Quen Joshua Cheng

HS Assistant Clinical Professor, Medicine, University of California Los Angeles

UC Profile

Publications

  1. Gorin A, Harriott N, Koduvayur V, Cheng QJ, Hoffmann A. IFNγ-induced memory in human macrophages is not sustained by epigenetic changes but the durability of the cytokine itself.. bioRxiv : the preprint server for biology, 2025.
  2. Chavez C, Lin K, Malveaux A, Gorin A, Brizuela S, Cheng QJ, Hoffmann A. IRF1 cooperates with ISGF3 or GAF to form innate immune de novo enhancers in macrophages.. Science signaling, 2025.
  3. Chetrit DA, Aung T, Cheng QJ, King J. The Use of Next-Generation Sequencing to Assist in the Diagnosis of Atypical Vasculitis.. Cureus, 2024.
  4. Guerrero P, Bono C, Sobén M, Guiu A, Cheng QJ, Gil ML, Yáñez A. GM-CSF receptor expression determines opposing innate memory phenotypes at different stages of myelopoiesis.. Blood, 2024.
  5. Cheng QJ, Farrell K, Fenn J, Ma Z, Makanani SK, Siemsen J. Dectin-1 ligands produce distinct training phenotypes in human monocytes through differential activation of signaling networks.. Scientific reports, 2024.
  6. Wilder CL, Lefaudeux D, Mathenge R, Kishimoto K, Zuniga Munoz A, Nguyen MA, Meyer AS, Cheng QJ, Hoffmann A. A stimulus-contingent positive feedback loop enables IFN-β dose-dependent activation of pro-inflammatory genes.. Molecular systems biology, 2023.
  7. Kim J, Sheu KM, Cheng QJ, Hoffmann A, Enciso G. Stochastic models of nucleosome dynamics reveal regulatory rules of stimulus-induced epigenome remodeling.. Cell reports, 2022.
  8. Cheng QJ, Ohta S, Sheu KM, Spreafico R, Adelaja A, Taylor B, Hoffmann A. NF-κB dynamics determine the stimulus specificity of epigenomic reprogramming in macrophages.. Science (New York, N.Y.), 2021.
  9. Kishimoto K, Wilder CL, Buchanan J, Nguyen M, Okeke C, Hoffmann A, Cheng QJ. High Dose IFN-β Activates GAF to Enhance Expression of ISGF3 Target Genes in MLE12 Epithelial Cells.. Frontiers in immunology, 2021.
  10. Mitchell S, Mercado EL, Adelaja A, Ho JQ, Cheng QJ, Ghosh G, Hoffmann A. An NFκB Activity Calculator to Delineate Signaling Crosstalk: Type I and II Interferons Enhance NFκB via Distinct Mechanisms.. Frontiers in immunology, 2019.
  11. Humphries RM, Yang S, Kim S, Muthusamy VR, Russell D, Trout AM, Zaroda T, Cheng QJ, Aldrovandi G, Uslan DZ, Hemarajata P, Rubin ZA. Duodenoscope-Related Outbreak of a Carbapenem-Resistant Klebsiella pneumoniae Identified Using Advanced Molecular Diagnostics.. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2017.
  12. Cheng QJ, Engelage EM, Grogan TR, Currier JS, Hoffman RM. Who Provides Primary Care? An Assessment of HIV Patient and Provider Practices and Preferences.. Journal of AIDS & clinical research, 2014.
  13. Fan L, Fuss JO, Cheng QJ, Arvai AS, Hammel M, Roberts VA, Cooper PK, Tainer JA. XPD helicase structures and activities: insights into the cancer and aging phenotypes from XPD mutations.. Cell, 2008.