Roxana Radu
Assistant Professor-in-Residence, Ophthalmology, University of California Los Angeles
radu@jsei.ucla.edu
310-825-4005
UCLA JSEI-Oph
BOX 957000, A-222A JSEI Bldg
Los Angeles, CA 90095
Work Phone Number:
310-267-2683
Dr. Roxana A. Radu holds the Vernon O. Underwood Family Chair in Ophthalmology.
Affiliations
Member, Molecular, Cellular & Integrative Physiology GPB Home Area
Biography:
Dr. Radu is an Assistant Professor of Ophthalmology at the UCLA Stein Eye Institute. Roxana Radu received her MD from University of Medicine and Pharmacy of Craiova, Romania and completed a postdoctoral fellowship in retinoid biochemistry at UCLA studying the metabolism of vitamin A in the eye.
Publications
- Ng ESY, Kady N, Hu J, Dave A, Jiang Z, Pei J, Gorin MB, Matynia A, Radu RA. Membrane Attack Complex Mediates Retinal Pigment Epithelium Cell Death in Stargardt Macular Degeneration.. Cells, 2022.
- Moran AL, Carter SP, Kaylor JJ, Jiang Z, Broekman S, Dillon ET, G?mez S?nchez A, Minhas SK, van Wijk E, Radu RA, Travis GH, Carey M, Blacque OE, Kennedy BN. Dawn and dusk peaks of outer segment phagocytosis, and visual cycle function require Rab28.. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2022.
- Matynia A, Wang J, Kim S, Li Y, Dimashkie A, Jiang Z, Hu J, Strom SP, Radu RA, Chen R, Gorin MB. Assessing Variant Causality and Severity Using Retinal Pigment Epithelial Cells Derived from Stargardt Disease Patients.. Translational vision science & technology, 2022.
- Morshedian A, Sendek G, Ng SY, Boyd K, Radu RA, Liu M, Artemyev NO, Sampath AP, Fain GL. Reproducibility of the Rod Photoreceptor Response Depends Critically on the Concentration of the Phosphodiesterase Effector Enzyme.. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2022.
- Pan C, Banerjee K, Lehmann GL, Almeida D, Hajjar KA, Benedicto I, Jiang Z, Radu RA, Thompson DH, Rodriguez-Boulan E, Nociari MM. Lipofuscin causes atypical necroptosis through lysosomal membrane permeabilization.. Proceedings of the National Academy of Sciences of the United States of America, 2021.
- Hu J, Pauer GJ, Hagstrom SA, Bok D, DeBenedictis MJ, Bonilha VL, Hollyfield JG, Radu RA. Evidence of complement dysregulation in outer retina of Stargardt disease donor eyes.. Redox biology, 2020.
- Bonilha VL, Bell BA, Hu J, Milliner C, Pauer GJ, Hagstrom SA, Radu RA, Hollyfield JG. Geographic Atrophy: Confocal Scanning Laser Ophthalmoscopy, Histology, and Inflammation in the Region of Expanding Lesions.. Investigative ophthalmology & visual science, 2020.
- Fang Y, Tschulakow A, Taubitz T, Illing B, Biesemeier A, Julien-Schraermeyer S, Radu RA, Jiang Z, Schraermeyer U. Fundus autofluorescence, spectral-domain optical coherence tomography, and histology correlations in a Stargardt disease mouse model.. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2020.
- Choudhary M, Ismail EN, Yao PL, Tayyari F, Radu RA, Nusinowitz S, Boulton ME, Apte RS, Ruberti JW, Handa JT, Tontonoz P, Malek G. LXRs regulate features of age-related macular degeneration and may be a potential therapeutic target.. JCI insight, 2020.
- Kim EW, De Leon A, Jiang Z, Radu RA, Martineau AR, Chan ED, Bai X, Su WL, Montoya DJ, Modlin RL, Liu PT. Vitamin A Metabolism by Dendritic Cells Triggers an Antimicrobial Response against Mycobacterium tuberculosis.. mSphere, 2019.
- Morshedian A, Kaylor JJ, Ng SY, Tsan A, Frederiksen R, Xu T, Yuan L, Sampath AP, Radu RA, Fain GL, Travis GH. Light-Driven Regeneration of Cone Visual Pigments through a Mechanism Involving RGR Opsin in M�ller Glial Cells.. Neuron, 2019.
- Huang J, Gu S, Chen M, Zhang SJ, Jiang Z, Chen X, Jiang C, Liu G, Radu RA, Sun X, Vollrath D, Du J, Yan B, Zhao C. Abnormal mTORC1 signaling leads to retinal pigment epithelium degeneration.. Theranostics, 2019.
- McClements ME, Barnard AR, Singh MS, Charbel Issa P, Jiang Z, Radu RA, MacLaren RE. An AAV Dual Vector Strategy Ameliorates the Stargardt Phenotype in Adult Abca4-/- Mice.. Human gene therapy, 2018.
- Lenis TL, Hu J, Ng SY, Jiang Z, Sarfare S, Lloyd MB, Esposito NJ, Samuel W, Jaworski C, Bok D, Finnemann SC, Radeke MJ, Redmond TM, Travis GH, Radu RA. Expression of ABCA4 in the retinal pigment epithelium and its implications for Stargardt macular degeneration.. Proceedings of the National Academy of Sciences of the United States of America, 2018.
- Cook JD, Ng SY, Lloyd M, Eddington S, Sun H, Nathans J, Bok D, Radu RA, Travis GH. Peropsin modulates transit of vitamin A from retina to retinal pigment epithelium.. The Journal of biological chemistry, 2017.
- Lenis TL, Sarfare S, Jiang Z, Lloyd MB, Bok D, Radu RA. Complement modulation in the retinal pigment epithelium rescues photoreceptor degeneration in a mouse model of Stargardt disease.. Proceedings of the National Academy of Sciences of the United States of America, 2017.
- M?ller PL, Gliem M, Mangold E, Bolz HJ, Finger RP, McGuinness M, Betz C, Jiang Z, Weber BH, MacLaren RE, Holz FG, Radu RA, Charbel Issa P. Monoallelic ABCA4 Mutations Appear Insufficient to Cause Retinopathy: A Quantitative Autofluorescence Study.. Investigative ophthalmology & visual science, 2015.
- Kaylor JJ, Radu RA, Bischoff N, Makshanoff J, Hu J, Lloyd M, Eddington S, Bianconi T, Bok D, Travis GH. Diacylglycerol O-acyltransferase type-1 synthesizes retinyl esters in the retina and retinal pigment epithelium.. PloS one, 2015.
- Smit-McBride Z, Oltjen SL, Radu RA, Estep J, Nguyen AT, Gong Q, Hjelmeland LM. Localization of complement factor H gene expression and protein distribution in the mouse outer retina.. Molecular vision, 2015.
- Toops KA, Tan LX, Jiang Z, Radu RA, Lakkaraju A. Cholesterol-mediated activation of acid sphingomyelinase disrupts autophagy in the retinal pigment epithelium.. Molecular biology of the cell, 2014.
- Nociari MM, Lehmann GL, Perez Bay AE, Radu RA, Jiang Z, Goicochea S, Schreiner R, Warren JD, Shan J, Adam de Beaumais S, M?nand M, Sollogoub M, Maxfield FR, Rodriguez-Boulan E. Beta cyclodextrins bind, stabilize, and remove lipofuscin bisretinoids from retinal pigment epithelium.. Proceedings of the National Academy of Sciences of the United States of America, 2014.
- Radu RA, Hu J, Jiang Z, Bok D. Bisretinoid-mediated complement activation on retinal pigment epithelial cells is dependent on complement factor H haplotype.. The Journal of biological chemistry, 2014.
- Charbel Issa P, Barnard AR, Singh MS, Carter E, Jiang Z, Radu RA, Schraermeyer U, MacLaren RE. Fundus autofluorescence in the Abca4(-/-) mouse model of Stargardt disease--correlation with accumulation of A2E, retinal function, and histology.. Investigative ophthalmology & visual science, 2013.
- Ruiz A, Mark M, Jacobs H, Klopfenstein M, Hu J, Lloyd M, Habib S, Tosha C, Radu RA, Ghyselinck NB, Nusinowitz S, Bok D. Retinoid content, visual responses, and ocular morphology are compromised in the retinas of mice lacking the retinol-binding protein receptor, STRA6.. Investigative ophthalmology & visual science, 2012.
- Mullins RF, Kuehn MH, Radu RA, Enriquez GS, East JS, Schindler EI, Travis GH, Stone EM. Autosomal recessive retinitis pigmentosa due to ABCA4 mutations: clinical, pathologic, and molecular characterization.. Investigative ophthalmology & visual science, 2012.
- Lopes VS, Gibbs D, Libby RT, Aleman TS, Welch DL, Lillo C, Jacobson SG, Radu RA, Steel KP, Williams DS. The Usher 1B protein, MYO7A, is required for normal localization and function of the visual retinoid cycle enzyme, RPE65.. Human molecular genetics, 2011.
- Radu RA, Hu J, Yuan Q, Welch DL, Makshanoff J, Lloyd M, McMullen S, Travis GH, Bok D. Complement system dysregulation and inflammation in the retinal pigment epithelium of a mouse model for Stargardt macular degeneration.. The Journal of biological chemistry, 2011.
- Linton JD, Holzhausen LC, Babai N, Song H, Miyagishima KJ, Stearns GW, Lindsay K, Wei J, Chertov AO, Peters TA, Caffe R, Pluk H, Seeliger MW, Tanimoto N, Fong K, Bolton L, Kuok DL, Sweet IR, Bartoletti TM, Radu RA, Travis GH, Zagotta WN, Townes-Anderson E, Parker E, Van der Zee CE, Sampath AP, Sokolov M, Thoreson WB, Hurley JB. Flow of energy in the outer retina in darkness and in light.. Proceedings of the National Academy of Sciences of the United States of America, 2010.
- Jin M, Li S, Nusinowitz S, Lloyd M, Hu J, Radu RA, Bok D, Travis GH. The role of interphotoreceptor retinoid-binding protein on the translocation of visual retinoids and function of cone photoreceptors.. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2009.
- Radu RA, Yuan Q, Hu J, Peng JH, Lloyd M, Nusinowitz S, Bok D, Travis GH. Accelerated accumulation of lipofuscin pigments in the RPE of a mouse model for ABCA4-mediated retinal dystrophies following Vitamin A supplementation.. Investigative ophthalmology & visual science, 2008.
- Radu RA, Hu J, Peng J, Bok D, Mata NL, Travis GH. Retinal pigment epithelium-retinal G protein receptor-opsin mediates light-dependent translocation of all-trans-retinyl esters for synthesis of visual chromophore in retinal pigment epithelial cells.. The Journal of biological chemistry, 2008.
- Brill E, Malanson KM, Radu RA, Boukharov NV, Wang Z, Chung HY, Lloyd MB, Bok D, Travis GH, Obin M, Lem J. A novel form of transducin-dependent retinal degeneration: accelerated retinal degeneration in the absence of rod transducin.. Investigative ophthalmology & visual science, 2007.
- Bakall B, Radu RA, Stanton JB, Burke JM, McKay BS, Wadelius C, Mullins RF, Stone EM, Travis GH, Marmorstein AD. Enhanced accumulation of A2E in individuals homozygous or heterozygous for mutations in BEST1 (VMD2).. Experimental eye research, 2007.
- Bui TV, Han Y, Radu RA, Travis GH, Mata NL. Characterization of native retinal fluorophores involved in biosynthesis of A2E and lipofuscin-associated retinopathies.. The Journal of biological chemistry, 2006.
- Radu RA, Han Y, Bui TV, Nusinowitz S, Bok D, Lichter J, Widder K, Travis GH, Mata NL. Reductions in serum vitamin A arrest accumulation of toxic retinal fluorophores: a potential therapy for treatment of lipofuscin-based retinal diseases.. Investigative ophthalmology & visual science, 2005.
- Mata NL, Ruiz A, Radu RA, Bui TV, Travis GH. Chicken retinas contain a retinoid isomerase activity that catalyzes the direct conversion of all-trans-retinol to 11-cis-retinol.. Biochemistry, 2005.
- Radu RA, Mata NL, Bagla A, Travis GH. Light exposure stimulates formation of A2E oxiranes in a mouse model of Stargardt's macular degeneration.. Proceedings of the National Academy of Sciences of the United States of America, 2004.
- Radu RA, Mata NL, Nusinowitz S, Liu X, Travis GH. Isotretinoin treatment inhibits lipofuscin accumulation in a mouse model of recessive Stargardt's macular degeneration.. Novartis Foundation symposium, 2004.
- Mata NL, Moghrabi WN, Lee JS, Bui TV, Radu RA, Horwitz J, Travis GH. Rpe65 is a retinyl ester binding protein that presents insoluble substrate to the isomerase in retinal pigment epithelial cells.. The Journal of biological chemistry, 2003.
- Radu RA, Mata NL, Nusinowitz S, Liu X, Sieving PA, Travis GH. Treatment with isotretinoin inhibits lipofuscin accumulation in a mouse model of recessive Stargardt's macular degeneration.. Proceedings of the National Academy of Sciences of the United States of America, 2003.
- Mata NL, Radu RA, Clemmons RC, Travis GH. Isomerization and oxidation of vitamin a in cone-dominant retinas: a novel pathway for visual-pigment regeneration in daylight.. Neuron, 2002.