Peyman Golshani
Professor-in-Residence, Neurology, University of California Los Angeles
Professor-in-Residence, Psychiatry and Biobehavioral Sciences, University of California Los Angeles
pgolshani@mednet.ucla.edu
(310) 825-2752
BOX 951769, 10833 Le Conte Ave, LA CA
Los Angeles, CA 90095
Peyman Golshani, M.D., Ph.D., holds the John Mazziotta Endowed Chair in Neurology.
Affiliations
Member, Neuroscience GPB Home Area
Biography:
Dr. Golshani obtained his MD/PhD from UC Irvine and UC Davis where he trained under the mentorship of Dr. Edward G. Jones on the development of corticothalamic synapse. He then completed his Neurology residency at UCLA and obtained postdoctoral training with Dr. Felix Schweizer and Dr. Guoping Fan where he studied the role of DNA methylation in development of cortical circuits. He then became faculty and in collaboration with Dr. Portera-Cailliau and Dr. Stelios Smirnakis studied the developmental desynchronization of internally generated activity in the cerebral cortex. His independent laboratory now investigates how cortical microcircuits in the awake behaving animal encode sensory input and how disorders such as autism and developmental epilepsies disrupt functional cortical connectivity.
Publications
- Choe KY, Bethlehem RAI, Safrin M, Dong H, Salman E, Li Y, Grinevich V, Golshani P, DeNardo LA, Pe?agarikano O, Harris NG, Geschwind DH. Oxytocin normalizes altered circuit connectivity for social rescue of the Cntnap2 knockout mouse.. Neuron, 2021.
- Samarasinghe RA, Miranda OA, Buth JE, Mitchell S, Ferando I, Watanabe M, Allison TF, Kurdian A, Fotion NN, Gandal MJ, Golshani P, Plath K, Lowry WE, Parent JM, Mody I, Novitch BG. Identification of neural oscillations and epileptiform changes in human brain organoids.. Nature neuroscience, 2021.
- Saravanapandian V, Nadkarni D, Hsu SH, Hussain SA, Maski K, Golshani P, Colwell CS, Balasubramanian S, Dixon A, Geschwind DH, Jeste SS. Abnormal sleep physiology in children with 15q11.2-13.1 duplication (Dup15q) syndrome.. Molecular autism, 2021.
- Nagai J, Bellafard A, Qu Z, Yu X, Ollivier M, Gangwani MR, Diaz-Castro B, Coppola G, Schumacher SM, Golshani P, Gradinaru V, Khakh BS. Specific and behaviorally consequential astrocyte Gq GPCR signaling attenuation in�vivo with i�ARK.. Neuron, 2021.
- Hintiryan H, Bowman I, Johnson DL, Korobkova L, Zhu M, Khanjani N, Gou L, Gao L, Yamashita S, Bienkowski MS, Garcia L, Foster NN, Benavidez NL, Song MY, Lo D, Cotter KR, Becerra M, Aquino S, Cao C, Cabeen RP, Stanis J, Fayzullina M, Ustrell SA, Boesen T, Tugangui AJ, Zhang ZG, Peng B, Fanselow MS, Golshani P, Hahn JD, Wickersham IR, Ascoli GA, Zhang LI, Dong HW. Connectivity characterization of the mouse basolateral amygdalar complex.. Nature communications, 2021.
- Latifi S, Mitchell S, Habibey R, Hosseini F, Donzis E, Estrada-S?nchez AM, Nejad HR, Levine M, Golshani P, Carmichael ST. Neuronal Network Topology Indicates Distinct Recovery Processes after Stroke.. Cerebral cortex (New York, N.Y. : 1991), 2020.
- Taxidis J, Pnevmatikakis EA, Dorian CC, Mylavarapu AL, Arora JS, Samadian KD, Hoffberg EA, Golshani P. Differential Emergence and Stability of Sensory and Temporal Representations in Context-Specific Hippocampal Sequences.. Neuron, 2020.
- Saravanapandian V, Frohlich J, Hipp JF, Hyde C, Scheffler AW, Golshani P, Cook EH, Reiter LT, Senturk D, Jeste SS. Properties of beta oscillations in Dup15q syndrome.. Journal of neurodevelopmental disorders, 2020.
- Donzis EJ, Estrada-S?nchez AM, Indersmitten T, Oikonomou K, Tran CH, Wang C, Latifi S, Golshani P, Cepeda C, Levine MS. Cortical Network Dynamics Is Altered in Mouse Models of Huntington's Disease.. Cerebral cortex (New York, N.Y. : 1991), 2020.
- Shuman T, Aharoni D, Cai DJ, Lee CR, Chavlis S, Page-Harley L, Vetere LM, Feng Y, Yang CY, Mollinedo-Gajate I, Chen L, Pennington ZT, Taxidis J, Flores SE, Cheng K, Javaherian M, Kaba CC, Rao N, La-Vu M, Pandi I, Shtrahman M, Bakhurin KI, Masmanidis SC, Khakh BS, Poirazi P, Silva AJ, Golshani P. Breakdown of spatial coding and interneuron synchronization in epileptic mice.. Nature neuroscience, 2020.
- Frohlich J, Reiter LT, Saravanapandian V, DiStefano C, Huberty S, Hyde C, Chamberlain S, Bearden CE, Golshani P, Irimia A, Olsen RW, Hipp JF, Jeste SS. Correction to: Mechanisms underlying the EEG biomarker in Dup15q syndrome.. Molecular autism, 2019.
- Sun Y, Jin S, Lin X, Chen L, Qiao X, Jiang L, Zhou P, Johnston KG, Golshani P, Nie Q, Holmes TC, Nitz DA, Xu X. CA1-projecting subiculum neurons facilitate object-place learning.. Nature neuroscience, 2019.
- G?sp?r ME, Polack PO, Golshani P, Lengyel M, Orb?n G. Representational untangling by the firing rate nonlinearity in V1 simple cells.. eLife, 2019.
- Frohlich J, Reiter LT, Saravanapandian V, DiStefano C, Huberty S, Hyde C, Chamberlain S, Bearden CE, Golshani P, Irimia A, Olsen RW, Hipp JF, Jeste SS. Mechanisms underlying the EEG biomarker in Dup15q syndrome.. Molecular autism, 2019.
- Kingsbury L, Huang S, Wang J, Gu K, Golshani P, Wu YE, Hong W. Correlated Neural Activity and Encoding of Behavior across Brains of Socially Interacting Animals.. Cell, 2019.
- Wykes RC, Khoo HM, Caciagli L, Blumenfeld H, Golshani P, Kapur J, Stern JM, Bernasconi A, Dedeurwaerdere S, Bernasconi N. WONOEP appraisal: Network concept from an imaging perspective.. Epilepsia, 2019.
- Lazaro MT, Taxidis J, Shuman T, Bachmutsky I, Ikrar T, Santos R, Marcello GM, Mylavarapu A, Chandra S, Foreman A, Goli R, Tran D, Sharma N, Azhdam M, Dong H, Choe KY, Pe?agarikano O, Masmanidis SC, R?cz B, Xu X, Geschwind DH, Golshani P. Reduced Prefrontal Synaptic Connectivity and Disturbed Oscillatory Population Dynamics in the CNTNAP2 Model of Autism.. Cell reports, 2019.
- Octeau JC, Gangwani MR, Allam SL, Tran D, Huang S, Hoang-Trong TM, Golshani P, Rumbell TH, Kozloski JR, Khakh BS. Transient, Consequential Increases in Extracellular Potassium Ions Accompany Channelrhodopsin2 Excitation.. Cell reports, 2019.
- Arac A, Zhao P, Dobkin BH, Carmichael ST, Golshani P. DeepBehavior: A Deep Learning Toolbox for Automated Analysis of Animal and Human Behavior Imaging Data.. Frontiers in systems neuroscience, 2019.
- Aharoni D, Khakh BS, Silva AJ, Golshani P. All the light that we can see: a new era in miniaturized microscopy.. Nature methods, 2019.
- Howe JR, Bear MF, Golshani P, Klann E, Lipton SA, Mucke L, Sahin M, Silva AJ. The mouse as a model for neuropsychiatric drug development.. Current biology : CB, 2018.
- Yu X, Taylor AMW, Nagai J, Golshani P, Evans CJ, Coppola G, Khakh BS. Reducing Astrocyte Calcium Signaling In�Vivo Alters Striatal Microcircuits and Causes Repetitive Behavior.. Neuron, 2018.
- Skocek O, N?bauer T, Weilguny L, Traub FM, Xia CN, Molodtsov MI, Grama A, Yamagata M, Aharoni D, Cox DD, Golshani P, Vaziri A. Author Correction: High-speed volumetric imaging of neuronal activity in freely moving rodents.. Nature methods, 2018.
- Skocek O, Nöbauer T, Weilguny L, Martínez Traub F, Xia CN, Molodtsov MI, Grama A, Yamagata M, Aharoni D, Cox DD, Golshani P, Vaziri A. High-speed volumetric imaging of neuronal activity in freely moving rodents.. Nature methods, 2018.
- Meyer JF, Golshani P, Smirnakis SM. The Effect of Single Pyramidal Neuron Firing Within Layer 2/3 and Layer 4 in Mouse V1.. Frontiers in neural circuits, 2018.
- Watanabe M, Buth JE, Vishlaghi N, de la Torre-Ubieta L, Taxidis J, Khakh BS, Coppola G, Pearson CA, Yamauchi K, Gong D, Dai X, Damoiseaux R, Aliyari R, Liebscher S, Schenke-Layland K, Caneda C, Huang EJ, Zhang Y, Cheng G, Geschwind DH, Golshani P, Sun R, Novitch BG. Self-Organized Cerebral Organoids with Human-Specific Features Predict Effective Drugs to Combat Zika Virus Infection.. Cell reports, 2017.
- Einstein MC, Polack PO, Tran DT, Golshani P. Visually Evoked 3-5 Hz Membrane Potential Oscillations Reduce the Responsiveness of Visual Cortex Neurons in Awake Behaving Mice.. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2017.
- Shuman T, Amendolara B, Golshani P. Theta Rhythmopathy as a Cause of Cognitive Disability in TLE.. Epilepsy currents, 2017.
- Frohlich J, Senturk D, Saravanapandian V, Golshani P, Reiter LT, Sankar R, Thibert RL, DiStefano C, Huberty S, Cook EH, Jeste SS. A Quantitative Electrophysiological Biomarker of Duplication 15q11.2-q13.1 Syndrome.. PloS one, 2016.
- Srinivasan R, Lu TY, Chai H, Xu J, Huang BS, Golshani P, Coppola G, Khakh BS. New Transgenic Mouse Lines for Selectively Targeting Astrocytes and Studying Calcium Signals in Astrocyte Processes In Situ and In�Vivo.. Neuron, 2016.
- Prevedel R, Verhoef AJ, Pern?a-Andrade AJ, Weisenburger S, Huang BS, N?bauer T, Fern?ndez A, Delcour JE, Golshani P, Baltuska A, Vaziri A. Fast volumetric calcium imaging across multiple cortical layers using sculpted light.. Nature methods, 2016.
- Cantero G, Liu XB, Mervis RF, Lazaro MT, Cederbaum SD, Golshani P, Lipshutz GS. Rescue of the Functional Alterations of Motor Cortical Circuits in Arginase Deficiency by Neonatal Gene Therapy.. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2016.
- Cai DJ, Aharoni D, Shuman T, Shobe J, Biane J, Song W, Wei B, Veshkini M, La-Vu M, Lou J, Flores SE, Kim I, Sano Y, Zhou M, Baumgaertel K, Lavi A, Kamata M, Tuszynski M, Mayford M, Golshani P, Silva AJ. A shared neural ensemble links distinct contextual memories encoded close in time.. Nature, 2016.
- Bakhurin KI, Mac V, Golshani P, Masmanidis SC. Temporal correlations among functionally specialized striatal neural ensembles in reward-conditioned mice.. Journal of neurophysiology, 2016.
- Gdalyahu A, Lazaro M, Penagarikano O, Golshani P, Trachtenberg JT, Geschwind DH. Correction: The Autism Related Protein Contactin-Associated Protein-Like 2 (CNTNAP2) Stabilizes New Spines: An In Vivo Mouse Study.. PloS one, 2015.
- Gdalyahu A, Lazaro M, Penagarikano O, Golshani P, Trachtenberg JT, Geschwind DH, Gescwind DH. The Autism Related Protein Contactin-Associated Protein-Like 2 (CNTNAP2) Stabilizes New Spines: An In Vivo Mouse Study.. PloS one, 2015.
- Srinivasan R, Huang BS, Venugopal S, Johnston AD, Chai H, Zeng H, Golshani P, Khakh BS. Ca(2+) signaling in astrocytes from Ip3r2(-/-) mice in brain slices and during startle responses in vivo.. Nature neuroscience, 2015.
- L?zaro MT, Golshani P. The utility of rodent models of autism spectrum disorders.. Current opinion in neurology, 2015.
- Pe?agarikano O, L?zaro MT, Lu XH, Gordon A, Dong H, Lam HA, Peles E, Maidment NT, Murphy NP, Yang XW, Golshani P, Geschwind DH. Exogenous and evoked oxytocin restores social behavior in the Cntnap2 mouse model of autism.. Science translational medicine, 2015.
- Sano Y, Shobe JL, Zhou M, Huang S, Shuman T, Cai DJ, Golshani P, Kamata M, Silva AJ. CREB regulates memory allocation in the insular cortex.. Current biology : CB, 2014.
- Varga C, Oijala M, Lish J, Szabo GG, Bezaire M, Marchionni I, Golshani P, Soltesz I. Functional fission of parvalbumin interneuron classes during fast network events.. eLife, 2014.
- Cowansage KK, Shuman T, Dillingham BC, Chang A, Golshani P, Mayford M. Direct reactivation of a coherent neocortical memory of context.. Neuron, 2014.
- Mantoan Ritter L, Golshani P, Takahashi K, Dufour S, Valiante T, Kokaia M. WONOEP appraisal: optogenetic tools to suppress seizures and explore the mechanisms of epileptogenesis.. Epilepsia, 2014.
- Garcia-Junco-Clemente P, Golshani P. PTEN: A master regulator of neuronal structure, function, and plasticity.. Communicative & integrative biology, 2014.
- Mehta SQ, Golshani P. Clinical neurogenetics: autism spectrum disorders.. Neurologic clinics, 2013.
- Garcia-Junco-Clemente P, Chow DK, Tring E, Lazaro MT, Trachtenberg JT, Golshani P. Overexpression of calcium-activated potassium channels underlies cortical dysfunction in a model of PTEN-associated autism.. Proceedings of the National Academy of Sciences of the United States of America, 2013.
- Polack PO, Friedman J, Golshani P. Cellular mechanisms of brain state-dependent gain modulation in visual cortex.. Nature neuroscience, 2013.
- Gon?alves JT, Anstey JE, Golshani P, Portera-Cailliau C. Circuit level defects in the developing neocortex of Fragile X mice.. Nature neuroscience, 2013.
- Varga C, Golshani P, Soltesz I. Frequency-invariant temporal ordering of interneuronal discharges during hippocampal oscillations in awake mice.. Proceedings of the National Academy of Sciences of the United States of America, 2012.
- Gdalyahu A, Tring E, Polack PO, Gruver R, Golshani P, Fanselow MS, Silva AJ, Trachtenberg JT. Associative fear learning enhances sparse network coding in primary sensory cortex.. Neuron, 2012.
- Pe?agarikano O, Abrahams BS, Herman EI, Winden KD, Gdalyahu A, Dong H, Sonnenblick LI, Gruver R, Almajano J, Bragin A, Golshani P, Trachtenberg JT, Peles E, Geschwind DH. Absence of CNTNAP2 leads to epilepsy, neuronal migration abnormalities, and core autism-related deficits.. Cell, 2011.
- Cheng A, Gon?alves JT, Golshani P, Arisaka K, Portera-Cailliau C. Simultaneous two-photon calcium imaging at different depths with spatiotemporal multiplexing.. Nature methods, 2011.
- Golshani P, Gonçalves JT, Khoshkhoo S, Mostany R, Smirnakis S, Portera-Cailliau C. Internally mediated developmental desynchronization of neocortical network activity.. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2009.
- Hutnick LK, Golshani P, Namihira M, Xue Z, Matynia A, Yang XW, Silva AJ, Schweizer FE, Fan G. DNA hypomethylation restricted to the murine forebrain induces cortical degeneration and impairs postnatal neuronal maturation.. Human molecular genetics, 2009.
- Ratnaparkhi A, Lawless GM, Schweizer FE, Golshani P, Jackson GR. A Drosophila model of ALS: human ALS-associated mutation in VAP33A suggests a dominant negative mechanism.. PloS one, 2008.
- Golshani P, Portera-Cailliau C. In vivo 2-photon calcium imaging in layer 2/3 of mice.. Journal of visualized experiments : JoVE, 2008.
- Golshani P, Hutnick L, Schweizer F, Fan G. Conditional Dnmt1 deletion in dorsal forebrain disrupts development of somatosensory barrel cortex and thalamocortical long-term potentiation.. Thalamus & related systems, 2005.