Soban Umar

Associate Professor-in-Residence, Anesthesiology, University of California Los Angeles

(310) 267-8678

Awards and Honors

  • Junior Faculty Research Award, Association of University Anesthesiologists (AUA), 2017.
  • Thomas M. Grove Chair in Anesthesiology, UCLA, 2023.
  • Dillon Award For outstanding performance as an Assistant Professor, UCLA Department of Anesthesiology and Perioperative Medicine, 2019.
  • Assembly on Pulmonary Circulation Early Career Research Achievement Award, American Thoracic Society (ATS), 2021.


  1. Hon A, Hsu JJ, Zambrano A, Xia Y, Lu M, Echeverri D, Kalanski S, Umar S, Demer LL, Tintut Y. Effects of activity levels on aortic calcification in hyperlipidemic mice as measured by microPETmicroCT.. Atherosclerosis, 2023.
  2. Hoftman N, Umar S. Ventilation and Complications after Lung Resection: Comment.. Anesthesiology, 2023.
  3. Razee A, Banerjee S, Hong J, Magaki S, Fishbein G, Ajijola OA, Umar S. Thoracic Spinal Cord Neuroinflammation as a Novel Therapeutic Target in Pulmonary Hypertension.. Hypertension (Dallas, Tex. : 1979), 2023.
  4. Hong J, Wong B, Huynh C, Tang B, Ruffenach G, Li M, Umar S, Yang X, Eghbali M. Tm4sf1-marked Endothelial Subpopulation Is Dysregulated in Pulmonary Arterial Hypertension.. American journal of respiratory cell and molecular biology, 2023.
  5. Park JF, Liang J, Umar S. Electrical Remodeling in Right Ventricular Failure Due to Pulmonary Hypertension: Unraveling Novel Therapeutic Targets.. International journal of molecular sciences, 2023.
  6. Banerjee S, Zargari M, Medzikovic L, Russino H, Mikhael M, Koons N, Grogan T, Rahman S, Eghbali M, Umar S. Intralipid® improves left ventricular function in rats with lipopolysaccharide-induced endotoxaemia by a Src-STAT3-mediated mechanism.. British journal of anaesthesia, 2022.
  7. Zhang V, Ganz T, Nemeth E, Umar S, Kim A. Bmpr2 mutant mice are an inadequate model for studying iron deficiency in pulmonary hypertension.. Pulmonary circulation, 2022.
  8. Banerjee S, Hong J, Umar S. Comparative analysis of right ventricular metabolic reprogramming in pre-clinical rat models of severe pulmonary hypertension-induced right ventricular failure.. Frontiers in cardiovascular medicine, 2022.
  9. Sherman C, Koons N, Zargari M, Cha C, Hirsch J, Hong R, Eghbali M, Umar S. Intralipid fails to rescue bupivacaine-induced cardiotoxicity in late-pregnant rats.. Frontiers in medicine, 2022.
  10. Cunningham CM, Li M, Ruffenach G, Doshi M, Aryan L, Hong J, Park J, Hrncir H, Medzikovic L, Umar S, Arnold AP, Eghbali M. Y-Chromosome Gene, Uty, Protects Against Pulmonary Hypertension by Reducing Proinflammatory Chemokines.. American journal of respiratory and critical care medicine, 2022.
  11. Park J, Banerjee S, Hong J, Umar S. Response by Park et al to Letter Regarding Article, "Transcriptomic Analysis of Right Ventricular Remodeling in Two Rat Models of Pulmonary Hypertension: Identification and Validation of Epithelial-to-Mesenchymal Transition in Human Right Ventricular Failure".. Circulation. Heart failure, 2022.
  12. Borna R, Rahimian R, Natalie Koons BS, Grogan TR, Umar S, Turner J. Needlestick injuries among anesthesia providers from a large US academic center: A 10-year retrospective analysis.. Journal of clinical anesthesia, 2022.
  13. Potus F, Frump AL, Umar S, R Vanderpool R, Al Ghouleh I, Lai YC. Recent advancements in pulmonary arterial hypertension and right heart failure research: overview of selected abstracts from ATS2020 and emerging COVID-19 research.. Pulmonary circulation, 2021.
  14. Hong J, Arneson D, Umar S, Ruffenach G, Cunningham CM, Ahn IS, Diamante G, Bhetraratana M, Park JF, Said E, Huynh C, Le T, Medzikovic L, Humbert M, Soubrier F, Montani D, Girerd B, Trégouët DA, Channick R, Saggar R, Eghbali M, Yang X. Single-Cell Study of Two Rat Models of Pulmonary Arterial Hypertension Reveals Connections to Human Pathobiology and Drug Repositioning.. American journal of respiratory and critical care medicine, 2021.
  15. Park JF, Clark VR, Banerjee S, Hong J, Razee A, Williams T, Fishbein G, Saddic L, Umar S. Transcriptomic Analysis of Right Ventricular Remodeling in Two Rat Models of Pulmonary Hypertension: Identification and Validation of Epithelial-to-Mesenchymal Transition in Human Right Ventricular Failure.. Circulation. Heart failure, 2021.
  16. Seger CD, Wang L, Dong X, Tebon P, Kwon S, Liew EC, Marijic J, Umar S, Hoftman NN. A Novel Negative Pressure Isolation Device for Aerosol Transmissible COVID-19.. Anesthesia and analgesia, 2020.
  17. Ruffenach G, O'Connor E, Vaillancourt M, Hong J, Cao N, Sarji S, Moazeni S, Papesh J, Grijalva V, Cunningham CM, Shu L, Chattopadhyay A, Tiwari S, Mercier O, Perros F, Umar S, Yang X, Gomes AV, Fogelman AM, Reddy ST, Eghbali M. Oral 15-Hydroxyeicosatetraenoic Acid Induces Pulmonary Hypertension in Mice by Triggering T Cell-Dependent Endothelial Cell Apoptosis.. Hypertension (Dallas, Tex. : 1979), 2020.
  18. Bae DJ, Tehrani DM, Rabadia SV, Frost M, Parikh RV, Calfon-Press M, Aksoy O, Umar S, Ardehali R, Rabbani A, Bokhoor P, Nsair A, Currier J, Tobis J, Fonarow GC, Dave R, Rafique AM. Angiotensin Converting Enzyme Inhibitor and Angiotensin II Receptor Blocker Use Among Outpatients Diagnosed With COVID-19.. The American journal of cardiology, 2020.
  19. Park JF, Banerjee S, Umar S. In the eye of the storm: the right ventricle in COVID-19.. Pulmonary circulation, 2020.
  20. Aryan L, Younessi D, Zargari M, Banerjee S, Agopian J, Rahman S, Borna R, Ruffenach G, Umar S, Eghbali M. The Role of Estrogen Receptors in Cardiovascular Disease.. International journal of molecular sciences, 2020.
  21. Anwar A, Seger C, Tollefson A, Diachun CAB, Tanaka P, Umar S. Medical education in the COVID-19 era: Impact on anesthesiology trainees.. Journal of clinical anesthesia, 2020.
  22. Razee A, Umar S. Editorial Commentary: Pulmonary Artery Denervation for Pulmonary Hypertension: Recent Updates and Future Perspectives.. Trends in cardiovascular medicine, 2020.
  23. Aryan L, Medzikovic L, Umar S, Eghbali M. Pregnancy-associated cardiac dysfunction and the regulatory role of microRNAs.. Biology of sex differences, 2020.
  24. Umar S, Ruffenach G, Moazeni S, Vaillancourt M, Hong J, Cunningham C, Cao N, Navab S, Sarji S, Li M, Lee L, Fishbein G, Ardehali A, Navab M, Reddy ST, Eghbali M. Involvement of Low-Density Lipoprotein Receptor in the Pathogenesis of Pulmonary Hypertension.. Journal of the American Heart Association, 2020.
  25. Mikhael M, Makar C, Wissa A, Le T, Eghbali M, Umar S. Oxidative Stress and Its Implications in the Right Ventricular Remodeling Secondary to Pulmonary Hypertension.. Frontiers in physiology, 2019.
  26. Vaillancourt M, Chia P, Medzikovic L, Cao N, Ruffenach G, Younessi D, Umar S. Experimental Pulmonary Hypertension Is Associated With Neuroinflammation in the Spinal Cord.. Frontiers in physiology, 2019.
  27. Ruffenach G, Umar S, Vaillancourt M, Hong J, Cao N, Sarji S, Moazeni S, Cunningham CM, Ardehali A, Reddy ST, Saggar R, Fishbein G, Eghbali M. Histological hallmarks and role of Slug/PIP axis in pulmonary hypertension secondary to pulmonary fibrosis.. EMBO molecular medicine, 2019.
  28. Le T, Makar C, Morway P, Hoftman N, Umar S. Pulmonary artery denervation: a novel treatment modality for pulmonary hypertension.. Journal of thoracic disease, 2019.
  29. Umar S, Eghbali M. In Reply.. Anesthesiology, 2019.
  30. Iorga A, Umar S, Ruffenach G, Aryan L, Li J, Sharma S, Motayagheni N, Nadadur RD, Bopassa JC, Eghbali M. Estrogen rescues heart failure through estrogen receptor Beta activation.. Biology of sex differences, 2018.
  31. Umar S, Li J, Hannabass K, Vaillancourt M, Cunningham CM, Moazeni S, Mahajan A, Eghbali M. Free Fatty Acid Receptor G-protein-coupled Receptor 40 Mediates Lipid Emulsion-induced Cardioprotection.. Anesthesiology, 2018.
  32. Umar S, Cunningham CM, Itoh Y, Moazeni S, Vaillancourt M, Sarji S, Centala A, Arnold AP, Eghbali M. The Y Chromosome Plays a Protective Role in Experimental Hypoxic Pulmonary Hypertension.. American journal of respiratory and critical care medicine, 2018.
  33. Hsu JJ, Lu J, Umar S, Lee JT, Kulkarni RP, Ding Y, Chang CC, Hsiai TK, Hokugo A, Gkouveris I, Tetradis S, Nishimura I, Demer LL, Tintut Y. Effects of teriparatide on morphology of aortic calcification in aged hyperlipidemic mice.. American journal of physiology. Heart and circulatory physiology, 2018.
  34. Vaillancourt M, Chia P, Sarji S, Nguyen J, Hoftman N, Ruffenach G, Eghbali M, Mahajan A, Umar S. Autonomic nervous system involvement in pulmonary arterial hypertension.. Respiratory research, 2017.
  35. Iorga A, Cunningham CM, Moazeni S, Ruffenach G, Umar S, Eghbali M. The protective role of estrogen and estrogen receptors in cardiovascular disease and the controversial use of estrogen therapy.. Biology of sex differences, 2017.
  36. Umar S, Partow-Navid R, Ruffenach G, Iorga A, Moazeni S, Eghbali M. Severe pulmonary hypertension in aging female apolipoprotein E-deficient mice is rescued by estrogen replacement therapy.. Biology of sex differences, 2017.
  37. Li J, Ruffenach G, Kararigas G, Cunningham CM, Motayagheni N, Barakai N, Umar S, Regitz-Zagrosek V, Eghbali M. Intralipid protects the heart in late pregnancy against ischemia/reperfusion injury via Caveolin2/STAT3/GSK-3β pathway.. Journal of molecular and cellular cardiology, 2016.
  38. Sharma S, Ruffenach G, Umar S, Motayagheni N, Reddy ST, Eghbali M. Role of oxidized lipids in pulmonary arterial hypertension.. Pulmonary circulation, 2016.
  39. Anwar A, Ruffenach G, Mahajan A, Eghbali M, Umar S. Novel biomarkers for pulmonary arterial hypertension.. Respiratory research, 2016.
  40. Iorga A, Li J, Sharma S, Umar S, Bopassa JC, Nadadur RD, Centala A, Ren S, Saito T, Toro L, Wang Y, Stefani E, Eghbali M. Rescue of Pressure Overload-Induced Heart Failure by Estrogen Therapy.. Journal of the American Heart Association, 2016.
  41. Sharma S, Umar S, Centala A, Eghbali M. Role of miR206 in genistein-induced rescue of pulmonary hypertension in monocrotaline model.. Journal of applied physiology (Bethesda, Md. : 1985), 2015.
  42. Partownavid P, Sharma S, Li J, Umar S, Rahman S, Eghbali M. Involvement of Opioid Receptors in the Lipid Rescue of Bupivacaine-Induced Cardiotoxicity.. Anesthesia and analgesia, 2015.
  43. van der Laarse A, Cobbaert CM, Umar S. Stem and progenitor cell therapy for pulmonary arterial hypertension: effects on the right ventricle (2013 Grover Conference Series).. Pulmonary circulation, 2015.
  44. Sharma S, Umar S, Potus F, Iorga A, Wong G, Meriwether D, Breuils-Bonnet S, Mai D, Navab K, Ross D, Navab M, Provencher S, Fogelman AM, Bonnet S, Reddy ST, Eghbali M. Apolipoprotein A-I mimetic peptide 4F rescues pulmonary hypertension by inducing microRNA-193-3p.. Circulation, 2014.
  45. Li J, Chen X, McClusky R, Ruiz-Sundstrom M, Itoh Y, Umar S, Arnold AP, Eghbali M. The number of X chromosomes influences protection from cardiac ischaemia/reperfusion injury in mice: one X is better than two.. Cardiovascular research, 2014.
  46. Ypey DL, van Meerwijk WP, Umar S, Pijnappels DA, Schalij MJ, van der Laarse A. Depolarization-induced automaticity in rat ventricular cardiomyocytes is based on the gating properties of L-type calcium and slow Kv channels.. European biophysics journal : EBJ, 2012.
  47. Li J, Iorga A, Sharma S, Youn JY, Partow-Navid R, Umar S, Cai H, Rahman S, Eghbali M. Intralipid, a clinically safe compound, protects the heart against ischemia-reperfusion injury more efficiently than cyclosporine-A.. Anesthesiology, 2012.
  48. Umar S, Nadadur R, Iorga A, Amjedi M, Matori H, Eghbali M. Cardiac structural and hemodynamic changes associated with physiological heart hypertrophy of pregnancy are reversed postpartum.. Journal of applied physiology (Bethesda, Md. : 1985), 2012.
  49. Partownavid P, Umar S, Li J, Rahman S, Eghbali M. Fatty-acid oxidation and calcium homeostasis are involved in the rescue of bupivacaine-induced cardiotoxicity by lipid emulsion in rats.. Critical care medicine, 2012.
  50. Li J, Umar S, Amjedi M, Iorga A, Sharma S, Nadadur RD, Regitz-Zagrosek V, Eghbali M. New frontiers in heart hypertrophy during pregnancy.. American journal of cardiovascular disease, 2012.
  51. Matori H, Umar S, Nadadur RD, Sharma S, Partow-Navid R, Afkhami M, Amjedi M, Eghbali M. Genistein, a soy phytoestrogen, reverses severe pulmonary hypertension and prevents right heart failure in rats.. Hypertension (Dallas, Tex. : 1979), 2012.
  52. Li J, Umar S, Iorga A, Youn JY, Wang Y, Regitz-Zagrosek V, Cai H, Eghbali M. Cardiac vulnerability to ischemia/reperfusion injury drastically increases in late pregnancy.. Basic research in cardiology, 2012.
  53. Nadadur RD, Umar S, Wong G, Eghbali M, Iorga A, Matori H, Partow-Navid R, Eghbali M. Reverse right ventricular structural and extracellular matrix remodeling by estrogen in severe pulmonary hypertension.. Journal of applied physiology (Bethesda, Md. : 1985), 2012.
  54. Umar S, Rabinovitch M, Eghbali M. Estrogen paradox in pulmonary hypertension: current controversies and future perspectives.. American journal of respiratory and critical care medicine, 2012.
  55. Umar S, Lee JH, de Lange E, Iorga A, Partow-Navid R, Bapat A, van der Laarse A, Saggar R, Saggar R, Ypey DL, Karagueuzian HS, Eghbali M. Spontaneous ventricular fibrillation in right ventricular failure secondary to chronic pulmonary hypertension.. Circulation. Arrhythmia and electrophysiology, 2011.
  56. Rahman S, Li J, Bopassa JC, Umar S, Iorga A, Partownavid P, Eghbali M. Phosphorylation of GSK-3β mediates intralipid-induced cardioprotection against ischemia/reperfusion injury.. Anesthesiology, 2011.
  57. Umar S, Nadadur RD, Li J, Maltese F, Partownavid P, van der Laarse A, Eghbali M. Intralipid prevents and rescues fatal pulmonary arterial hypertension and right ventricular failure in rats.. Hypertension (Dallas, Tex. : 1979), 2011.
  58. Umar S, Iorga A, Matori H, Nadadur RD, Li J, Maltese F, van der Laarse A, Eghbali M. Estrogen rescues preexisting severe pulmonary hypertension in rats.. American journal of respiratory and critical care medicine, 2011.
  59. Swildens J, de Vries AA, Li Z, Umar S, Atsma DE, Schalij MJ, van der Laarse A. Integrin stimulation favors uptake of macromolecules by cardiomyocytes in vitro.. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2011.
  60. Umar S, de Visser YP, Steendijk P, Schutte CI, Laghmani el H, Wagenaar GT, Bax WH, Mantikou E, Pijnappels DA, Atsma DE, Schalij MJ, van der Wall EE, van der Laarse A. Allogenic stem cell therapy improves right ventricular function by improving lung pathology in rats with pulmonary hypertension.. American journal of physiology. Heart and circulatory physiology, 2009.
  61. Umar S, van der Laarse A. Nitric oxide and nitric oxide synthase isoforms in the normal, hypertrophic, and failing heart.. Molecular and cellular biochemistry, 2009.
  62. Umar S, Bax JJ, Klok M, van Bommel RJ, Hessel MH, den Adel B, Bleeker GB, Henneman MM, Atsma DE, van der Wall EE, Schalij MJ, van der Laarse A. Myocardial collagen metabolism in failing hearts before and during cardiac resynchronization therapy.. European journal of heart failure, 2008.
  63. Umar S, Hessel M, Steendijk P, Bax W, Schutte C, Schalij M, van der Wall E, Atsma D, van der Laarse A. Activation of signaling molecules and matrix metalloproteinases in right ventricular myocardium of rats with pulmonary hypertension.. Pathology, research and practice, 2007.