
Nicholas C Brecha
Professor, Neurobiology, University of California Los Angeles
Professor, Medicine, University of California Los Angeles
Professor, Ophthalmology, University of California Los Angeles
73-244 CHS
Los Angeles, CA 90095
Lab Number:
310-825-6758
Research Interests
Biography
Neurochemical and Anatomical Pathways in the Vertebrate Retina that Mediate Vision Dr. Brecha’s major research interest is concerned with understanding the functional organization of the mammalian retina by elucidating its morphology and neurochemistry. Specific investigations are focused on defining the microcircuitry of the inner retina, evaluating the neurochemical organization and regulation of both its fast (amino acid) and slow (peptide) transmitter systems, and the function of bipolar, amacrine and ganglion cell populations, which are major retinal cell types that play critical roles in the processing of visual information. Recent investigations concerned with peptide-containing cell populations are defining the cellular expression patterns of tachykinin, somatostatin, neuropeptide Y and opiate receptors, and their functional role in modulating bipolar cell responsiveness. Morphological studies have shown that peptide receptor subtypes are selectively expressed by different populations of bipolar, amacrine and ganglion cells. These observations have provided important clues to the organization of the retinal microcircuits mediating different aspects of vision, as well as the sites of action of several previously identified retinal transmitter substances. A new research direction, developed over the past three years has been focused on determining the function of peptides in the retina. The rationale of these studies is to define the cellular actions of peptides found in the retina, which we hypothesize modulate cellular responsiveness, to influence ion channels and other intercellular messenger systems. Initial studies have focused on somatostatin; our findings demonstrate that this peptide inhibits both K+ and Ca2+ ion channels in the axonal terminals of bipolar cells and photoreceptors at low concentrations. Interestingly, these cells prominently express the somatostatin receptor subtype, sst2A suggesting this action is mediated through this receptor. These investigations provide further support for a role of somatostatin in the presynaptic modulation of transmitter release from retinal cells.
Publications
A selected list of publications:
- Liu Xue, Hirano Arlene A, Sun Xiaoping, Brecha Nicholas C, Barnes Steven Calcium channels in rat horizontal cells regulate feedback inhibition of photoreceptors through an unconventional GABA- and pH-sensitive mechanism The Journal of physiology, 2013; .
- Zampighi GA, Schietroma C, Zampighi LM, Woodruff M, Wright EM, Brecha NC Conical tomography of a ribbon synapse: structural evidence for vesicle fusion PLoS One, 2011; 6(3): e16944.
- Zampighi Guido A, Schietroma Cataldo, Zampighi Lorenzo M, Woodruff Michael, Wright Ernest M, Brecha Nicholas C Conical tomography of a ribbon synapse: structural evidence for vesicle fusion PloS one, 2011; 6(3): e16944.
- Hirano AA, Brandstätter JH, Morgans CW, Brecha NC SNAP25 expression in mammalian retinal horizontal cells J Comp Neurol, 2011; 519(5): 972-88.
- Hirano Arlene A, Brandstätter Johann Helmut, Morgans Catherine W, Brecha Nicholas C SNAP25 expression in mammalian retinal horizontal cells The Journal of comparative neurology, 2011; 519(5): 972-88.
- Guo C, Hirano AA, Stella SL Jr, Bitzer M, Brecha NC Guinea pig horizontal cells express GABA, the GABA-synthesizing enzyme GAD 65, and the GABA vesicular transporter J Comp Neurol, 2010; 518(10): 1674-69.
- Guo Chenying, Hirano Arlene A, Stella Salvatore L, Bitzer Michaela, Brecha Nicholas C Guinea pig horizontal cells express GABA, the GABA-synthesizing enzyme GAD 65, and the GABA vesicular transporter The Journal of comparative neurology, 2010; 518(10): 1647-69.
- Lee H, Brecha NC Immunocytochemical evidence for SNARE protein-dependent transmitter release from guinea pig horizontal cells Eur J Neurosci, 2010; 31(8): 1388-401.
- Lee Helen, Brecha Nicholas C Immunocytochemical evidence for SNARE protein-dependent transmitter release from guinea pig horizontal cells The European journal of neuroscience, 2010; 31(8): 1388-401.
- Farrell SR, Raymond ID, Foote M, Brecha NC, Barnes S Modulation of voltage-gated ion channels in rat retinal ganglion cells mediated by somatostatin receptor subtype 4 J Neurophysiol, 2010; 104(3): 1347-54.
- Raymond ID, Pool AL, Vila A, Brecha NC A Thy1-CFP DBA/2J mouse line with cyan fluorescent protein expression in retinal ganglion cells Vis Neurosci. 2009 Nov;26(5-6):453-65, 2009; 26(5-6): 453-65.
- Raymond Iona D, Pool Angela L, Vila Alejandro, Brecha Nicholas C A Thy1-CFP DBA/2J mouse line with cyan fluorescent protein expression in retinal ganglion cells Visual neuroscience, 2009; 26(5-6): 453-65.
- Stella SL Jr, Hu WD, Brecha NC Adenosine suppresses exocytosis from cone terminals of the salamander retina Neuroreport, 2009; 20(10): 923-9.
- Stella Salvatore L, Hu Wanda D, Brecha Nicholas C Adenosine suppresses exocytosis from cone terminals of the salamander retina Neuroreport, 2009; 20(10): 923-9.
- Guo Chenying, Stella Salvatore L, Hirano Arlene A, Brecha Nicholas C Plasmalemmal and vesicular gamma-aminobutyric acid transporter expression in the developing mouse retina The Journal of comparative neurology, 2009; 512(1): 6-26.
- Stella Salvatore L, Li Stefanie, Sabatini Andrea, Vila Alejandro, Brecha Nicholas C Comparison of the ontogeny of the vesicular glutamate transporter 3 (VGLUT3) with VGLUT1 and VGLUT2 in the rat retina Brain research, 2008; 1215(1): 20-9.
- Raymond Iona D, Vila Alejandro, Huynh Uyen-Chi N, Brecha Nicholas C Cyan fluorescent protein expression in ganglion and amacrine cells in a thy1-CFP transgenic mouse retina Molecular vision, 2008; 14(1): 1559-74.
- Anselmi Nicholas C, Stella Nicholas C, Brecha Nicholas C, Sternini Nicholas C Galanin inhibition of voltage-dependent Ca(2+) influx in rat cultured myenteric neurons is mediated by galanin receptor 1 Journal of neuroscience research, 2008; 512(1): 1107-14.
- Hirano Arlene A, Brandstätter Johann Helmut, Vila Alejandro, Brecha Nicholas C Robust syntaxin-4 immunoreactivity in mammalian horizontal cell processes Visual neuroscience, 2008; 24(4): 489-502.
- Stella Salvatore L, Hu Wanda D, Vila Alejandro, Brecha Nicholas C Adenosine inhibits voltage-dependent Ca2+ influx in cone photoreceptor terminals of the tiger salamander retina Journal of neuroscience research, 2007; 85(5): 1126-37.
- Wang Yuan, Luksch Harald, Brecha Nicholas C, Karten Harvey J Columnar projections from the cholinergic nucleus isthmi to the optic tectum in chicks (Gallus gallus): a possible substrate for synchronizing tectal channels The Journal of comparative neurology, 2006; 494(1): 7-35.
- Casini Giovanni, Rickman Dennis W, Brecha Nicholas C Expression of the gamma-aminobutyric acid (GABA) plasma membrane transporter-1 in monkey and human retina Investigative ophthalmology & visual science, 2006; 47(4): 1682-90.
- Chang Bo, Heckenlively John R, Bayley Philippa R, Brecha Nicholas C, Davisson Muriel T, Hawes Norm L, Hirano Arlene A, Hurd Ronald E, Ikeda Akihiro, Johnson Britt A, McCall Maureen A, Morgans Catherine W, Nusinowitz Steve, Peachey Neal S, Rice Dennis S, Vessey Kirstan A, Gregg Ronald G The nob2 mouse, a null mutation in Cacna1f: anatomical and functional abnormalities in the outer retina and their consequences on ganglion cell visual responses Visual neuroscience, 2006; 23(1): 11-24.
- Hirano Arlene A, Brandstätter Johann H, Brecha Nicholas C Cellular distribution and subcellular localization of molecular components of vesicular transmitter release in horizontal cells of rabbit retina The Journal of comparative neurology, 2005; 488(1): 70-81.
- D’Angelo I, Brecha NC. Y2 receptor expression and inhibition of voltage-dependent Ca2+ influx into rod bipolar cell terminals, Neuroscience, 2004; 125(4): 1039-49.
- Minnis JG, Patierno S, Kohlmeier SE, Brecha NC, Tonini M, Sternini C. Ligand-induced mu opioid receptor and endocytosis and recycling in enteric neurons, Neuroscience, 2003; 119(1): 33-42.
- Oh Su-Ja, D’Angelo Iona, Lee Eun-Jin, Chun Myung-Hoon, Brecha Nicholas C Distribution and synaptic connectivity of neuropeptide Y-immunoreactive amacrine cells in the rat retina The Journal of comparative neurology, 2002; 446(3): 219-34.
- Casini, G Sabatini, A Catalani, E Willems, D Bosco, L Brecha, NC Expression of the neurokinin 1 receptor in the rabbit retina Neuroscience. , 2002; 115(4): 1309-21.
- D’Angelo Iona, Oh Su-Ja, Chun Myung-Hoon, Brecha Nicholas C Localization of neuropeptide Y1 receptor immunoreactivity in the rat retina and the synaptic connectivity of Y1 immunoreactive cells The Journal of comparative neurology, 2002; 454(4): 373-82.
- Cueva Juan G, Haverkamp Silke, Reimer Richard J, Edwards Robert, Wässle Heinz, Brecha Nicholas C Vesicular gamma-aminobutyric acid transporter expression in amacrine and horizontal cells The Journal of comparative neurology, 2002; 445(3): 227-37.
- Kang, WS Lim, MY Lee, EJ Kim, IB Oh, SJ Brecha, NC Park, CB Chun, MH Light- and electron-microscopic analysis of neuropeptide Y-immunoreactive amacrine cells in the guinea pig retina Cell and tissue research. , 2001; 306(3): 363-71.
- Casini, G Brecha, NC Bosco, L Rickman, DW Developmental expression of neurokinin-1 and neurokinin-3 receptors in the rat retina The Journal of comparative neurology. , 2000; 421(2): 275-87.
- Melone, M Brecha, NC Sternini, C Evans, C Conti, F Etorphine increases the number of mu-opioid receptor-positive cells in the cerebral cortex Neuroscience. , 2000; 100(3): 439-43.
- Sternini, C Brecha, NC Minnis, J D’Agostino, G Balestra, B Fiori, E Tonini, M Role of agonist-dependent receptor internalization in the regulation of mu opioid receptors Neuroscience. , 2000; 98(2): 233-41.
- Akopian, A., Johnson, J., Gabriel, R., Brecha, N.C. and P. Witkovsky Somatostatin modulates voltage-gated K+ and Ca2+ currents in rod and cone photoreceptors of the salamander retina, Journal of Neuroscience 20:929-936, 2000; 20: 929-936.
- Johnson, J Wu, V Wong, H Walsh, JH Brecha, NC Somatostatin receptor subtype 2A expression in the rat retina Neuroscience. , 1999; 94(3): 675-83.
- Johnson, J Wong, H Walsh, JH Brecha, NC Expression of the somatostatin subtype 2A receptor in the rabbit retina The Journal of comparative neurology. , 1998; 393(1): 93-101.
- Casini, G Rickman, DW Sternini, C Brecha, NC Neurokinin 1 receptor expression in the rat retina The Journal of comparative neurology. , 1997; 389(3): 496-507.
- Johnson, J., Chen, T.K., Rickman, D.W., Evans, C., and Brecha, N.C Multiple g-aminobutyric acid plasma membrane transporters (GAT-1, GAT-2 and GAT-3) in the rat retina, Journal of Comparative Neurology, 1996; 375: 212-224.
- Rickman, DW Blanks, JC Brecha, NC Somatostatin-immunoreactive neurons in the adult rabbit retina The Journal of comparative neurology. , 1996; 365(3): 491-503.
- Brecha, N., Johnson, J., Kui, R., Anton, B., Keith Jr., D., Evans, C., and Sternini, C. Mu opioid receptor immunoreactivity is expressed in the retina and retinal-recipient nuclei, Analgesia, 1995; 1: 331-334.
- Corey, JL Davidson, N Lester, HA Brecha, N Quick, MW Protein kinase C modulates the activity of a cloned gamma-aminobutyric acid transporter expressed in Xenopus oocytes via regulated subcellular redistribution of the transporter The Journal of biological chemistry. , 1994; 269(20): 14759-67.
Publications
- Chen AM, Azar SS, Harris A, Brecha NC, Pérez de Sevilla Müller L. PTEN Expression Regulates Gap Junction Connectivity in the Retina.. Frontiers in neuroanatomy, 2021.
- Hirano AA, Vuong HE, Kornmann HL, Schietroma C, Stella SL, Barnes S, Brecha NC. Vesicular Release of GABA by Mammalian Horizontal Cells Mediates Inhibitory Output to Photoreceptors.. Frontiers in cellular neuroscience, 2020.
- Barnes S, Grove JCR, McHugh CF, Hirano AA, Brecha NC. Horizontal Cell Feedback to Cone Photoreceptors in Mammalian Retina: Novel Insights From the GABA-pH Hybrid Model.. Frontiers in cellular neuroscience, 2020.
- Veldman MB, Park CS, Eyermann CM, Zhang JY, Zuniga-Sanchez E, Hirano AA, Daigle TL, Foster NN, Zhu M, Langfelder P, Lopez IA, Brecha NC, Zipursky SL, Zeng H, Dong HW, Yang XW. Brainwide Genetic Sparse Cell Labeling to Illuminate the Morphology of Neurons and Glia with Cre-Dependent MORF Mice.. Neuron, 2020.
- Burger CA, Alevy J, Casasent AK, Jiang D, Albrecht NE, Liang JH, Hirano AA, Brecha NC, Samuel MA. LKB1 coordinates neurite remodeling to drive synapse layer emergence in the outer retina.. eLife, 2020.
- Zhang Y, Williams PR, Jacobi A, Wang C, Goel A, Hirano AA, Brecha NC, Kerschensteiner D, He Z. Elevating Growth Factor Responsiveness and Axon Regeneration by Modulating Presynaptic Inputs.. Neuron, 2019.
- Grove JCR, Hirano AA, de Los Santos J, McHugh CF, Purohit S, Field GD, Brecha NC, Barnes S. Novel hybrid action of GABA mediates inhibitory feedback in the mammalian retina.. PLoS biology, 2019.
- Hirano AA, Liu X, Brecha NC, Barnes S. Analysis of Feedback Signaling from Horizontal Cells to Photoreceptors in Mice.. Methods in molecular biology (Clifton, N.J.), 2018.
- Travis AM, Heflin SJ, Hirano AA, Brecha NC, Arshavsky VY. Dopamine-Dependent Sensitization of Rod Bipolar Cells by GABA Is Conveyed through Wide-Field Amacrine Cells.. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2017.
- P?rez de Sevilla M?ller L, Solomon A, Sheets K, Hapukino H, Rodriguez AR, Brecha NC. Multiple cell types form the VIP amacrine cell population.. The Journal of comparative neurology, 2017.
- Sun X, Hirano AA, Brecha NC, Barnes S. Calcium-activated BKCa channels govern dynamic membrane depolarizations of horizontal cells in rodent retina.. The Journal of physiology, 2017.
- P?rez de Sevilla M?ller L, Azar SS, de Los Santos J, Brecha NC. Prox1 Is a Marker for AII Amacrine Cells in the Mouse Retina.. Frontiers in neuroanatomy, 2017.
- Matynia A, Nguyen E, Sun X, Blixt FW, Parikh S, Kessler J, P?rez de Sevilla M?ller L, Habib S, Kim P, Wang ZZ, Rodriguez A, Charles A, Nusinowitz S, Edvinsson L, Barnes S, Brecha NC, Gorin MB. Peripheral Sensory Neurons Expressing Melanopsin Respond to Light.. Frontiers in neural circuits, 2016.
- Wang Y, Wang W, Liu J, Huang X, Liu R, Xia H, Brecha NC, Pu M, Gao J. Protective Effect of ALA in Crushed Optic Nerve Cat Retinal Ganglion Cells Using a New Marker RBPMS.. PloS one, 2016.
- Liu X, Grove JC, Hirano AA, Brecha NC, Barnes S. Dopamine D1 receptor modulation of calcium channel currents in horizontal cells of mouse retina.. Journal of neurophysiology, 2016.
- Hirano AA, Liu X, Boulter J, Grove J, P?rez de Sevilla M?ller L, Barnes S, Brecha NC. Targeted Deletion of Vesicular GABA Transporter from Retinal Horizontal Cells Eliminates Feedback Modulation of Photoreceptor Calcium Channels.. eNeuro, 2016.
- Vuong HE, Hardi CN, Barnes S, Brecha NC. Parallel Inhibition of Dopamine Amacrine Cells and Intrinsically Photosensitive Retinal Ganglion Cells in a Non-Image-Forming Visual Circuit of the Mouse Retina.. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2015.
- Hoon M, Sinha R, Okawa H, Suzuki SC, Hirano AA, Brecha N, Rieke F, Wong RO. Neurotransmission plays contrasting roles in the maturation of inhibitory synapses on axons and dendrites of retinal bipolar cells.. Proceedings of the National Academy of Sciences of the United States of America, 2015.
- Vuong HE, P?rez de Sevilla M?ller L, Hardi CN, McMahon DG, Brecha NC. Heterogeneous transgene expression in the retinas of the TH-RFP, TH-Cre, TH-BAC-Cre and DAT-Cre mouse lines.. Neuroscience, 2015.
- P?rez de Sevilla M?ller L, Sargoy A, Fern?ndez-S?nchez L, Rodriguez A, Liu J, Cuenca N, Brecha N. Expression and cellular localization of the voltage-gated calcium channel a2d3 in the rodent retina.. The Journal of comparative neurology, 2015.
- Anselmi L, Huynh J, Duraffourd C, Jaramillo I, Vegezzi G, Saccani F, Boschetti E, Brecha NC, De Giorgio R, Sternini C. Activation of � opioid receptors modulates inflammation in acute experimental colitis.. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society, 2015.
- Pan H, He M, Liu R, Brecha NC, Yu AC, Pu M. Sulforaphane protects rodent retinas against ischemia-reperfusion injury through the activation of the Nrf2/HO-1 antioxidant pathway.. PloS one, 2014.
- Sargoy A, Barnes S, Brecha NC, P?rez De Sevilla M?ller L. Immunohistochemical and calcium imaging methods in wholemount rat retina.. Journal of visualized experiments : JoVE, 2014.
- Duraffourd C, Kumala E, Anselmi L, Brecha NC, Sternini C. Opioid-induced mitogen-activated protein kinase signaling in rat enteric neurons following chronic morphine treatment.. PloS one, 2014.
- Fern?ndez-S?nchez L, de Sevilla M?ller LP, Brecha NC, Cuenca N. Loss of outer retinal neurons and circuitry alterations in the DBA/2J mouse.. Investigative ophthalmology & visual science, 2014.
- Rodriguez AR, de Sevilla M?ller LP, Brecha NC. The RNA binding protein RBPMS is a selective marker of ganglion cells in the mammalian retina.. The Journal of comparative neurology, 2014.
- Wilson AM, Chiodo VA, Boye SL, Brecha NC, Hauswirth WW, Di Polo A. Inhibitor of apoptosis-stimulating protein of p53 (iASPP) is required for neuronal survival after axonal injury.. PloS one, 2014.
- P?rez de Sevilla M?ller L, Sargoy A, Rodriguez AR, Brecha NC. Melanopsin ganglion cells are the most resistant retinal ganglion cell type to axonal injury in the rat retina.. PloS one, 2014.
- Sargoy A, Sun X, Barnes S, Brecha NC. Differential calcium signaling mediated by voltage-gated calcium channels in rat retinal ganglion cells and their unmyelinated axons.. PloS one, 2014.
- He M, Pan H, Chang RC, So KF, Brecha NC, Pu M. Activation of the Nrf2/HO-1 antioxidant pathway contributes to the protective effects of Lycium barbarum polysaccharides in the rodent retina after ischemia-reperfusion-induced damage.. PloS one, 2014.
- Farrell SR, Sargoy A, Brecha NC, Barnes S. Modulation of voltage-gated Ca2+ channels in rat retinal ganglion cells by gabapentin.. Visual neuroscience, 2014.
- Farrell SR, Rankin DR, Brecha NC, Barnes S. Somatostatin receptor subtype 4 modulates L-type calcium channels via G�? and PKC signaling in rat retinal ganglion cells.. Channels (Austin, Tex.), 2014.
- De Sevilla M?ller LP, Liu J, Solomon A, Rodriguez A, Brecha NC. Expression of voltage-gated calcium channel a(2)d(4) subunits in the mouse and rat retina.. The Journal of comparative neurology, 2013.
- Zhang Q, Vuong H, Huang X, Wang Y, Brecha NC, Pu M, Gao J. Melanopsin-expressing retinal ganglion cell loss and behavioral analysis in the Thy1-CFP-DBA/2J mouse model of glaucoma.. Science China. Life sciences, 2013.
- Liu X, Hirano AA, Sun X, Brecha NC, Barnes S. Calcium channels in rat horizontal cells regulate feedback inhibition of photoreceptors through an unconventional GABA- and pH-sensitive mechanism.. The Journal of physiology, 2013.
- Stella SL, Vila A, Hung AY, Rome ME, Huynh U, Sheng M, Kreienkamp HJ, Brecha NC. Association of shank 1A scaffolding protein with cone photoreceptor terminals in the mammalian retina.. PloS one, 2012.
- Hirano AA, Brandst?tter JH, Morgans CW, Brecha NC. SNAP25 expression in mammalian retinal horizontal cells.. The Journal of comparative neurology, 2011.
- Zampighi GA, Schietroma C, Zampighi LM, Woodruff M, Wright EM, Brecha NC. Conical tomography of a ribbon synapse: structural evidence for vesicle fusion.. PloS one, 2011.
- Mercer AJ, Rabl K, Riccardi GE, Brecha NC, Stella SL, Thoreson WB. Location of release sites and calcium-activated chloride channels relative to calcium channels at the photoreceptor ribbon synapse.. Journal of neurophysiology, 2010.
- Farrell SR, Raymond ID, Foote M, Brecha NC, Barnes S. Modulation of voltage-gated ion channels in rat retinal ganglion cells mediated by somatostatin receptor subtype 4.. Journal of neurophysiology, 2010.
- Guo C, Hirano AA, Stella SL, Bitzer M, Brecha NC. Guinea pig horizontal cells express GABA, the GABA-synthesizing enzyme GAD 65, and the GABA vesicular transporter.. The Journal of comparative neurology, 2010.
- Lee H, Brecha NC. Immunocytochemical evidence for SNARE protein-dependent transmitter release from guinea pig horizontal cells.. The European journal of neuroscience, 2010.
- Raymond ID, Pool AL, Vila A, Brecha NC. A Thy1-CFP DBA/2J mouse line with cyan fluorescent protein expression in retinal ganglion cells.. Visual neuroscience, 2009.
- Stella SL, Hu WD, Brecha NC. Adenosine suppresses exocytosis from cone terminals of the salamander retina.. Neuroreport, 2009.
- Anselmi L, Stella SL, Brecha NC, Sternini C. Galanin inhibition of voltage-dependent Ca(2+) influx in rat cultured myenteric neurons is mediated by galanin receptor 1.. Journal of neuroscience research, 2009.
- Guo C, Stella SL, Hirano AA, Brecha NC. Plasmalemmal and vesicular gamma-aminobutyric acid transporter expression in the developing mouse retina.. The Journal of comparative neurology, 2009.
- Raymond ID, Vila A, Huynh UC, Brecha NC. Cyan fluorescent protein expression in ganglion and amacrine cells in a thy1-CFP transgenic mouse retina.. Molecular vision, 2008.
- Stella SL, Li S, Sabatini A, Vila A, Brecha NC. Comparison of the ontogeny of the vesicular glutamate transporter 3 (VGLUT3) with VGLUT1 and VGLUT2 in the rat retina.. Brain research, 2008.
- Hirano AA, Brandstätter JH, Vila A, Brecha NC. Robust syntaxin-4 immunoreactivity in mammalian horizontal cell processes.. Visual neuroscience, 2007.
- Stella SL, Hu WD, Vila A, Brecha NC. Adenosine inhibits voltage-dependent Ca2+ influx in cone photoreceptor terminals of the tiger salamander retina.. Journal of neuroscience research, 2007.
- Casini G, Rickman DW, Brecha NC. Expression of the gamma-aminobutyric acid (GABA) plasma membrane transporter-1 in monkey and human retina.. Investigative ophthalmology & visual science, 2006.
- Wang Y, Luksch H, Brecha NC, Karten HJ. Columnar projections from the cholinergic nucleus isthmi to the optic tectum in chicks (Gallus gallus): a possible substrate for synchronizing tectal channels.. The Journal of comparative neurology, 2006.
- Chang B, Heckenlively JR, Bayley PR, Brecha NC, Davisson MT, Hawes NL, Hirano AA, Hurd RE, Ikeda A, Johnson BA, McCall MA, Morgans CW, Nusinowitz S, Peachey NS, Rice DS, Vessey KA, Gregg RG. The nob2 mouse, a null mutation in Cacna1f: anatomical and functional abnormalities in the outer retina and their consequences on ganglion cell visual responses.. Visual neuroscience, 2006.
- Hirano AA, Brandstätter JH, Brecha NC. Cellular distribution and subcellular localization of molecular components of vesicular transmitter release in horizontal cells of rabbit retina.. The Journal of comparative neurology, 2005.
- D'Angelo I, Brecha NC. Y2 receptor expression and inhibition of voltage-dependent Ca2+ influx into rod bipolar cell terminals.. Neuroscience, 2004.
- Minnis JG, Patierno S, Kohlmeier SE, Brecha NC, Tonini M, Sternini C. Ligand-induced mu opioid receptor endocytosis and recycling in enteric neurons.. Neuroscience, 2003.
- D'Angelo I, Oh SJ, Chun MH, Brecha NC. Localization of neuropeptide Y1 receptor immunoreactivity in the rat retina and the synaptic connectivity of Y1 immunoreactive cells.. The Journal of comparative neurology, 2002.
- Oh SJ, D'Angelo I, Lee EJ, Chun MH, Brecha NC. Distribution and synaptic connectivity of neuropeptide Y-immunoreactive amacrine cells in the rat retina.. The Journal of comparative neurology, 2002.
- Cueva JG, Haverkamp S, Reimer RJ, Edwards R, Wässle H, Brecha NC. Vesicular gamma-aminobutyric acid transporter expression in amacrine and horizontal cells.. The Journal of comparative neurology, 2002.
- Casini G, Sabatini A, Catalani E, Willems D, Bosco L, Brecha NC. Expression of the neurokinin 1 receptor in the rabbit retina.. Neuroscience, 2002.
- Kang WS, Lim MY, Lee EJ, Kim IB, Oh SJ, Brecha NC, Park CB, Chun MH. Light- and electron-microscopic analysis of neuropeptide Y-immunoreactive amacrine cells in the guinea pig retina.. Cell and tissue research, 2001.
- Johnson J, Caravelli ML, Brecha NC. Somatostatin inhibits calcium influx into rat rod bipolar cell axonal terminals.. Visual neuroscience, 2001.
- Johnson J, Rickman DW, Brecha NC. Somatostatin and somatostatin subtype 2A expression in the mammalian retina.. Microscopy research and technique, 2000.
- Casini G, Brecha NC, Bosco L, Rickman DW. Developmental expression of neurokinin-1 and neurokinin-3 receptors in the rat retina.. The Journal of comparative neurology, 2000.
- Melone M, Brecha NC, Sternini C, Evans C, Conti F. Etorphine increases the number of mu-opioid receptor-positive cells in the cerebral cortex.. Neuroscience, 2000.
- Sternini C, Brecha NC, Minnis J, D'Agostino G, Balestra B, Fiori E, Tonini M. Role of agonist-dependent receptor internalization in the regulation of mu opioid receptors.. Neuroscience, 2000.
- Conti F, Zuccarello LV, Barbaresi P, Minelli A, Brecha NC, Melone M. Neuronal, glial, and epithelial localization of gamma-aminobutyric acid transporter 2, a high-affinity gamma-aminobutyric acid plasma membrane transporter, in the cerebral cortex and neighboring structures.. The Journal of comparative neurology, 1999.
- McConalogue K, Grady EF, Minnis J, Balestra B, Tonini M, Brecha NC, Bunnett NW, Sternini C. Activation and internalization of the mu-opioid receptor by the newly discovered endogenous agonists, endomorphin-1 and endomorphin-2.. Neuroscience, 1999.
- Johnson J, Wu V, Wong H, Walsh JH, Brecha NC. Somatostatin receptor subtype 2A expression in the rat retina.. Neuroscience, 1999.
- Tonini M, Fiori E, Balestra B, Spelta V, D'Agostino G, Di Nucci A, Brecha NC, Sternini C. Endomorphin-1 and endomorphin-2 activate mu-opioid receptors in myenteric neurons of the guinea-pig small intestine.. Naunyn-Schmiedeberg's archives of pharmacology, 1998.
- Casini G, Rickman DW, Trasarti L, Brecha NC. Postnatal development of parvalbumin immunoreactive amacrine cells in the rabbit retina.. Brain research. Developmental brain research, 1998.
- Conti F, Melone M, De Biasi S, Minelli A, Brecha NC, Ducati A. Neuronal and glial localization of GAT-1, a high-affinity gamma-aminobutyric acid plasma membrane transporter, in human cerebral cortex: with a note on its distribution in monkey cortex.. The Journal of comparative neurology, 1998.
- De Biasi S, Vitellaro-Zuccarello L, Brecha NC. Immunoreactivity for the GABA transporter-1 and GABA transporter-3 is restricted to astrocytes in the rat thalamus. A light and electron-microscopic immunolocalization.. Neuroscience, 1998.
- Johnson J, Wong H, Walsh JH, Brecha NC. Expression of the somatostatin subtype 2A receptor in the rabbit retina.. The Journal of comparative neurology, 1998.
- Casini G, Rickman DW, Sternini C, Brecha NC. Neurokinin 1 receptor expression in the rat retina.. The Journal of comparative neurology, 1997.
- Yang CY, Brecha NC, Tsao E. Immunocytochemical localization of gamma-aminobutyric acid plasma membrane transporters in the tiger salamander retina.. The Journal of comparative neurology, 1997.
- Sternini C, Wong H, Wu SV, de Giorgio R, Yang M, Reeve J, Brecha NC, Walsh JH. Somatostatin 2A receptor is expressed by enteric neurons, and by interstitial cells of Cajal and enterochromaffin-like cells of the gastrointestinal tract.. The Journal of comparative neurology, 1997.
- Morara S, Brecha NC, Marcotti W, Provini L, Rosina A. Neuronal and glial localization of the GABA transporter GAT-1 in the cerebellar cortex.. Neuroreport, 1996.
- Johnson J, Chen TK, Rickman DW, Evans C, Brecha NC. Multiple gamma-Aminobutyric acid plasma membrane transporters (GAT-1, GAT-2, GAT-3) in the rat retina.. The Journal of comparative neurology, 1996.
- De Giorgio R, Su D, Peter D, Edwards RH, Brecha NC, Sternini C. Vesicular monoamine transporter 2 expression in enteric neurons and enterochromaffin-like cells of the rat.. Neuroscience letters, 1996.
- Ribak CE, Tong WM, Brecha NC. Astrocytic processes compensate for the apparent lack of GABA transporters in the axon terminals of cerebellar Purkinje cells.. Anatomy and embryology, 1996.
- Minelli A, DeBiasi S, Brecha NC, Zuccarello LV, Conti F. GAT-3, a high-affinity GABA plasma membrane transporter, is localized to astrocytic processes, and it is not confined to the vicinity of GABAergic synapses in the cerebral cortex.. The Journal of neuroscience : the official journal of the Society for Neuroscience, 1996.
- Sternini C, Spann M, Anton B, Keith DE, Bunnett NW, von Zastrow M, Evans C, Brecha NC. Agonist-selective endocytosis of mu opioid receptor by neurons in vivo.. Proceedings of the National Academy of Sciences of the United States of America, 1996.
- Sternini C, Su D, Arakawa J, de Giorgio R, Rickman DW, Davis BM, Albers KM, Brecha NC. Cellular localization of Pan-trk immunoreactivity and trkC mRNA in the enteric nervous system.. The Journal of comparative neurology, 1996.
- Ribak CE, Tong WM, Brecha NC. GABA plasma membrane transporters, GAT-1 and GAT-3, display different distributions in the rat hippocampus.. The Journal of comparative neurology, 1996.
- Rickman DW, Blanks JC, Brecha NC. Somatostatin-immunoreactive neurons in the adult rabbit retina.. The Journal of comparative neurology, 1996.
- Minelli A, Brecha NC, Karschin C, DeBiasi S, Conti F. GAT-1, a high-affinity GABA plasma membrane transporter, is localized to neurons and astroglia in the cerebral cortex.. The Journal of neuroscience : the official journal of the Society for Neuroscience, 1995.
- Kohan SA, Pescatori M, Brecha NC, Mastrogiacomo A, Umbach JA, Gundersen CB. Cysteine string protein immunoreactivity in the nervous system and adrenal gland of rat.. The Journal of neuroscience : the official journal of the Society for Neuroscience, 1995.
- Sottili M, Sternini C, Reinshagen M, Brecha NC, Nast CC, Walsh JH, Eysselein VE. Up-regulation of transforming growth factor alpha binding sites in experimental rabbit colitis.. Gastroenterology, 1995.
- Casini G, Rickman DW, Brecha NC. AII amacrine cell population in the rabbit retina: identification by parvalbumin immunoreactivity.. The Journal of comparative neurology, 1995.
- Rickman DW, Brecha NC. Expression of the proto-oncogene, trk, receptors in the developing rat retina.. Visual neuroscience, 1995.
- De Giorgio R, Zittel TT, Parodi JE, Becker JM, Brunicardi FC, Go VL, Brecha NC, Sternini C. Peptide immunoreactivities in the ganglionated plexuses and nerve fibers innervating the human gallbladder.. Journal of the autonomic nervous system, 1995.
- Molnar M, Casini G, Davis BM, Brecha NC, Bagnoli P. Preproenkephalin messenger RNA-containing amacrine cells in the chicken retina identified with in situ hybridization histochemistry.. Visual neuroscience, 1995.
- Conti F, Minelli A, Brecha NC. Cellular localization and laminar distribution of AMPA glutamate receptor subunits mRNAs and proteins in the rat cerebral cortex.. The Journal of comparative neurology, 1994.
- Molnar M, Casini G, Davis BM, Bagnoli P, Brecha NC. Distribution of preproenkephalin mRNA in the chicken and pigeon telencephalon.. The Journal of comparative neurology, 1994.
- Brecha NC, Weigmann C. Expression of GAT-1, a high-affinity gamma-aminobutyric acid plasma membrane transporter in the rat retina.. The Journal of comparative neurology, 1994.
- Conti F, Minelli A, Molnar M, Brecha NC. Cellular localization and laminar distribution of NMDAR1 mRNA in the rat cerebral cortex.. The Journal of comparative neurology, 1994.
- De Giorgio R, Parodi JE, Brecha NC, Brunicardi FC, Becker JM, Go VL, Sternini C. Nitric oxide producing neurons in the monkey and human digestive system.. The Journal of comparative neurology, 1994.
- Casini G, Molnar M, Brecha NC. Vasoactive intestinal polypeptide/peptide histidine isoleucine messenger RNA in the rat retina: adult distribution and developmental expression.. Neuroscience, 1994.
- De Giorgio R, Sternini C, Widdison AL, Alvarez C, Brecha NC, Reber HA, Go VL. Differential effects of experimentally induced chronic pancreatitis on neuropeptide immunoreactivities in the feline pancreas.. Pancreas, 1993.
- Zittel TT, De Giorgio R, Brecha NC, Sternini C, Raybould HE. Abdominal surgery induces c-fos expression in the nucleus of the solitary tract in the rat.. Neuroscience letters, 1993.
- Casini G, Brecha NC. Postnatal development of tyrosine hydroxylase immunoreactive amacrine cells in the rabbit retina: I. Morphological characterization.. The Journal of comparative neurology, 1992.
- Casini G, Brecha NC. Postnatal development of tyrosine hydroxylase immunoreactive amacrine cells in the rabbit retina: II. Quantitative analysis.. The Journal of comparative neurology, 1992.
- Sottili M, Sternini C, Brecha NC, Lezoche E, Walsh JH. Transforming growth factor alpha receptor binding sites in the canine gastrointestinal tract.. Gastroenterology, 1992.
- Casini G, Brecha NC. Colocalization of vasoactive intestinal polypeptide and GABA immunoreactivities in a population of wide-field amacrine cells in the rabbit retina.. Visual neuroscience, 1992.
- De Giorgio R, Sternini C, Brecha NC, Widdison AL, Karanjia ND, Reber HA, Go VL. Patterns of innervation of vasoactive intestinal polypeptide, neuropeptide Y, and gastrin-releasing peptide immunoreactive nerves in the feline pancreas.. Pancreas, 1992.
- De Giorgio R, Sternini C, Anderson K, Brecha NC, Go VL. Tissue distribution and innervation pattern of peptide immunoreactivities in the rat pancreas.. Peptides, 1992.
- Brecha NC, Sternini C, Humphrey MF. Cellular distribution of L-glutamate decarboxylase (GAD) and gamma-aminobutyric acidA (GABAA) receptor mRNAs in the retina.. Cellular and molecular neurobiology, 1991.
- Casini G, Brecha NC. Vasoactive intestinal polypeptide-containing cells in the rabbit retina: immunohistochemical localization and quantitative analysis.. The Journal of comparative neurology, 1991.
- White CA, Chalupa LM, Johnson D, Brecha NC. Somatostatin-immunoreactive cells in the adult cat retina.. The Journal of comparative neurology, 1990.
- Karten HJ, Keyser KT, Brecha NC. Biochemical and morphological heterogeneity of retinal ganglion cells.. Research publications - Association for Research in Nervous and Mental Disease, 1990.
- Brecha NC, Sternini C, Anderson K, Krause JE. Expression and cellular localization of substance P/neurokinin A and neurokinin B mRNAs in the rat retina.. Visual neuroscience, 1989.
- Kruger L, Silverman JD, Mantyh PW, Sternini C, Brecha NC. Peripheral patterns of calcitonin-gene-related peptide general somatic sensory innervation: cutaneous and deep terminations.. The Journal of comparative neurology, 1989.
- Kruger L, Mantyh PW, Sternini C, Brecha NC, Mantyh CR. Calcitonin gene-related peptide (CGRP) in the rat central nervous system: patterns of immunoreactivity and receptor binding sites.. Brain research, 1988.
- Kruger L, Sternini C, Brecha NC, Mantyh PW. Distribution of calcitonin gene-related peptide immunoreactivity in relation to the rat central somatosensory projection.. The Journal of comparative neurology, 1988.
- Goehler LE, Sternini C, Brecha NC. Calcitonin gene-related peptide immunoreactivity in the biliary pathway and liver of the guinea-pig: distribution and colocalization with substance P.. Cell and tissue research, 1988.
- Fain GL, Smolka A, Cilluffo MC, Fain MJ, Lee DA, Brecha NC, Sachs G. Monoclonal antibodies to the H+-K+ ATPase of gastric mucosa selectively stain the non-pigmented cells of the rabbit ciliary body epithelium.. Investigative ophthalmology & visual science, 1988.
- Schwaber JS, Sternini C, Brecha NC, Rogers WT, Card JP. Neurons containing calcitonin gene-related peptide in the parabrachial nucleus project to the central nucleus of the amygdala.. The Journal of comparative neurology, 1988.
- Mantyh CR, Kruger L, Brecha NC, Mantyh PW. Localization of specific binding sites for atrial natriuretic factor in the central nervous system of rat, guinea pig, cat and human.. Brain research, 1987.
- Citron MC, Erinoff L, Rickman DW, Brecha NC. Modification of electroretinograms in dopamine-depleted retinas.. Brain research, 1985.
- Clague JR, Sternini C, Brecha NC. Localization of calcitonin gene-related peptide-like immunoreactivity in neurons of the rat gastrointestinal tract.. Neuroscience letters, 1985.
- Reiner A, Davis BM, Brecha NC, Karten HJ. The distribution of enkephalinlike immunoreactivity in the telencephalon of the adult and developing domestic chicken.. The Journal of comparative neurology, 1984.
- Brecha NC, Oyster CW, Takahashi ES. Identification and characterization of tyrosine hydroxylase immunoreactive amacrine cells.. Investigative ophthalmology & visual science, 1984.
- Erichsen JT, Karten HJ, Eldred WD, Brecha NC. Localization of substance P-like and enkephalin-like immunoreactivity within preganglionic terminals of the avian ciliary ganglion: light and electron microscopy.. The Journal of neuroscience : the official journal of the Society for Neuroscience, 1982.
- Reiner A, Brecha NC, Karten HJ. Basal ganglia pathways to the tectum: the afferent and efferent connections of the lateral spiriform nucleus of pigeon.. The Journal of comparative neurology, 1982.
- Reiner A, Karten HJ, Brecha NC. Enkephalin-mediated basal ganglia influences over the optic tectum: immunohistochemistry of the tectum and the lateral spiriform nucleus in pigeon.. The Journal of comparative neurology, 1982.
- Schulman JA, Finger TE, Brecha NC, Karten HJ. Enkephalin immunoreactivity in Golgi cells and mossy fibers of mammalian, avian, amphibian and teleost cerebellum.. Neuroscience, 1981.
- Brecha NC, Karten HJ. Organization of the avian accessory optic system.. Annals of the New York Academy of Sciences, 1981.