Publications

1. Janilkarn-Urena I, Tse A, Lin J, Tafolla-Aguirre B, Idrissova A, Zhang M, Skinner SG, Mostowfi N, Kim J, Kalapatapu N, Chang X, Efthymiou C, Williams CK, Magaki SD, Vinters HV, Gonen T, Ahmed SK, Gukasyan HJ, Davies DL, Seidler PM. Improving the solubility of pseudo-hydrophobic chemicals through co-crystal formulation.. PNAS nexus, 2025.
2. Nicolas WJ, Gillman C, Weaver SJ, Clabbers MTB, Shiriaeva A, Her AS, Martynowycz MW, Gonen T. Comprehensive microcrystal electron diffraction sample preparation for cryo-EM.. Nature protocols, 2024.
3. Liu X, Xia X, Martynowycz MW, Gonen T, Zhou ZH. Molecular sociology of virus-induced cellular condensates supporting reovirus assembly and replication.. Nature communications, 2024.
4. Lin J, Unge J, Gonen T. MicroED Structures of Fluticasone Furoate and Fluticasone Propionate Provide New Insights to Their Function.. bioRxiv : the preprint server for biology, 2024.
5. Lin J, Bu G, Unge J, Gonen T. An Updated Structure of Oxybutynin Hydrochloride.. Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2024.
6. Clabbers MTB, Hattne J, Martynowycz MW, Gonen T. Energy filtering enables macromolecular MicroED data at sub-atomic resolution.. bioRxiv : the preprint server for biology, 2024.
7. Lin J, Bu G, Unge J, Gonen T. Uncovering the Elusive Structures and Mechanisms of Prevalent Antidepressants.. Advanced therapeutics, 2024.
8. Ruma YN, Bu G, Hattne J, Gonen T. MicroED structure of the C11 cysteine protease clostripain.. Journal of structural biology: X, 2024.
9. Lin J, Bu G, Unge J, Gonen T. An Updated Structure of Oxybutynin Hydrochloride.. bioRxiv : the preprint server for biology, 2024.
10. Gillman C, Bu G, Danelius E, Hattne J, Nannenga BL, Gonen T. Eliminating the missing cone challenge through innovative approaches.. Journal of structural biology: X, 2024.
11. Nicolas WJ, Shiriaeva A, Martynowycz MW, Grey AC, Ruma Y, Donaldson PJ, Gonen T. Structure of the lens MP20 mediated adhesive junction.. bioRxiv : the preprint server for biology, 2024.
12. Unge J, Lin J, Weaver SJ, Sae Her A, Gonen T. Compositional Analysis of Complex Mixtures using Automatic MicroED Data Collection.. Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2024.
13. Xia X, Sung PY, Martynowycz MW, Gonen T, Roy P, Zhou ZH. RNA genome packaging and capsid assembly of bluetongue virus visualized in host cells.. Cell, 2024.
14. Bu G, Danelius E, Wieske LHE, Gonen T. Polymorphic Structure Determination of the Macrocyclic Drug Paritaprevir by MicroED.. Advanced biology, 2024.
15. Gillman C, Bu G, Danelius E, Hattne J, Nannenga B, Gonen T. Eliminating the Missing Cone Challenge through Innovative Approaches.. bioRxiv : the preprint server for biology, 2024.
16. Ruma YN, Bu G, Gonen T. MicroED structure of the C11 cysteine protease Clostripain.. bioRxiv : the preprint server for biology, 2024.
17. Lin J, Unge J, Gonen T. Unraveling the Structure of Meclizine Dihydrochloride with MicroED.. Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2023.
18. Hattne J, Clabbers MTB, Martynowycz MW, Gonen T. Electron counting with direct electron detectors in MicroED.. Structure (London, England : 1993), 2023.
19. Danelius E, Bu G, Wieske LHE, Gonen T. MicroED as a Powerful Tool for Structure Determination of Macrocyclic Drug Compounds Directly from Their Powder Formulations.. ACS chemical biology, 2023.
20. Walsh MA, Nannenga BL, Gonen T, Sexton PM, Wootten D, Chiu W, Sun F, Carragher B, Potter CS, Agard D, Burley SK. The next decade in structural biology.. Structure (London, England : 1993), 2023.
21. Bai XC, Gonen T, Gronenborn AM, Perrakis A, Thorn A, Yang J. Challenges and opportunities in macromolecular structure determination.. Nature reviews. Molecular cell biology, 2023.
22. Lin J, Unge J, Gonen T. Distinct Conformations of Mirabegron Determined by MicroED.. Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2023.
23. Bu G, Danelius E, Wieske LH, Gonen T. Polymorphic Structure Determination of the Macrocyclic Drug Paritaprevir by MicroED.. bioRxiv : the preprint server for biology, 2023.
24. Lin J, Unge J, Gonen T. Unraveling the Structure of Meclizine Dihydrochloride with MicroED.. bioRxiv : the preprint server for biology, 2023.
25. Nannenga BL, Gonen T. The 2023 Structural Biology Summit at UCLA.. Structure (London, England : 1993), 2023.
26. Haymaker A, Bardin AA, Gonen T, Martynowycz MW, Nannenga BL. Structure determination of a DNA crystal by MicroED.. Structure (London, England : 1993), 2023.
27. Danelius E, Bu G, Wieske H, Gonen T. MicroED as a powerful tool for structure determination of macrocyclic drug compounds directly from their powder formulations.. bioRxiv : the preprint server for biology, 2023.
28. Shiriaeva A, Martynowycz MW, Nicolas WJ, Cherezov V, Gonen T. MicroED structure of the human vasopressin 1B receptor.. bioRxiv : the preprint server for biology, 2023.
29. Gillman C, Nicolas WJ, Martynowycz MW, Gonen T. Design and implementation of suspended drop crystallization.. IUCrJ, 2023.
30. Hattne J, Clabbers MTB, Martynowycz MW, Gonen T. Electron-counting in MicroED.. bioRxiv : the preprint server for biology, 2023.
31. Lin J, Unge J, Gonen T. Distinct Conformations of Mirabegron Determined by MicroED.. bioRxiv : the preprint server for biology, 2023.
32. Gillman C, Patel K, Unge J, Gonen T. The structure of the neurotoxin palytoxin determined by MicroED.. bioRxiv : the preprint server for biology, 2023.
33. Nguyen C, Lei HT, Lai LTF, Gallenito MJ, Mu X, Matthies D, Gonen T. Lipid flipping in the omega-3 fatty-acid transporter.. Nature communications, 2023.
34. Tse A, Janilkarn-Urena I, Lin J, Chang X, Efthymiou C, Idrissova A, Zhang M, Williams CK, Magaki S, Vinters HV, Davies DL, Gonen T, Gukasyan HJ, Seidler PM. Improving the solubility of pseudo-hydrophobic Alzheimer's Disease medicinal chemicals through co-crystal formulation.. bioRxiv : the preprint server for biology, 2023.
35. Haymaker A, Bardin AA, Gonen T, Martynowycz MW, Nannenga BL. Structure determination of a DNA crystal by MicroED.. bioRxiv : the preprint server for biology, 2023.
36. Gillman C, Nicolas WJ, Martynowycz MW, Gonen T. Design and implementation of suspended drop crystallization.. bioRxiv : the preprint server for biology, 2023.
37. Danelius E, Porter NJ, Unge J, Arnold FH, Gonen T. MicroED Structure of a Protoglobin Reactive Carbene Intermediate.. Journal of the American Chemical Society, 2023.
38. Martynowycz MW, Shiriaeva A, Clabbers MTB, Nicolas WJ, Weaver SJ, Hattne J, Gonen T. A robust approach for MicroED sample preparation of lipidic cubic phase embedded membrane protein crystals.. Nature communications, 2023.
39. Danelius E, Patel K, Gonzalez B, Gonen T. MicroED in drug discovery.. Current opinion in structural biology, 2023.
40. Clabbers MTB, Martynowycz MW, Hattne J, Gonen T. Hydrogens and hydrogen-bond networks in macromolecular MicroED data.. Journal of structural biology: X, 2022.
41. Clabbers MTB, Martynowycz MW, Hattne J, Nannenga BL, Gonen T. Electron-counting MicroED data with the K2 and K3 direct electron detectors.. Journal of structural biology, 2022.
42. Martynowycz M, Gonen T. Unlocking the potential of MICROCRYSTAL ELECTRON DIFFRACTION.. Physics today, 2022.
43. Martynowycz MW, Clabbers MTB, Hattne J, Gonen T. Ab initio phasing macromolecular structures using electron-counted MicroED data.. Nature methods, 2022.
44. Porter NJ, Danelius E, Gonen T, Arnold FH. Biocatalytic Carbene Transfer Using Diazirines.. Journal of the American Chemical Society, 2022.
45. Gallenito MJ, Gonen T. Studying membrane proteins with MicroED.. Biochemical Society transactions, 2022.
46. Clabbers MTB, Shiriaeva A, Gonen T. MicroED: conception, practice and future opportunities.. IUCrJ, 2022.
47. Martynowycz MW, Clabbers MTB, Unge J, Hattne J, Gonen T. Benchmarking the ideal sample thickness in cryo-EM.. Proceedings of the National Academy of Sciences of the United States of America, 2021.
48. Clark LJ, Bu G, Nannenga BL, Gonen T. MicroED for the study of protein-ligand interactions and the potential for drug discovery.. Nature reviews. Chemistry, 2021.
49. Martynowycz MW, Shiriaeva A, Ge X, Hattne J, Nannenga BL, Cherezov V, Gonen T. MicroED structure of the human adenosine receptor determined from a single nanocrystal in LCP.. Proceedings of the National Academy of Sciences of the United States of America, 2021.
50. Martynowycz MW, Gonen T. Protocol for the use of focused ion-beam milling to prepare crystalline lamellae for microcrystal electron diffraction (MicroED).. STAR protocols, 2021.
51. Mu X, Gillman C, Nguyen C, Gonen T. An Overview of Microcrystal Electron Diffraction (MicroED).. Annual review of biochemistry, 2021.
52. Nannenga BL, Gonen T. Publisher Correction: The cryo-EM method microcrystal electron diffraction (MicroED).. Nature methods, 2021.
53. Martynowycz MW, Gonen T. Microcrystal Electron Diffraction of Small Molecules.. Journal of visualized experiments : JoVE, 2021.
54. Halaby S, Martynowycz M, Zhu Z, Tretiak S, Zhugayevych A, Gonen T, Seifrid M. Microcrystal Electron Diffraction for Molecular Design of Functional Non-Fullerene Acceptor Structures.. Chemistry of materials : a publication of the American Chemical Society, 2021.
55. Danelius E, Gonen T. Protein and Small Molecule Structure Determination by the Cryo-EM Method MicroED.. Methods in molecular biology (Clifton, N.J.), 2021.
56. Martynowycz MW, Gonen T. Studying Membrane Protein Structures by MicroED.. Methods in molecular biology (Clifton, N.J.), 2021.
57. Lei HT, Mu X, Hattne J, Gonen T. A conformational change in the N terminus of SLC38A9 signals mTORC1 activation.. Structure (London, England : 1993), 2020.
58. Martynowycz MW, Khan F, Hattne J, Abramson J, Gonen T. MicroED structure of lipid-embedded mammalian mitochondrial voltage-dependent anion channel.. Proceedings of the National Academy of Sciences of the United States of America, 2020.
59. Martynowycz MW, Gonen T. Ligand Incorporation into Protein Microcrystals for MicroED by On-Grid Soaking.. Structure (London, England : 1993), 2020.
60. Danelius E, Halaby S, van der Donk WA, Gonen T. MicroED in natural product and small molecule research.. Natural product reports, 2020.
61. Zhu L, Bu G, Jing L, Shi D, Lee MY, Gonen T, Liu W, Nannenga BL. Structure Determination from Lipidic Cubic Phase Embedded Microcrystals by MicroED.. Structure (London, England : 1993), 2020.
62. Richards LS, Millán C, Miao J, Martynowycz MW, Sawaya MR, Gonen T, Borges RJ, Usón I, Rodriguez JA. Fragment-based determination of a proteinase K structure from MicroED data using ARCIMBOLDO_SHREDDER.. Acta crystallographica. Section D, Structural biology, 2020.
63. Nguyen C, Gonen T. Beyond protein structure determination with MicroED.. Current opinion in structural biology, 2020.
64. Wolff AM, Young ID, Sierra RG, Brewster AS, Martynowycz MW, Nango E, Sugahara M, Nakane T, Ito K, Aquila A, Bhowmick A, Biel JT, Carbajo S, Cohen AE, Cortez S, Gonzalez A, Hino T, Im D, Koralek JD, Kubo M, Lazarou TS, Nomura T, Owada S, Samelson AJ, Tanaka T, Tanaka R, Thompson EM, van den Bedem H, Woldeyes RA, Yumoto F, Zhao W, Tono K, Boutet S, Iwata S, Gonen T, Sauter NK, Fraser JS, Thompson MC. Comparing serial X-ray crystallography and microcrystal electron diffraction (MicroED) as methods for routine structure determination from small macromolecular crystals.. IUCrJ, 2020.
65. Martynowycz MW, Hattne J, Gonen T. Experimental Phasing of MicroED Data Using Radiation Damage.. Structure (London, England : 1993), 2020.
66. Dick M, Sarai NS, Martynowycz MW, Gonen T, Arnold FH. Tailoring Tryptophan Synthase TrpB for Selective Quaternary Carbon Bond Formation.. Journal of the American Chemical Society, 2019.
67. Griner SL, Seidler P, Bowler J, Murray KA, Yang TP, Sahay S, Sawaya MR, Cascio D, Rodriguez JA, Philipp S, Sosna J, Glabe CG, Gonen T, Eisenberg DS. Structure-based inhibitors of amyloid beta core suggest a common interface with tau.. eLife, 2019.
68. Hattne J, Martynowycz MW, Penczek PA, Gonen T. MicroED with the Falcon III direct electron detector.. IUCrJ, 2019.
69. Martynowycz MW, Zhao W, Hattne J, Jensen GJ, Gonen T. Qualitative Analyses of Polishing and Precoating FIB Milled Crystals for MicroED.. Structure (London, England : 1993), 2019.
70. Warmack RA, Boyer DR, Zee CT, Richards LS, Sawaya MR, Cascio D, Gonen T, Eisenberg DS, Clarke SG. Structure of amyloid-β (20-34) with Alzheimer's-associated isomerization at Asp23 reveals a distinct protofilament interface.. Nature communications, 2019.
71. Ting CP, Funk MA, Halaby SL, Zhang Z, Gonen T, van der Donk WA. Use of a scaffold peptide in the biosynthesis of amino acid-derived natural products.. Science (New York, N.Y.), 2019.
72. Nannenga BL, Gonen T. The cryo-EM method microcrystal electron diffraction (MicroED).. Nature methods, 2019.
73. de la Cruz MJ, Martynowycz MW, Hattne J, Gonen T. MicroED data collection with SerialEM.. Ultramicroscopy, 2019.
74. Zee CT, Glynn C, Gallagher-Jones M, Miao J, Santiago CG, Cascio D, Gonen T, Sawaya MR, Rodriguez JA. Homochiral and racemic MicroED structures of a peptide repeat from the ice-nucleation protein InaZ.. IUCrJ, 2019.
75. Ma J, Lei HT, Reyes FE, Sanchez-Martinez S, Sarhan MF, Hattne J, Gonen T. Structural basis for substrate binding and specificity of a sodium-alanine symporter AgcS.. Proceedings of the National Academy of Sciences of the United States of America, 2019.
76. Martynowycz MW, Zhao W, Hattne J, Jensen GJ, Gonen T. Collection of Continuous Rotation MicroED Data from Ion Beam-Milled Crystals of Any Size.. Structure (London, England : 1993), 2019.
77. Purdy MD, Shi D, Chrustowicz J, Hattne J, Gonen T, Yeager M. MicroED structures of HIV-1 Gag CTD-SP1 reveal binding interactions with the maturation inhibitor bevirimat.. Proceedings of the National Academy of Sciences of the United States of America, 2018.
78. Jones CG, Martynowycz MW, Hattne J, Fulton TJ, Stoltz BM, Rodriguez JA, Nelson HM, Gonen T. The CryoEM Method MicroED as a Powerful Tool for Small Molecule Structure Determination.. ACS central science, 2018.
79. Nannenga BL, Gonen T. Correction: MicroED: a versatile cryoEM method for structure determination.. Emerging topics in life sciences, 2018.
80. Lei HT, Ma J, Sanchez Martinez S, Gonen T. Crystal structure of arginine-bound lysosomal transporter SLC38A9 in the cytosol-open state.. Nature structural & molecular biology, 2018.
81. Liu S, Gonen T. MicroED structure of the NaK ion channel reveals a Na+ partition process into the selectivity filter.. Communications biology, 2018.
82. Hattne J, Shi D, Glynn C, Zee CT, Gallagher-Jones M, Martynowycz MW, Rodriguez JA, Gonen T. Analysis of Global and Site-Specific Radiation Damage in Cryo-EM.. Structure (London, England : 1993), 2018.
83. Guenther EL, Ge P, Trinh H, Sawaya MR, Cascio D, Boyer DR, Gonen T, Zhou ZH, Eisenberg DS. Atomic-level evidence for packing and positional amyloid polymorphism by segment from TDP-43 RRM2.. Nature structural & molecular biology, 2018.
84. Liu Y, Gonen S, Gonen T, Yeates TO. Near-atomic cryo-EM imaging of a small protein displayed on a designed scaffolding system.. Proceedings of the National Academy of Sciences of the United States of America, 2018.
85. Hughes MP, Sawaya MR, Boyer DR, Goldschmidt L, Rodriguez JA, Cascio D, Chong L, Gonen T, Eisenberg DS. Atomic structures of low-complexity protein segments reveal kinked β sheets that assemble networks.. Science (New York, N.Y.), 2018.
86. Nannenga BL, Gonen T. MicroED: a versatile cryoEM method for structure determination.. Emerging topics in life sciences, 2018.
87. Martynowycz MW, Gonen T. From electron crystallography of 2D crystals to MicroED of 3D crystals.. Current opinion in colloid & interface science, 2018.
88. Gallagher-Jones M, Glynn C, Boyer DR, Martynowycz MW, Hernandez E, Miao J, Zee CT, Novikova IV, Goldschmidt L, McFarlane HT, Helguera GF, Evans JE, Sawaya MR, Cascio D, Eisenberg DS, Gonen T, Rodriguez JA. Sub-ångström cryo-EM structure of a prion protofibril reveals a polar clasp.. Nature structural & molecular biology, 2018.
89. Krotee P, Griner SL, Sawaya MR, Cascio D, Rodriguez JA, Shi D, Philipp S, Murray K, Saelices L, Lee J, Seidler P, Glabe CG, Jiang L, Gonen T, Eisenberg DS. Common fibrillar spines of amyloid-β and human islet amyloid polypeptide revealed by microelectron diffraction and structure-based inhibitors.. The Journal of biological chemistry, 2017.
90. Seidler PM, Boyer DR, Rodriguez JA, Sawaya MR, Cascio D, Murray K, Gonen T, Eisenberg DS. Structure-based inhibitors of tau aggregation.. Nature chemistry, 2017.
91. Vergara S, Lukes DA, Martynowycz MW, Santiago U, Plascencia-Villa G, Weiss SC, de la Cruz MJ, Black DM, Alvarez MM, López-Lozano X, Barnes CO, Lin G, Weissker HC, Whetten RL, Gonen T, Yacaman MJ, Calero G. MicroED Structure of Au146(p-MBA)57 at Subatomic Resolution Reveals a Twinned FCC Cluster.. The journal of physical chemistry letters, 2017.
92. Wright ZVF, McCarthy S, Dickman R, Reyes FE, Sanchez-Martinez S, Cryar A, Kilford I, Hall A, Takle AK, Topf M, Gonen T, Thalassinos K, Tabor AB. The Role of Disulfide Bond Replacements in Analogues of the Tarantula Toxin ProTx-II and Their Effects on Inhibition of the Voltage-Gated Sodium Ion Channel Nav1.7.. Journal of the American Chemical Society, 2017.
93. Rodriguez JA, Eisenberg DS, Gonen T. Taking the measure of MicroED.. Current opinion in structural biology, 2017.
94. de la Cruz MJ, Hattne J, Shi D, Seidler P, Rodriguez J, Reyes FE, Sawaya MR, Cascio D, Weiss SC, Kim SK, Hinck CS, Hinck AP, Calero G, Eisenberg D, Gonen T. Atomic-resolution structures from fragmented protein crystals with the cryoEM method MicroED.. Nature methods, 2017.
95. Krotee P, Rodriguez JA, Sawaya MR, Cascio D, Reyes FE, Shi D, Hattne J, Nannenga BL, Oskarsson ME, Philipp S, Griner S, Jiang L, Glabe CG, Westermark GT, Gonen T, Eisenberg DS. Atomic structures of fibrillar segments of hIAPP suggest tightly mated β-sheets are important for cytotoxicity.. eLife, 2017.
96. Hsia Y, Bale JB, Gonen S, Shi D, Sheffler W, Fong KK, Nattermann U, Xu C, Huang PS, Ravichandran R, Yi S, Davis TN, Gonen T, King NP, Baker D. Corrigendum: Design of a hyperstable 60-subunit protein icosahedron.. Nature, 2016.
97. Nannenga BL, Gonen T. MicroED opens a new era for biological structure determination.. Current opinion in structural biology, 2016.
98. Sawaya MR, Rodriguez J, Cascio D, Collazo MJ, Shi D, Reyes FE, Hattne J, Gonen T, Eisenberg DS. Ab initio structure determination from prion nanocrystals at atomic resolution by MicroED.. Proceedings of the National Academy of Sciences of the United States of America, 2016.
99. Liu S, Hattne J, Reyes FE, Sanchez-Martinez S, Jason de la Cruz M, Shi D, Gonen T. Atomic resolution structure determination by the cryo-EM method MicroED.. Protein science : a publication of the Protein Society, 2016.
100. Bale JB, Gonen S, Liu Y, Sheffler W, Ellis D, Thomas C, Cascio D, Yeates TO, Gonen T, King NP, Baker D. Accurate design of megadalton-scale two-component icosahedral protein complexes.. Science (New York, N.Y.), 2016.
101. Rodriguez JA, Gonen T. High-Resolution Macromolecular Structure Determination by MicroED, a cryo-EM Method.. Methods in enzymology, 2016.
102. Hsia Y, Bale JB, Gonen S, Shi D, Sheffler W, Fong KK, Nattermann U, Xu C, Huang PS, Ravichandran R, Yi S, Davis TN, Gonen T, King NP, Baker D. Design of a hyperstable 60-subunit protein dodecahedron. [corrected].. Nature, 2016.
103. Hattne J, Shi D, de la Cruz MJ, Reyes FE, Gonen T. Modeling truncated pixel values of faint reflections in MicroED images.. Journal of applied crystallography, 2016.
104. Shi D, Nannenga BL, de la Cruz MJ, Liu J, Sawtelle S, Calero G, Reyes FE, Hattne J, Gonen T. The collection of MicroED data for macromolecular crystallography.. Nature protocols, 2016.
105. Meyer PA, Socias S, Key J, Ransey E, Tjon EC, Buschiazzo A, Lei M, Botka C, Withrow J, Neau D, Rajashankar K, Anderson KS, Baxter RH, Blacklow SC, Boggon TJ, Bonvin AM, Borek D, Brett TJ, Caflisch A, Chang CI, Chazin WJ, Corbett KD, Cosgrove MS, Crosson S, Dhe-Paganon S, Di Cera E, Drennan CL, Eck MJ, Eichman BF, Fan QR, Ferré-D'Amaré AR, Fromme JC, Garcia KC, Gaudet R, Gong P, Harrison SC, Heldwein EE, Jia Z, Keenan RJ, Kruse AC, Kvansakul M, McLellan JS, Modis Y, Nam Y, Otwinowski Z, Pai EF, Pereira PJ, Petosa C, Raman CS, Rapoport TA, Roll-Mecak A, Rosen MK, Rudenko G, Schlessinger J, Schwartz TU, Shamoo Y, Sondermann H, Tao YJ, Tolia NH, Tsodikov OV, Westover KD, Wu H, Foster I, Fraser JS, Maia FR, Gonen T, Kirchhausen T, Diederichs K, Crosas M, Sliz P. Data publication with the structural biology data grid supports live analysis.. Nature communications, 2016.
106. Rodriguez JA, Ivanova MI, Sawaya MR, Cascio D, Reyes FE, Shi D, Sangwan S, Guenther EL, Johnson LM, Zhang M, Jiang L, Arbing MA, Nannenga BL, Hattne J, Whitelegge J, Brewster AS, Messerschmidt M, Boutet S, Sauter NK, Gonen T, Eisenberg DS. Structure of the toxic core of α-synuclein from invisible crystals.. Nature, 2015.
107. Bale JB, Park RU, Liu Y, Gonen S, Gonen T, Cascio D, King NP, Yeates TO, Baker D. Structure of a designed tetrahedral protein assembly variant engineered to have improved soluble expression.. Protein science : a publication of the Protein Society, 2015.
108. Hattne J, Reyes FE, Nannenga BL, Shi D, de la Cruz MJ, Leslie AG, Gonen T. MicroED data collection and processing.. Acta crystallographica. Section A, Foundations and advances, 2015.
109. Gonen S, DiMaio F, Gonen T, Baker D. Design of ordered two-dimensional arrays mediated by noncovalent protein-protein interfaces.. Science (New York, N.Y.), 2015.
110. Huang PS, Oberdorfer G, Xu C, Pei XY, Nannenga BL, Rogers JM, DiMaio F, Gonen T, Luisi B, Baker D. High thermodynamic stability of parametrically designed helical bundles.. Science (New York, N.Y.), 2014.
111. Nannenga BL, Shi D, Hattne J, Reyes FE, Gonen T. Structure of catalase determined by MicroED.. eLife, 2014.
112. Gonen T, Waksman G. Editorial overview: Membranes: recent methods in the study of membrane protein structure.. Current opinion in structural biology, 2014.
113. Wisedchaisri G, Park MS, Iadanza MG, Zheng H, Gonen T. Proton-coupled sugar transport in the prototypical major facilitator superfamily protein XylE.. Nature communications, 2014.
114. Nannenga BL, Shi D, Leslie AGW, Gonen T. High-resolution structure determination by continuous-rotation data collection in MicroED.. Nature methods, 2014.
115. Russell AB, Wexler AG, Harding BN, Whitney JC, Bohn AJ, Goo YA, Tran BQ, Barry NA, Zheng H, Peterson SB, Chou S, Gonen T, Goodlett DR, Goodman AL, Mougous JD. A type VI secretion-related pathway in Bacteroidetes mediates interbacterial antagonism.. Cell host & microbe, 2014.
116. Iadanza MG, Gonen T. A suite of software for processing MicroED data of extremely small protein crystals.. Journal of applied crystallography, 2014.
117. King NP, Bale JB, Sheffler W, McNamara DE, Gonen S, Gonen T, Yeates TO, Baker D. Accurate design of co-assembling multi-component protein nanomaterials.. Nature, 2014.
118. Nannenga BL, Gonen T. Protein structure determination by MicroED.. Current opinion in structural biology, 2014.
119. Anderson TM, Clay MC, Cioffi AG, Diaz KA, Hisao GS, Tuttle MD, Nieuwkoop AJ, Comellas G, Maryum N, Wang S, Uno BE, Wildeman EL, Gonen T, Rienstra CM, Burke MD. Amphotericin forms an extramembranous and fungicidal sterol sponge.. Nature chemical biology, 2014.
120. Shi D, Nannenga BL, Iadanza MG, Gonen T. Three-dimensional electron crystallography of protein microcrystals.. eLife, 2013.
121. Smith FD, Reichow SL, Esseltine JL, Shi D, Langeberg LK, Scott JD, Gonen T. Intrinsic disorder within an AKAP-protein kinase A complex guides local substrate phosphorylation.. eLife, 2013.
122. Gold MG, Gonen T, Scott JD. Local cAMP signaling in disease at a glance.. Journal of cell science, 2013.
123. Silverman JM, Agnello DM, Zheng H, Andrews BT, Li M, Catalano CE, Gonen T, Mougous JD. Haemolysin coregulated protein is an exported receptor and chaperone of type VI secretion substrates.. Molecular cell, 2013.
124. Reichow SL, Clemens DM, Freites JA, Németh-Cahalan KL, Heyden M, Tobias DJ, Hall JE, Gonen T. Allosteric mechanism of water-channel gating by Ca2+-calmodulin.. Nature structural & molecular biology, 2013.
125. Zheng H, Wisedchaisri G, Gonen T. Crystal structure of a nitrate/nitrite exchanger.. Nature, 2013.
126. Shi L, Zheng H, Zheng H, Borkowski BA, Shi D, Gonen T, Jiang QX. Retraction for Shi et al., "Voltage sensor ring in a native structure of a membrane-embedded potassium channel".. Proceedings of the National Academy of Sciences of the United States of America, 2013.
127. Shi L, Zheng H, Zheng H, Borkowski BA, Shi D, Gonen T, Jiang QX. Voltage sensor ring in a native structure of a membrane-embedded potassium channel.. Proceedings of the National Academy of Sciences of the United States of America, 2013.
128. Stokes DL, Ubarretxena-Belandia I, Gonen T, Engel A. High-throughput methods for electron crystallography.. Methods in molecular biology (Clifton, N.J.), 2013.
129. Nannenga BL, Iadanza MG, Vollmar BS, Gonen T. Overview of electron crystallography of membrane proteins: crystallization and screening strategies using negative stain electron microscopy.. Current protocols in protein science, 2013.
130. Wisedchaisri G, Gonen T. Phasing electron diffraction data by molecular replacement: strategy for structure determination and refinement.. Methods in molecular biology (Clifton, N.J.), 2013.
131. Gonen T. The collection of high-resolution electron diffraction data.. Methods in molecular biology (Clifton, N.J.), 2013.
132. Filbin ME, Vollmar BS, Shi D, Gonen T, Kieft JS. HCV IRES manipulates the ribosome to promote the switch from translation initiation to elongation.. Nature structural & molecular biology, 2012.
133. Umbreit NT, Gestaut DR, Tien JF, Vollmar BS, Gonen T, Asbury CL, Davis TN. The Ndc80 kinetochore complex directly modulates microtubule dynamics.. Proceedings of the National Academy of Sciences of the United States of America, 2012.
134. Gonen S, Akiyoshi B, Iadanza MG, Shi D, Duggan N, Biggins S, Gonen T. The structure of purified kinetochores reveals multiple microtubule-attachment sites.. Nature structural & molecular biology, 2012.
135. Gonen T, Waksman G. Recent progress in membrane protein structures and investigation methods.. Current opinion in structural biology, 2012.
136. King NP, Sheffler W, Sawaya MR, Vollmar BS, Sumida JP, André I, Gonen T, Yeates TO, Baker D. Computational design of self-assembling protein nanomaterials with atomic level accuracy.. Science (New York, N.Y.), 2012.
137. Jiang QX, Gonen T. The influence of lipids on voltage-gated ion channels.. Current opinion in structural biology, 2012.
138. Lo SY, Brett CL, Plemel RL, Vignali M, Fields S, Gonen T, Merz AJ. Intrinsic tethering activity of endosomal Rab proteins.. Nature structural & molecular biology, 2011.
139. Gold MG, Reichow SL, O'Neill SE, Weisbrod CR, Langeberg LK, Bruce JE, Gonen T, Scott JD. AKAP2 anchors PKA with aquaporin-0 to support ocular lens transparency.. EMBO molecular medicine, 2011.
140. Wisedchaisri G, Reichow SL, Gonen T. Advances in structural and functional analysis of membrane proteins by electron crystallography.. Structure (London, England : 1993), 2011.
141. Wisedchaisri G, Gonen T. Fragment-based phase extension for three-dimensional structure determination of membrane proteins by electron crystallography.. Structure (London, England : 1993), 2011.
142. Budzinski KL, Sgro AE, Fujimoto BS, Gadd JC, Shuart NG, Gonen T, Bajjaleih SM, Chiu DT. Synaptosomes as a platform for loading nanoparticles into synaptic vesicles.. ACS chemical neuroscience, 2011.
143. Korotkov KV, Gonen T, Hol WG. Secretins: dynamic channels for protein transport across membranes.. Trends in biochemical sciences, 2011.
144. Reichow SL, Korotkov KV, Gonen M, Sun J, Delarosa JR, Hol WG, Gonen T. The binding of cholera toxin to the periplasmic vestibule of the type II secretion channel.. Channels (Austin, Tex.), 2011.
145. Jehle S, Vollmar BS, Bardiaux B, Dove KK, Rajagopal P, Gonen T, Oschkinat H, Klevit RE. N-terminal domain of alphaB-crystallin provides a conformational switch for multimerization and structural heterogeneity.. Proceedings of the National Academy of Sciences of the United States of America, 2011.
146. Akiyoshi B, Sarangapani KK, Powers AF, Nelson CR, Reichow SL, Arellano-Santoyo H, Gonen T, Ranish JA, Asbury CL, Biggins S. Tension directly stabilizes reconstituted kinetochore-microtubule attachments.. Nature, 2010.
147. Wisedchaisri G, Dranow DM, Lie TJ, Bonanno JB, Patskovsky Y, Ozyurt SA, Sauder JM, Almo SC, Wasserman SR, Burley SK, Leigh JA, Gonen T. Structural underpinnings of nitrogen regulation by the prototypical nitrogen-responsive transcriptional factor NrpR.. Structure (London, England : 1993), 2010.
148. Hall Sedlak R, Hnilova M, Gachelet E, Przybyla L, Dranow D, Gonen T, Sarikaya M, Tamerler C, Traxler B. An engineered DNA-binding protein self-assembles metallic nanostructures.. Chembiochem : a European journal of chemical biology, 2010.
149. Reichow SL, Korotkov KV, Hol WG, Gonen T. Structure of the cholera toxin secretion channel in its closed state.. Nature structural & molecular biology, 2010.
150. Sanowar S, Singh P, Pfuetzner RA, André I, Zheng H, Spreter T, Strynadka NC, Gonen T, Baker D, Goodlett DR, Miller SI. Interactions of the transmembrane polymeric rings of the Salmonella enterica serovar Typhimurium type III secretion system.. mBio, 2010.
151. Tien JF, Umbreit NT, Gestaut DR, Franck AD, Cooper J, Wordeman L, Gonen T, Asbury CL, Davis TN. Cooperation of the Dam1 and Ndc80 kinetochore complexes enhances microtubule coupling and is regulated by aurora B.. The Journal of cell biology, 2010.
152. Zheng H, Taraska J, Merz AJ, Gonen T. The prototypical H+/galactose symporter GalP assembles into functional trimers.. Journal of molecular biology, 2009.
153. Reichow SL, Gonen T. Lipid-protein interactions probed by electron crystallography.. Current opinion in structural biology, 2009.
154. Reichow SL, Gonen T. Noncanonical binding of calmodulin to aquaporin-0: implications for channel regulation.. Structure (London, England : 1993), 2008.
155. Andrews S, Reichow SL, Gonen T. Electron crystallography of aquaporins.. IUBMB life, 2008.
156. Zheng H, Olia AS, Gonen M, Andrews S, Cingolani G, Gonen T. A conformational switch in bacteriophage p22 portal protein primes genome injection.. Molecular cell, 2008.
157. Engel A, Fujiyoshi Y, Gonen T, Walz T. Junction-forming aquaporins.. Current opinion in structural biology, 2008.
158. Hite RK, Gonen T, Harrison SC, Walz T. Interactions of lipids with aquaporin-0 and other membrane proteins.. Pflugers Archiv : European journal of physiology, 2007.
159. Gonen T, Hite RK, Cheng Y, Petre BM, Kistler J, Walz T. Polymorphic assemblies and crystalline arrays of lens tetraspanin MP20.. Journal of molecular biology, 2007.
160. Franck AD, Powers AF, Gestaut DR, Gonen T, Davis TN, Asbury CL. Tension applied through the Dam1 complex promotes microtubule elongation providing a direct mechanism for length control in mitosis.. Nature cell biology, 2007.
161. Viadiu H, Gonen T, Walz T. Projection map of aquaporin-9 at 7 A resolution.. Journal of molecular biology, 2006.
162. Gonen T, Walz T. The structure of aquaporins.. Quarterly reviews of biophysics, 2006.
163. Gonen T, Cheng Y, Sliz P, Hiroaki Y, Fujiyoshi Y, Harrison SC, Walz T. Lipid-protein interactions in double-layered two-dimensional AQP0 crystals.. Nature, 2005.
164. Gonen T, Cheng Y, Kistler J, Walz T. Aquaporin-0 membrane junctions form upon proteolytic cleavage.. Journal of molecular biology, 2004.
165. Gonen T, Sliz P, Kistler J, Cheng Y, Walz T. Aquaporin-0 membrane junctions reveal the structure of a closed water pore.. Nature, 2004.
166. Grey AC, Jacobs MD, Gonen T, Kistler J, Donaldson PJ. Insertion of MP20 into lens fibre cell plasma membranes correlates with the formation of an extracellular diffusion barrier.. Experimental eye research, 2003.
167. Gonen T, Grey AC, Jacobs MD, Donaldson PJ, Kistler J. MP20, the second most abundant lens membrane protein and member of the tetraspanin superfamily, joins the list of ligands of galectin-3.. BMC cell biology, 2001.
168. Gonen T, Donaldson P, Kistler J. Galectin-3 is associated with the plasma membrane of lens fiber cells.. Investigative ophthalmology & visual science, 2000.