and expression.. The Journal of biological chemistry, 2001.
  37. Santacruz-Toloza L, Ottolia M, Nicoll DA, Philipson KD. Functional analysis of a disulfide bond in the cardiac Na(+)-Ca(2+) exchanger.. The Journal of biological chemistry, 2000.
  38. Groh S, Marty I, Ottolia M, Prestipino G, Chapel A, Villaz M, Ronjat M. Functional interaction of the cytoplasmic domain of triadin with the skeletal ryanodine receptor.. The Journal of biological chemistry, 1999.
  39. Ottolia M, Babini E, Gazzotti P, Possani LD, Prestipino G. Reconstitution of a voltage and calcium dependent potassium channel from rat cerebellum.. Brain research, 1999.
  40. Nicoll DA, Ottolia M, Lu L, Lu Y, Philipson KD. A new topological model of the cardiac sarcolemmal Na+-Ca2+ exchanger.. The Journal of biological chemistry, 1999.
  41. Ottolia M, Platano D, Qin N, Noceti F, Birnbaumer M, Toro L, Birnbaumer L, Stefani E, Olcese R. Functional coupling between human E-type Ca2+ channels and mu opioid receptors expressed in Xenopus oocytes.. FEBS letters, 1998.
  42. Pisciotta M, Ottolia M, Possani LD, Prestipino G. A novel toxin form the scorpion Androctonus australis blocks Shaker K+ channels expressed in Xenopus oocytes.. Biochemical and biophysical research communications, 1998.
  43. Treves S, Scutari E, Robert M, Groh S, Ottolia M, Prestipino G, Ronjat M, Zorzato F. Interaction of S100A1 with the Ca2+ release channel (ryanodine receptor) of skeletal muscle.. Biochemistry, 1997.
  44. Stefani E, Ottolia M, Noceti F, Olcese R, Wallner M, Latorre R, Toro L. Voltage-controlled gating in a large conductance Ca2+-sensitive K+channel (hslo).. Proceedings of the National Academy of Sciences of the United States of America, 1997.
  45. Ottolia M, Toro L. Reconstitution in lipid bilayers of an ATP-sensitive K+ channel from pig coronary smooth muscle.. The Journal of membrane biology, 1996.
  46. Wallner M, Meera P, Ottolia M, Kaczorowski GJ, Latorre R, Garcia ML, Stefani E, Toro L. Characterization of and modulation by a beta-subunit of a human maxi KCa channel cloned from myometrium.. Receptors & channels, 1995.
  47. Ottolia M, Toro L. Potentiation of large conductance KCa channels by niflumic, flufenamic, and mefenamic acids.. Biophysical journal, 1994.
  48. Toro L, Ottolia M, Stefani E, Latorre R. Structural determinants in the interaction of Shaker inactivating peptide and a Ca(2+)-activated K+ channel.. Biochemistry, 1994.