Steven David Mittelman

Professor, Pediatrics, University of California Los Angeles

Steven Mittelman, M.D., Ph.D., holds the Solomon A. and Marie M. Kaplan Chair of Pediatric Endocrinology.


  1. Buono R, Tucci J, Cutri R, Guidi N, Mangul S, Raucci F, Pellegrini M, Mittelman SD, Longo VD. Fasting-Mimicking Diet Inhibits Autophagy and Synergizes with Chemotherapy to Promote T-Cell-Dependent Leukemia-Free Survival.. Cancers, 2023.
  2. Chimatapu SN, Mittelman SD, Habib M, Osuna-Garcia A, Vidmar AP. Wearable Devices Beyond Activity Trackers in Youth With Obesity: Summary of Options.. Childhood obesity (Print), 2023.
  3. Yao T, Yan H, Zhu X, Zhang Q, Kong X, Guo S, Feng Y, Wang H, Hua Y, Zhang J, Mittelman SD, Tontonoz P, Zhou Z, Liu T, Kong X. Erratum. Obese Skeletal Muscle-Expressed Interferon Regulatory Factor 4 Transcriptionally Regulates Mitochondrial Branched-Chain Aminotransferase Reprogramming Metabolome. Diabetes 2022;71:2256-2271.. Diabetes, 2023.
  4. Vidmar AP, Salvy SJ, Wee CP, Pretlow R, Fox DS, Yee JK, Garell C, Glasner S, Mittelman SD. An addiction-based digital weight loss intervention: A multi-centre randomized controlled trial.. Pediatric obesity, 2022.
  5. Orgel E, Mittelman SD. From soup to nuts: Obesity impairs chemotherapy during early and late phases of acute lymphoblastic leukemia treatment.. Cancer, 2022.
  6. Yao T, Yan H, Zhu X, Zhang Q, Kong X, Guo S, Feng Y, Wang H, Hua Y, Zhang J, Mittelman SD, Tontonoz P, Zhou Z, Liu T, Kong X. Obese Skeletal Muscle-Expressed Interferon Regulatory Factor 4 Transcriptionally Regulates Mitochondrial Branched-Chain Aminotransferase Reprogramming Metabolome.. Diabetes, 2022.
  7. Abt ER, Rashid K, Le TM, Li S, Lee HR, Lok V, Li L, Creech AL, Labora AN, Mandl HK, Lam AK, Cho A, Rezek V, Wu N, Abril-Rodriguez G, Rosser EW, Mittelman SD, Hugo W, Mehrling T, Bantia S, Ribas A, Donahue TR, Crooks GM, Wu TT, Radu CG. Purine nucleoside phosphorylase enables dual metabolic checkpoints that prevent T cell immunodeficiency and TLR7-associated autoimmunity.. The Journal of clinical investigation, 2022.
  8. Kang DW, Wilson RL, Gonzalo-Encabo P, Norris MK, Hans M, Tahbaz M, Dawson J, Nguyen D, Normann AJ, Yunker AG, Sami N, Uno H, Ligibel JA, Mittelman SD, Dieli-Conwright CM. Targeting Adiposity and Inflammation With Movement to Improve Prognosis in Breast Cancer Survivors (The AIM Trial): Rationale, Design, and Methods.. Frontiers in oncology, 2022.
  9. Mittelman SD, Kim J, Raca G, Li G, Oberley MJ, Orgel E. Increased prevalence of CRLF2 rearrangements in obesity-associated acute lymphoblastic leukemia.. Blood, 2021.
  10. Tucci J, Chen T, Margulis K, Orgel E, Paszkiewicz RL, Cohen MD, Oberley MJ, Wahhab R, Jones AE, Divakaruni AS, Hsu CC, Noll SE, Sheng X, Zare RN, Mittelman SD. Adipocytes Provide Fatty Acids to Acute Lymphoblastic Leukemia Cells.. Frontiers in oncology, 2021.
  11. Orgel E, Framson C, Buxton R, Kim J, Li G, Tucci J, Freyer DR, Sun W, Oberley MJ, Dieli-Conwright C, Mittelman SD. Caloric and nutrient restriction to augment chemotherapy efficacy for acute lymphoblastic leukemia: the IDEAL trial.. Blood advances, 2021.
  12. Krall AS, Mullen PJ, Surjono F, Momcilovic M, Schmid EW, Halbrook CJ, Thambundit A, Mittelman SD, Lyssiotis CA, Shackelford DB, Knott SRV, Christofk HR. Asparagine couples mitochondrial respiration to ATF4 activity and tumor growth.. Cell metabolism, 2021.
  13. Orgel E, Nabais T, Douglas C, Mittelman SD, Neely M. Effect of Body Fat on Population Pharmacokinetics of High-Dose Methotrexate in Pediatric Patients With Acute Lymphoblastic Leukemia.. Journal of clinical pharmacology, 2021.
  14. Shenoy RV, Mittelman SD, Relan A, Reh C, Yazdani S. Flattening the Learning Curve: A Case-Based Video Orientation for a Subspeciality Residency Rotation.. Academic pediatrics, 2020.
  15. Gang EJ, Kim HN, Hsieh YT, Ruan Y, Ogana HA, Lee S, Pham J, Geng H, Park E, Klemm L, Willman CL, Carroll WL, Mittelman SD, Orgel E, Oberley MJ, Parekh C, Abdel-Azim H, Bhojwani D, Wayne AS, De Arcangelis A, Georges-Labouesse E, Wayner E, Bonig H, Minasyan A, Ten Hoeve J, Graeber TG, Müschen M, Heisterkamp N, Kim YM. Integrin α6 mediates the drug resistance of acute lymphoblastic B-cell leukemia.. Blood, 2020.
  16. Mittelman SD. The Role of Diet in Cancer Prevention and Chemotherapy Efficacy.. Annual review of nutrition, 2020.
  17. Sea JL, Orgel E, Chen T, Paszkiewicz RL, Krall AS, Oberley MJ, Stiles L, Mittelman SD. Levocarnitine does not impair chemotherapy cytotoxicity against acute lymphoblastic leukemia.. Leukemia & lymphoma, 2019.
  18. Orgel E, Sea JL, Mittelman SD. Mechanisms by Which Obesity Impacts Survival from Acute Lymphoblastic Leukemia.. Journal of the National Cancer Institute. Monographs, 2019.
  19. Mueske NM, Mittelman SD, Wren TAL, Gilsanz V, Orgel E. Myosteatosis in adolescents and young adults treated for acute lymphoblastic leukemia.. Leukemia & lymphoma, 2019.
  20. Rosen EL, Thambundit A, Mehler PS, Mittelman SD. Central diabetes insipidus associated with refeeding in anorexia nervosa: A case report.. The International journal of eating disorders, 2019.
  21. Singer K, Katz ML, Mittelman SD, PES Research Affairs Committee. Proposed endocrine funding priorities for the NICHD strategic plan: expert opinion from the Pediatric Endocrine Society.. Pediatric research, 2019.
  22. Fallah R, Du L, Braverman LE, He X, Segura-Harrison M, Yeh MW, Pearce EN, Chiu HK, Mittelman SD, Leung AM. Iodine Nutrition in Weaning Infants in the United States.. Thyroid : official journal of the American Thyroid Association, 2019.
  23. Vidmar AP, Fink C, Torres B, Manzanarez B, Mittelman SD, Wee CP, Borzutzky C. Energy Management for Personalized Weight Reduction (EMPOWER) Program: Three-Year Outcome Data.. Advances in clinical endocrinology and metabolism, 2019.
  24. Vidmar AP, Salvy SJ, Pretlow R, Mittelman SD, Wee CP, Fink C, Steven Fox D, Raymond JK. An addiction-based mobile health weight loss intervention: protocol of a randomized controlled trial.. Contemporary clinical trials, 2019.
  25. Oliveira FMS, Tran WH, Lesser DJ, Bhatia R, Keens TG, Mittelman SD, Davidson Ward SL, Khoo MCK. Abnormalities in autonomic function in obese boys at-risk for insulin resistance and obstructive sleep apnea.. Pediatric research, 2018.
  26. Tucci J, Alhushki W, Chen T, Sheng X, Kim YM, Mittelman SD. Switch to low-fat diet improves outcome of acute lymphoblastic leukemia in obese mice.. Cancer & metabolism, 2018.
  27. Vidmar AP, Pretlow R, Borzutzky C, Wee CP, Fox DS, Fink C, Mittelman SD. An addiction model-based mobile health weight loss intervention in adolescents with obesity.. Pediatric obesity, 2018.
  28. Mittelman SD, Orgel E. Adipocyte metabolism of the chemotherapy daunorubicin.. Oncoscience, 2018.
  29. Prasca S, Carmona R, Ji L, Ko RH, Bhojwani D, Rawlins YA, Mittelman SD, Young G, Orgel E. Obesity and risk for venous thromboembolism from contemporary therapy for pediatric acute lymphoblastic leukemia.. Thrombosis research, 2018.
  30. Dieli-Conwright CM, Parmentier JH, Sami N, Lee K, Spicer D, Mack WJ, Sattler F, Mittelman SD. Adipose tissue inflammation in breast cancer survivors: effects of a 16-week combined aerobic and resistance exercise training intervention.. Breast cancer research and treatment, 2017.
  31. Sheng X, Parmentier JH, Tucci J, Pei H, Cortez-Toledo O, Dieli-Conwright CM, Oberley MJ, Neely M, Orgel E, Louie SG, Mittelman SD. Adipocytes Sequester and Metabolize the Chemotherapeutic Daunorubicin.. Molecular cancer research : MCR, 2017.
  32. Maggi M, Mittelman SD, Parmentier JH, Colombo G, Meli M, Whitmire JM, Merrell DS, Whitelegge J, Scotti C. A protease-resistant Escherichia coli asparaginase with outstanding stability and enhanced anti-leukaemic activity in vitro.. Scientific reports, 2017.
  33. Orgel E, Mueske NM, Sposto R, Gilsanz V, Wren TAL, Freyer DR, Butturini AM, Mittelman SD. A randomized controlled trial testing an adherence-optimized Vitamin D regimen to mitigate bone change in adolescents being treated for acute lymphoblastic leukemia.. Leukemia & lymphoma, 2017.
  34. Sheng X, Tucci J, Parmentier JH, Ji L, Behan JW, Heisterkamp N, Mittelman SD. Adipocytes cause leukemia cell resistance to daunorubicin via oxidative stress response.. Oncotarget, 2016.
  35. Salehi P, Hsu I, Azen CG, Mittelman SD, Geffner ME, Jeandron D. Effects of exenatide on weight and appetite in overweight adolescents and young adults with Prader-Willi syndrome.. Pediatric obesity, 2016.
  36. Orgel E, Mueske NM, Wren TA, Gilsanz V, Butturini AM, Freyer DR, Mittelman SD. Early injury to cortical and cancellous bone from induction chemotherapy for adolescents and young adults treated for acute lymphoblastic leukemia.. Bone, 2016.
  37. Orgel E, Mueske NM, Sposto R, Gilsanz V, Freyer DR, Mittelman SD. Limitations of body mass index to assess body composition due to sarcopenic obesity during leukemia therapy.. Leukemia & lymphoma, 2016.
  38. Van Speybroeck A, Mueske NM, Mittelman SD, Kremer RK, Ryan DD, Wren TA. Fasting serum blood measures of bone and lipid metabolism in children with myelomeningocele for early detection of cardiovascular and bone fragility risk factors.. The journal of spinal cord medicine, 2015.
  39. Kim MS, Ryabets-Lienhard A, Dao-Tran A, Mittelman SD, Gilsanz V, Schrager SM, Geffner ME. Increased Abdominal Adiposity in Adolescents and Young Adults With Classical Congenital Adrenal Hyperplasia due to 21-Hydroxylase Deficiency.. The Journal of clinical endocrinology and metabolism, 2015.
  40. Lin MH, Wood JR, Mittelman SD, Freyer DR. Institutional adherence to cardiovascular risk factor screening guidelines for young survivors of acute lymphoblastic leukemia.. Journal of pediatric hematology/oncology, 2015.
  41. Parmentier JH, Maggi M, Tarasco E, Scotti C, Avramis VI, Mittelman SD. Glutaminase activity determines cytotoxicity of L-asparaginases on most leukemia cell lines.. Leukemia research, 2015.
  42. McConnell R, Gilliland FD, Goran M, Allayee H, Hricko A, Mittelman S. Does near-roadway air pollution contribute to childhood obesity?. Pediatric obesity, 2015.
  43. Alderete TL, Sattler FR, Richey JM, Allayee H, Mittelman SD, Sheng X, Tucci J, Gyllenhammer LE, Grant EG, Goran MI. Salsalate treatment improves glycemia without altering adipose tissue in nondiabetic obese hispanics.. Obesity (Silver Spring, Md.), 2015.
  44. Huang KE, Mittelman SD, Coates TD, Geffner ME, Wood JC. A significant proportion of thalassemia major patients have adrenal insufficiency detectable on provocative testing.. Journal of pediatric hematology/oncology, 2015.
  45. Shih EM, Mittelman S, Pitukcheewanont P, Azen CG, Monzavi R. Effects of vitamin D repletion on glycemic control and inflammatory cytokines in adolescents with type 1 diabetes.. Pediatric diabetes, 2014.
  46. Orgel E, Tucci J, Alhushki W, Malvar J, Sposto R, Fu CH, Freyer DR, Abdel-Azim H, Mittelman SD. Obesity is associated with residual leukemia following induction therapy for childhood B-precursor acute lymphoblastic leukemia.. Blood, 2014.
  47. Sheng X, Mittelman SD. The role of adipose tissue and obesity in causing treatment resistance of acute lymphoblastic leukemia.. Frontiers in pediatrics, 2014.
  48. Alderete TL, Sattler FR, Sheng X, Tucci J, Mittelman SD, Grant EG, Goran MI. A novel biopsy method to increase yield of subcutaneous abdominal adipose tissue.. International journal of obesity (2005), 2014.
  49. Behan JW, Ehsanipour EA, Sheng X, Pramanik R, Wang X, Hsieh YT, Kim YM, Mittelman SD. Activation of adipose tissue macrophages in obese mice does not require lymphocytes.. Obesity (Silver Spring, Md.), 2013.
  50. Sheng X, Tucci J, Malvar J, Mittelman SD. Adipocyte differentiation is affected by media height above the cell layer.. International journal of obesity (2005), 2013.
  51. Ehsanipour EA, Sheng X, Behan JW, Wang X, Butturini A, Avramis VI, Mittelman SD. Adipocytes cause leukemia cell resistance to L-asparaginase via release of glutamine.. Cancer research, 2013.
  52. Orgel E, Mittelman SD. The links between insulin resistance, diabetes, and cancer.. Current diabetes reports, 2013.
  53. Pramanik R, Sheng X, Ichihara B, Heisterkamp N, Mittelman SD. Adipose tissue attracts and protects acute lymphoblastic leukemia cells from chemotherapy.. Leukemia research, 2013.
  54. Lesser DJ, Bhatia R, Tran WH, Oliveira F, Ortega R, Keens TG, Mittelman SD, Khoo MC, Davidson Ward SL. Sleep fragmentation and intermittent hypoxemia are associated with decreased insulin sensitivity in obese adolescent Latino males.. Pediatric research, 2012.
  55. Antony R, Sheng X, Ehsanipour EA, Ng E, Pramanik R, Klemm L, Ichihara B, Mittelman SD. Vitamin D protects acute lymphoblastic leukemia cells from dexamethasone.. Leukemia research, 2012.
  56. Noetzli LJ, Panigrahy A, Mittelman SD, Hyderi A, Dongelyan A, Coates TD, Wood JC. Pituitary iron and volume predict hypogonadism in transfusional iron overload.. American journal of hematology, 2011.
  57. Noetzli LJ, Mittelman SD, Watanabe RM, Coates TD, Wood JC. Pancreatic iron and glucose dysregulation in thalassemia major.. American journal of hematology, 2011.
  58. Reh CM, Mittelman SD, Wee CP, Shah AC, Kaufman FR, Wood JR. A longitudinal assessment of lipids in youth with type 1 diabetes.. Pediatric diabetes, 2011.
  59. Chung SA, Dorey F, Mittelman S, Gilsanz V. Effect of gender on intra-abdominal fat in teenagers and young adults.. Pediatric radiology, 2010.
  60. Yun JP, Behan JW, Heisterkamp N, Butturini A, Klemm L, Ji L, Groffen J, Müschen M, Mittelman SD. Diet-induced obesity accelerates acute lymphoblastic leukemia progression in two murine models.. Cancer prevention research (Philadelphia, Pa.), 2010.
  61. Wood JC, Noetzl L, Hyderi A, Joukar M, Coates T, Mittelman S. Predicting pituitary iron and endocrine dysfunction.. Annals of the New York Academy of Sciences, 2010.
  62. Mittelman SD, Klier K, Braun S, Azen C, Geffner ME, Buchanan TA. Obese adolescents show impaired meal responses of the appetite-regulating hormones ghrelin and PYY.. Obesity (Silver Spring, Md.), 2010.
  63. Behan JW, Avramis VI, Yun JP, Louie SG, Mittelman SD. Diet-induced obesity alters vincristine pharmacokinetics in blood and tissues of mice.. Pharmacological research, 2010.
  64. Oliveira FM, Tran WH, Lesser D, Bhatia R, Ortega R, Mittelman SD, Keens TG, Davidson Ward SL, Khoo MC. Autonomic and metabolic effects of OSA in childhood obesity.. Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference, 2010.
  65. Mittelman SD, Gilsanz P, Mo AO, Wood J, Dorey F, Gilsanz V. Adiposity predicts carotid intima-media thickness in healthy children and adolescents.. The Journal of pediatrics, 2009.
  66. Behan JW, Yun JP, Proektor MP, Ehsanipour EA, Arutyunyan A, Moses AS, Avramis VI, Louie SG, Butturini A, Heisterkamp N, Mittelman SD. Adipocytes impair leukemia treatment in mice.. Cancer research, 2009.
  67. Gilsanz V, Chalfant J, Mo AO, Lee DC, Dorey FJ, Mittelman SD. Reciprocal relations of subcutaneous and visceral fat to bone structure and strength.. The Journal of clinical endocrinology and metabolism, 2009.
  68. Di Iorgi N, Mittelman SD, Gilsanz V. Differential effect of marrow adiposity and visceral and subcutaneous fat on cardiovascular risk in young, healthy adults.. International journal of obesity (2005), 2008.
  69. Di Iorgi N, Rosol M, Mittelman SD, Gilsanz V. Reciprocal relation between marrow adiposity and the amount of bone in the axial and appendicular skeleton of young adults.. The Journal of clinical endocrinology and metabolism, 2008.
  70. Karantza MV, Mittelman SD, Dorey F, Samie S, Kaiserman K, Halvorson M, Kaufman FR. Relationship of highly sensitive C-reactive protein and lipid levels in adolescents with type 1 diabetes mellitus.. Pediatric diabetes, 2007.
  71. Janicka A, Wren TA, Sanchez MM, Dorey F, Kim PS, Mittelman SD, Gilsanz V. Fat mass is not beneficial to bone in adolescents and young adults.. The Journal of clinical endocrinology and metabolism, 2006.
  72. Mittelman SD, Hendy GN, Fefferman RA, Canaff L, Mosesova I, Cole DE, Burkett L, Geffner ME. A hypocalcemic child with a novel activating mutation of the calcium-sensing receptor gene: successful treatment with recombinant human parathyroid hormone.. The Journal of clinical endocrinology and metabolism, 2006.
  73. Kovanlikaya A, Mittelman SD, Ward A, Geffner ME, Dorey F, Gilsanz V. Obesity and fat quantification in lean tissues using three-point Dixon MR imaging.. Pediatric radiology, 2005.
  74. van Citters GW, Kabir M, Kim SP, Mittelman SD, Dea MK, Brubaker PL, Bergman RN. Elevated glucagon-like peptide-1-(7-36)-amide, but not glucose, associated with hyperinsulinemic compensation for fat feeding.. The Journal of clinical endocrinology and metabolism, 2002.
  75. Mittelman SD, Van Citters GW, Kirkman EL, Bergman RN. Extreme insulin resistance of the central adipose depot in vivo.. Diabetes, 2002.
  76. Fosgerau K, Mittelman SD, Sunehag A, Dea MK, Lundgren K, Bergman RN. Lack of hepatic "interregulation" during inhibition of glycogenolysis in a canine model.. American journal of physiology. Endocrinology and metabolism, 2001.
  77. Bergman RN, Van Citters GW, Mittelman SD, Dea MK, Hamilton-Wessler M, Kim SP, Ellmerer M. Central role of the adipocyte in the metabolic syndrome.. Journal of investigative medicine : the official publication of the American Federation for Clinical Research, 2001.
  78. Mittelman SD, Van Citters GW, Kim SP, Davis DA, Dea MK, Hamilton-Wessler M, Bergman RN. Longitudinal compensation for fat-induced insulin resistance includes reduced insulin clearance and enhanced beta-cell response.. Diabetes, 2000.
  79. Dea MK, Van Citters GW, Ader M, Mittelman SD, Sunehag AL, Bergman RN. Paradoxical effect of troglitazone in normal animals: enhancement of adipocyte but reduction of liver insulin sensitivity.. Diabetes, 2000.
  80. Mittelman SD, Bergman RN. Inhibition of lipolysis causes suppression of endogenous glucose production independent of changes in insulin.. American journal of physiology. Endocrinology and metabolism, 2000.
  81. Getty L, Panteleon AE, Mittelman SD, Dea MK, Bergman RN. Rapid oscillations in omental lipolysis are independent of changing insulin levels in vivo.. The Journal of clinical investigation, 2000.
  82. Carpentier A, Mittelman SD, Bergman RN, Giacca A, Lewis GF. Prolonged elevation of plasma free fatty acids impairs pancreatic beta-cell function in obese nondiabetic humans but not in individuals with type 2 diabetes.. Diabetes, 2000.
  83. Carpentier A, Mittelman SD, Lamarche B, Bergman RN, Giacca A, Lewis GF. Acute enhancement of insulin secretion by FFA in humans is lost with prolonged FFA elevation.. The American journal of physiology, 1999.
  84. Steil GM, Rebrin K, Mittelman SD, Bergman RN. Role of portal insulin delivery in the disappearance of intravenous glucose and assessment of insulin sensitivity.. Diabetes, 1998.
  85. Bergman RN, Mittelman SD. Central role of the adipocyte in insulin resistance.. Journal of basic and clinical physiology and pharmacology, 1998.
  86. Mittelman SD, Fu YY, Rebrin K, Steil G, Bergman RN. Indirect effect of insulin to suppress endogenous glucose production is dominant, even with hyperglucagonemia.. The Journal of clinical investigation, 1997.
  87. Rebrin K, Steil GM, Mittelman SD, Bergman RN. Causal linkage between insulin suppression of lipolysis and suppression of liver glucose output in dogs.. The Journal of clinical investigation, 1996.