Publications

• Tayeb-Fligelman E, Bowler JT, Tai CE, Sawaya MR, Jiang YX, Garcia G, Griner SL, Cheng X, Salwinski L, Lutter L, Seidler PM, Lu J, Rosenberg GM, Hou K, Abskharon R, Pan H, Zee CT, Boyer DR, Li Y, Anderson DH, Murray KA, Falcon G, Cascio D, Saelices L, Damoiseaux R, Arumugaswami V, Guo F, Eisenberg DS. Low complexity domains of the nucleocapsid protein of SARS-CoV-2 form amyloid fibrils.. Nature communications, 2023.
• Ghezzi C, Chen BY, Damoiseaux R, Clark PM. Pacritinib inhibits glucose consumption in squamous cell lung cancer cells by targeting FLT3.. Scientific reports, 2023.
• Storey CM, Altai M, Bicak M, Veach DR, Lueckerath K, Adrian G, McDevitt MR, Kalidindi T, Park JE, Herrmann K, Abou D, Zedan W, Peekhaus N, Klein RJ, Damoiseaux R, Larson SM, Lilja H, Thorek D, Ulmert D. Quantitative In Vivo Imaging of the Androgen Receptor Axis Reveals Degree of Prostate Cancer Radiotherapy Response.. Molecular cancer research : MCR, 2023.
• Ghezzi C, Perez S, Ryan K, Wong A, Chen BY, Damoiseaux R, Clark PM. Early Reduction of Glucose Consumption Is a Biomarker of Kinase Inhibitor Efficacy Which Can Be Reversed with GLUT1 Overexpression in Lung Cancer Cells.. Molecular imaging and biology, 2022.
• Scoles DR, Gandelman M, Paul S, Dexheimer T, Dansithong W, Figueroa KP, Pflieger LT, Redlin S, Kales SC, Sun H, Maloney D, Damoiseaux R, Henderson MJ, Simeonov A, Jadhav A, Pulst SM. A quantitative high-throughput screen identifies compounds that lower expression of the SCA2-and ALS-associated gene ATXN2.. The Journal of biological chemistry, 2022.
• Liang J, Sohrabi A, Epperson M, Rad LM, Tamura K, Sathialingam M, Skandakumar T, Lue P, Huang J, Popoli J, Yackly A, Bick M, Wang ZZ, Chen CC, Varuzhanyan G, Damoiseaux R, Seidlits SK. Hydrogel Arrays Enable Increased Throughput for Screening Effects of Matrix Components and Therapeutics in 3D Tumor Models.. Journal of visualized experiments : JoVE, 2022.
• Herbig M, Isozaki A, Di Carlo D, Guck J, Nitta N, Damoiseaux R, Kamikawaji S, Suyama E, Shintaku H, Wu AR, Nikaido I, Goda K. Best practices for reporting throughput in biomedical research.. Nature methods, 2022.
• Hairapetian L, Cortes E, Zhao J, Wang Y, Huang R, Damoiseaux R, Pushkarsky I. Simplified, High-throughput Analysis of Single-cell Contractility using Micropatterned Elastomers.. Journal of visualized experiments : JoVE, 2022.
• de Rutte J, Dimatteo R, Archang MM, van Zee M, Koo D, Lee S, Sharrow AC, Krohl PJ, Mellody M, Zhu S, Eichenbaum JV, Kizerwetter M, Udani S, Ha K, Willson RC, Bertozzi AL, Spangler JB, Damoiseaux R, Di Carlo D. Suspendable Hydrogel Nanovials for Massively Parallel Single-Cell Functional Analysis and Sorting.. ACS nano, 2022.
• Li S, Yokota T, Wang P, Ten Hoeve J, Ma F, Le TM, Abt ER, Zhou Y, Wu R, Nanthavongdouangsy M, Rodriguez A, Wang Y, Lin YJ, Muranaka H, Sharpley M, Braddock DT, MacRae VE, Banerjee U, Chiou PY, Seldin M, Huang D, Teitell M, Gertsman I, Jung M, Bensinger SJ, Damoiseaux R, Faull K, Pellegrini M, Lusis AJ, Graeber TG, Radu CG, Deb A. Cardiomyocytes disrupt pyrimidine biosynthesis in nonmyocytes to regulate heart repair.. The Journal of clinical investigation, 2022.
• Abt ER, Le TM, Dann AM, Capri JR, Poddar S, Lok V, Li L, Liang K, Creech AL, Rashid K, Kim W, Wu N, Cui J, Cho A, Lee HR, Rosser EW, Link JM, Czernin J, Wu TT, Damoiseaux R, Dawson DW, Donahue TR, Radu CG. Reprogramming of nucleotide metabolism by interferon confers dependence on the replication stress response pathway in pancreatic cancer cells.. Cell reports, 2022.
• Luu AP, Yao Z, Ramachandran S, Azzopardi SA, Miles LA, Schneider WM, Hoffmann HH, Bozzacco L, Garcia G, Gong D, Damoiseaux R, Tang H, Morizono K, Rudin CM, Sun R, Arumugaswami V, Poirier JT, MacDonald MR, Rice CM, Li MMH. A CRISPR Activation Screen Identifies an Atypical Rho GTPase That Enhances Zika Viral Entry.. Viruses, 2021.
• Liu X, Verma A, Garcia G, Ramage H, Lucas A, Myers RL, Michaelson JJ, Coryell W, Kumar A, Charney AW, Kazanietz MG, Rader DJ, Ritchie MD, Berrettini WH, Schultz DC, Cherry S, Damoiseaux R, Arumugaswami V, Klein PS. Targeting the coronavirus nucleocapsid protein through GSK-3 inhibition.. Proceedings of the National Academy of Sciences of the United States of America, 2021.
• Liu X, Verma A, Garcia G, Ramage H, Myers RL, Lucas A, Michaelson JJ, Coryell W, Kumar A, Charney AW, Kazanietz MG, Rader DJ, Ritchie MD, Berrettini WH, Schultz DC, Cherry S, Damoiseaux R, Arumugaswami V, Klein PS. Targeting the Coronavirus Nucleocapsid Protein through GSK-3 Inhibition.. medRxiv : the preprint server for health sciences, 2021.
• Bloom JS, Sathe L, Munugala C, Jones EM, Gasperini M, Lubock NB, Yarza F, Thompson EM, Kovary KM, Park J, Marquette D, Kay S, Lucas M, Love T, Sina Booeshaghi A, Brandenberg OF, Guo L, Boocock J, Hochman M, Simpkins SW, Lin I, LaPierre N, Hong D, Zhang Y, Oland G, Choe BJ, Chandrasekaran S, Hilt EE, Butte MJ, Damoiseaux R, Kravit C, Cooper AR, Yin Y, Pachter L, Garner OB, Flint J, Eskin E, Luo C, Kosuri S, Kruglyak L, Arboleda VA. Massively scaled-up testing for SARS-CoV-2 RNA via next-generation sequencing of pooled and barcoded nasal and saliva samples.. Nature biomedical engineering, 2021.
• Micewicz ED, Damoiseaux RD, Deng G, Gomez A, Iwamoto KS, Jung ME, Nguyen C, Norris AJ, Ratikan JA, Ruchala P, Sayre JW, Schaue D, Whitelegge JP, McBride WH. Classes of Drugs that Mitigate Radiation Syndromes.. Frontiers in pharmacology, 2021.
• Guo X, Ramirez I, Garcia YA, Velasquez EF, Gholkar AA, Cohn W, Whitelegge JP, Tofig B, Damoiseaux R, Torres JZ. DUSP7 regulates the activity of ERK2 to promote proper chromosome alignment during cell division.. The Journal of biological chemistry, 2021.
• Mullen PJ, Garcia G, Purkayastha A, Matulionis N, Schmid EW, Momcilovic M, Sen C, Langerman J, Ramaiah A, Shackelford DB, Damoiseaux R, French SW, Plath K, Gomperts BN, Arumugaswami V, Christofk HR. SARS-CoV-2 infection rewires host cell metabolism and is potentially susceptible to mTORC1 inhibition.. Nature communications, 2021.
• Garcia G, Sharma A, Ramaiah A, Sen C, Purkayastha A, Kohn DB, Parcells MS, Beck S, Kim H, Bakowski MA, Kirkpatrick MG, Riva L, Wolff KC, Han B, Yuen C, Ulmert D, Purbey PK, Scumpia P, Beutler N, Rogers TF, Chatterjee AK, Gabriel G, Bartenschlager R, Gomperts B, Svendsen CN, Betz UAK, Damoiseaux RD, Arumugaswami V. Antiviral drug screen identifies DNA-damage response inhibitor as potent blocker of SARS-CoV-2 replication.. Cell reports, 2021.
• Tayeb-Fligelman E, Cheng X, Tai C, Bowler JT, Griner S, Sawaya MR, Seidler PM, Jiang YX, Lu J, Rosenberg GM, Salwinski L, Abskharon R, Zee CT, Hou K, Li Y, Boyer DR, Murray KA, Falcon G, Anderson DH, Cascio D, Saelices L, Damoiseaux R, Guo F, Eisenberg DS. Inhibition of amyloid formation of the Nucleoprotein of SARS-CoV-2.. bioRxiv : the preprint server for biology, 2021.
• Bloom JS, Sathe L, Munugala C, Jones EM, Gasperini M, Lubock NB, Yarza F, Thompson EM, Kovary KM, Park J, Marquette D, Kay S, Lucas M, Love T, Booeshaghi AS, Brandenberg OF, Guo L, Boocock J, Hochman M, Simpkins SW, Lin I, LaPierre N, Hong D, Zhang Y, Oland G, Choe BJ, Chandrasekaran S, Hilt EE, Butte MJ, Damoiseaux R, Kravit C, Cooper AR, Yin Y, Pachter L, Garner OB, Flint J, Eskin E, Luo C, Kosuri S, Kruglyak L, Arboleda VA. Swab-Seq: A high-throughput platform for massively scaled up SARS-CoV-2 testing.. medRxiv : the preprint server for health sciences, 2021.
• Ramirez I, Gholkar AA, Velasquez EF, Guo X, Tofig B, Damoiseaux R, Torres JZ. The myosin regulatory light chain Myl5 localizes to mitotic spindle poles and is required for proper cell division.. Cytoskeleton (Hoboken, N.J.), 2021.
• Veach DR, Storey CM, Lückerath K, Braun K, von Bodman C, Lamminmäki U, Kalidindi T, Strand SE, Strand J, Altai M, Damoiseaux R, Zanzonico P, Benabdallah N, Pankov D, Scher HI, Scardino P, Larson SM, Lilja H, McDevitt MR, Thorek DLJ, Ulmert D. PSA-Targeted Alpha-, Beta-, and Positron-Emitting Immunotheranostics in Murine Prostate Cancer Models and Nonhuman Primates.. Clinical cancer research : an official journal of the American Association for Cancer Research, 2021.
• Zhang D, Damoiseaux R, Babayan L, Rivera-Meza EK, Yang Y, Bergsneider M, Wang MB, Yong WH, Kelly K, Heaney AP. Targeting Corticotroph HDAC and PI3-Kinase in Cushing Disease.. The Journal of clinical endocrinology and metabolism, 2021.
• Ahn TS, Han B, Krogstad P, Bun C, Kohn LA, Garcia-Lloret MI, Damoiseaux R, Butte MJ. Commercial immunoglobulin products contain cross-reactive but not neutralizing antibodies against SARS-CoV-2.. The Journal of allergy and clinical immunology, 2020.
• Hilfenhaus G, Mompeón A, Freshman J, Prajapati DP, Hernandez G, Freitas VM, Ma F, Langenbacher AD, Mirkov S, Song D, Cho BK, Goo YA, Pellegrini M, Chen JN, Damoiseaux R, Iruela-Arispe ML. A High-Content Screen Identifies Drugs That Restrict Tumor Cell Extravasation across the Endothelial Barrier.. Cancer research, 2020.
• Lee CYD, Wang N, Shen K, Stricos M, Langfelder P, Cheon KH, Cortés EP, Vinters HV, Vonsattel JP, Wexler NS, Damoiseaux R, Frydman J, Yang XW. Disease-related Huntingtin seeding activities in cerebrospinal fluids of Huntington's disease patients.. Scientific reports, 2020.
• Liu J, Campagna J, John V, Damoiseaux R, Mokhonova E, Becerra D, Meng H, McNally EM, Pyle AD, Kramerova I, Spencer MJ. A Small-Molecule Approach to Restore a Slow-Oxidative Phenotype and Defective CaMKIIβ Signaling in Limb Girdle Muscular Dystrophy.. Cell reports. Medicine, 2020.
• Kalbasi A, Tariveranmoshabad M, Hakimi K, Kremer S, Campbell KM, Funes JM, Vega-Crespo A, Parisi G, Champekar A, Nguyen C, Torrejon D, Shin D, Zaretsky JM, Damoiseaux RD, Speiser DE, Lopez-Casas PP, Quintero M, Ribas A. Uncoupling interferon signaling and antigen presentation to overcome immunotherapy resistance due to JAK1 loss in melanoma.. Science translational medicine, 2020.
• Shu C, Parfenova L, Mokhonova E, Collado JR, Damoiseaux R, Campagna J, John V, Crosbie RH. High-throughput screening identifies modulators of sarcospan that stabilize muscle cells and exhibit activity in the mouse model of Duchenne muscular dystrophy.. Skeletal muscle, 2020.
• Liu SH, Yu J, Creeden JF, Sutton JM, Markowiak S, Sanchez R, Nemunaitis J, Kalinoski A, Zhang JT, Damoiseaux R, Erhardt P, Brunicardi FC. Repurposing metformin, simvastatin and digoxin as a combination for targeted therapy for pancreatic ductal adenocarcinoma.. Cancer letters, 2020.
• Bicak M, Lückerath K, Kalidindi T, Phelps ME, Strand SE, Morris MJ, Radu CG, Damoiseaux R, Peltola MT, Peekhaus N, Ho A, Veach D, Malmborg Hager AC, Larson SM, Lilja H, McDevitt MR, Klein RJ, Ulmert D. Genetic signature of prostate cancer mouse models resistant to optimized hK2 targeted α-particle therapy.. Proceedings of the National Academy of Sciences of the United States of America, 2020.
• Zhou QD, Chi X, Lee MS, Hsieh WY, Mkrtchyan JJ, Feng AC, He C, York AG, Bui VL, Kronenberger EB, Ferrari A, Xiao X, Daly AE, Tarling EJ, Damoiseaux R, Scumpia PO, Smale ST, Williams KJ, Tontonoz P, Bensinger SJ. Interferon-mediated reprogramming of membrane cholesterol to evade bacterial toxins.. Nature immunology, 2020.
• Gosschalk JE, Chang C, Sue CK, Siegel SD, Wu C, Kattke MD, Yi SW, Damoiseaux R, Jung ME, Ton-That H, Clubb RT. A Cell-based Screen in Actinomyces oris to Identify Sortase Inhibitors.. Scientific reports, 2020.
• Bhat K, Saki M, Vlashi E, Cheng F, Duhachek-Muggy S, Alli C, Yu G, Medina P, He L, Damoiseaux R, Pellegrini M, Zemke NR, Nghiemphu PL, Cloughesy TF, Liau LM, Kornblum HI, Pajonk F. The dopamine receptor antagonist trifluoperazine prevents phenotype conversion and improves survival in mouse models of glioblastoma.. Proceedings of the National Academy of Sciences of the United States of America, 2020.
• Olugbami JO, Damoiseaux R, Odunola OA, Gimzewski JK. Mitigation of aflatoxin B1- and sodium arsenite-induced cytotoxicities in HUC-PC urinary bladder cells by curcumin and Khaya senegalensis.. Journal of basic and clinical physiology and pharmacology, 2020.
• Sun DL, Poddar S, Pan RD, Rosser EW, Abt ER, Van Valkenburgh J, Le TM, Lok V, Hernandez SP, Song J, Li J, Turlik A, Chen X, Cheng CA, Chen W, Mona CE, Stuparu AD, Vergnes L, Reue K, Damoiseaux R, Zink JI, Czernin J, Donahue TR, Houk KN, Jung ME, Radu CG. Isoquinoline thiosemicarbazone displays potent anticancer activity with in vivo efficacy against aggressive leukemias.. RSC medicinal chemistry, 2020.
• Aros CJ, Paul MK, Pantoja CJ, Bisht B, Meneses LK, Vijayaraj P, Sandlin JM, France B, Tse JA, Chen MW, Shia DW, Rickabaugh TM, Damoiseaux R, Gomperts BN. High-Throughput Drug Screening Identifies a Potent Wnt Inhibitor that Promotes Airway Basal Stem Cell Homeostasis.. Cell reports, 2020.
• Shu C, Kaxon-Rupp AN, Collado JR, Damoiseaux R, Crosbie RH. Development of a high-throughput screen to identify small molecule enhancers of sarcospan for the treatment of Duchenne muscular dystrophy.. Skeletal muscle, 2019.
• Garcia-Diaz A, Shin DS, Moreno BH, Saco J, Escuin-Ordinas H, Rodriguez GA, Zaretsky JM, Sun L, Hugo W, Wang X, Parisi G, Saus CP, Torrejon DY, Graeber TG, Comin-Anduix B, Hu-Lieskovan S, Damoiseaux R, Lo RS, Ribas A. Interferon Receptor Signaling Pathways Regulating PD-L1 and PD-L2 Expression.. Cell reports, 2019.
• Vijayaraj P, Minasyan A, Durra A, Karumbayaram S, Mehrabi M, Aros CJ, Ahadome SD, Shia DW, Chung K, Sandlin JM, Darmawan KF, Bhatt KV, Manze CC, Paul MK, Wilkinson DC, Yan W, Clark AT, Rickabaugh TM, Wallace WD, Graeber TG, Damoiseaux R, Gomperts BN. Modeling Progressive Fibrosis with Pluripotent Stem Cells Identifies an Anti-fibrotic Small Molecule.. Cell reports, 2019.
• Ghezzi C, Wong A, Chen BY, Ribalet B, Damoiseaux R, Clark PM. A high-throughput screen identifies that CDK7 activates glucose consumption in lung cancer cells.. Nature communications, 2019.
• Abt ER, Rosser EW, Durst MA, Lok V, Poddar S, Le TM, Cho A, Kim W, Wei L, Song J, Capri JR, Xu S, Wu N, Slavik R, Jung ME, Damoiseaux R, Czernin J, Donahue TR, Lavie A, Radu CG. Metabolic Modifier Screen Reveals Secondary Targets of Protein Kinase Inhibitors within Nucleotide Metabolism.. Cell chemical biology, 2019.
• Bulterys PL, Toesca IJ, Norris MH, Maloy JP, Fitz-Gibbon ST, France B, Toffig B, Morselli M, Somprasong N, Pellegrini M, Schweizer HP, Tuanyok A, Damoiseaux R, French CT, Miller JF. An in situ high-throughput screen identifies inhibitors of intracellular Burkholderia pseudomallei with therapeutic efficacy.. Proceedings of the National Academy of Sciences of the United States of America, 2019.
• Zhang Y, Roos M, Himburg H, Termini CM, Quarmyne M, Li M, Zhao L, Kan J, Fang T, Yan X, Pohl K, Diers E, Jin Gim H, Damoiseaux R, Whitelegge J, McBride W, Jung ME, Chute JP. PTPσ inhibitors promote hematopoietic stem cell regeneration.. Nature communications, 2019.
• Xia X, Lo YC, Gholkar AA, Senese S, Ong JY, Velasquez EF, Damoiseaux R, Torres JZ. Leukemia Cell Cycle Chemical Profiling Identifies the G2-Phase Leukemia Specific Inhibitor Leusin-1.. ACS chemical biology, 2019.
• Mognol GP, González-Avalos E, Ghosh S, Spreafico R, Gudlur A, Rao A, Damoiseaux R, Hogan PG. Targeting the NFAT:AP-1 transcriptional complex on DNA with a small-molecule inhibitor.. Proceedings of the National Academy of Sciences of the United States of America, 2019.
• Phan N, Hong JJ, Tofig B, Mapua M, Elashoff D, Moatamed NA, Huang J, Memarzadeh S, Damoiseaux R, Soragni A. A simple high-throughput approach identifies actionable drug sensitivities in patient-derived tumor organoids.. Communications biology, 2019.
• Micewicz ED, Iwamoto KS, Ratikan JA, Nguyen C, Xie MW, Cheng G, Boxx GM, Deriu E, Damoiseaux RD, Whitelegge JP, Ruchala PP, Avetisyan R, Jung ME, Lawson G, Nemeth E, Ganz T, Sayre JW, McBride WH, Schaue D. The Aftermath of Surviving Acute Radiation Hematopoietic Syndrome and its Mitigation.. Radiation research, 2019.
• Gill NK, Ly C, Nyberg KD, Lee L, Qi D, Tofig B, Reis-Sobreiro M, Dorigo O, Rao J, Wiedemeyer R, Karlan B, Lawrenson K, Freeman MR, Damoiseaux R, Rowat AC. A scalable filtration method for high throughput screening based on cell deformability.. Lab on a chip, 2019.
• Bhat K, Duhachek-Muggy S, Ramanathan R, Saki M, Alli C, Medina P, Damoiseaux R, Whitelegge J, McBride WH, Schaue D, Vlashi E, Pajonk F. 1-(4-nitrobenzenesulfonyl)-4-penylpiperazine increases the number of Peyer's patch-associated regenerating crypts in the small intestines after radiation injury.. Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 2018.
• Li M, van Zee M, Riche CT, Tofig B, Gallaher SD, Merchant SS, Damoiseaux R, Goda K, Di Carlo D. A Gelatin Microdroplet Platform for High-Throughput Sorting of Hyperproducing Single-Cell-Derived Microalgal Clones.. Small (Weinheim an der Bergstrasse, Germany), 2018.
• Tekin E, White C, Kang TM, Singh N, Cruz-Loya M, Damoiseaux R, Savage VM, Yeh PJ. Prevalence and patterns of higher-order drug interactions in Escherichia coli.. NPJ systems biology and applications, 2018.
• Cruz-Loya M, Kang TM, Lozano NA, Watanabe R, Tekin E, Damoiseaux R, Savage VM, Yeh PJ. Stressor interaction networks suggest antibiotic resistance co-opted from stress responses to temperature.. The ISME journal, 2018.
• Orfanos S, Jude J, Deeney BT, Cao G, Rastogi D, van Zee M, Pushkarsky I, Munoz HE, Damoiseaux R, Di Carlo D, Panettieri RA. Obesity increases airway smooth muscle responses to contractile agonists.. American journal of physiology. Lung cellular and molecular physiology, 2018.
• Xu S, Catapang A, Braas D, Stiles L, Doh HM, Lee JT, Graeber TG, Damoiseaux R, Shirihai O, Herschman HR. A precision therapeutic strategy for hexokinase 1-null, hexokinase 2-positive cancers.. Cancer & metabolism, 2018.
• Laks DR, Oses-Prieto JA, Alvarado AG, Nakashima J, Chand S, Azzam DB, Gholkar AA, Sperry J, Ludwig K, Condro MC, Nazarian S, Cardenas A, Shih MYS, Damoiseaux R, France B, Orozco N, Visnyei K, Crisman TJ, Gao F, Torres JZ, Coppola G, Burlingame AL, Kornblum HI. A molecular cascade modulates MAP1B and confers resistance to mTOR inhibition in human glioblastoma.. Neuro-oncology, 2018.
• Pushkarsky I, Tseng P, Black D, France B, Warfe L, Koziol-White CJ, Jester WF, Trinh RK, Lin J, Scumpia PO, Morrison SL, Panettieri RA, Damoiseaux R, Di Carlo D. Publisher Correction: Elastomeric sensor surfaces for high-throughput single-cell force cytometry.. Nature biomedical engineering, 2018.
• Pushkarsky I, Tseng P, Black D, France B, Warfe L, Koziol-White CJ, Jester WF, Trinh RK, Lin J, Scumpia PO, Morrison SL, Panettieri RA, Damoiseaux R, Di Carlo D. Elastomeric sensor surfaces for high-throughput single-cell force cytometry.. Nature biomedical engineering, 2018.
• Keegan A, Plath K, Damoiseaux R. High-Throughput Screening of a Luciferase Reporter of Gene Silencing on the Inactive X Chromosome.. Methods in molecular biology (Clifton, N.J.), 2018.
• Welch G, Damoiseaux R, Miraglia L. Making It All Work: Functional Genomics and Reporter Gene Assays.. Methods in molecular biology (Clifton, N.J.), 2018.
• Welch G, Damoiseaux R, Miraglia L. Reporter Gene Assays Using Transfectable Functional Genomics Libraries.. Methods in molecular biology (Clifton, N.J.), 2018.
• Bowers PM, Boyle WJ, Damoiseaux R. The Use of Somatic Hypermutation for the Affinity Maturation of Therapeutic Antibodies.. Methods in molecular biology (Clifton, N.J.), 2018.
• Yoo EJ, Cao G, Koziol-White CJ, Ojiaku CA, Sunder K, Jude JA, Michael JV, Lam H, Pushkarsky I, Damoiseaux R, Di Carlo D, Ahn K, An SS, Penn RB, Panettieri RA. Gα12 facilitates shortening in human airway smooth muscle by modulating phosphoinositide 3-kinase-mediated activation in a RhoA-dependent manner.. British journal of pharmacology, 2017.
• Senese S, Lo YC, Gholkar AA, Li CM, Huang Y, Mottahedeh J, Kornblum HI, Damoiseaux R, Torres JZ. Microtubins: a novel class of small synthetic microtubule targeting drugs that inhibit cancer cell proliferation.. Oncotarget, 2017.
• Watanabe M, Buth JE, Vishlaghi N, de la Torre-Ubieta L, Taxidis J, Khakh BS, Coppola G, Pearson CA, Yamauchi K, Gong D, Dai X, Damoiseaux R, Aliyari R, Liebscher S, Schenke-Layland K, Caneda C, Huang EJ, Zhang Y, Cheng G, Geschwind DH, Golshani P, Sun R, Novitch BG. Self-Organized Cerebral Organoids with Human-Specific Features Predict Effective Drugs to Combat Zika Virus Infection.. Cell reports, 2017.
• Hong A, Moriceau G, Sun L, Lomeli S, Piva M, Damoiseaux R, Holmen SL, Sharpless NE, Hugo W, Lo RS. Exploiting Drug Addiction Mechanisms to Select against MAPKi-Resistant Melanoma.. Cancer discovery, 2017.
• Lo YC, Senese S, France B, Gholkar AA, Damoiseaux R, Torres JZ. Computational Cell Cycle Profiling of Cancer Cells for Prioritizing FDA-Approved Drugs with Repurposing Potential.. Scientific reports, 2017.
• Song C, Piva M, Sun L, Hong A, Moriceau G, Kong X, Zhang H, Lomeli S, Qian J, Yu CC, Damoiseaux R, Kelley MC, Dahlman KB, Scumpia PO, Sosman JA, Johnson DB, Ribas A, Hugo W, Lo RS. Recurrent Tumor Cell-Intrinsic and -Extrinsic Alterations during MAPKi-Induced Melanoma Regression and Early Adaptation.. Cancer discovery, 2017.
• Olugbami JO, Damoiseaux R, France B, Onibiyo EM, Gbadegesin MA, Sharma S, Gimzewski JK, Odunola OA. A comparative assessment of antiproliferative properties of resveratrol and ethanol leaf extract of Anogeissus leiocarpus (DC) Guill and Perr against HepG2 hepatocarcinoma cells.. BMC complementary and alternative medicine, 2017.
• Micewicz ED, Kim K, Iwamoto KS, Ratikan JA, Cheng G, Boxx GM, Damoiseaux RD, Whitelegge JP, Ruchala P, Nguyen C, Purbey P, Loo J, Deng G, Jung ME, Sayre JW, Norris AJ, Schaue D, McBride WH. 4-(Nitrophenylsulfonyl)piperazines mitigate radiation damage to multiple tissues.. PloS one, 2017.
• Hershman JM, France B, Hon K, Damoiseaux R. Direct quantification of gamma H2AX by cell-based high throughput screening for evaluation of genotoxicity of pesticides in a human thyroid cell lines.. Environmental and molecular mutagenesis, 2017.
• Garcia-Diaz A, Shin DS, Moreno BH, Saco J, Escuin-Ordinas H, Rodriguez GA, Zaretsky JM, Sun L, Hugo W, Wang X, Parisi G, Saus CP, Torrejon DY, Graeber TG, Comin-Anduix B, Hu-Lieskovan S, Damoiseaux R, Lo RS, Ribas A. Interferon Receptor Signaling Pathways Regulating PD-L1 and PD-L2 Expression.. Cell reports, 2017.
• Beppler C, Tekin E, White C, Mao Z, Miller JH, Damoiseaux R, Savage VM, Yeh PJ. When more is less: Emergent suppressive interactions in three-drug combinations.. BMC microbiology, 2017.
• Olugbami JO, Damoiseaux R, France B, Gbadegesin MA, Stieg AZ, Sharma S, Odunola OA, Gimzewski JK. Atomic force microscopy correlates antimetastatic potentials of HepG2 cell line with its redox/energy status: effects of curcumin and Khaya senegalensis.. Journal of integrative medicine, 2017.
• Miyata N, Tang Z, Conti MA, Johnson ME, Douglas CJ, Hasson SA, Damoiseaux R, Chang CA, Koehler CM. Adaptation of a Genetic Screen Reveals an Inhibitor for Mitochondrial Protein Import Component Tim44.. The Journal of biological chemistry, 2017.
• Soh LMJ, Mak WS, Lin PP, Mi L, Chen FY, Damoiseaux R, Siegel JB, Liao JC. Engineering a Thermostable Keto Acid Decarboxylase Using Directed Evolution and Computationally Directed Protein Design.. ACS synthetic biology, 2017.
• Koziol-White CJ, Yoo EJ, Cao G, Zhang J, Papanikolaou E, Pushkarsky I, Andrews A, Himes BE, Damoiseaux RD, Liggett SB, Di Carlo D, Kurten RC, Panettieri RA. Inhibition of PI3K promotes dilation of human small airways in a rho kinase-dependent manner.. British journal of pharmacology, 2016.
• Lo YC, Senese S, Damoiseaux R, Torres JZ. 3D Chemical Similarity Networks for Structure-Based Target Prediction and Scaffold Hopping.. ACS chemical biology, 2016.
• Reyes VC, Spitzmiller MR, Hong-Hermesdorf A, Kropat J, Damoiseaux RD, Merchant SS, Mahendra S. Copper status of exposed microorganisms influences susceptibility to metallic nanoparticles.. Environmental toxicology and chemistry, 2016.
• Wu TY, Chen CT, Liu JT, Bogorad IW, Damoiseaux R, Liao JC. Characterization and evolution of an activator-independent methanol dehydrogenase from Cupriavidus necator N-1.. Applied microbiology and biotechnology, 2016.
• Zuo J, Kye S, Quinn KK, Cooper P, Damoiseaux R, Krogstad P. Discovery of Structurally Diverse Small-Molecule Compounds with Broad Antiviral Activity against Enteroviruses.. Antimicrobial agents and chemotherapy, 2015.
• Minkovsky A, Sahakyan A, Bonora G, Damoiseaux R, Dimitrova E, Rubbi L, Pellegrini M, Radu CG, Plath K. A high-throughput screen of inactive X chromosome reactivation identifies the enhancement of DNA demethylation by 5-aza-2'-dC upon inhibition of ribonucleotide reductase.. Epigenetics & chromatin, 2015.
• Rathbun JY, Droniou ME, Damoiseaux R, Haworth KG, Henley JE, Exline CM, Choe H, Cannon PM. Novel Arenavirus Entry Inhibitors Discovered by Using a Minigenome Rescue System for High-Throughput Drug Screening.. Journal of virology, 2015.
• Huynh TP, Barwe SP, Lee SJ, McSpadden R, Franco OE, Hayward SW, Damoiseaux R, Grubbs SS, Petrelli NJ, Rajasekaran AK. Glucocorticoids suppress renal cell carcinoma progression by enhancing Na,K-ATPase beta-1 subunit expression.. PloS one, 2015.
• Lo YC, Senese S, Li CM, Hu Q, Huang Y, Damoiseaux R, Torres JZ. Large-scale chemical similarity networks for target profiling of compounds identified in cell-based chemical screens.. PLoS computational biology, 2015.
• Ting PY, Damoiseaux R, Titz B, Bradley KA, Graeber TG, Fernández-Vega V, Bannister TD, Chase P, Nair R, Scampavia L, Hodder P, Spicer TP, Colicelli J. Identification of small molecules that disrupt signaling between ABL and its positive regulator RIN1.. PloS one, 2015.
• Parodi DA, Damoiseaux R, Allard P. Comprehensive assessment of germline chemical toxicity using the nematode Caenorhabditis elegans.. Journal of visualized experiments : JoVE, 2015.
• Eshraghi A, Dixon SD, Tamilselvam B, Kim EJ, Gargi A, Kulik JC, Damoiseaux R, Blanke SR, Bradley KA. Cytolethal distending toxins require components of the ER-associated degradation pathway for host cell entry.. PLoS pathogens, 2014.
• Damoiseaux R. UCLA's Molecular Screening Shared Resource: enhancing small molecule discovery with functional genomics and new technology.. Combinatorial chemistry & high throughput screening, 2014.
• Kim KD, Srikanth S, Tan YV, Yee MK, Jew M, Damoiseaux R, Jung ME, Shimizu S, An DS, Ribalet B, Waschek JA, Gwack Y. Calcium signaling via Orai1 is essential for induction of the nuclear orphan receptor pathway to drive Th17 differentiation.. Journal of immunology (Baltimore, Md. : 1950), 2013.
• Gillespie EJ, Ho CL, Balaji K, Clemens DL, Deng G, Wang YE, Elsaesser HJ, Tamilselvam B, Gargi A, Dixon SD, France B, Chamberlain BT, Blanke SR, Cheng G, de la Torre JC, Brooks DG, Jung ME, Colicelli J, Damoiseaux R, Bradley KA. Selective inhibitor of endosomal trafficking pathways exploited by multiple toxins and viruses.. Proceedings of the National Academy of Sciences of the United States of America, 2013.
• Solaimani P, Damoiseaux R, Hankinson O. Genome-wide RNAi high-throughput screen identifies proteins necessary for the AHR-dependent induction of CYP1A1 by 2,3,7,8-tetrachlorodibenzo-p-dioxin.. Toxicological sciences : an official journal of the Society of Toxicology, 2013.
• Murphy JM, Armijo AL, Nomme J, Lee CH, Smith QA, Li Z, Campbell DO, Liao HI, Nathanson DA, Austin WR, Lee JT, Darvish R, Wei L, Wang J, Su Y, Damoiseaux R, Sadeghi S, Phelps ME, Herschman HR, Czernin J, Alexandrova AN, Jung ME, Lavie A, Radu CG. Development of new deoxycytidine kinase inhibitors and noninvasive in vivo evaluation using positron emission tomography.. Journal of medicinal chemistry, 2013.
• Du L, Jung ME, Damoiseaux R, Completo G, Fike F, Ku JM, Nahas S, Piao C, Hu H, Gatti RA. A new series of small molecular weight compounds induce read through of all three types of nonsense mutations in the ATM gene.. Molecular therapy : the journal of the American Society of Gene Therapy, 2013.
• Zheng S, Damoiseaux R, Chen L, Black DL. A broadly applicable high-throughput screening strategy identifies new regulators of Dlg4 (Psd-95) alternative splicing.. Genome research, 2013.
• Dabir DV, Hasson SA, Setoguchi K, Johnson ME, Wongkongkathep P, Douglas CJ, Zimmerman J, Damoiseaux R, Teitell MA, Koehler CM. A small molecule inhibitor of redox-regulated protein translocation into mitochondria.. Developmental cell, 2013.
• Fung E, Sugianto P, Hsu J, Damoiseaux R, Ganz T, Nemeth E. High-throughput screening of small molecules identifies hepcidin antagonists.. Molecular pharmacology, 2013.
• Kendall GC, Mokhonova EI, Moran M, Sejbuk NE, Wang DW, Silva O, Wang RT, Martinez L, Lu QL, Damoiseaux R, Spencer MJ, Nelson SF, Miceli MC. Dantrolene enhances antisense-mediated exon skipping in human and mouse models of Duchenne muscular dystrophy.. Science translational medicine, 2012.
• Lin S, Zhao Y, Ji Z, Ear J, Chang CH, Zhang H, Low-Kam C, Yamada K, Meng H, Wang X, Liu R, Pokhrel S, Mädler L, Damoiseaux R, Xia T, Godwin HA, Lin S, Nel AE. Zebrafish high-throughput screening to study the impact of dissolvable metal oxide nanoparticles on the hatching enzyme, ZHE1.. Small (Weinheim an der Bergstrasse, Germany), 2012.
• Reyes VC, Li M, Hoek EM, Mahendra S, Damoiseaux R. Genome-wide assessment in Escherichia coli reveals time-dependent nanotoxicity paradigms.. ACS nano, 2012.
• Xiong S, George S, Yu H, Damoiseaux R, France B, Ng KW, Loo JS. Size influences the cytotoxicity of poly (lactic-co-glycolic acid) (PLGA) and titanium dioxide (TiO(2)) nanoparticles.. Archives of toxicology, 2012.
• Xiong S, George S, Ji Z, Lin S, Yu H, Damoiseaux R, France B, Ng KW, Loo SC. Size of TiO(2) nanoparticles influences their phototoxicity: an in vitro investigation.. Archives of toxicology, 2012.
• Tsirulnikov K, Abuladze N, Bragin A, Faull K, Cascio D, Damoiseaux R, Schibler MJ, Pushkin A. Inhibition of aminoacylase 3 protects rat brain cortex neuronal cells from the toxicity of 4-hydroxy-2-nonenal mercapturate and 4-hydroxy-2-nonenal.. Toxicology and applied pharmacology, 2012.
• Zuo J, Quinn KK, Kye S, Cooper P, Damoiseaux R, Krogstad P. Fluoxetine is a potent inhibitor of coxsackievirus replication.. Antimicrobial agents and chemotherapy, 2012.
• Fung AO, Damoiseaux R, Grundeen S, Panes JL, Horton DH, Judy JW, Moore TB. Quantitative detection of PfHRP2 in saliva of malaria patients in the Philippines.. Malaria journal, 2012.
• Zhang H, Ji Z, Xia T, Meng H, Low-Kam C, Liu R, Pokhrel S, Lin S, Wang X, Liao YP, Wang M, Li L, Rallo R, Damoiseaux R, Telesca D, Mädler L, Cohen Y, Zink JI, Nel AE. Use of metal oxide nanoparticle band gap to develop a predictive paradigm for oxidative stress and acute pulmonary inflammation.. ACS nano, 2012.
• Liu R, Lin S, Rallo R, Zhao Y, Damoiseaux R, Xia T, Lin S, Nel A, Cohen Y. Automated phenotype recognition for zebrafish embryo based in vivo high throughput toxicity screening of engineered nano-materials.. PloS one, 2012.
• Tai S, Sun Y, Liu N, Ding B, Hsia E, Bhuta S, Thor RK, Damoiseaux R, Liang C, Huang J. Combination of Rad001 (everolimus) and propachlor synergistically induces apoptosis through enhanced autophagy in prostate cancer cells.. Molecular cancer therapeutics, 2012.
• Ivask A, Suarez E, Patel T, Boren D, Ji Z, Holden P, Telesca D, Damoiseaux R, Bradley KA, Godwin H. Genome-wide bacterial toxicity screening uncovers the mechanisms of toxicity of a cationic polystyrene nanomaterial.. Environmental science & technology, 2012.
• Li M, Noriega-Trevino ME, Nino-Martinez N, Marambio-Jones C, Wang J, Damoiseaux R, Ruiz F, Hoek EM. Synergistic bactericidal activity of Ag-TiO₂ nanoparticles in both light and dark conditions.. Environmental science & technology, 2011.
• Miraglia LJ, King FJ, Damoiseaux R. Seeing the light: luminescent reporter gene assays.. Combinatorial chemistry & high throughput screening, 2011.
• Lin S, Zhao Y, Xia T, Meng H, Ji Z, Liu R, George S, Xiong S, Wang X, Zhang H, Pokhrel S, Mädler L, Damoiseaux R, Lin S, Nel AE. High content screening in zebrafish speeds up hazard ranking of transition metal oxide nanoparticles.. ACS nano, 2011.
• Visnyei K, Onodera H, Damoiseaux R, Saigusa K, Petrosyan S, De Vries D, Ferrari D, Saxe J, Panosyan EH, Masterman-Smith M, Mottahedeh J, Bradley KA, Huang J, Sabatti C, Nakano I, Kornblum HI. A molecular screening approach to identify and characterize inhibitors of glioblastoma stem cells.. Molecular cancer therapeutics, 2011.
• Kim K, Damoiseaux R, Norris AJ, Rivina L, Bradley K, Jung ME, Gatti RA, Schiestl RH, McBride WH. High throughput screening of small molecule libraries for modifiers of radiation responses.. International journal of radiation biology, 2011.
• Zhang H, Xia T, Meng H, Xue M, George S, Ji Z, Wang X, Liu R, Wang M, France B, Rallo R, Damoiseaux R, Cohen Y, Bradley KA, Zink JI, Nel AE. Differential expression of syndecan-1 mediates cationic nanoparticle toxicity in undifferentiated versus differentiated normal human bronchial epithelial cells.. ACS nano, 2011.
• George S, Xia T, Rallo R, Zhao Y, Ji Z, Lin S, Wang X, Zhang H, France B, Schoenfeld D, Damoiseaux R, Liu R, Lin S, Bradley KA, Cohen Y, Nel AE. Use of a high-throughput screening approach coupled with in vivo zebrafish embryo screening to develop hazard ranking for engineered nanomaterials.. ACS nano, 2011.
• Damoiseaux R, George S, Li M, Pokhrel S, Ji Z, France B, Xia T, Suarez E, Rallo R, Mädler L, Cohen Y, Hoek EM, Nel A. No time to lose--high throughput screening to assess nanomaterial safety.. Nanoscale, 2011.
• Rallo R, France B, Liu R, Nair S, George S, Damoiseaux R, Giralt F, Nel A, Bradley K, Cohen Y. Self-organizing map analysis of toxicity-related cell signaling pathways for metal and metal oxide nanoparticles.. Environmental science & technology, 2011.
• Walter MA, Benz MR, Hildebrandt IJ, Laing RE, Hartung V, Damoiseaux RD, Bockisch A, Phelps ME, Czernin J, Weber WA. Metabolic imaging allows early prediction of response to vandetanib.. Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2011.
• Kamei K, Sun J, Tseng HR, Damoiseaux R. Microfluidic image cytometry.. Methods in molecular biology (Clifton, N.J.), 2011.
• Li M, Pokhrel S, Jin X, Mädler L, Damoiseaux R, Hoek EM. Stability, bioavailability, and bacterial toxicity of ZnO and iron-doped ZnO nanoparticles in aquatic media.. Environmental science & technology, 2010.
• Jin X, Li M, Wang J, Marambio-Jones C, Peng F, Huang X, Damoiseaux R, Hoek EM. High-throughput screening of silver nanoparticle stability and bacterial inactivation in aquatic media: influence of specific ions.. Environmental science & technology, 2010.
• Peng F, Hoek EM, Damoiseaux R. High-content screening for biofilm assays.. Journal of biomolecular screening, 2010.
• Aghajan M, Jonai N, Flick K, Fu F, Luo M, Cai X, Ouni I, Pierce N, Tang X, Lomenick B, Damoiseaux R, Hao R, Del Moral PM, Verma R, Li Y, Li C, Houk KN, Jung ME, Zheng N, Huang L, Deshaies RJ, Kaiser P, Huang J. Chemical genetics screen for enhancers of rapamycin identifies a specific inhibitor of an SCF family E3 ubiquitin ligase.. Nature biotechnology, 2010.
• Hasson SA, Damoiseaux R, Glavin JD, Dabir DV, Walker SS, Koehler CM. Substrate specificity of the TIM22 mitochondrial import pathway revealed with small molecule inhibitor of protein translocation.. Proceedings of the National Academy of Sciences of the United States of America, 2010.
• Lee DJ, Li H, Ochoa MT, Tanaka M, Carbone RJ, Damoiseaux R, Burdick A, Sarno EN, Rea TH, Modlin RL. Integrated pathways for neutrophil recruitment and inflammation in leprosy.. The Journal of infectious diseases, 2010.
• Wolf MC, Freiberg AN, Zhang T, Akyol-Ataman Z, Grock A, Hong PW, Li J, Watson NF, Fang AQ, Aguilar HC, Porotto M, Honko AN, Damoiseaux R, Miller JP, Woodson SE, Chantasirivisal S, Fontanes V, Negrete OA, Krogstad P, Dasgupta A, Moscona A, Hensley LE, Whelan SP, Faull KF, Holbrook MR, Jung ME, Lee B. A broad-spectrum antiviral targeting entry of enveloped viruses.. Proceedings of the National Academy of Sciences of the United States of America, 2010.
• George S, Pokhrel S, Xia T, Gilbert B, Ji Z, Schowalter M, Rosenauer A, Damoiseaux R, Bradley KA, Mädler L, Nel AE. Use of a rapid cytotoxicity screening approach to engineer a safer zinc oxide nanoparticle through iron doping.. ACS nano, 2010.
• Kim K, Pollard JM, Norris AJ, McDonald JT, Sun Y, Micewicz E, Pettijohn K, Damoiseaux R, Iwamoto KS, Sayre JW, Price BD, Gatti RA, McBride WH. High-throughput screening identifies two classes of antibiotics as radioprotectors: tetracyclines and fluoroquinolones.. Clinical cancer research : an official journal of the American Association for Cancer Research, 2009.
• Du L, Damoiseaux R, Nahas S, Gao K, Hu H, Pollard JM, Goldstine J, Jung ME, Henning SM, Bertoni C, Gatti RA. Nonaminoglycoside compounds induce readthrough of nonsense mutations.. The Journal of experimental medicine, 2009.
• Ohno I, Eibl G, Odinokova I, Edderkaoui M, Damoiseaux RD, Yazbec M, Abrol R, Goddard WA, Yokosuka O, Pandol SJ, Gukovskaya AS. Rottlerin stimulates apoptosis in pancreatic cancer cells through interactions with proteins of the Bcl-2 family.. American journal of physiology. Gastrointestinal and liver physiology, 2009.
• Suree N, Yi SW, Thieu W, Marohn M, Damoiseaux R, Chan A, Jung ME, Clubb RT. Discovery and structure-activity relationship analysis of Staphylococcus aureus sortase A inhibitors.. Bioorganic & medicinal chemistry, 2009.
• Damoiseaux R, Sherman SP, Alva JA, Peterson C, Pyle AD. Integrated chemical genomics reveals modifiers of survival in human embryonic stem cells.. Stem cells (Dayton, Ohio), 2009.
• Poulos JL, Jeon TJ, Damoiseaux R, Gillespie EJ, Bradley KA, Schmidt JJ. Ion channel and toxin measurement using a high throughput lipid membrane platform.. Biosensors & bioelectronics, 2008.
• Lee S, Deng H, Yu F, Melega WP, Damoiseaux R, Bradley KA, Sun R. Regulation of Kaposi's sarcoma-associated herpesvirus reactivation by dopamine receptor-mediated signaling pathways.. Journal of acquired immune deficiency syndromes (1999), 2008.
• Stoilov P, Lin CH, Damoiseaux R, Nikolic J, Black DL. A high-throughput screening strategy identifies cardiotonic steroids as alternative splicing modulators.. Proceedings of the National Academy of Sciences of the United States of America, 2008.
• Sanchez AM, Thomas D, Gillespie EJ, Damoiseaux R, Rogers J, Saxe JP, Huang J, Manchester M, Bradley KA. Amiodarone and bepridil inhibit anthrax toxin entry into host cells.. Antimicrobial agents and chemotherapy, 2007.
• Waki H, Park KW, Mitro N, Pei L, Damoiseaux R, Wilpitz DC, Reue K, Saez E, Tontonoz P. The small molecule harmine is an antidiabetic cell-type-specific regulator of PPARgamma expression.. Cell metabolism, 2007.
• Wu X, Zhong H, Song J, Damoiseaux R, Yang Z, Lin S. Mycophenolic acid is a potent inhibitor of angiogenesis.. Arteriosclerosis, thrombosis, and vascular biology, 2006.
• Kamata M, Wu RP, An DS, Saxe JP, Damoiseaux R, Phelps ME, Huang J, Chen IS. Cell-based chemical genetic screen identifies damnacanthal as an inhibitor of HIV-1 Vpr induced cell death.. Biochemical and biophysical research communications, 2006.