Patricia E. Phelps
pphelps@physci.ucla.edu
(310) 825-7264
Laboratory Address:
Terasaki Life Science Building
610 Charles Young Dr.
Los Angeles, CA 90095
Lab Number:
(310) 825-8108
Work Address:
610 Charles Young Dr.
Los Angeles, CA 90095
Affiliations
Professor, Integrative Biology and Physiology
Member, Brain Research Institute, Cell & Developmental Biology GPB Home Area, Molecular, Cellular & Integrative Physiology GPB Home Area, Neuroscience GPB Home Area
Member, Brain Research Institute, Cell & Developmental Biology GPB Home Area, Molecular, Cellular & Integrative Physiology GPB Home Area, Neuroscience GPB Home Area
Research Interests
A major focus in the lab is to determine if molecules that are important for axonal outgrowth during development are also required for regeneration after spinal cord injury. Our recent studies involve transplantation of growth-promoting olfactory ensheathing glia (OEG) combined with extensive step training to promote axon regeneration following complete spinal cord transection in adult rodents. Together the repair strategies of OEG transplantation and training result in some functional recovery of hindlimb motor function and axon regeneration across the lesion site.
Publications
A selected list of publications:
- Moore K.D, Chen R., Cilluffo M., Golden J.A., Phelps P.E. Lis1 reduction causes tangential migratory errors in mouse spinal cord The Journal of Comparative Neurology, 2012; 520: 1198-211.
- Ziegler MD, Hsu D, Takeoka A, Zhong H, Ramón-Cueto A, Phelps PE, Roy RR, and Edgerton VR Further evidence of Olfactory Ensheathing Glia facilitating axonal regeneration after a complete spinal cord transection, Experimental Neurology, 2011; 229: 109-119.
- Takeoka, A., D.L. Jindrich, C. Muñoz-Quiles, H. Zhong, R. van den Brand, D.L. Pham, M.D. Ziegler, A. Ramón-Cueto, R.R. Roy, V.R. Edgerton, and P.E. Phelps Axon regeneration can facilitate or suppress hindlimb function after OEG transplantation, Journal of Neuroscience, 2011; 31: 4298-4310.
Download - Takeoka, A, Kubasak, MD, Zhong, H, Kaplan, J, Roy, RR, Phelps, PE Noradrenergic innervation of the rat spinal cord caudal to a complete spinal cord transection: Effects of olfactory ensheathing glia Experimental Neurology, 2010; 222: 59-69.
Download - Shields*, S.D., K.D. Moore*, P.E. Phelps, and A.I. Basbaum Olfactory ensheathing glia express Aquaporin 1, Journal of Comparative Neurology , 2010; 518: 4329-4341.
Download - Phelps Patricia E Reelin induces a common signal for spinal cord and cerebral cortical migration (commentary on Kruger et al.) The European Journal of Neuroscience, 2010; 32: 1609-10.
- Runyan, SA, Phelps, PE Mouse olfactory ensheathing glia enhance axon outgrowth on a myelin Experimental Neurology, 2009; 216: 95-104.
Download - Takeoka Aya, Kubasak Marc D, Zhong Hui, Roy Roland R, Phelps Patricia E Serotonergic innervation of the caudal spinal stump in rats after complete spinal transection: Effect of olfactory ensheathing glia Journal of Comparative Neurology, 2009; 515: 664-76.
Download - Akopians Alin L, Babayan Alex H, Beffert Uwe, Herz Joachim, Basbaum Allan I, Phelps Patricia E Contribution of the Reelin signaling pathways to nociceptive processing European Journal of Neuroscience, 2008; 27: 523-37.
Download - Kubasak, MD, Jindrich, DL, Zhong, H, Takeoka, A, McFarland, KC, Munoz-Quiles, C, Roy, RR, Edgerton, VR, Ramon-Cueto, A, Phelps, PE OEG implantation and step training enhance hindlimb-stepping ability in adult spinal transected rats Brain, 2008; 131: 264-76.
Download - Runyan SA, Roy RR, Zhong H, Phelps PE L1 cell adhesion molecule is not required for small-diameter primary afferent sprouting after deafferentation Neuroscience, 2007; 150: 959-69.
Download - Villeda, SA, Akopians, AL, Babayan, AH, Basbaum, AI, and Phelps, PE Absence of reelin results in altered nociception and aberrant neuronal positioning in the dorsal spinal cord, Neuroscience, 2006; 139: 1385-1396.
Download - Kubasak, MD Brooks, R Chen, S Villeda, SA Phelps, PE Developmental distribution of reelin-positive cells and their secreted product in the rodent spinal cord Journal of Comparative Neurology, 2004; 468: 165-78.
Download - Tran, TS, Cohen-Cory, S and Phelps, PE Embryonic GABAergic spinal commissural neurons project rostrally to mesencepahlic targets Journal of Comparative Neurology, 2004; 475: 327-339.
Download - Akopians, A Runyan, SA Phelps, PE Expression of L1 decreases during postnatal development of rat spinal cord Journal of Comparative Neurology, 2003; 467: 375-88.
Download - Tran, TS Alijani, A Phelps, PE Unique developmental patterns of GABAergic neurons in rat spinal cord Journal Comparative Neurology , 2003; 456(2): 112-26.
Download - Phelps, PE, Rich, R, Dupuy-Davies, S, Rios, Y, and Wong, T Evidence for a cell-specific action of Reelin in the spinal cord Developmental Biology, 2002; 244: 180-198.
Download - Orlino, EN Wong, CM Phelps, PE L1 and GAD65 are expressed on dorsal commissural axons in embryonic rat spinal cord Developmental Brain Research, 2000; 125(1-2): 117-30.
Download - Phelps, PE Alijani, A Tran, TS Ventrally located commissural neurons express the GABAergic phenotype in developing rat spinal cord Journal Comparative Neurology, 1999; 409(2): 285-98.
- Wang, X., A.H. Babayan, A.I. Basbaum and P.E. Phelps Loss of the Reelin-signaling pathway differentially disrupts heat, mechanical and chemical nociceptive processing. , Neuroscience, 2012; 226: 441-450.
- Awe, J.P., P.C. Lee, C. Ramathal, A. Vega-Crespo, J. Durruthy-Durruthy, A. Cooper, S. Karumbayaram, W. Lowry, A. Clark, J. Zack, V. Sebastiano, D. Kohn, A. Pyle, M. Martin, G.S. Lipshutz, P.E. Phelps, R. Reijo Pera and J.A. Byrne Generation and characterization of transgene-free human induced pluripotent stem cells and conversion to putative clinical-grade status, Stem Cell Research & Therapy, 2013; 4: 87.
- Abadesco, A., M. Cilluffo, G.M. Yvone, E.M. Carpenter, B.W. Howell, and P.E. Phelps Novel Disabled-1-expressing neurons identified in adult brain and spinal cord, European Journal of Neuroscience , 2014; 39: 579-592.
- Khankan, R.R., I.B. Wanner, and P.E. Phelps Olfactory ensheathing cell-neurite alignment enhances neurite outgrowth in scar-like cultures, Experimental Neurology, 2015; 269: 93-101.