Philip O Scumpia

Associate Professor-in-Residence, Medicine, University of California Los Angeles

UC Profile
Scumpia Lab Website

Dr. Scumpia is an Associate Professor of Medicine at the David Geffen School of Medicine at UCLA and a clinical dermatologist and dermatopathologist at UCLA and the West LA VAMC. He is a member of the I3T Theme, the Jonnson Comprehensive Cancer Center, and the Molecular Biology Institute at UCLA. Dr. Scumpia graduated from the University of Florida College of Medicine with his M.D and completed his PhD from the University of Florida in Microbiology and Immunology. He completed residency training in Dermatology followed by Dermatopathology fellowship training at UCLA. Dr. Scumpia completed post doctoral training in the STAR program at UCLA with Stephen Smale. The Scumpia Lab investigates how the cutaneous immune system affects wound healing and/or scarring, infection, and skin cancer. A major focus is to develop immunomodulatory biomaterials for wound healing, cutaneous regeneration, vaccines, and cancer immunotherapies. Dr. Scumpia was a recipient of a Dermatology Foundation Career Development Award and an NIH K Award. The Scumpia Lab is currently funded by grants from the NIH (NIAMS R01), LEO Foundation, American Cancer Society, and VA (Merit awards).

Interests

Immunomodulatory biomaterials, tissue regeneration, immunotherapy, host defense

Education and Training

University of FloridaM.D.06/2009Medicine
University of FloridaPh.D.06/2007Microbiology and Immunology

Awards and Honors

  • AOA Research Award, Excellence in research, 2009.
  • Alpha Omega Apha, Member, 2009.

Publications

  1. Miwa H, Antao OQ, Kelly-Scumpia KM, Baghdasarian S, Mayer DP, Shang L, Sanchez GM, Archang MM, Scumpia PO, Weinstein JS, Di Carlo D. Improved Humoral Immunity and Protection against Influenza Virus Infection with a 3d Porous Biomaterial Vaccine.. Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2023.
  2. VanderWalde A, Bellasea SL, Kendra KL, Khushalani NI, Campbell KM, Scumpia PO, Kuklinski LF, Collichio F, Sosman JA, Ikeguchi A, Victor AI, Truong TG, Chmielowski B, Portnoy DC, Chen Y, Margolin K, Bane C, Dasanu CA, Johnson DB, Eroglu Z, Chandra S, Medina E, Gonzalez CR, Baselga-Carretero I, Vega-Crespo A, Garcilazo IP, Sharon E, Hu-Lieskovan S, Patel SP, Grossmann KF, Moon J, Wu MC, Ribas A. Ipilimumab with or without nivolumab in PD-1 or PD-L1 blockade refractory metastatic melanoma: a randomized phase 2 trial.. Nature medicine, 2023.
  3. Liu S, Dharanipragada P, Lomeli SH, Wang Y, Zhang X, Yang Z, Lim RJ, Dumitras C, Scumpia PO, Dubinett SM, Moriceau G, Johnson DB, Moschos SJ, Lo RS. Multi-organ landscape of therapy-resistant melanoma.. Nature medicine, 2023.
  4. Pruett LJ, Kenny HL, Swift WM, Catallo KJ, Apsel ZR, Salopek LS, Scumpia PO, Cottler PS, Griffin DR, Daniero JJ. De novo tissue formation using custom microporous annealed particle hydrogel provides long-term vocal fold augmentation.. NPJ Regenerative medicine, 2023.
  5. Moore TM, Cheng L, Wolf DM, Ngo J, Segawa M, Zhu X, Strumwasser AR, Cao Y, Clifford BL, Ma A, Scumpia P, Shirihai OS, Vallim TQA, Laakso M, Lusis AJ, Hevener AL, Zhou Z. Parkin regulates adiposity by coordinating mitophagy with mitochondrial biogenesis in white adipocytes.. Nature communications, 2022.
  6. Li J, Garfinkel J, Zhang X, Wu D, Zhang Y, de Haan K, Wang H, Liu T, Bai B, Rivenson Y, Rubinstein G, Scumpia PO, Ozcan A. Biopsy-free in vivo virtual histology of skin using deep learning.. Light, science & applications, 2021.
  7. Escuin-Ordinas H, Liu Y, Sun L, Hugo W, Dimatteo R, Huang RR, Krystofinski P, Azhdam A, Lee J, Comin-Anduix B, Cochran AJ, Lo RS, Segura T, Scumpia PO, Ribas A. Wound healing with topical BRAF inhibitor therapy in a diabetic model suggests tissue regenerative effects.. PloS one, 2021.
  8. Kim YJ, Sheu KM, Tsoi J, Abril-Rodriguez G, Medina E, Grasso CS, Torrejon DY, Champhekar AS, Litchfield K, Swanton C, Speiser DE, Scumpia PO, Hoffmann A, Graeber TG, Puig-Saus C, Ribas A. Melanoma dedifferentiation induced by IFN-γ epigenetic remodeling in response to anti-PD-1 therapy.. The Journal of clinical investigation, 2021.
  9. Vandiver AR, Thomas BJ, Karimzada M, Knowles BC, Botten GA, Spreafico R, Rotman JN, Gharavi NM, Chesnut C, Wesel K, Mangul S, Soriano T, Scumpia PO. Detection of viral gene expression in risk-stratified biopsies reveals no active HPV in cutaneous squamous cell carcinoma.. Experimental dermatology, 2021.
  10. Garcia G, Sharma A, Ramaiah A, Sen C, Purkayastha A, Kohn DB, Parcells MS, Beck S, Kim H, Bakowski MA, Kirkpatrick MG, Riva L, Wolff KC, Han B, Yuen C, Ulmert D, Purbey PK, Scumpia P, Beutler N, Rogers TF, Chatterjee AK, Gabriel G, Bartenschlager R, Gomperts B, Svendsen CN, Betz UAK, Damoiseaux RD, Arumugaswami V. Antiviral drug screen identifies DNA-damage response inhibitor as potent blocker of SARS-CoV-2 replication.. Cell reports, 2021.
  11. Hong A, Piva M, Liu S, Hugo W, Lomeli SH, Zoete V, Randolph CE, Yang Z, Wang Y, Lee JJ, Lo SJ, Sun L, Vega-Crespo A, Garcia AJ, Shackelford DB, Dubinett SM, Scumpia PO, Byrum SD, Tackett AJ, Donahue TR, Michielin O, Holmen SL, Ribas A, Moriceau G, Lo RS. Durable Suppression of Acquired MEK Inhibitor Resistance in Cancer by Sequestering MEK from ERK and Promoting Antitumor T-cell Immunity.. Cancer discovery, 2020.
  12. Griffin DR, Archang MM, Kuan CH, Weaver WM, Weinstein JS, Feng AC, Ruccia A, Sideris E, Ragkousis V, Koh J, Plikus MV, Di Carlo D, Segura T, Scumpia PO. Activating an adaptive immune response from a hydrogel scaffold imparts regenerative wound healing.. Nature materials, 2020.
  13. Zhou QD, Chi X, Lee MS, Hsieh WY, Mkrtchyan JJ, Feng AC, He C, York AG, Bui VL, Kronenberger EB, Ferrari A, Xiao X, Daly AE, Tarling EJ, Damoiseaux R, Scumpia PO, Smale ST, Williams KJ, Tontonoz P, Bensinger SJ. Interferon-mediated reprogramming of membrane cholesterol to evade bacterial toxins.. Nature immunology, 2020.
  14. Hsieh WY, Zhou QD, York AG, Williams KJ, Scumpia PO, Kronenberger EB, Hoi XP, Su B, Chi X, Bui VL, Khialeeva E, Kaplan A, Son YM, Divakaruni AS, Sun J, Smale ST, Flavell RA, Bensinger SJ. Toll-Like Receptors Induce Signal-Specific Reprogramming of the Macrophage Lipidome.. Cell metabolism, 2020.
  15. Kelly-Scumpia KM, Choi A, Shirazi R, Bersabe H, Park E, Scumpia PO, Ochoa MT, Yu J, Ma F, Pellegrini M, Modlin RL. ER Stress Regulates Immunosuppressive Function of Myeloid Derived Suppressor Cells in Leprosy that Can Be Overcome in the Presence of IFN-γ.. iScience, 2020.
  16. Zhang Z, Feng AC, Salisbury D, Liu X, Wu X, Kim J, Lapina I, Wang D, Lee B, Fraga J, Pan C, Williams KJ, Lusis AJ, Scumpia P, Sallam T. Collaborative interactions of heterogenous ribonucleoproteins contribute to transcriptional regulation of sterol metabolism in mice.. Nature communications, 2020.
  17. Koh J, Griffin DR, Archang MM, Feng AC, Horn T, Margolis M, Zalazar D, Segura T, Scumpia PO, Di Carlo D. Enhanced In Vivo Delivery of Stem Cells using Microporous Annealed Particle Scaffolds.. Small (Weinheim an der Bergstrasse, Germany), 2019.
  18. Keegan C, Krutzik S, Schenk M, Scumpia PO, Lu J, Pang YLJ, Russell BS, Lim KS, Shell S, Prestwich E, Su D, Elashoff D, Hershberg RM, Bloom BR, Belisle JT, Fortune S, Dedon PC, Pellegrini M, Modlin RL. Mycobacterium tuberculosis Transfer RNA Induces IL-12p70 via Synergistic Activation of Pattern Recognition Receptors within a Cell Network.. Journal of immunology (Baltimore, Md. : 1950), 2018.
  19. Pushkarsky I, Tseng P, Black D, France B, Warfe L, Koziol-White CJ, Jester WF, Trinh RK, Lin J, Scumpia PO, Morrison SL, Panettieri RA, Damoiseaux R, Di Carlo D. Publisher Correction: Elastomeric sensor surfaces for high-throughput single-cell force cytometry.. Nature biomedical engineering, 2018.
  20. Dreyer S, Mednik S, Truong A, Worswick S, Scumpia P, Neill D, Kannan S, Hogeling M. Skin lesions serve as clues to relapse of pediatric blastic plasmacytoid dendritic cell neoplasm.. Pediatric dermatology, 2018.
  21. Pushkarsky I, Tseng P, Black D, France B, Warfe L, Koziol-White CJ, Jester WF, Trinh RK, Lin J, Scumpia PO, Morrison SL, Panettieri RA, Damoiseaux R, Di Carlo D. Elastomeric sensor surfaces for high-throughput single-cell force cytometry.. Nature biomedical engineering, 2018.
  22. Moon H, Donahue LR, Choi E, Scumpia PO, Lowry WE, Grenier JK, Zhu J, White AC. Melanocyte Stem Cell Activation and Translocation Initiate Cutaneous Melanoma in Response to UV Exposure.. Cell stem cell, 2017.
  23. Okhovat JP, Hsiao JL, Scumpia P, Yoo KY. Levofloxacin-induced purpura annularis telangiectodes of Majocchi.. Cutis, 2017.
  24. Purbey PK, Scumpia PO, Kim PJ, Tong AJ, Iwamoto KS, McBride WH, Smale ST. Defined Sensing Mechanisms and Signaling Pathways Contribute to the Global Inflammatory Gene Expression Output Elicited by Ionizing Radiation.. Immunity, 2017.
  25. Song C, Piva M, Sun L, Hong A, Moriceau G, Kong X, Zhang H, Lomeli S, Qian J, Yu CC, Damoiseaux R, Kelley MC, Dahlman KB, Scumpia PO, Sosman JA, Johnson DB, Ribas A, Hugo W, Lo RS. Recurrent Tumor Cell-Intrinsic and -Extrinsic Alterations during MAPKi-Induced Melanoma Regression and Early Adaptation.. Cancer discovery, 2017.
  26. Madigan CA, Cambier CJ, Kelly-Scumpia KM, Scumpia PO, Cheng TY, Zailaa J, Bloom BR, Moody DB, Smale ST, Sagasti A, Modlin RL, Ramakrishnan L. A Macrophage Response to Mycobacterium leprae Phenolic Glycolipid Initiates Nerve Damage in Leprosy.. Cell, 2017.
  27. Scumpia PO, Botten GA, Norman JS, Kelly-Scumpia KM, Spreafico R, Ruccia AR, Purbey PK, Thomas BJ, Modlin RL, Smale ST. Opposing roles of Toll-like receptor and cytosolic DNA-STING signaling pathways for Staphylococcus aureus cutaneous host defense.. PLoS pathogens, 2017.
  28. Wynn JL, Wilson CS, Hawiger J, Scumpia PO, Marshall AF, Liu JH, Zharkikh I, Wong HR, Lahni P, Benjamin JT, Plosa EJ, Weitkamp JH, Sherwood ER, Moldawer LL, Ungaro R, Baker HV, Lopez MC, McElroy SJ, Colliou N, Mohamadzadeh M, Moore DJ. Targeting IL-17A attenuates neonatal sepsis mortality induced by IL-18.. Proceedings of the National Academy of Sciences of the United States of America, 2016.
  29. Twu O, Mednik S, Scumpia P, Doaty S, Worswick S. Use of Becaplermin for nondiabetic ulcers: pyoderma gangrenosum and calciphylaxis.. Dermatologic therapy, 2015.
  30. Cam C, Zhu S, Truong NF, Scumpia PO, Segura T. Systematic evaluation of natural scaffolds in cutaneous wound healing.. Journal of materials chemistry. B, 2015.
  31. Wynn JL, Scumpia PO, Stocks BT, Romano-Keeler J, Alrifai MW, Liu JH, Kim AS, Alford CE, Matta P, Weitkamp JH, Moore DJ. Neonatal CD71+ Erythroid Cells Do Not Modify Murine Sepsis Mortality.. Journal of immunology (Baltimore, Md. : 1950), 2015.
  32. Griffin DR, Weaver WM, Scumpia PO, Di Carlo D, Segura T. Accelerated wound healing by injectable microporous gel scaffolds assembled from annealed building blocks.. Nature materials, 2015.
  33. Anastasiou C, Scumpia PO, Smart C, Young LC. Papules on the face and body.. Cutis, 2015.
  34. Cuenca AG, Joiner DN, Gentile LF, Cuenca AL, Wynn JL, Kelly-Scumpia KM, Scumpia PO, Behrns KE, Efron PA, Nacionales D, Lui C, Wallet SM, Reeves WH, Mathews CE, Moldawer LL. TRIF-dependent innate immune activation is critical for survival to neonatal gram-negative sepsis.. Journal of immunology (Baltimore, Md. : 1950), 2014.
  35. Inkeles MS, Scumpia PO, Swindell WR, Lopez D, Teles RMB, Graeber TG, Meller S, Homey B, Elder JT, Gilliet M, Modlin RL, Pellegrini M. Comparison of molecular signatures from multiple skin diseases identifies mechanisms of immunopathogenesis.. The Journal of investigative dermatology, 2014.
  36. Cuenca AG, Cuenca AL, Winfield RD, Joiner DN, Gentile L, Delano MJ, Kelly-Scumpia KM, Scumpia PO, Matheny MK, Scarpace PJ, Vila L, Efron PA, LaFace DM, Moldawer LL. Novel role for tumor-induced expansion of myeloid-derived cells in cancer cachexia.. Journal of immunology (Baltimore, Md. : 1950), 2014.
  37. White AC, Khuu JK, Dang CY, Hu J, Tran KV, Liu A, Gomez S, Zhang Z, Yi R, Scumpia P, Grigorian M, Lowry WE. Stem cell quiescence acts as a tumour suppressor in squamous tumours.. Nature cell biology, 2013.
  38. Scumpia PO, Kelly-Scumpia K, Stevens BR. Alpha-lipoic acid effects on brain glial functions accompanying double-stranded RNA antiviral and inflammatory signaling.. Neurochemistry international, 2013.
  39. Weinstein JS, Delano MJ, Xu Y, Kelly-Scumpia KM, Nacionales DC, Li Y, Lee PY, Scumpia PO, Yang L, Sobel E, Moldawer LL, Reeves WH. Maintenance of anti-Sm/RNP autoantibody production by plasma cells residing in ectopic lymphoid tissue and bone marrow memory B cells.. Journal of immunology (Baltimore, Md. : 1950), 2013.
  40. Kelly-Scumpia KM, Scumpia PO, Weinstein JS, Delano MJ, Cuenca AG, Nacionales DC, Wynn JL, Lee PY, Kumagai Y, Efron PA, Akira S, Wasserfall C, Atkinson MA, Moldawer LL. B cells enhance early innate immune responses during bacterial sepsis.. The Journal of experimental medicine, 2011.
  41. Delano MJ, Kelly-Scumpia KM, Thayer TC, Winfield RD, Scumpia PO, Cuenca AG, Harrington PB, O'Malley KA, Warner E, Gabrilovich S, Mathews CE, Laface D, Heyworth PG, Ramphal R, Strieter RM, Moldawer LL, Efron PA. Neutrophil mobilization from the bone marrow during polymicrobial sepsis is dependent on CXCL12 signaling.. Journal of immunology (Baltimore, Md. : 1950), 2011.
  42. Cuenca AG, Wynn JL, Kelly-Scumpia KM, Scumpia PO, Vila L, Delano MJ, Mathews CE, Wallet SM, Reeves WH, Behrns KE, Nacionales DC, Efron PA, Kunkel SL, Moldawer LL. Critical role for CXC ligand 10/CXC receptor 3 signaling in the murine neonatal response to sepsis.. Infection and immunity, 2011.
  43. Delano MJ, Thayer T, Gabrilovich S, Kelly-Scumpia KM, Winfield RD, Scumpia PO, Cuenca AG, Warner E, Wallet SM, Wallet MA, O'Malley KA, Ramphal R, Clare-Salzer M, Efron PA, Mathews CE, Moldawer LL. Sepsis induces early alterations in innate immunity that impact mortality to secondary infection.. Journal of immunology (Baltimore, Md. : 1950), 2010.
  44. Cuenca AG, Delano MJ, Kelly-Scumpia KM, Moreno C, Scumpia PO, Laface DM, Heyworth PG, Efron PA, Moldawer LL. A paradoxical role for myeloid-derived suppressor cells in sepsis and trauma.. Molecular medicine (Cambridge, Mass.), 2010.
  45. Scumpia PO, Kelly-Scumpia KM, Delano MJ, Weinstein JS, Cuenca AG, Al-Quran S, Bovio I, Akira S, Kumagai Y, Moldawer LL. Cutting edge: bacterial infection induces hematopoietic stem and progenitor cell expansion in the absence of TLR signaling.. Journal of immunology (Baltimore, Md. : 1950), 2010.
  46. Kelly-Scumpia KM, Scumpia PO, Delano MJ, Weinstein JS, Cuenca AG, Wynn JL, Moldawer LL. Type I interferon signaling in hematopoietic cells is required for survival in mouse polymicrobial sepsis by regulating CXCL10.. The Journal of experimental medicine, 2010.
  47. Efron PA, Matsumoto T, McAuliffe PF, Scumpia P, Ungaro R, Fujita S, Moldawer LL, Foley D, Hemming AW. Major hepatectomy induces phenotypic changes in circulating dendritic cells and monocytes.. Journal of clinical immunology, 2009.
  48. Winfield RD, Delano MJ, Pande K, Scumpia PO, Laface D, Moldawer LL. Myeloid-derived suppressor cells in cancer cachexia syndrome: a new explanation for an old problem.. JPEN. Journal of parenteral and enteral nutrition, 2008.
  49. Weinstein JS, Nacionales DC, Lee PY, Kelly-Scumpia KM, Yan XJ, Scumpia PO, Vale-Cruz DS, Sobel E, Satoh M, Chiorazzi N, Reeves WH. Colocalization of antigen-specific B and T cells within ectopic lymphoid tissue following immunization with exogenous antigen.. Journal of immunology (Baltimore, Md. : 1950), 2008.
  50. Wynn JL, Scumpia PO, Winfield RD, Delano MJ, Kelly-Scumpia K, Barker T, Ungaro R, Levy O, Moldawer LL. Defective innate immunity predisposes murine neonates to poor sepsis outcome but is reversed by TLR agonists.. Blood, 2008.
  51. Lee PY, Weinstein JS, Nacionales DC, Scumpia PO, Li Y, Butfiloski E, van Rooijen N, Moldawer L, Satoh M, Reeves WH. A novel type I IFN-producing cell subset in murine lupus.. Journal of immunology (Baltimore, Md. : 1950), 2008.
  52. Caicedo RA, Li N, Des Robert C, Scumpia PO, Hubsher CP, Wasserfall CH, Schatz DA, Atkinson MA, Neu J. Neonatal formula feeding leads to immunological alterations in an animal model of type 1 diabetes.. Pediatric research, 2008.
  53. Tsujimoto H, Ono S, Efron PA, Scumpia PO, Moldawer LL, Mochizuki H. Role of Toll-like receptors in the development of sepsis.. Shock (Augusta, Ga.), 2008.
  54. Wynn JL, Scumpia PO, Delano MJ, O'Malley KA, Ungaro R, Abouhamze A, Moldawer LL. Increased mortality and altered immunity in neonatal sepsis produced by generalized peritonitis.. Shock (Augusta, Ga.), 2007.
  55. Kelly-Scumpia KM, Nacionales DC, Scumpia PO, Weinstein JS, Narain S, Moldawer LL, Satoh M, Reeves WH. In vivo adjuvant activity of the RNA component of the Sm/RNP lupus autoantigen.. Arthritis and rheumatism, 2007.
  56. Scumpia PO, Delano MJ, Kelly-Scumpia KM, Weinstein JS, Wynn JL, Winfield RD, Xia C, Chung CS, Ayala A, Atkinson MA, Reeves WH, Clare-Salzler MJ, Moldawer LL. Treatment with GITR agonistic antibody corrects adaptive immune dysfunction in sepsis.. Blood, 2007.
  57. Delano MJ, Scumpia PO, Weinstein JS, Coco D, Nagaraj S, Kelly-Scumpia KM, O'Malley KA, Wynn JL, Antonenko S, Al-Quran SZ, Swan R, Chung CS, Atkinson MA, Ramphal R, Gabrilovich DI, Reeves WH, Ayala A, Phillips J, Laface D, Heyworth PG, Clare-Salzler M, Moldawer LL. MyD88-dependent expansion of an immature GR-1(+)CD11b(+) population induces T cell suppression and Th2 polarization in sepsis.. The Journal of experimental medicine, 2007.
  58. Uchida T, Scumpia PO, Murasko DM, Seki S, Woulfe S, Clare-Salzler MJ, Moldawer LL. Variable requirement of dendritic cells for recruitment of NK and T cells to different TLR agonists.. Journal of immunology (Baltimore, Md. : 1950), 2007.
  59. Scumpia PO, Delano MJ, Kelly KM, O'Malley KA, Efron PA, McAuliffe PF, Brusko T, Ungaro R, Barker T, Wynn JL, Atkinson MA, Reeves WH, Salzler MJ, Moldawer LL. Increased natural CD4+CD25+ regulatory T cells and their suppressor activity do not contribute to mortality in murine polymicrobial sepsis.. Journal of immunology (Baltimore, Md. : 1950), 2006.
  60. Matsumoto T, O'Malley K, Efron PA, Burger C, McAuliffe PF, Scumpia PO, Uchida T, Tschoeke SK, Fujita S, Moldawer LL, Hemming AW, Foley DP. Interleukin-6 and STAT3 protect the liver from hepatic ischemia and reperfusion injury during ischemic preconditioning.. Surgery, 2006.
  61. Sethu P, Moldawer LL, Mindrinos MN, Scumpia PO, Tannahill CL, Wilhelmy J, Efron PA, Brownstein BH, Tompkins RG, Toner M. Microfluidic isolation of leukocytes from whole blood for phenotype and gene expression analysis.. Analytical chemistry, 2006.
  62. Kelly KM, Zhuang H, Nacionales DC, Scumpia PO, Lyons R, Akaogi J, Lee P, Williams B, Yamamoto M, Akira S, Satoh M, Reeves WH. "Endogenous adjuvant" activity of the RNA components of lupus autoantigens Sm/RNP and Ro 60.. Arthritis and rheumatism, 2006.
  63. McAuliffe PF, Murday ME, Efron PA, Scumpia PO, Ungaro R, Abouhamze A, Tannahill CL, Hutchins B, LaFace D, Moldawer LL. Dose-dependent improvements in outcome with adenoviral expression of interleukin-10 in a murine model of multisystem organ failure.. Gene therapy, 2006.
  64. Lee PY, Scumpia PO, Byars JA, Kelly KM, Zhuang H, Shuster JS, Theriaque DW, Segal MS, Reeves WH, Brantly ML. Short-term atorvastatin treatment enhances specific antibody production following tetanus toxoid vaccination in healthy volunteers.. Vaccine, 2006.
  65. Scumpia PO, Moldawer LL. Biology of interleukin-10 and its regulatory roles in sepsis syndromes.. Critical care medicine, 2005.
  66. Scumpia PO, Kelly KM, Reeves WH, Stevens BR. Double-stranded RNA signals antiviral and inflammatory programs and dysfunctional glutamate transport in TLR3-expressing astrocytes.. Glia, 2005.
  67. McAuliffe PF, Efron PA, Scumpia PO, Uchida T, Mutschlecner SC, Rout WR, Moldawer LL, Cendan JC. Varying blood monocyte and dendritic cell responses after laparoscopic versus open gastric bypass surgery.. Obesity surgery, 2005.
  68. Scumpia PO, McAuliffe PF, O'Malley KA, Ungaro R, Uchida T, Matsumoto T, Remick DG, Clare-Salzler MJ, Moldawer LL, Efron PA. CD11c+ dendritic cells are required for survival in murine polymicrobial sepsis.. Journal of immunology (Baltimore, Md. : 1950), 2005.
  69. Tsujimoto H, Uchida T, Efron PA, Scumpia PO, Verma A, Matsumoto T, Tschoeke SK, Ungaro RF, Ono S, Seki S, Clare-Salzler MJ, Baker HV, Mochizuki H, Ramphal R, Moldawer LL. Flagellin enhances NK cell proliferation and activation directly and through dendritic cell-NK cell interactions.. Journal of leukocyte biology, 2005.
  70. Oberholzer A, Oberholzer C, Efron PA, Scumpia PO, Uchida T, Bahjat K, Ungaro R, Tannahill CL, Murday M, Bahjat FR, Tsai V, Hutchins B, Moldawer LL, Laface D, Clare-Salzler MJ. Functional modification of dendritic cells with recombinant adenovirus encoding interleukin 10 for the treatment of sepsis.. Shock (Augusta, Ga.), 2005.
  71. Liboni KC, Li N, Scumpia PO, Neu J. Glutamine modulates LPS-induced IL-8 production through IkappaB/NF-kappaB in human fetal and adult intestinal epithelium.. The Journal of nutrition, 2005.
  72. Demarco VG, Scumpia PO, Bosanquet JP, Skimming JW. alpha-lipoic acid inhibits endotoxin-stimulated expression of iNOS and nitric oxide independent of the heat shock response in RAW 264.7 cells.. Free radical research, 2004.
  73. Scumpia PO, Sarcia PJ, Kelly KM, DeMarco VG, Skimming JW. Hypothermia induces anti-inflammatory cytokines and inhibits nitric oxide and myeloperoxidase-mediated damage in the hearts of endotoxemic rats.. Chest, 2004.
  74. Sarcia PJ, Scumpia PO, Moldawer LL, DeMarco VG, Skimming JW. Hypothermia induces interleukin-10 and attenuates injury in the lungs of endotoxemic rats.. Shock (Augusta, Ga.), 2003.
  75. Haque IU, Huang CJ, Scumpia PO, Nasiroglu O, Skimming JW. Intravascular infusion of acid promotes intrapulmonary inducible nitric oxide synthase activity and impairs blood oxygenation in rats.. Critical care medicine, 2003.
  76. Skimming JW, Nasiroglu O, Huang CJ, Wood CE, Stevens BR, Haque IU, Scumpia PO, Sarcia PJ. Dexamethasone suppresses iNOS yet induces GTPCH and CAT-2 mRNA expression in rat lungs.. American journal of physiology. Lung cellular and molecular physiology, 2003.
  77. Scumpia PO, Sarcia PJ, DeMarco VG, Stevens BR, Skimming JW. Hypothermia attenuates iNOS, CAT-1, CAT-2, and nitric oxide expression in lungs of endotoxemic rats.. American journal of physiology. Lung cellular and molecular physiology, 2002.