Nicolas Massaly

Assistant Professor-in-Residence, Anesthesiology, University of California Los Angeles


  1. Markovic T, Higginbotham J, Ruyle B, Massaly N, Yoon HJ, Kuo CC, Kim JR, Yi J, Garcia JJ, Sze E, Abt J, Teich RH, Dearman JJ, McCall JG, Morón JA. A locus coeruleus to dorsal hippocampus pathway mediates cue-induced reinstatement of opioid self-administration in male and female rats.. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2024.
  2. Ibrahim KM, Massaly N, Yoon HJ, Sandoval R, Widman AJ, Heuermann RJ, Williams S, Post W, Pathiranage S, Lintz T, Zec A, Park A, Yu W, Kash TL, Gereau RW, Morón JA. Dorsal hippocampus to nucleus accumbens projections drive reinforcement via activation of accumbal dynorphin neurons.. Nature communications, 2024.
  3. Tejeda HA, Massaly N, Corder G, Cahill CM. Editorial: Broadening our conceptual understanding of endogenous opioids in systems neuroscience.. Frontiers in systems neuroscience, 2023.
  4. Higginbotham JA, Markovic T, Massaly N, Morón JA. Endogenous opioid systems alterations in pain and opioid use disorder.. Frontiers in systems neuroscience, 2022.
  5. Burek DJ, Massaly N, Yoon HJ, Doering M, Morón JA. Behavioral outcomes of complete Freund adjuvant-induced inflammatory pain in the rodent hind paw: a systematic review and meta-analysis.. Pain, 2022.
  6. Markovic T, Pedersen CE, Massaly N, Vachez YM, Ruyle B, Murphy CA, Abiraman K, Shin JH, Garcia JJ, Yoon HJ, Alvarez VA, Bruchas MR, Creed MC, Morón JA. Pain induces adaptations in ventral tegmental area dopamine neurons to drive anhedonia-like behavior.. Nature neuroscience, 2021.
  7. Burek DJ, Massaly N, Doering M, Zec A, Gaelen J, Morón JA. Long-term inflammatory pain does not impact exploratory behavior and stress coping strategies in mice.. Pain, 2021.
  8. Massaly N, Markovic T, Creed M, Al-Hasani R, Cahill CM, Moron JA. Pain, negative affective states and opioid-based analgesics: Safer pain therapies to dampen addiction.. International review of neurobiology, 2021.
  9. Massaly N, Temp J, Machelska H, Stein C. Uncovering the analgesic effects of a pH-dependent mu-opioid receptor agonist using a model of nonevoked ongoing pain.. Pain, 2020.
  10. Faouzi A, Uprety R, Gomes I, Massaly N, Keresztes AI, Le Rouzic V, Gupta A, Zhang T, Yoon HJ, Ansonoff M, Allaoa A, Pan YX, Pintar J, Morón JA, Streicher JM, Devi LA, Majumdar S. Synthesis and Pharmacology of a Novel μ-δ Opioid Receptor Heteromer-Selective Agonist Based on the Carfentanyl Template.. Journal of medicinal chemistry, 2020.
  11. Meyer J, Del Vecchio G, Seitz V, Massaly N, Stein C. Modulation of μ-opioid receptor activation by acidic pH is dependent on ligand structure and an ionizable amino acid residue.. British journal of pharmacology, 2019.
  12. Massaly N, Copits BA, Wilson-Poe AR, Hipólito L, Markovic T, Yoon HJ, Liu S, Walicki MC, Bhatti DL, Sirohi S, Klaas A, Walker BM, Neve R, Cahill CM, Shoghi KI, Gereau RW, McCall JG, Al-Hasani R, Bruchas MR, Morón JA. Pain-Induced Negative Affect Is Mediated via Recruitment of The Nucleus Accumbens Kappa Opioid System.. Neuron, 2019.
  13. Massaly N, Morón JA. Pain And Opioid Systems, Implications In The Opioid Epidemic.. Current opinion in behavioral sciences, 2018.
  14. Spahn V, Del Vecchio G, Labuz D, Rodriguez-Gaztelumendi A, Massaly N, Temp J, Durmaz V, Sabri P, Reidelbach M, Machelska H, Weber M, Stein C. A nontoxic pain killer designed by modeling of pathological receptor conformations.. Science (New York, N.Y.), 2017.
  15. Massaly N, Morón JA, Al-Hasani R. A Trigger for Opioid Misuse: Chronic Pain and Stress Dysregulate the Mesolimbic Pathway and Kappa Opioid System.. Frontiers in neuroscience, 2016.
  16. Fakira AK, Massaly N, Cohensedgh O, Berman A, Morón JA. Morphine-Associated Contextual Cues Induce Structural Plasticity in Hippocampal CA1 Pyramidal Neurons.. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2016.
  17. Massaly N, Francès B, Moulédous L. Roles of the ubiquitin proteasome system in the effects of drugs of abuse.. Frontiers in molecular neuroscience, 2015.
  18. Massaly N, Dahan L, Baudonnat M, Hovnanian C, Rekik K, Solinas M, David V, Pech S, Zajac JM, Roullet P, Mouledous L, Frances B. Involvement of protein degradation by the ubiquitin proteasome system in opiate addictive behaviors.. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2012.
  19. Duparc T, Colom A, Cani PD, Massaly N, Rastrelli S, Drougard A, Le Gonidec S, Moulédous L, Frances B, Leclercq I, Llorens-Cortes C, Pospisilik JA, Delzenne NM, Valet P, Castan-Laurell I, Knauf C. Central apelin controls glucose homeostasis via a nitric oxide-dependent pathway in mice.. Antioxidants & redox signaling, 2011.
  20. Duparc T, Naslain D, Colom A, Muccioli GG, Massaly N, Delzenne NM, Valet P, Cani PD, Knauf C. Jejunum inflammation in obese and diabetic mice impairs enteric glucose detection and modifies nitric oxide release in the hypothalamus.. Antioxidants & redox signaling, 2010.