Rene R S Packard

Assistant Professor-in-Residence, Medicine, University of California Los Angeles

Assistant Professor-in-Residence, Physiology, University of California Los Angeles

Education and Training

UCLA College of Letters and Science and David Geffen School of MedicinePhD2016Molecular, Cellular, and Integrative Physiology
UCLA Medical Center Program, David Geffen School of Medicine, University of California, Los Angeles2016Cardiovascular Medicine, Advanced Cardiac Imaging
University Hospitals Cleveland Medical Center Program, Case Western Reserve University2011Internal Medicine
Brigham and Women’s Hospital, Harvard Medical School2009Cardiovascular Biology
University of Geneva, Faculty of MedicineMD2004Medicine

Awards and Honors

  • Tibor Fabian Research Award, UCLA, 2012-2015.
  • Lauren B. Leichtman and Arthur E. Levine Cardiovascular Discovery Fund Investigator, UCLA, 2021-2023.
  • Basic Cardiovascular Sciences Early Career Mentorship Program, American Heart Association, 2020.
  • Kenneth Brown Award, American Society of Nuclear Cardiology, 2018.
  • David Geffen School of Medicine Dean's Seed Grant, UCLA, 2022-2023.
  • 1st Place, Cardiovascular Council Young Investigator Award, Society of Nuclear Medicine and Molecular Imaging, 2019.
  • T32 Fellowship, NIH/NHLBI Cardiovascular Scientist Training Program, UCLA, 2012-2015.
  • Outstanding Research Award, Cardiology Fellowship Training Program, UCLA, 2015.
  • Outstanding Distinction in Cardiology Fellowship Award, Cardiovascular Research Foundation of Southern California, 2016.

Publications

  1. Packard RRS. Expanding the repertoire of 18F-labeled PET MPI radiotracers.. Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, 2024.
  2. Packard RRS, Votaw JR, Cooke CD, Van Train KF, Garcia EV, Maddahi J. 18F-flurpiridaz positron emission tomography segmental and territory myocardial blood flow metrics: incremental value beyond perfusion for coronary artery disease categorization.. European heart journal. Cardiovascular Imaging, 2022.
  3. Packard RRS. Cardiac fibrosis in oncologic therapies.. Current opinion in physiology, 2022.
  4. Jong J, Pinney JR, Packard RRS. Anthracycline-induced cardiotoxicity: From pathobiology to identification of molecular targets for nuclear imaging.. Frontiers in cardiovascular medicine, 2022.
  5. Chen J, Zhu AJ, Packard RRS, Vondriska TM, Chapski DJ. genomeSidekick: A user-friendly epigenomics data analysis tool.. Frontiers in bioinformatics, 2022.
  6. Ding Y, Gudapati V, Lin R, Fei Y, Packard RRS, Song S, Chang CC, Baek KI, Wang Z, Roustaei M, Kuang D, Kuo CJ, Hsiai TK. Saak Transform-Based Machine Learning for Light-Sheet Imaging of Cardiac Trabeculation.. IEEE transactions on bio-medical engineering, 2020.
  7. Packard RRS, Lazewatsky JL, Orlandi C, Maddahi J. Diagnostic Performance of PET Versus SPECT Myocardial Perfusion Imaging in Patients with Smaller Left Ventricles: A Substudy of the 18F-Flurpiridaz Phase III Clinical Trial.. Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2020.
  8. Packard RRS, Cooke CD, Van Train KF, Votaw JR, Sayre JW, Lazewatsky JL, Champagne KM, Orlandi C, Garcia EV, Maddahi J. Development, diagnostic performance, and interobserver agreement of a 18F-flurpiridaz PET automated perfusion quantitation system.. Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, 2020.
  9. Jong J, Packard RRS. 18F-FDG PET imaging of myocardial inflammation and viability following experimental infarction and anti-inflammatory treatment with compound MCC950.. Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, 2020.
  10. Khan MO, Tran JS, Zhu H, Boyd J, Packard RRS, Karlsberg RP, Kahn AM, Marsden AL. Low Wall Shear Stress Is Associated with Saphenous Vein Graft Stenosis in Patients with Coronary Artery Bypass Grafting.. Journal of cardiovascular translational research, 2020.
  11. Chen J, Packard RRS. Displacement Analysis of Myocardial Mechanical Deformation (DIAMOND) Reveals Segmental Heterogeneity of Cardiac Function in Embryonic Zebrafish.. Journal of visualized experiments : JoVE, 2020.
  12. Votaw JR, Packard RRS. Motion correction to enhance absolute myocardial blood flow quantitation by PET.. Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, 2019.
  13. Ding Y, Dvornikov AV, Ma X, Zhang H, Wang Y, Lowerison M, Packard RR, Wang L, Chen J, Zhang Y, Hsiai T, Lin X, Xu X. Haploinsufficiency of mechanistic target of rapamycin ameliorates bag3 cardiomyopathy in adult zebrafish.. Disease models & mechanisms, 2019.
  14. Chen J, Ding Y, Chen M, Gau J, Jen N, Nahal C, Tu S, Chen C, Zhou S, Chang CC, Lyu J, Xu X, Hsiai TK, Packard RRS. Displacement analysis of myocardial mechanical deformation (DIAMOND) reveals segmental susceptibility to doxorubicin-induced injury and regeneration.. JCI insight, 2019.
  15. Tuzovic M, Yang EH, Sevag Packard RR, Ganz PA, Fonarow GC, Ziaeian B. National Outcomes in Hospitalized Patients With Cancer and Comorbid Heart Failure.. Journal of cardiac failure, 2019.
  16. Packard RRS. Dipyridamole infusion protocols for absolute myocardial blood flow quantitation by PET.. Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, 2018.
  17. Erbilgin A, Seldin MM, Wu X, Mehrabian M, Zhou Z, Qi H, Dabirian KS, Sevag Packard RR, Hsieh W, Bensinger SJ, Sinha S, Lusis AJ. Transcription Factor Zhx2 Deficiency Reduces Atherosclerosis and Promotes Macrophage Apoptosis in Mice.. Arteriosclerosis, thrombosis, and vascular biology, 2018.
  18. Ding Y, Ma J, Langenbacher AD, Baek KI, Lee J, Chang CC, Hsu JJ, Kulkarni RP, Belperio J, Shi W, Ranjbarvaziri S, Ardehali R, Tintut Y, Demer LL, Chen JN, Fei P, Packard RRS, Hsiai TK. Multiscale light-sheet for rapid imaging of cardiopulmonary system.. JCI insight, 2018.
  19. Abiri A, Ding Y, Abiri P, Packard RRS, Vedula V, Marsden A, Kuo CJ, Hsiai TK. Simulating Developmental Cardiac Morphology in Virtual Reality Using a Deformable Image Registration Approach.. Annals of biomedical engineering, 2018.
  20. Lee J, Vedula V, Baek KI, Chen J, Hsu JJ, Ding Y, Chang CC, Kang H, Small A, Fei P, Chuong CM, Li R, Demer L, Packard RRS, Marsden AL, Hsiai TK. Spatial and temporal variations in hemodynamic forces initiate cardiac trabeculation.. JCI insight, 2018.
  21. Baek KI, Ding Y, Chang CC, Chang M, Sevag Packard RR, Hsu JJ, Fei P, Hsiai TK. Advanced microscopy to elucidate cardiovascular injury and regeneration: 4D light-sheet imaging.. Progress in biophysics and molecular biology, 2018.
  22. Ding Y, Lee J, Hsu JJ, Chang CC, Baek KI, Ranjbarvaziri S, Ardehali R, Packard RRS, Hsiai TK. Light-Sheet Imaging to Elucidate Cardiovascular Injury and Repair.. Current cardiology reports, 2018.
  23. Luo Y, Abiri P, Zhang S, Chang CC, Kaboodrangi AH, Li R, Sahib AK, Bui A, Kumar R, Woo M, Li Z, Packard RRS, Tai YC, Hsiai TK. Non-Invasive Electrical Impedance Tomography for Multi-Scale Detection of Liver Fat Content.. Theranostics, 2018.
  24. Packard RRS, Maddahi J. Assessment of left ventricular mass by SPECT MPI.. Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, 2017.
  25. Baek KI, Packard RRS, Hsu JJ, Saffari A, Ma Z, Luu AP, Pietersen A, Yen H, Ren B, Ding Y, Sioutas C, Li R, Hsiai TK. Ultrafine Particle Exposure Reveals the Importance of FOXO1/Notch Activation Complex for Vascular Regeneration.. Antioxidants & redox signaling, 2017.
  26. Ding Y, Abiri A, Abiri P, Li S, Chang CC, Baek KI, Hsu JJ, Sideris E, Li Y, Lee J, Segura T, Nguyen TP, Bui A, Sevag Packard RR, Fei P, Hsiai TK. Integrating light-sheet imaging with virtual reality to recapitulate developmental cardiac mechanics.. JCI insight, 2017.
  27. Votaw JR, Packard RRS. Technical aspects of acquiring and measuring myocardial blood flow: Method, technique, and QA.. Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, 2017.
  28. Packard RRS, Baek KI, Beebe T, Jen N, Ding Y, Shi F, Fei P, Kang BJ, Chen PH, Gau J, Chen M, Tang JY, Shih YH, Ding Y, Li D, Xu X, Hsiai TK. Automated Segmentation of Light-Sheet Fluorescent Imaging to Characterize Experimental Doxorubicin-Induced Cardiac Injury and Repair.. Scientific reports, 2017.
  29. Abiri P, Abiri A, Packard RRS, Ding Y, Yousefi A, Ma J, Bersohn M, Nguyen KL, Markovic D, Moloudi S, Hsiai TK. Inductively powered wireless pacing via a miniature pacemaker and remote stimulation control system.. Scientific reports, 2017.
  30. Packard RRS, Luo Y, Abiri P, Jen N, Aksoy O, Suh WM, Tai YC, Hsiai TK. 3-D Electrochemical Impedance Spectroscopy Mapping of Arteries to Detect Metabolically Active but Angiographically Invisible Atherosclerotic Lesions.. Theranostics, 2017.
  31. Maddahi J, Packard RRS. PET should replace SPECT in cardiac imaging for diagnosis and risk assessment of patients with known or suspected CAD: Pro.. Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, 2017.
  32. Packard RRS, Maddahi J. Regadenoson-induced hyperemia for absolute myocardial blood flow quantitation by 13N-ammonia PET and detection of cardiac allograft vasculopathy.. Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, 2017.
  33. Sevag Packard RR, Karlsberg RP. Integrating FFRCT Into Routine Clinical Practice: A Solid PLATFORM or Slippery Slope?. Journal of the American College of Cardiology, 2016.
  34. Lee J, Fei P, Sevag Packard RR, Kang H, Xu H, Baek KI, Jen N, Chen J, Yen H, Kuo CC, Chi NC, Ho CM, Li R, Hsiai TK. 4-Dimensional light-sheet microscopy to elucidate shear stress modulation of cardiac trabeculation.. The Journal of clinical investigation, 2016.
  35. Packard RR, Li D, Budoff MJ, Karlsberg RP. Fractional flow reserve by computerized tomography and subsequent coronary revascularization.. European heart journal. Cardiovascular Imaging, 2016.
  36. Ma J, Luo Y, Sevag Packard RR, Ma T, Ding Y, Abiri P, Tai YC, Zhou Q, Shung KK, Li R, Hsiai T. Ultrasonic Transducer-Guided Electrochemical Impedance Spectroscopy to Assess Lipid-Laden Plaques.. Sensors and actuators. B, Chemical, 2016.
  37. Lee J, Fei P, Packard RR, Kang H, Xu H, Baek KI, Jen N, Chen J, Yen H, Kuo CC, Chi NC, Ho CM, Li R, Hsiai TK. 4-Dimensional light-sheet microscopy to elucidate shear stress modulation of cardiac trabeculation.. The Journal of clinical investigation, 2016.
  38. Fei P, Lee J, Packard RR, Sereti KI, Xu H, Ma J, Ding Y, Kang H, Chen H, Sung K, Kulkarni R, Ardehali R, Kuo CC, Xu X, Ho CM, Hsiai TK. Cardiac Light-Sheet Fluorescent Microscopy for Multi-Scale and Rapid Imaging of Architecture and Function.. Scientific reports, 2016.
  39. Packard RR, Zhang X, Luo Y, Ma T, Jen N, Ma J, Demer LL, Zhou Q, Sayre JW, Li R, Tai YC, Hsiai TK. Two-Point Stretchable Electrode Array for Endoluminal Electrochemical Impedance Spectroscopy Measurements of Lipid-Laden Atherosclerotic Plaques.. Annals of biomedical engineering, 2016.
  40. Bennett BJ, Davis RC, Civelek M, Orozco L, Wu J, Qi H, Pan C, Packard RR, Eskin E, Yan M, Kirchgessner T, Wang Z, Li X, Gregory JC, Hazen SL, Gargalovic PS, Lusis AJ. Genetic Architecture of Atherosclerosis in Mice: A Systems Genetics Analysis of Common Inbred Strains.. PLoS genetics, 2015.
  41. Lee J, Packard RR, Hsiai TK. Blood flow modulation of vascular dynamics.. Current opinion in lipidology, 2015.
  42. Maddahi J, Packard RR. Cardiac PET perfusion tracers: current status and future directions.. Seminars in nuclear medicine, 2014.
  43. Packard RR, Huang SC, Dahlbom M, Czernin J, Maddahi J. Absolute quantitation of myocardial blood flow in human subjects with or without myocardial ischemia using dynamic flurpiridaz F 18 PET.. Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2014.
  44. Bhutani S, Tobis J, Gevorgyan R, Sinha A, Suh W, Honda HM, Vorobiof G, Packard RR, Steadman R, Wray C, Busuttil R, Tseng CH. Accuracy of stress myocardial perfusion imaging to diagnose coronary artery disease in end stage liver disease patients.. The American journal of cardiology, 2013.
  45. Croce K, Gao H, Wang Y, Mooroka T, Sakuma M, Shi C, Sukhova GK, Packard RR, Hogg N, Libby P, Simon DI. Myeloid-related protein-8/14 is critical for the biological response to vascular injury.. Circulation, 2009.
  46. Cao Z, Wara AK, Icli B, Sun X, Packard RR, Esen F, Stapleton CJ, Subramaniam M, Kretschmer K, Apostolou I, von Boehmer H, Hansson GK, Spelsberg TC, Libby P, Feinberg MW. Kruppel-like factor KLF10 targets transforming growth factor-beta1 to regulate CD4(+)CD25(-) T cells and T regulatory cells.. The Journal of biological chemistry, 2009.
  47. Packard RR, Lichtman AH, Libby P. Innate and adaptive immunity in atherosclerosis.. Seminars in immunopathology, 2009.
  48. Smadja DM, Godier A, Susen S, Packard RR, Fabiani JN, Aiach M, Gaussem P. Endothelial progenitor cells are selectively mobilised immediately after coronary artery bypass grafting or valve surgery.. Thrombosis and haemostasis, 2009.
  49. Packard RR, Maganto-García E, Gotsman I, Tabas I, Libby P, Lichtman AH. CD11c(+) dendritic cells maintain antigen processing, presentation capabilities, and CD4(+) T-cell priming efficacy under hypercholesterolemic conditions associated with atherosclerosis.. Circulation research, 2008.
  50. Packard RR, Libby P. Inflammation in atherosclerosis: from vascular biology to biomarker discovery and risk prediction.. Clinical chemistry, 2008.
  51. Packard RR, Schlegel S, Senouf D, Burger F, Sigaud P, Perneger T, Siegrist CA, Mach F. Atorvastatin treatment and vaccination efficacy.. Journal of clinical pharmacology, 2007.
  52. Packard RR, Shi GP. Atherosclerosis progression and monocyte emigration from plaque.. Future cardiology, 2006.