Tomas Ganz

Professor, Medicine, University of California Los Angeles

Professor, Pathology and Laboratory Medicine, University of California Los Angeles

Email: tganz@mednet.ucla.edu

Phone: (310) 825-6112

Tomas Ganz is a Distinguished Professor of Medicine and Pathology at UCLA. He received his PhD from the California Institute of Technology in Applied Physics and MD and advanced medical training from UCLA. He discovered and characterized hepcidin and erythroferrone, the principal hormones of iron homeostasis, authoring more than 400 publications and more than 30 book chapters, with current H-index of 166 (Google Scholar). Dr. Ganz has served as an Associate Editor of Blood, President of the International Bioiron Society and a member of the hematology-focused study sections of the National Institutes of Health. He has helped start three biotechnology enterprises, focused on the diagnostic and therapeutic applications of hepcidin and erythroferrone, and has advised leading pharmaceutical and biotechnology companies. He received the Marcel Simon Award of the International Bioiron Society in 2005, for the discovery of hepcidin and the American Society of Hematology E. Donnall Thomas Award in 2014 for “groundbreaking research in iron homeostasis, including the discovery of the iron-regulatory hormone hepcidin and investigation of its roles in iron metabolism”. He has trained more than thirty graduate students, postdoctoral fellows and junior faculty in his research laboratory. His current research interests include systemic iron metabolism and its regulation, the role of iron in innate immunity and infection, the interaction between erythropoiesis and iron homeostasis, and the pathogenesis of beta-thalassemia and other iron-loading anemias.

Interests

hemochromatosis, hepcidin hormone, erythroferrone hormone, anemia, innate immunity, iron metabolism, inflammation

Education and Training

California Institute of Technology	PhD	06/76	Applied Physics
UCLA	BS	06/70	Physics
UCLA School of Medicine	MD	05/78	Medicine

Awards and Honors

Elected Member, American Association of Physicians, 2006.
Medical Science Award, UCLA Medical Alumni Association, 2007.
Marcel Simon Prize, International Bioiron Society, 2005.
Gold Medal for Achievements in Immunology and Pathophysiology, Charles University of Prague, 2021.
E. Donnall Thomas Prize, American Society of Hematology, 2014.

Publications

Olivera J, Zhang V, Nemeth E, Ganz T. Erythroferrone exacerbates iron overload and ineffective extramedullary erythropoiesis in a mouse model of β-thalassemia.. Blood advances, 2023.
Liu W, Zhang S, Li Q, Wu Y, Jia X, Feng W, Li Z, Shi Y, Hou Q, Ma J, Liu Y, Gao P, Ganz T, Liu S. Lactate modulates iron metabolism by binding soluble adenylyl cyclase.. Cell metabolism, 2023.
Shah BN, Zhang X, Sergueeva AI, Miasnikova GY, Ganz T, Prchal JT, Gordeuk VR. Increased transferrin protects from thrombosis in Chuvash erythrocytosis.. American journal of hematology, 2023.
Song J, Sundar KM, Horvathova M, Gangaraju R, Indrak K, Christensen RD, Genzor S, Lundby C, Divoky V, Ganz T, Prchal JT. Increased blood reactive oxygen species and hepcidin in obstructive sleep apnea precludes expected erythrocytosis.. American journal of hematology, 2023.
Ganz T, Locatelli F, Arici M, Akizawa T, Reusch M. Iron Parameters in Patients Treated with Roxadustat for Anemia of Chronic Kidney Disease.. Journal of clinical medicine, 2023.
Ganz T, Nemeth E. Hypoferremia of inflammation: Innate host defense against infections.. Blood cells, molecules & diseases, 2023.
Sangkhae V, Fisher AL, Ganz T, Nemeth E. Iron Homeostasis During Pregnancy: Maternal, Placental, and Fetal Regulatory Mechanisms.. Annual review of nutrition, 2023.
Delaney KM, Barad A, Castillo LF, Hasund CM, Guillet R, Pressman EK, Katzman PJ, Ganz T, Nemeth E, O'Brien KO. Placental Erythroferrone and Erythropoietin mRNA Expression is not Associated with Maternal or Neonatal Iron Status in Adolescents Carrying Singletons and Adult Women Carrying Multiples.. The Journal of nutrition, 2023.
Stetka J, Usart M, Kubovcakova L, Rai S, Rao TN, Sutter J, Hao-Shen H, Dirnhofer S, Geier F, Bader MS, Passweg JR, Manolova V, Dürrenberger F, Ahmed N, Schroeder T, Ganz T, Nemeth E, Silvestri L, Nai A, Camaschella C, Skoda RC. Iron is a modifier of the phenotypes of JAK2-mutant myeloproliferative neoplasms.. Blood, 2023.
Zhang V, Jenkitkasemwong S, Liu Q, Ganz T, Nemeth E, Knutson MD, Kim A. A mouse model characterizes the roles of ZIP8 in systemic iron recycling and lung inflammation and infection.. Blood advances, 2023.
Sardo U, Perrier P, Cormier K, Sotin M, Desquesnes A, Cannizzo L, Ruiz-Martinez M, Thevenin J, Billoré B, Jung G, Abboud E, Peyssonnaux C, Nemeth E, Ginzburg YZ, Ganz T, Kautz L. The hepatokine FGL1 regulates hepcidin and iron metabolism during the recovery from hemorrhage-induced anemia in mice.. bioRxiv : the preprint server for biology, 2023.
Ganz T, Nemeth E. Pathogenic Mechanisms in Thalassemia II: Iron Overload.. Hematology/oncology clinics of North America, 2023.
Azucenas CR, Ruwe TA, Bonamer JP, Qiao B, Ganz T, Jormakka M, Nemeth E, Mackenzie B. Comparative analysis of the functional properties of human and mouse ferroportin.. American journal of physiology. Cell physiology, 2023.
Ganz T, Nemeth E, Rivella S, Goldberg P, Dibble AR, McCaleb ML, Guo S, Monia BP, Barrett TD. TMPRSS6 as a Therapeutic Target for Disorders of Erythropoiesis and Iron Homeostasis.. Advances in therapy, 2023.
Zhang V, Ganz T, Nemeth E, Umar S, Kim A. Bmpr2 mutant mice are an inadequate model for studying iron deficiency in pulmonary hypertension.. Pulmonary circulation, 2022.
Feng W, Xiao Y, Zhao C, Zhang Z, Liu W, Ma J, Ganz T, Zhang J, Liu S. New Deferric Amine Compounds Efficiently Chelate Excess Iron to Treat Iron Overload Disorders and to Prevent Ferroptosis.. Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2022.
Sangkhae V, Yu V, Coffey R, O'Brien KO, Ganz T, Nemeth E. Erythroferrone contributes to iron mobilization for embryo erythropoiesis in iron-deficient mouse pregnancies.. American journal of hematology, 2022.
Nemeth E, Ganz T. Hepcidin and Iron in Health and Disease.. Annual review of medicine, 2022.
Koury MJ, Agarwal R, Chertow GM, Eckardt KU, Fishbane S, Ganz T, Haase VH, Hanudel MR, Parfrey PS, Pergola PE, Roy-Chaudhury P, Tumlin JA, Anders R, Farag YMK, Luo W, Minga T, Solinsky C, Vargo DL, Winkelmayer WC. Erythropoietic effects of vadadustat in patients with anemia associated with chronic kidney disease.. American journal of hematology, 2022.
Fishbane S, Ganz T, Pratt RD. Ferric pyrophosphate citrate for parenteral administration of maintenance iron: structure, mechanism of action, clinical efficacy and safety.. Current medical research and opinion, 2022.
Breenfeldt Andersen A, Bejder J, Bonne TC, Sørensen H, Sørensen H, Jung G, Ganz T, Nemeth E, Secher NH, Johansson PI, Nordsborg NB. Hepcidin and Erythroferrone Complement the Athlete Biological Passport in the Detection of Autologous Blood Transfusion.. Medicine and science in sports and exercise, 2022.
Hanudel MR, Czaya B, Wong S, Jung G, Chua K, Qiao B, Gabayan V, Ganz T. Renoprotective effects of ferric citrate in a mouse model of chronic kidney disease.. Scientific reports, 2022.
Luo G, Zhang J, Wang H, Sun Y, Cheng B, Xu Z, Zhang Y, Li H, Lu W, Nemeth E, Ganz T, Fang X. Human defensin-inspired discovery of peptidomimetic antibiotics.. Proceedings of the National Academy of Sciences of the United States of America, 2022.
Zhou A, Kong T, Fowles JS, Jung CL, Allen MJ, Fisher DAC, Fulbright M, Nemeth E, Ganz T, Oh ST. Hepcidin is elevated in primary and secondary myelofibrosis and remains elevated in patients treated with ruxolitinib.. British journal of haematology, 2022.
Coffey R, Jung G, Olivera JD, Karin G, Pereira RC, Nemeth E, Ganz T. Erythroid overproduction of erythroferrone causes iron overload and developmental abnormalities in mice.. Blood, 2022.
Zhu J, Fu Q, Wang S, Ren L, Feng W, Wei S, Zhang Z, Xu Y, Ganz T, Liu S. Palladium Nanoplate-Based IL-6 Receptor Antagonists Ameliorate Cancer-Related Anemia and Simultaneously Inhibit Cancer Progression.. Nano letters, 2022.
Hanudel MR, Czaya B, Wong S, Rappaport M, Namjoshi S, Chua K, Jung G, Gabayan V, Qiao B, Nemeth E, Ganz T. Enteral ferric citrate absorption is dependent on the iron transport protein ferroportin.. Kidney international, 2021.
Delaney KM, Guillet R, Pressman EK, Ganz T, Nemeth E, O'Brien KO. Umbilical Cord Erythroferrone Is Inversely Associated with Hepcidin, but Does Not Capture the Most Variability in Iron Status of Neonates Born to Teens Carrying Singletons and Women Carrying Multiples.. The Journal of nutrition, 2021.
Fisher AL, Srole DN, Palaskas NJ, Meriwether D, Reddy ST, Ganz T, Nemeth E. Iron loading induces cholesterol synthesis and sensitizes endothelial cells to TNFα-mediated apoptosis.. The Journal of biological chemistry, 2021.
Ganz T. New regulators of systemic iron homeostasis.. Signal transduction and targeted therapy, 2021.
Delaney KM, Guillet R, Pressman EK, Ganz T, Nemeth E, O'Brien KO. Serum Erythroferrone During Pregnancy Is Related to Erythropoietin but Does Not Predict the Risk of Anemia.. The Journal of nutrition, 2021.
Fisher AL, Sangkhae V, Balušíková K, Palaskas NJ, Ganz T, Nemeth E. Iron-dependent apoptosis causes embryotoxicity in inflamed and obese pregnancy.. Nature communications, 2021.
Breenfeldt Andersen A, Bonne TC, Bejder J, Jung G, Ganz T, Nemeth E, Olsen NV, Huertas JR, Nordsborg NB. Effects of altitude and recombinant human erythropoietin on iron metabolism: a randomized controlled trial.. American journal of physiology. Regulatory, integrative and comparative physiology, 2021.
Nemeth E, Ganz T. Hepcidin-Ferroportin Interaction Controls Systemic Iron Homeostasis.. International journal of molecular sciences, 2021.
Matte A, Federti E, Kung C, Kosinski PA, Narayanaswamy R, Russo R, Federico G, Carlomagno F, Desbats MA, Salviati L, Leboeuf C, Valenti MT, Turrini F, Janin A, Yu S, Beneduce E, Ronseaux S, Iatcenko I, Dang L, Ganz T, Jung CL, Iolascon A, Brugnara C, De Franceschi L. The pyruvate kinase activator mitapivat reduces hemolysis and improves anemia in a β-thalassemia mouse model.. The Journal of clinical investigation, 2021.
Hanudel MR, Wong S, Jung G, Qiao B, Gabayan V, Zuk A, Ganz T. Amelioration of chronic kidney disease-associated anemia by vadadustat in mice is not dependent on erythroferrone.. Kidney international, 2021.
Emrich IE, Scheuer A, Wagenpfeil S, Ganz T, Heine GH. Increase of plasma erythroferrone levels during high-altitude exposure: A sub-analysis of the TOP OF HOMe study.. American journal of hematology, 2021.
Kaunitz JD, Ganz T. AGA Clinical Practice Guidelines on the Gastrointestinal Evaluation of Iron Deficiency Anemia.. Gastroenterology, 2021.
Kalantar-Zadeh K, Ganz T, Trumbo H, Seid MH, Goodnough LT, Levine MA. Parenteral iron therapy and phosphorus homeostasis: A review.. American journal of hematology, 2021.
Goncalves Monteiro D, van Dijk JWA, Aliyanto R, Fung E, Nemeth E, Ganz T, Rosengren J, Clark RJ. Pursuing Orally Bioavailable Hepcidin Analogues via Cyclic N-Methylated Mini-Hepcidins.. Biomedicines, 2021.
Srole DN, Ganz T. Erythroferrone structure, function, and physiology: Iron homeostasis and beyond.. Journal of cellular physiology, 2020.
Deshpande CN, Azucenas CR, Qiao B, Nomura N, Xin V, Font J, Iwata S, Ganz T, Nemeth E, Mackenzie B, Jormakka M. Isolation and thermal stabilization of mouse ferroportin.. FEBS open bio, 2020.
Sangkhae V, Fisher AL, Chua KJ, Ruchala P, Ganz T, Nemeth E. Maternal hepcidin determines embryo iron homeostasis in mice.. Blood, 2020.
Ganz T. The role of hepcidin in fetal iron homeostasis.. Blood, 2020.
Oh ST, Talpaz M, Gerds AT, Gupta V, Verstovsek S, Mesa R, Miller CB, Rivera CE, Fleischman AG, Goel S, Heaney ML, O'Connell C, Arcasoy MO, Zhang Y, Kawashima J, Ganz T, Kowalski M, Brachmann CB. ACVR1/JAK1/JAK2 inhibitor momelotinib reverses transfusion dependency and suppresses hepcidin in myelofibrosis phase 2 trial.. Blood advances, 2020.
Jerzak KJ, Lohmann AE, Ennis M, Nemeth E, Ganz T, Goodwin PJ. Prognostic associations of plasma hepcidin in women with early breast cancer.. Breast cancer research and treatment, 2020.
Gutschow P, Han H, Olbina G, Westerman K, Nemeth E, Ganz T, Copeland K, Westerman M, Ostland V. Clinical Immunoassay for Human Hepcidin Predicts Iron Deficiency in First-Time Blood Donors.. The journal of applied laboratory medicine, 2020.
Hsu D, Kim A, Ganz T, Suh JD, Wang M, Wu TJ, Lee JT. Expression of Iron-Regulatory Hormone Hepcidin and Iron Transporters Ferroportin and ZIP8 in Patients With and Without Chronic Rhinosinusitis.. Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, 2020.
Honda H, Tanaka K, Michihata T, Shibagaki K, Yuza T, Hirao K, Tomosugi N, Ganz T, Higashimoto Y. Erythropoiesis stimulating agents are associated with serum fibroblast growth factor 23 metabolism in patients on hemodialysis.. Clinical kidney journal, 2020.
Zhang V, Ganz T, Nemeth E, Kim A. Iron overload causes a mild and transient increase in acute lung injury.. Physiological reports, 2020.
Sharma S, Hanudel MR, Ix JH, Salusky IB, Ganz T, Nguyen KL. The Authors Reply.. Kidney international reports, 2020.
Kautz L, Jung G, Valore EV, Rivella S, Nemeth E, Ganz T. Author Correction: Identification of erythroferrone as an erythroid regulator of iron metabolism.. Nature genetics, 2020.
Ganz T, Aronoff GR, Gaillard CAJM, Goodnough LT, Macdougall IC, Mayer G, Porto G, Winkelmayer WC, Wish JB. Iron Administration, Infection, and Anemia Management in CKD: Untangling the Effects of Intravenous Iron Therapy on Immunity and Infection Risk.. Kidney medicine, 2020.
Fisher AL, Sangkhae V, Presicce P, Chougnet CA, Jobe AH, Kallapur SG, Tabbah S, Buhimschi CS, Buhimschi IA, Ganz T, Nemeth E. Fetal and amniotic fluid iron homeostasis in healthy and complicated murine, macaque, and human pregnancy.. JCI insight, 2020.
Ganz T. Drugging erythroferrone to treat anemias.. Blood, 2020.
Sangkhae V, Fisher AL, Wong S, Koenig MD, Tussing-Humphreys L, Chu A, Lelic M, Ganz T, Nemeth E. Effects of maternal iron status on placental and fetal iron homeostasis.. The Journal of clinical investigation, 2020.
Hanudel MR, Eisenga MF, Rappaport M, Chua K, Qiao B, Jung G, Gabayan V, Gales B, Ramos G, de Jong MA, van Zanden JJ, de Borst MH, Bakker SJL, Nemeth E, Salusky IB, Gaillard CAJM, Ganz T. Effects of erythropoietin on fibroblast growth factor 23 in mice and humans.. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2019.
Ganz T. Anemia of Inflammation.. The New England journal of medicine, 2019.
Sharma S, Hanudel MR, Ix JH, Salusky IB, Ganz T, Nguyen KL. Elevated Fibroblast Growth Factor 23 Levels Are Associated With Greater Diastolic Dysfunction in ESRD.. Kidney international reports, 2019.
Bondu S, Alary AS, Lefèvre C, Houy A, Jung G, Lefebvre T, Rombaut D, Boussaid I, Bousta A, Guillonneau F, Perrier P, Alsafadi S, Wassef M, Margueron R, Rousseau A, Droin N, Cagnard N, Kaltenbach S, Winter S, Kubasch AS, Bouscary D, Santini V, Toma A, Hunault M, Stamatoullas A, Gyan E, Cluzeau T, Platzbecker U, Adès L, Puy H, Stern MH, Karim Z, Mayeux P, Nemeth E, Park S, Ganz T, Kautz L, Kosmider O, Fontenay M. A variant erythroferrone disrupts iron homeostasis in SF3B1-mutated myelodysplastic syndrome.. Science translational medicine, 2019.
Pergola PE, Fishbane S, Ganz T. Novel Oral Iron Therapies for Iron Deficiency Anemia in Chronic Kidney Disease.. Advances in chronic kidney disease, 2019.
Altamura S, Vegi NM, Hoppe PS, Schroeder T, Aichler M, Walch A, Okreglicka K, Hültner L, Schneider M, Ladinig C, Kuklik-Roos C, Mysliwietz J, Janik D, Neff F, Rathkolb B, de Angelis MTH, Buske C, Silva ARD, Muedder K, Conrad M, Ganz T, Kopf M, Muckenthaler MU, Bornkamm GW. Glutathione peroxidase 4 and vitamin E control reticulocyte maturation, stress erythropoiesis and iron homeostasis.. Haematologica, 2019.
Ganz T. The Discovery of the Iron-Regulatory Hormone Hepcidin.. Clinical chemistry, 2019.
Ganz T, Bino A, Salusky IB. Mechanism of Action and Clinical Attributes of Auryxia® (Ferric Citrate).. Drugs, 2019.
Ganz T, Ganz P. William Ganz and His Legacy.. Annals of internal medicine, 2019.
Honda H, Hosaka N, Ganz T, Shibata T. Iron Metabolism in Chronic Kidney Disease Patients.. Contributions to nephrology, 2019.
Liu J, Liu W, Liu Y, Miao Y, Guo Y, Song H, Wang F, Zhou H, Ganz T, Yan B, Liu S. New thiazolidinones reduce iron overload in mouse models of hereditary hemochromatosis and β-thalassemia.. Haematologica, 2019.
Micewicz ED, Iwamoto KS, Ratikan JA, Nguyen C, Xie MW, Cheng G, Boxx GM, Deriu E, Damoiseaux RD, Whitelegge JP, Ruchala PP, Avetisyan R, Jung ME, Lawson G, Nemeth E, Ganz T, Sayre JW, McBride WH, Schaue D. The Aftermath of Surviving Acute Radiation Hematopoietic Syndrome and its Mitigation.. Radiation research, 2019.
Chen Q, Yang Y, Hou J, Shu Q, Yin Y, Fu W, Han F, Hou T, Zeng C, Nemeth E, Linzmeier R, Ganz T, Fang X. Increased gene copy number of DEFA1/DEFA3 worsens sepsis by inducing endothelial pyroptosis.. Proceedings of the National Academy of Sciences of the United States of America, 2019.
Guo Y, Zhang N, Zhang D, Ren Q, Ganz T, Liu S, Nemeth E. Iron homeostasis in pregnancy and spontaneous abortion.. American journal of hematology, 2018.
Ganz T. Erythrocytes and erythroblasts give up iron.. Blood, 2018.
Weiss G, Ganz T, Goodnough LT. Anemia of inflammation.. Blood, 2018.
Ganz T. Erythropoietin and iron-a conflicted alliance?. Kidney international, 2018.
Gagliano-Jucá T, Pencina KM, Ganz T, Travison TG, Kantoff PW, Nguyen PL, Taplin ME, Kibel AS, Li Z, Huang G, Edwards RR, Nemeth E, Basaria S. Mechanisms responsible for reduced erythropoiesis during androgen deprivation therapy in men with prostate cancer.. American journal of physiology. Endocrinology and metabolism, 2018.
Coffey R, Sardo U, Kautz L, Gabayan V, Nemeth E, Ganz T. Erythroferrone is not required for the glucoregulatory and hematologic effects of chronic erythropoietin treatment in mice.. Physiological reports, 2018.
Deshpande CN, Ruwe TA, Shawki A, Xin V, Vieth KR, Valore EV, Qiao B, Ganz T, Nemeth E, Mackenzie B, Jormakka M. Calcium is an essential cofactor for metal efflux by the ferroportin transporter family.. Nature communications, 2018.
Ginzburg YZ, Feola M, Zimran E, Varkonyi J, Ganz T, Hoffman R. Dysregulated iron metabolism in polycythemia vera: etiology and consequences.. Leukemia, 2018.
Ganz T. Erythropoietic regulators of iron metabolism.. Free radical biology & medicine, 2018.
Stefanova D, Raychev A, Deville J, Humphries R, Campeau S, Ruchala P, Nemeth E, Ganz T, Bulut Y. Hepcidin Protects against Lethal Escherichia coli Sepsis in Mice Inoculated with Isolates from Septic Patients.. Infection and immunity, 2018.
Cox HD, Miller GD, Lai A, Cushman D, Ganz T, Eichner D. Evaluation of serum markers for improved detection of autologous blood transfusions.. Haematologica, 2018.
Stasiak IM, Smith DA, Ganz T, Crawshaw GJ, Hammermueller JD, Bienzle D, Lillie BN. Iron storage disease (hemochromatosis) and hepcidin response to iron load in two species of pteropodid fruit bats relative to the common vampire bat.. Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology, 2018.
Coffey R, Ganz T. Erythroferrone: An Erythroid Regulator of Hepcidin and Iron Metabolism.. HemaSphere, 2018.
Adams P, Altes A, Brissot P, Butzeck B, Cabantchik I, Cançado R, Distante S, Evans P, Evans R, Ganz T, Girelli D, Hultcrantz R, McLaren G, Marris B, Milman N, Nemeth E, Nielsen P, Pineau B, Piperno A, Porto G, Prince D, Ryan J, Sanchez M, Santos P, Swinkels D, Teixeira E, Toska K, Vanclooster A, White D, Contributors and Hemochromatosis International Taskforce. Therapeutic recommendations in HFE hemochromatosis for p.Cys282Tyr (C282Y/C282Y) homozygous genotype.. Hepatology international, 2018.
Meznarich JA, Draper L, Christensen RD, Yaish HM, Luem ND, Pysher TJ, Jung G, Nemeth E, Ganz T, Ward DM. Fetal presentation of congenital dyserythropoietic anemia type 1 with novel compound heterozygous CDAN1 mutations.. Blood cells, molecules & diseases, 2018.
Wish JB, Aronoff GR, Bacon BR, Brugnara C, Eckardt KU, Ganz T, Macdougall IC, Núñez J, Perahia AJ, Wood JC. Positive Iron Balance in Chronic Kidney Disease: How Much is Too Much and How to Tell?. American journal of nephrology, 2018.
Hanudel MR, Rappaport M, Chua K, Gabayan V, Qiao B, Jung G, Salusky IB, Ganz T, Nemeth E. Levels of the erythropoietin-responsive hormone erythroferrone in mice and humans with chronic kidney disease.. Haematologica, 2018.
Rzymski P, Ganz T. Comment on "Serum Hepcidin and Soluble Transferrin Receptor in the Assessment of Iron Metabolism in Children on a Vegetarian Diet".. Biological trace element research, 2018.
Ganz T. Correction to: Iron and infection.. International journal of hematology, 2018.
Aschemeyer S, Qiao B, Stefanova D, Valore EV, Sek AC, Ruwe TA, Vieth KR, Jung G, Casu C, Rivella S, Jormakka M, Mackenzie B, Ganz T, Nemeth E. Structure-function analysis of ferroportin defines the binding site and an alternative mechanism of action of hepcidin.. Blood, 2017.
Chow JKL, Ganz T, Ruthazer R, Simpson MA, Pomfret EA, Gordon FD, Westerman ME, Snydman DR. Iron-related markers are associated with infection after liver transplantation.. Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society, 2017.
Ganz T. Iron and infection.. International journal of hematology, 2017.
Khorramian E, Fung E, Chua K, Gabayan V, Ganz T, Nemeth E, Kim A. In a Mouse Model of Sepsis, Hepcidin Ablation Ameliorates Anemia More Effectively than Iron and Erythropoietin Treatment.. Shock (Augusta, Ga.), 2017.
Matte A, De Falco L, Federti E, Cozzi A, Iolascon A, Levi S, Mohandas N, Zamo A, Bruno M, Lebouef C, Janin A, Siciliano A, Ganz T, Federico G, Carlomagno F, Mueller S, Silva I, Carbone C, Melisi D, Kim DW, Choi SY, De Franceschi L. Peroxiredoxin-2: A Novel Regulator of Iron Homeostasis in Ineffective Erythropoiesis.. Antioxidants & redox signaling, 2017.
Clinkenbeard EL, Hanudel MR, Stayrook KR, Appaiah HN, Farrow EG, Cass TA, Summers LJ, Ip CS, Hum JM, Thomas JC, Ivan M, Richine BM, Chan RJ, Clemens TL, Schipani E, Sabbagh Y, Xu L, Srour EF, Alvarez MB, Kacena MA, Salusky IB, Ganz T, Nemeth E, White KE. Erythropoietin stimulates murine and human fibroblast growth factor-23, revealing novel roles for bone and bone marrow.. Haematologica, 2017.
Vos JM, Tsakmaklis N, Patterson CJ, Meid K, Castillo JJ, Brodsky P, Ganz T, Pals ST, Kersten MJ, Xu L, Yang G, Treon SP, Hunter ZR. CXCL13 levels are elevated in patients with Waldenström macroglobulinemia, and are predictive of major response to ibrutinib.. Haematologica, 2017.
McLachlan S, Page KE, Lee SM, Loguinov A, Valore E, Hui ST, Jung G, Zhou J, Lusis AJ, Fuqua B, Ganz T, Nemeth E, Vulpe CD. Hamp1 mRNA and plasma hepcidin levels are influenced by sex and strain but do not predict tissue iron levels in inbred mice.. American journal of physiology. Gastrointestinal and liver physiology, 2017.
Antman EM, Di Corleto PE, Freeman MW, Ganz T, Golan DE, Kitterman R, Loscalzo J, Low M, McKenna E, O'Connor AC, Palazzolo M, Parrish J, Reizes O, Ross RS, Vaughan C, Vince DG, Watts L, NIH Centers for Accelerated Innovations. NIH Centers for Accelerated Innovations Program: principles, practices, successes and challenges.. Nature reviews. Drug discovery, 2017.
Ganz T, Jung G, Naeim A, Ginzburg Y, Pakbaz Z, Walter PB, Kautz L, Nemeth E. Immunoassay for human serum erythroferrone.. Blood, 2017.
Coffey R, Ganz T. Iron homeostasis: An anthropocentric perspective.. The Journal of biological chemistry, 2017.
Ganz T. Does Pathological Iron Overload Impair the Function of Human Lungs?. EBioMedicine, 2017.
Stefanova D, Raychev A, Arezes J, Ruchala P, Gabayan V, Skurnik M, Dillon BJ, Horwitz MA, Ganz T, Bulut Y, Nemeth E. Endogenous hepcidin and its agonist mediate resistance to selected infections by clearing non-transferrin-bound iron.. Blood, 2017.
Michels KR, Zhang Z, Bettina AM, Cagnina RE, Stefanova D, Burdick MD, Vaulont S, Nemeth E, Ganz T, Mehrad B. Hepcidin-mediated iron sequestration protects against bacterial dissemination during pneumonia.. JCI insight, 2017.
Preziosi ME, Singh S, Valore EV, Jung G, Popovic B, Poddar M, Nagarajan S, Ganz T, Monga SP. Mice lacking liver-specific β-catenin develop steatohepatitis and fibrosis after iron overload.. Journal of hepatology, 2017.
Aschemeyer S, Gabayan V, Ganz T, Nemeth E, Kautz L. Erythroferrone and matriptase-2 independently regulate hepcidin expression.. American journal of hematology, 2017.
Hanudel MR, Rappaport M, Gabayan V, Jung G, Salusky IB, Nemeth E, Ganz T, Zaritsky J. Increased serum hepcidin contributes to the anemia of chronic kidney disease in a murine model.. Haematologica, 2016.
Hanudel MR, Chua K, Rappaport M, Gabayan V, Valore E, Goltzman D, Ganz T, Nemeth E, Salusky IB. Effects of dietary iron intake and chronic kidney disease on fibroblast growth factor 23 metabolism in wild-type and hepcidin knockout mice.. American journal of physiology. Renal physiology, 2016.
Ganz T. Macrophages and Iron Metabolism.. Microbiology spectrum, 2016.
Latour C, Wlodarczyk MF, Jung G, Gineste A, Blanchard N, Ganz T, Roth MP, Coppin H, Kautz L. Erythroferrone contributes to hepcidin repression in a mouse model of malarial anemia.. Haematologica, 2016.
Casu C, Oikonomidou PR, Chen H, Nandi V, Ginzburg Y, Prasad P, Fleming RE, Shah YM, Valore EV, Nemeth E, Ganz T, MacDonald B, Rivella S. Minihepcidin peptides as disease modifiers in mice affected by β-thalassemia and polycythemia vera.. Blood, 2016.
Ganz T, Nemeth E. Iron Balance and the Role of Hepcidin in Chronic Kidney Disease.. Seminars in nephrology, 2016.
Kalinowski DS, Stefani C, Toyokuni S, Ganz T, Anderson GJ, Subramaniam NV, Trinder D, Olynyk JK, Chua A, Jansson PJ, Sahni S, Lane DJ, Merlot AM, Kovacevic Z, Huang ML, Lee CS, Richardson DR. Redox cycling metals: Pedaling their roles in metabolism and their use in the development of novel therapeutics.. Biochimica et biophysica acta, 2016.
Ganz T. Hepcidin.. [Rinsho ketsueki] The Japanese journal of clinical hematology, 2016.
Drakesmith H, Nemeth E, Ganz T. Ironing out Ferroportin.. Cell metabolism, 2015.
Kim A, Fung E, Parikh SG, Gabayan V, Nemeth E, Ganz T. Isocitrate treatment of acute anemia of inflammation in a mouse model.. Blood cells, molecules & diseases, 2015.
Michels K, Nemeth E, Ganz T, Mehrad B. Hepcidin and Host Defense against Infectious Diseases.. PLoS pathogens, 2015.
Kautz L, Jung G, Du X, Gabayan V, Chapman J, Nasoff M, Nemeth E, Ganz T. Erythroferrone contributes to hepcidin suppression and iron overload in a mouse model of β-thalassemia.. Blood, 2015.
Ganz T, Nemeth E. Iron homeostasis in host defence and inflammation.. Nature reviews. Immunology, 2015.
Keel SB, Doty R, Liu L, Nemeth E, Cherian S, Ganz T, Abkowitz JL. Evidence that the expression of transferrin receptor 1 on erythroid marrow cells mediates hepcidin suppression in the liver.. Experimental hematology, 2015.
Chua K, Fung E, Micewicz ED, Ganz T, Nemeth E, Ruchala P. Small cyclic agonists of iron regulatory hormone hepcidin.. Bioorganic & medicinal chemistry letters, 2015.
Arezes J, Jung G, Gabayan V, Valore E, Ruchala P, Gulig PA, Ganz T, Nemeth E, Bulut Y. Hepcidin-induced hypoferremia is a critical host defense mechanism against the siderophilic bacterium Vibrio vulnificus.. Cell host & microbe, 2015.
Fung E, Chua K, Ganz T, Nemeth E, Ruchala P. Thiol-derivatized minihepcidins retain biological activity.. Bioorganic & medicinal chemistry letters, 2015.
Ganz T. Hepcidin and the global burden of iron deficiency.. Clinical chemistry, 2014.
Gutschow P, Schmidt PJ, Han H, Ostland V, Bartnikas TB, Pettiglio MA, Herrera C, Butler JS, Nemeth E, Ganz T, Fleming MD, Westerman M. A competitive enzyme-linked immunosorbent assay specific for murine hepcidin-1: correlation with hepatic mRNA expression in established and novel models of dysregulated iron homeostasis.. Haematologica, 2014.
Macciò A, Madeddu C, Gramignano G, Mulas C, Tanca L, Cherchi MC, Floris C, Omoto I, Barracca A, Ganz T. The role of inflammation, iron, and nutritional status in cancer-related anemia: results of a large, prospective, observational study.. Haematologica, 2014.
Kautz L, Jung G, Nemeth E, Ganz T. Erythroferrone contributes to recovery from anemia of inflammation.. Blood, 2014.
Zhang S, Chen Y, Guo W, Yuan L, Zhang D, Xu Y, Nemeth E, Ganz T, Liu S. Disordered hepcidin-ferroportin signaling promotes breast cancer growth.. Cellular signalling, 2014.
Kautz L, Jung G, Valore EV, Rivella S, Nemeth E, Ganz T. Identification of erythroferrone as an erythroid regulator of iron metabolism.. Nature genetics, 2014.
Nemeth E, Ganz T. Anemia of inflammation.. Hematology/oncology clinics of North America, 2014.
Kim A, Rivera S, Shprung D, Limbrick D, Gabayan V, Nemeth E, Ganz T. Mouse models of anemia of cancer.. PloS one, 2014.
Kim A, Fung E, Parikh SG, Valore EV, Gabayan V, Nemeth E, Ganz T. A mouse model of anemia of inflammation: complex pathogenesis with partial dependence on hepcidin.. Blood, 2013.
Latour C, Kautz L, Besson-Fournier C, Island ML, Canonne-Hergaux F, Loréal O, Ganz T, Coppin H, Roth MP. Testosterone perturbs systemic iron balance through activation of epidermal growth factor receptor signaling in the liver and repression of hepcidin.. Hepatology (Baltimore, Md.), 2013.
Kautz L, Gabayan V, Wang X, Wu J, Onwuzurike J, Jung G, Qiao B, Lusis AJ, Ganz T, Nemeth E. Testing the iron hypothesis in a mouse model of atherosclerosis.. Cell reports, 2013.
Mitchell CJ, Shawki A, Ganz T, Nemeth E, Mackenzie B. Functional properties of human ferroportin, a cellular iron exporter reactive also with cobalt and zinc.. American journal of physiology. Cell physiology, 2013.
Rodriguez R, Jung CL, Gabayan V, Deng JC, Ganz T, Nemeth E, Bulut Y. Hepcidin induction by pathogens and pathogen-derived molecules is strongly dependent on interleukin-6.. Infection and immunity, 2013.
Ganz T. Systemic iron homeostasis.. Physiological reviews, 2013.
Clark RJ, Preza GC, Tan CC, van Dijk JW, Fung E, Nemeth E, Ganz T, Craik DJ. Design, synthesis, and characterization of cyclic analogues of the iron regulatory peptide hormone hepcidin.. Biopolymers, 2013.
McCranor BJ, Langdon JM, Prince OD, Femnou LK, Berger AE, Cheadle C, Civin CI, Kim A, Rivera S, Ganz T, Vaulont S, Xue QL, Walston JD, Roy CN. Investigation of the role of interleukin-6 and hepcidin antimicrobial peptide in the development of anemia with age.. Haematologica, 2013.
Preza GC, Pinon R, Ganz T, Nemeth E. Cellular catabolism of the iron-regulatory peptide hormone hepcidin.. PloS one, 2013.
Mast AE, Schlumpf KS, Wright DJ, Johnson B, Glynn SA, Busch MP, Olbina G, Westerman M, Nemeth E, Ganz T, NHLBI Retrovirus Epidemiology Donor Study-II (REDS-II). Hepcidin level predicts hemoglobin concentration in individuals undergoing repeated phlebotomy.. Haematologica, 2013.
Fung E, Sugianto P, Hsu J, Damoiseaux R, Ganz T, Nemeth E. High-throughput screening of small molecules identifies hepcidin antagonists.. Molecular pharmacology, 2013.
Ganz T. Preface: iron and cancer.. Critical reviews in oncogenesis, 2013.
Basseri RJ, Nemeth E, Vassilaki ME, Basseri B, Enayati P, Shaye O, Bourikas LA, Ganz T, Papadakis KA. Hepcidin is a key mediator of anemia of inflammation in Crohn's disease.. Journal of Crohn's & colitis, 2012.
Ramos E, Ruchala P, Goodnough JB, Kautz L, Preza GC, Nemeth E, Ganz T. Minihepcidins prevent iron overload in a hepcidin-deficient mouse model of severe hemochromatosis.. Blood, 2012.
Ganz T, Goff J, Klasing K, Nemeth E, Roth T. IOD in rhinos--immunity group report: report from the Immunity, Genetics and Toxicology Working Group of the International Workshop on Iron Overload Disorder in Browsing Rhinoceros (February 2011).. Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians, 2012.
Ganz T, Nemeth E. Iron homeostasis and its disorders in mice and men: potential lessons for rhinos.. Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians, 2012.
Goodnough JB, Ramos E, Nemeth E, Ganz T. Inhibition of hepcidin transcription by growth factors.. Hepatology (Baltimore, Md.), 2012.
Qiao B, Sugianto P, Fung E, Del-Castillo-Rueda A, Moran-Jimenez MJ, Ganz T, Nemeth E. Hepcidin-induced endocytosis of ferroportin is dependent on ferroportin ubiquitination.. Cell metabolism, 2012.
Ross SL, Tran L, Winters A, Lee KJ, Plewa C, Foltz I, King C, Miranda LP, Allen J, Beckman H, Cooke KS, Moody G, Sasu BJ, Nemeth E, Ganz T, Molineux G, Arvedson TL. Molecular mechanism of hepcidin-mediated ferroportin internalization requires ferroportin lysines, not tyrosines or JAK-STAT.. Cell metabolism, 2012.
Besson-Fournier C, Latour C, Kautz L, Bertrand J, Ganz T, Roth MP, Coppin H. Induction of activin B by inflammatory stimuli up-regulates expression of the iron-regulatory peptide hepcidin through Smad1/5/8 signaling.. Blood, 2012.
Ravasi G, Pelucchi S, Trombini P, Mariani R, Tomosugi N, Modignani GL, Pozzi M, Nemeth E, Ganz T, Hayashi H, Barisani D, Piperno A. Hepcidin expression in iron overload diseases is variably modulated by circulating factors.. PloS one, 2012.
Ganz T, Nemeth E. Iron metabolism: interactions with normal and disordered erythropoiesis.. Cold Spring Harbor perspectives in medicine, 2012.
Ganz T. Macrophages and systemic iron homeostasis.. Journal of innate immunity, 2012.
Ganz T, Nemeth E. Hepcidin and iron homeostasis.. Biochimica et biophysica acta, 2012.
Preza GC, Ruchala P, Pinon R, Ramos E, Qiao B, Peralta MA, Sharma S, Waring A, Ganz T, Nemeth E. Minihepcidins are rationally designed small peptides that mimic hepcidin activity in mice and may be useful for the treatment of iron overload.. The Journal of clinical investigation, 2011.
Gordeuk VR, Miasnikova GY, Sergueeva AI, Niu X, Nouraie M, Okhotin DJ, Polyakova LA, Ammosova T, Nekhai S, Ganz T, Prchal JT. Chuvash polycythemia VHLR200W mutation is associated with down-regulation of hepcidin expression.. Blood, 2011.
Miasnikova GY, Sergueeva AI, Nouraie M, Niu X, Okhotin DJ, Polyakova LA, Ganz T, Prchal JT, Gordeuk VR. The heterozygote advantage of the Chuvash polycythemia VHLR200W mutation may be protection against anemia.. Haematologica, 2011.
Pasricha SR, McQuilten Z, Westerman M, Keller A, Nemeth E, Ganz T, Wood E. Serum hepcidin as a diagnostic test of iron deficiency in premenopausal female blood donors.. Haematologica, 2011.
Trombini P, Paolini V, Pelucchi S, Mariani R, Nemeth E, Ganz T, Piperno A. Hepcidin response to acute iron intake and chronic iron loading in dysmetabolic iron overload syndrome.. Liver international : official journal of the International Association for the Study of the Liver, 2011.
Ramos E, Kautz L, Rodriguez R, Hansen M, Gabayan V, Ginzburg Y, Roth MP, Nemeth E, Ganz T. Evidence for distinct pathways of hepcidin regulation by acute and chronic iron loading in mice.. Hepatology (Baltimore, Md.), 2011.
Clark RJ, Tan CC, Preza GC, Nemeth E, Ganz T, Craik DJ. Understanding the structure/activity relationships of the iron regulatory peptide hepcidin.. Chemistry & biology, 2011.
Ganz T. Hepcidin and iron regulation, 10 years later.. Blood, 2011.
Ghoti H, Fibach E, Westerman M, Gordana O, Ganz T, Rachmilewitz EA. Increased serum hepcidin levels during treatment with deferasirox in iron-overloaded patients with myelodysplastic syndrome.. British journal of haematology, 2011.
Ganz T, Nemeth E. Hepcidin and disorders of iron metabolism.. Annual review of medicine, 2011.
Ganz T, Nemeth E. The hepcidin-ferroportin system as a therapeutic target in anemias and iron overload disorders.. Hematology. American Society of Hematology. Education Program, 2011.
Girelli D, Trombini P, Busti F, Campostrini N, Sandri M, Pelucchi S, Westerman M, Ganz T, Nemeth E, Piperno A, Camaschella C. A time course of hepcidin response to iron challenge in patients with HFE and TFR2 hemochromatosis.. Haematologica, 2010.
Piperno A, Galimberti S, Mariani R, Pelucchi S, Ravasi G, Lombardi C, Bilo G, Revera M, Giuliano A, Faini A, Mainini V, Westerman M, Ganz T, Valsecchi MG, Mancia G, Parati G, HIGHCARE investigators. Modulation of hepcidin production during hypoxia-induced erythropoiesis in humans in vivo: data from the HIGHCARE project.. Blood, 2010.
Goodnough LT, Nemeth E, Ganz T. Detection, evaluation, and management of iron-restricted erythropoiesis.. Blood, 2010.
Maes K, Nemeth E, Roodman GD, Huston A, Esteve F, Freytes C, Callander N, Katodritou E, Tussing-Humphreys L, Rivera S, Vanderkerken K, Lichtenstein A, Ganz T. In anemia of multiple myeloma, hepcidin is induced by increased bone morphogenetic protein 2.. Blood, 2010.
Bachman E, Feng R, Travison T, Li M, Olbina G, Ostland V, Ulloor J, Zhang A, Basaria S, Ganz T, Westerman M, Bhasin S. Testosterone suppresses hepcidin in men: a potential mechanism for testosterone-induced erythrocytosis.. The Journal of clinical endocrinology and metabolism, 2010.
Chen Q, Hakimi M, Wu S, Jin Y, Cheng B, Wang H, Xie G, Ganz T, Linzmeier RM, Fang X. Increased genomic copy number of DEFA1/DEFA3 is associated with susceptibility to severe sepsis in Chinese Han population.. Anesthesiology, 2010.
Ayoya MA, Spiekermann-Brouwer GM, Stoltzfus RJ, Nemeth E, Habicht JP, Ganz T, Rawat R, Traoré AK, Garza C. Alpha 1-acid glycoprotein, hepcidin, C-reactive protein, and serum ferritin are correlated in anemic schoolchildren with Schistosoma haematobium.. The American journal of clinical nutrition, 2010.
Zaritsky J, Young B, Gales B, Wang HJ, Rastogi A, Westerman M, Nemeth E, Ganz T, Salusky IB. Reduction of serum hepcidin by hemodialysis in pediatric and adult patients.. Clinical journal of the American Society of Nephrology : CJASN, 2010.
Bdeir K, Higazi AA, Kulikovskaya I, Christofidou-Solomidou M, Vinogradov SA, Allen TC, Idell S, Linzmeier R, Ganz T, Cines DB. Neutrophil alpha-defensins cause lung injury by disrupting the capillary-epithelial barrier.. American journal of respiratory and critical care medicine, 2010.
Ferrucci L, Semba RD, Guralnik JM, Ershler WB, Bandinelli S, Patel KV, Sun K, Woodman RC, Andrews NC, Cotter RJ, Ganz T, Nemeth E, Longo DL. Proinflammatory state, hepcidin, and anemia in older persons.. Blood, 2010.
Kroot JJ, Kemna EH, Bansal SS, Busbridge M, Campostrini N, Girelli D, Hider RC, Koliaraki V, Mamalaki A, Olbina G, Tomosugi N, Tselepis C, Ward DG, Ganz T, Hendriks JC, Swinkels DW. Results of the first international round robin for the quantification of urinary and plasma hepcidin assays: need for standardization.. Haematologica, 2009.
Nemeth E, Ganz T. The role of hepcidin in iron metabolism.. Acta haematologica, 2009.
Rivera S, Ganz T. Animal models of anemia of inflammation.. Seminars in hematology, 2009.
Ganz T, Nemeth E. Iron sequestration and anemia of inflammation.. Seminars in hematology, 2009.
Ayoya MA, Stoltzfus RJ, Spiekermann-Brouwer GM, Nemeth E, Traoré AK, Ganz T, Garza C. [Hepcidin and Plasmodium falciparum malaria in anemic school children in Mali].. Bulletin de la Societe de pathologie exotique (1990), 2009.
Girelli D, Pasino M, Goodnough JB, Nemeth E, Guido M, Castagna A, Busti F, Campostrini N, Martinelli N, Vantini I, Corrocher R, Ganz T, Fattovich G. Reduced serum hepcidin levels in patients with chronic hepatitis C.. Journal of hepatology, 2009.
Katodritou E, Ganz T, Terpos E, Verrou E, Olbina G, Gastari V, Hadjiaggelidou C, Varthaliti M, Georgiadou S, Westerman M, Zervas K. Sequential evaluation of serum hepcidin in anemic myeloma patients: study of correlations with myeloma treatment, disease variables, and anemia response.. American journal of hematology, 2009.
Sham RL, Phatak PD, Nemeth E, Ganz T. Hereditary hemochromatosis due to resistance to hepcidin: high hepcidin concentrations in a family with C326S ferroportin mutation.. Blood, 2009.
Tanno T, Porayette P, Sripichai O, Noh SJ, Byrnes C, Bhupatiraju A, Lee YT, Goodnough JB, Harandi O, Ganz T, Paulson RF, Miller JL. Identification of TWSG1 as a second novel erythroid regulator of hepcidin expression in murine and human cells.. Blood, 2009.
Zaritsky J, Young B, Wang HJ, Westerman M, Olbina G, Nemeth E, Ganz T, Rivera S, Nissenson AR, Salusky IB. Hepcidin--a potential novel biomarker for iron status in chronic kidney disease.. Clinical journal of the American Society of Nephrology : CJASN, 2009.
Fernandes A, Preza GC, Phung Y, De Domenico I, Kaplan J, Ganz T, Nemeth E. The molecular basis of hepcidin-resistant hereditary hemochromatosis.. Blood, 2009.
Ruivard M, Lainé F, Ganz T, Olbina G, Westerman M, Nemeth E, Rambeau M, Mazur A, Gerbaud L, Tournilhac V, Abergel A, Philippe P, Deugnier Y, Coudray C. Iron absorption in dysmetabolic iron overload syndrome is decreased and correlates with increased plasma hepcidin.. Journal of hepatology, 2009.
Troadec MB, Lainé F, Daniel V, Rochcongar P, Ropert M, Cabillic F, Perrin M, Morcet J, Loréal O, Olbina G, Westerman M, Nemeth E, Ganz T, Brissot P. Daily regulation of serum and urinary hepcidin is not influenced by submaximal cycling exercise in humans with normal iron metabolism.. European journal of applied physiology, 2009.
Ganz T. Iron in innate immunity: starve the invaders.. Current opinion in immunology, 2009.
Wilson CL, Schmidt AP, Pirilä E, Valore EV, Ferri N, Sorsa T, Ganz T, Parks WC. Differential Processing of {alpha}- and {beta}-Defensin Precursors by Matrix Metalloproteinase-7 (MMP-7).. The Journal of biological chemistry, 2009.
Ganz T, Olbina G, Girelli D, Nemeth E, Westerman M. Immunoassay for human serum hepcidin.. Blood, 2008.
De Domenico I, Nemeth E, Nelson JM, Phillips JD, Ajioka RS, Kay MS, Kushner JP, Ganz T, Ward DM, Kaplan J. The hepcidin-binding site on ferroportin is evolutionarily conserved.. Cell metabolism, 2008.
Sharma S, Nemeth E, Chen YH, Goodnough J, Huston A, Roodman GD, Ganz T, Lichtenstein A. Involvement of hepcidin in the anemia of multiple myeloma.. Clinical cancer research : an official journal of the American Association for Cancer Research, 2008.
Winder A, Lefkowitz R, Ghoti H, Leiba M, Ganz T, Nemeth E, Rachmilewitz EA. Urinary hepcidin excretion in patients with myelodysplastic syndrome and myelofibrosis.. British journal of haematology, 2008.
Barisani D, Pelucchi S, Mariani R, Galimberti S, Trombini P, Fumagalli D, Meneveri R, Nemeth E, Ganz T, Piperno A. Hepcidin and iron-related gene expression in subjects with Dysmetabolic Hepatic Iron Overload.. Journal of hepatology, 2008.
Ganz T. Iron homeostasis: fitting the puzzle pieces together.. Cell metabolism, 2008.
Bozzini C, Campostrini N, Trombini P, Nemeth E, Castagna A, Tenuti I, Corrocher R, Camaschella C, Ganz T, Olivieri O, Piperno A, Girelli D. Measurement of urinary hepcidin levels by SELDI-TOF-MS in HFE-hemochromatosis.. Blood cells, molecules & diseases, 2007.
Aberg KM, Radek KA, Choi EH, Kim DK, Demerjian M, Hupe M, Kerbleski J, Gallo RL, Ganz T, Mauro T, Feingold KR, Elias PM. Psychological stress downregulates epidermal antimicrobial peptide expression and increases severity of cutaneous infections in mice.. The Journal of clinical investigation, 2007.
Aberg KM, Man MQ, Gallo RL, Ganz T, Crumrine D, Brown BE, Choi EH, Kim DK, Schröder JM, Feingold KR, Elias PM. Co-regulation and interdependence of the mammalian epidermal permeability and antimicrobial barriers.. The Journal of investigative dermatology, 2007.
Trombini P, Coliva T, Nemeth E, Mariani R, Ganz T, Biondi A, Piperno A. Effects of plasma transfusion on hepcidin production in human congenital hypotransferrinemia.. Haematologica, 2007.
Valore EV, Ganz T. Posttranslational processing of hepcidin in human hepatocytes is mediated by the prohormone convertase furin.. Blood cells, molecules & diseases, 2007.
Bullard RS, Gibson W, Bose SK, Belgrave JK, Eaddy AC, Wright CJ, Hazen-Martin DJ, Lage JM, Keane TE, Ganz TA, Donald CD. Functional analysis of the host defense peptide Human Beta Defensin-1: new insight into its potential role in cancer.. Molecular immunology, 2007.
Lin L, Nemeth E, Goodnough JB, Thapa DR, Gabayan V, Ganz T. Soluble hemojuvelin is released by proprotein convertase-mediated cleavage at a conserved polybasic RNRR site.. Blood cells, molecules & diseases, 2007.
Piperno A, Girelli D, Nemeth E, Trombini P, Bozzini C, Poggiali E, Phung Y, Ganz T, Camaschella C. Blunted hepcidin response to oral iron challenge in HFE-related hemochromatosis.. Blood, 2007.
Tanno T, Bhanu NV, Oneal PA, Goh SH, Staker P, Lee YT, Moroney JW, Reed CH, Luban NL, Wang RH, Eling TE, Childs R, Ganz T, Leitman SF, Fucharoen S, Miller JL. High levels of GDF15 in thalassemia suppress expression of the iron regulatory protein hepcidin.. Nature medicine, 2007.
Lin L, Valore EV, Nemeth E, Goodnough JB, Gabayan V, Ganz T. Iron transferrin regulates hepcidin synthesis in primary hepatocyte culture through hemojuvelin and BMP2/4.. Blood, 2007.
De Domenico I, Ward DM, Langelier C, Vaughn MB, Nemeth E, Sundquist WI, Ganz T, Musci G, Kaplan J. The molecular mechanism of hepcidin-mediated ferroportin down-regulation.. Molecular biology of the cell, 2007.
Origa R, Galanello R, Ganz T, Giagu N, Maccioni L, Faa G, Nemeth E. Liver iron concentrations and urinary hepcidin in beta-thalassemia.. Haematologica, 2007.
Ganz T. Molecular control of iron transport.. Journal of the American Society of Nephrology : JASN, 2007.
Kearney SL, Nemeth E, Neufeld EJ, Thapa D, Ganz T, Weinstein DA, Cunningham MJ. Urinary hepcidin in congenital chronic anemias.. Pediatric blood & cancer, 2007.
Valore EV, Wiley DJ, Ganz T. Reversible deficiency of antimicrobial polypeptides in bacterial vaginosis.. Infection and immunity, 2006.
Tan BH, Meinken C, Bastian M, Bruns H, Legaspi A, Ochoa MT, Krutzik SR, Bloom BR, Ganz T, Modlin RL, Stenger S. Macrophages acquire neutrophil granules for antimicrobial activity against intracellular pathogens.. Journal of immunology (Baltimore, Md. : 1950), 2006.
De Domenico I, McVey Ward D, Nemeth E, Ganz T, Corradini E, Ferrara F, Musci G, Pietrangelo A, Kaplan J. Molecular and clinical correlates in iron overload associated with mutations in ferroportin.. Haematologica, 2006.
Pak M, Lopez MA, Gabayan V, Ganz T, Rivera S. Suppression of hepcidin during anemia requires erythropoietic activity.. Blood, 2006.
Pospisilova D, Mims MP, Nemeth E, Ganz T, Prchal JT. DMT1 mutation: response of anemia to darbepoetin administration and implications for iron homeostasis.. Blood, 2006.
Sørensen OE, Thapa DR, Roupé KM, Valore EV, Sjöbring U, Roberts AA, Schmidtchen A, Ganz T. Injury-induced innate immune response in human skin mediated by transactivation of the epidermal growth factor receptor.. The Journal of clinical investigation, 2006.
Nemeth E, Ganz T. Hepcidin and iron-loading anemias.. Haematologica, 2006.
Ganz T, Nemeth E. Regulation of iron acquisition and iron distribution in mammals.. Biochimica et biophysica acta, 2006.
Ganz T. Molecular pathogenesis of anemia of chronic disease.. Pediatric blood & cancer, 2006.
Linzmeier RM, Ganz T. Copy number polymorphisms are not a common feature of innate immune genes.. Genomics, 2006.
Ganz T, Nemeth E. Iron imports. IV. Hepcidin and regulation of body iron metabolism.. American journal of physiology. Gastrointestinal and liver physiology, 2006.
Ganz T. Hepcidin and its role in regulating systemic iron metabolism.. Hematology. American Society of Hematology. Education Program, 2006.
Ganz T. Hepcidin--a peptide hormone at the interface of innate immunity and iron metabolism.. Current topics in microbiology and immunology, 2006.
Nemeth E, Ganz T. Regulation of iron metabolism by hepcidin.. Annual review of nutrition, 2006.
Wehkamp J, Salzman NH, Porter E, Nuding S, Weichenthal M, Petras RE, Shen B, Schaeffeler E, Schwab M, Linzmeier R, Feathers RW, Chu H, Lima H, Fellermann K, Ganz T, Stange EF, Bevins CL. Reduced Paneth cell alpha-defensins in ileal Crohn's disease.. Proceedings of the National Academy of Sciences of the United States of America, 2005.
Roecker L, Meier-Buttermilch R, Brechtel L, Nemeth E, Ganz T. Iron-regulatory protein hepcidin is increased in female athletes after a marathon.. European journal of applied physiology, 2005.
Porto G, Roetto A, Daraio F, Pinto JP, Almeida S, Bacelar C, Nemeth E, Ganz T, Camaschella C. A Portuguese patient homozygous for the -25G>A mutation of the HAMP promoter shows evidence of steady-state transcription but fails to up-regulate hepcidin levels by iron.. Blood, 2005.
Cole AM, Thapa DR, Gabayan V, Liao HI, Liu L, Ganz T. Decreased clearance of Pseudomonas aeruginosa from airways of mice deficient in lysozyme M.. Journal of leukocyte biology, 2005.
Linzmeier RM, Ganz T. Human defensin gene copy number polymorphisms: comprehensive analysis of independent variation in alpha- and beta-defensin regions at 8p22-p23.. Genomics, 2005.
Nemeth E, Preza GC, Jung CL, Kaplan J, Waring AJ, Ganz T. The N-terminus of hepcidin is essential for its interaction with ferroportin: structure-function study.. Blood, 2005.
Porter E, Yang H, Yavagal S, Preza GC, Murillo O, Lima H, Greene S, Mahoozi L, Klein-Patel M, Diamond G, Gulati S, Ganz T, Rice PA, Quayle AJ. Distinct defensin profiles in Neisseria gonorrhoeae and Chlamydia trachomatis urethritis reveal novel epithelial cell-neutrophil interactions.. Infection and immunity, 2005.
Zoller H, McFarlane I, Theurl I, Stadlmann S, Nemeth E, Oxley D, Ganz T, Halsall DJ, Cox TM, Vogel W. Primary iron overload with inappropriate hepcidin expression in V162del ferroportin disease.. Hepatology (Baltimore, Md.), 2005.
Lin L, Goldberg YP, Ganz T. Competitive regulation of hepcidin mRNA by soluble and cell-associated hemojuvelin.. Blood, 2005.
Shen B, Porter EM, Reynoso E, Shen C, Ghosh D, Connor JT, Drazba J, Rho HK, Gramlich TL, Li R, Ormsby AH, Sy MS, Ganz T, Bevins CL. Human defensin 5 expression in intestinal metaplasia of the upper gastrointestinal tract.. Journal of clinical pathology, 2005.
De Domenico I, Ward DM, Nemeth E, Vaughn MB, Musci G, Ganz T, Kaplan J. The molecular basis of ferroportin-linked hemochromatosis.. Proceedings of the National Academy of Sciences of the United States of America, 2005.
Rivera S, Nemeth E, Gabayan V, Lopez MA, Farshidi D, Ganz T. Synthetic hepcidin causes rapid dose-dependent hypoferremia and is concentrated in ferroportin-containing organs.. Blood, 2005.
Ganz T. Hepcidin--a regulator of intestinal iron absorption and iron recycling by macrophages.. Best practice & research. Clinical haematology, 2005.
Miller LS, Sørensen OE, Liu PT, Jalian HR, Eshtiaghpour D, Behmanesh BE, Chung W, Starner TD, Kim J, Sieling PA, Ganz T, Modlin RL. TGF-alpha regulates TLR expression and function on epidermal keratinocytes.. Journal of immunology (Baltimore, Md. : 1950), 2005.
Ganz T. Defensins and other antimicrobial peptides: a historical perspective and an update.. Combinatorial chemistry & high throughput screening, 2005.
Liuzzi JP, Lichten LA, Rivera S, Blanchard RK, Aydemir TB, Knutson MD, Ganz T, Cousins RJ. Interleukin-6 regulates the zinc transporter Zip14 in liver and contributes to the hypozincemia of the acute-phase response.. Proceedings of the National Academy of Sciences of the United States of America, 2005.
Sørensen OE, Thapa DR, Rosenthal A, Liu L, Roberts AA, Ganz T. Differential regulation of beta-defensin expression in human skin by microbial stimuli.. Journal of immunology (Baltimore, Md. : 1950), 2005.
Détivaud L, Nemeth E, Boudjema K, Turlin B, Troadec MB, Leroyer P, Ropert M, Jacquelinet S, Courselaud B, Ganz T, Brissot P, Loréal O. Hepcidin levels in humans are correlated with hepatic iron stores, hemoglobin levels, and hepatic function.. Blood, 2005.
Ganz T. Cellular iron: ferroportin is the only way out.. Cell metabolism, 2005.
Papanikolaou G, Tzilianos M, Christakis JI, Bogdanos D, Tsimirika K, MacFarlane J, Goldberg YP, Sakellaropoulos N, Ganz T, Nemeth E. Hepcidin in iron overload disorders.. Blood, 2005.
Nemeth E, Tuttle MS, Powelson J, Vaughn MB, Donovan A, Ward DM, Ganz T, Kaplan J. Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization.. Science (New York, N.Y.), 2004.
Ross DJ, Cole AM, Yoshioka D, Park AK, Belperio JA, Laks H, Strieter RM, Lynch JP, Kubak B, Ardehali A, Ganz T. Increased bronchoalveolar lavage human beta-defensin type 2 in bronchiolitis obliterans syndrome after lung transplantation.. Transplantation, 2004.
Nemeth E, Roetto A, Garozzo G, Ganz T, Camaschella C. Hepcidin is decreased in TFR2 hemochromatosis.. Blood, 2004.
Rivera S, Liu L, Nemeth E, Gabayan V, Sorensen OE, Ganz T. Hepcidin excess induces the sequestration of iron and exacerbates tumor-associated anemia.. Blood, 2004.
Kalfa VC, Spector SL, Ganz T, Cole AM. Lysozyme levels in the nasal secretions of patients with perennial allergic rhinitis and recurrent sinusitis.. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 2004.
Ganz T. Hepcidin in iron metabolism.. Current opinion in hematology, 2004.
Matthes T, Aguilar-Martinez P, Pizzi-Bosman L, Darbellay R, Rubbia-Brandt L, Giostra E, Michel M, Ganz T, Beris P. Severe hemochromatosis in a Portuguese family associated with a new mutation in the 5'-UTR of the HAMP gene.. Blood, 2004.
Ganz T. Defensins: antimicrobial peptides of vertebrates.. Comptes rendus biologies, 2004.
Lee HY, Andalibi A, Webster P, Moon SK, Teufert K, Kang SH, Li JD, Nagura M, Ganz T, Lim DJ. Antimicrobial activity of innate immune molecules against Streptococcus pneumoniae, Moraxella catarrhalis and nontypeable Haemophilus influenzae.. BMC infectious diseases, 2004.
Nemeth E, Rivera S, Gabayan V, Keller C, Taudorf S, Pedersen BK, Ganz T. IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin.. The Journal of clinical investigation, 2004.
Hertz CJ, Wu Q, Porter EM, Zhang YJ, Weismüller KH, Godowski PJ, Ganz T, Randell SH, Modlin RL. Activation of Toll-like receptor 2 on human tracheobronchial epithelial cells induces the antimicrobial peptide human beta defensin-2.. Journal of immunology (Baltimore, Md. : 1950), 2003.
Papanikolaou G, Samuels ME, Ludwig EH, MacDonald ML, Franchini PL, Dubé MP, Andres L, MacFarlane J, Sakellaropoulos N, Politou M, Nemeth E, Thompson J, Risler JK, Zaborowska C, Babakaiff R, Radomski CC, Pape TD, Davidas O, Christakis J, Brissot P, Lockitch G, Ganz T, Hayden MR, Goldberg YP. Mutations in HFE2 cause iron overload in chromosome 1q-linked juvenile hemochromatosis.. Nature genetics, 2003.
Ganz T. Defensins: antimicrobial peptides of innate immunity.. Nature reviews. Immunology, 2003.
Milner SM, Cole A, Ortega MR, Bakir MH, Gulati S, Bhat S, Ganz T. Inducibility of HBD-2 in acute burns and chronic conditions of the lung.. Burns : journal of the International Society for Burn Injuries, 2003.
Ganz T. Antimicrobial polypeptides.. Journal of leukocyte biology, 2003.
Sørensen OE, Cowland JB, Theilgaard-Mönch K, Liu L, Ganz T, Borregaard N. Wound healing and expression of antimicrobial peptides/polypeptides in human keratinocytes, a consequence of common growth factors.. Journal of immunology (Baltimore, Md. : 1950), 2003.
Ganz T. Microbiology: Gut defence.. Nature, 2003.
Donald CD, Sun CQ, Lim SD, Macoska J, Cohen C, Amin MB, Young AN, Ganz TA, Marshall FF, Petros JA. Cancer-specific loss of beta-defensin 1 in renal and prostatic carcinomas.. Laboratory investigation; a journal of technical methods and pathology, 2003.
Oren A, Ganz T, Liu L, Meerloo T. In human epidermis, beta-defensin 2 is packaged in lamellar bodies.. Experimental and molecular pathology, 2003.
Ganz T. The role of antimicrobial peptides in innate immunity.. Integrative and comparative biology, 2003.
Ganz T. Hepcidin, a key regulator of iron metabolism and mediator of anemia of inflammation.. Blood, 2003.
Ganz T. Angiogenin: an antimicrobial ribonuclease.. Nature immunology, 2003.
Cole AM, Liao HI, Ganz T, Yang OO. Antibacterial activity of peptides derived from envelope glycoproteins of HIV-1.. FEBS letters, 2003.
Liu L, Roberts AA, Ganz T. By IL-1 signaling, monocyte-derived cells dramatically enhance the epidermal antimicrobial response to lipopolysaccharide.. Journal of immunology (Baltimore, Md. : 1950), 2003.
Com E, Bourgeon F, Evrard B, Ganz T, Colleu D, Jégou B, Pineau C. Expression of antimicrobial defensins in the male reproductive tract of rats, mice, and humans.. Biology of reproduction, 2003.
Cole AM, Liao HI, Stuchlik O, Tilan J, Pohl J, Ganz T. Cationic polypeptides are required for antibacterial activity of human airway fluid.. Journal of immunology (Baltimore, Md. : 1950), 2002.
Huang GT, Zhang HB, Kim D, Liu L, Ganz T. A model for antimicrobial gene therapy: demonstration of human beta-defensin 2 antimicrobial activities in vivo.. Human gene therapy, 2002.
Nemeth E, Valore EV, Territo M, Schiller G, Lichtenstein A, Ganz T. Hepcidin, a putative mediator of anemia of inflammation, is a type II acute-phase protein.. Blood, 2002.
Ganz T. Immunology. Versatile defensins.. Science (New York, N.Y.), 2002.
Ganz T. The role of hepcidin in iron sequestration during infections and in the pathogenesis of anemia of chronic disease.. The Israel Medical Association journal : IMAJ, 2002.
Ganz T, Gabayan V, Liao HI, Liu L, Oren A, Graf T, Cole AM. Increased inflammation in lysozyme M-deficient mice in response to Micrococcus luteus and its peptidoglycan.. Blood, 2002.
Ong PY, Ohtake T, Brandt C, Strickland I, Boguniewicz M, Ganz T, Gallo RL, Leung DY. Endogenous antimicrobial peptides and skin infections in atopic dermatitis.. The New England journal of medicine, 2002.
Valore EV, Park CH, Igreti SL, Ganz T. Antimicrobial components of vaginal fluid.. American journal of obstetrics and gynecology, 2002.
Hunter HN, Fulton DB, Ganz T, Vogel HJ. The solution structure of human hepcidin, a peptide hormone with antimicrobial activity that is involved in iron uptake and hereditary hemochromatosis.. The Journal of biological chemistry, 2002.
Hein M, Valore EV, Helmig RB, Uldbjerg N, Ganz T. Antimicrobial factors in the cervical mucus plug.. American journal of obstetrics and gynecology, 2002.
Moon SK, Lee HY, Li JD, Nagura M, Kang SH, Chun YM, Linthicum FH, Ganz T, Andalibi A, Lim DJ. Activation of a Src-dependent Raf-MEK1/2-ERK signaling pathway is required for IL-1alpha-induced upregulation of beta-defensin 2 in human middle ear epithelial cells.. Biochimica et biophysica acta, 2002.
Ghosh D, Porter E, Shen B, Lee SK, Wilk D, Drazba J, Yadav SP, Crabb JW, Ganz T, Bevins CL. Paneth cell trypsin is the processing enzyme for human defensin-5.. Nature immunology, 2002.
Levy O, Sisson RB, Fryer HE, Goldmann D, Valore E, Ganz T, White ML, Carroll SF, Lehmann L, Guinan EC. Neutrophil defense in patients undergoing bone marrow transplantation: bactericidal/permeability-increasing protein (BPI) and defensins in graft-derived neutrophils.. Transplantation, 2002.
Ganz T. Epithelia: not just physical barriers.. Proceedings of the National Academy of Sciences of the United States of America, 2002.
Ganz T. Antimicrobial polypeptides in host defense of the respiratory tract.. The Journal of clinical investigation, 2002.
Henneman E, Dracup K, Ganz T, Molayeme O, Cooper CB. Using a collaborative weaning plan to decrease duration of mechanical ventilation and length of stay in the intensive care unit for patients receiving long-term ventilation.. American journal of critical care : an official publication, American Association of Critical-Care Nurses, 2002.
Lehrer RI, Ganz T. Defensins of vertebrate animals.. Current opinion in immunology, 2002.
Liu AY, Destoumieux D, Wong AV, Park CH, Valore EV, Liu L, Ganz T. Human beta-defensin-2 production in keratinocytes is regulated by interleukin-1, bacteria, and the state of differentiation.. The Journal of investigative dermatology, 2002.
Sanchez JF, Wojcik F, Yang YS, Strub MP, Strub JM, Van Dorsselaer A, Martin M, Lehrer R, Ganz T, Chavanieu A, Calas B, Aumelas A. Overexpression and structural study of the cathelicidin motif of the protegrin-3 precursor.. Biochemistry, 2002.
Cole AM, Ganz T. Antimicrobial peptides and proteins in the CF airway.. Methods in molecular medicine, 2002.
Lehrer RI, Ganz T. Cathelicidins: a family of endogenous antimicrobial peptides.. Current opinion in hematology, 2002.
Porter EM, Bevins CL, Ghosh D, Ganz T. The multifaceted Paneth cell.. Cellular and molecular life sciences : CMLS, 2002.
Cole AM, Tahk S, Oren A, Yoshioka D, Kim YH, Park A, Ganz T. Determinants of Staphylococcus aureus nasal carriage.. Clinical and diagnostic laboratory immunology, 2001.
Porro GA, Lee JH, de Azavedo J, Crandall I, Whitehead T, Tullis E, Ganz T, Liu M, Slutsky AS, Zhang H. Direct and indirect bacterial killing functions of neutrophil defensins in lung explants.. American journal of physiology. Lung cellular and molecular physiology, 2001.
Sanchez JF, Hoh F, Strub MP, Strub JM, Van Dorsselaer A, Lehrer R, Ganz T, Chavanieu A, Calas B, Dumas C, Aumelas A. Expression, purification, crystallization and preliminary X-ray analysis of the cathelicidin motif of the protegrin-3 precursor.. Acta crystallographica. Section D, Biological crystallography, 2001.
Diamond DL, Kimball JR, Krisanaprakornkit S, Ganz T, Dale BA. Detection of beta-defensins secreted by human oral epithelial cells.. Journal of immunological methods, 2001.
Dale BA, Kimball JR, Krisanaprakornkit S, Roberts F, Robinovitch M, O'Neal R, Valore EV, Ganz T, Anderson GM, Weinberg A. Localized antimicrobial peptide expression in human gingiva.. Journal of periodontal research, 2001.
Hein M, Helmig RB, Schønheyder HC, Ganz T, Uldbjerg N. An in vitro study of antibacterial properties of the cervical mucus plug in pregnancy.. American journal of obstetrics and gynecology, 2001.
Cole AM, Kim YH, Tahk S, Hong T, Weis P, Waring AJ, Ganz T. Calcitermin, a novel antimicrobial peptide isolated from human airway secretions.. FEBS letters, 2001.
Ganz T. Chemistry. Rings of destruction.. Nature, 2001.
Cole AM, Ganz T, Liese AM, Burdick MD, Liu L, Strieter RM. Cutting edge: IFN-inducible ELR- CXC chemokines display defensin-like antimicrobial activity.. Journal of immunology (Baltimore, Md. : 1950), 2001.
Ganz T. Fatal attraction evaded. How pathogenic bacteria resist cationic polypeptides.. The Journal of experimental medicine, 2001.
Sawai MV, Jia HP, Liu L, Aseyev V, Wiencek JM, McCray PB, Ganz T, Kearney WR, Tack BF. The NMR structure of human beta-defensin-2 reveals a novel alpha-helical segment.. Biochemistry, 2001.
Ganz T. Antimicrobial proteins and peptides in host defense.. Seminars in respiratory infections, 2001.
Ganz T. Defensins in the urinary tract and other tissues.. The Journal of infectious diseases, 2001.
Henneman E, Dracup K, Ganz T, Molayeme O, Cooper C. Effect of a collaborative weaning plan on patient outcome in the critical care setting.. Critical care medicine, 2001.
Ceccarelli AV, Cole AM, Park AK, Tahk S, Yoshioka D, Ganz T. Therapeutic effect of a pig-derived peptide antibiotic on porcine wound infections.. Comparative medicine, 2001.
Jia HP, Schutte BC, Schudy A, Linzmeier R, Guthmiller JM, Johnson GK, Tack BF, Mitros JP, Rosenthal A, Ganz T, McCray PB. Discovery of new human beta-defensins using a genomics-based approach.. Gene, 2001.
Cole AM, Shi J, Ceccarelli A, Kim YH, Park A, Ganz T. Inhibition of neutrophil elastase prevents cathelicidin activation and impairs clearance of bacteria from wounds.. Blood, 2001.
Ernst WA, Thoma-Uszynski S, Teitelbaum R, Ko C, Hanson DA, Clayberger C, Krensky AM, Leippe M, Bloom BR, Ganz T, Modlin RL. Granulysin, a T cell product, kills bacteria by altering membrane permeability.. Journal of immunology (Baltimore, Md. : 1950), 2000.
Park CH, Valore EV, Waring AJ, Ganz T. Hepcidin, a urinary antimicrobial peptide synthesized in the liver.. The Journal of biological chemistry, 2000.
Ortega MR, Ganz T, Milner SM. Human beta defensin is absent in burn blister fluid.. Burns : journal of the International Society for Burn Injuries, 2000.
Cole AM, Ganz T. Human antimicrobial peptides: analysis and application.. BioTechniques, 2000.
O'Neil DA, Cole SP, Martin-Porter E, Housley MP, Liu L, Ganz T, Kagnoff MF. Regulation of human beta-defensins by gastric epithelial cells in response to infection with Helicobacter pylori or stimulation with interleukin-1.. Infection and immunity, 2000.
Higazi AA, Nassar T, Ganz T, Rader DJ, Udassin R, Bdeir K, Hiss E, Sachais BS, Williams KJ, Leitersdorf E, Cines DB. The alpha-defensins stimulate proteoglycan-dependent catabolism of low-density lipoprotein by vascular cells: a new class of inflammatory apolipoprotein and a possible contributor to atherogenesis.. Blood, 2000.
Ganz T. Paneth cells--guardians of the gut cell hatchery.. Nature immunology, 2000.
Bellm L, Lehrer RI, Ganz T. Protegrins: new antibiotics of mammalian origin.. Expert opinion on investigational drugs, 2000.
Tunzi CR, Harper PA, Bar-Oz B, Valore EV, Semple JL, Watson-MacDonell J, Ganz T, Ito S. Beta-defensin expression in human mammary gland epithelia.. Pediatric research, 2000.
Cole AM, Wu M, Kim YH, Ganz T. Microanalysis of antimicrobial properties of human fluids.. Journal of microbiological methods, 2000.
Borregaard N, Elsbach P, Ganz T, Garred P, Svejgaard A. Authors' corrections. Immunology today, 2000.
Borregaard N, Elsbach P, Ganz T, Garred P, Svejgaard A. Innate immunity: from plants to humans.. Immunology today, 2000.
O'Neil DA, Porter EM, Elewaut D, Anderson GM, Eckmann L, Ganz T, Kagnoff MF. Expression and regulation of the human beta-defensins hBD-1 and hBD-2 in intestinal epithelium.. Journal of immunology (Baltimore, Md. : 1950), 1999.
Bevins CL, Martin-Porter E, Ganz T. Defensins and innate host defence of the gastrointestinal tract.. Gut, 1999.
Levy O, Martin S, Eichenwald E, Ganz T, Valore E, Carroll SF, Lee K, Goldmann D, Thorne GM. Impaired innate immunity in the newborn: newborn neutrophils are deficient in bactericidal/permeability-increasing protein.. Pediatrics, 1999.
Ganz T. Defensins and host defense.. Science (New York, N.Y.), 1999.
Bdeir K, Cane W, Canziani G, Chaiken I, Weisel J, Koschinsky ML, Lawn RM, Bannerman PG, Sachais BS, Kuo A, Hancock MA, Tomaszewski J, Raghunath PN, Ganz T, Higazi AA, Cines DB. Defensin promotes the binding of lipoprotein(a) to vascular matrix.. Blood, 1999.
Ganz T. Oxygen-independent microbicidal mechanisms of phagocytes.. Proceedings of the Association of American Physicians, 1999.
Ganz T, Lehrer RI. Antibiotic peptides from higher eukaryotes: biology and applications.. Molecular medicine today, 1999.
Cole AM, Dewan P, Ganz T. Innate antimicrobial activity of nasal secretions.. Infection and immunity, 1999.
Linzmeier R, Ho CH, Hoang BV, Ganz T. A 450-kb contig of defensin genes on human chromosome 8p23.. Gene, 1999.
Rivas L, Ganz T. Eukaryotic antibiotic peptides: not only a membrane business.. Drug discovery today, 1999.
McKay MS, Olson E, Hesla MA, Panyutich A, Ganz T, Perkins S, Rossomando EF. Immunomagnetic recovery of human neutrophil defensins from the human gingival crevice.. Oral microbiology and immunology, 1999.
Shi J, Zhang G, Wu H, Ross C, Blecha F, Ganz T. Porcine epithelial beta-defensin 1 is expressed in the dorsal tongue at antimicrobial concentrations.. Infection and immunity, 1999.
Lehrer RI, Ganz T. Antimicrobial peptides in mammalian and insect host defence.. Current opinion in immunology, 1999.
Singh PK, Jia HP, Wiles K, Hesselberth J, Liu L, Conway BA, Greenberg EP, Valore EV, Welsh MJ, Ganz T, Tack BF, McCray PB. Production of beta-defensins by human airway epithelia.. Proceedings of the National Academy of Sciences of the United States of America, 1998.
Liu L, Wang L, Jia HP, Zhao C, Heng HH, Schutte BC, McCray PB, Ganz T. Structure and mapping of the human beta-defensin HBD-2 gene and its expression at sites of inflammation.. Gene, 1998.
Stenger S, Hanson DA, Teitelbaum R, Dewan P, Niazi KR, Froelich CJ, Ganz T, Thoma-Uszynski S, Melián A, Bogdan C, Porcelli SA, Bloom BR, Krensky AM, Modlin RL. An antimicrobial activity of cytolytic T cells mediated by granulysin.. Science (New York, N.Y.), 1998.
Porter EM, Poles MA, Lee JS, Naitoh J, Bevins CL, Ganz T. Isolation of human intestinal defensins from ileal neobladder urine.. FEBS letters, 1998.
Shi J, Ganz T. The role of protegrins and other elastase-activated polypeptides in the bactericidal properties of porcine inflammatory fluids.. Infection and immunity, 1998.
Valore EV, Park CH, Quayle AJ, Wiles KR, McCray PB, Ganz T. Human beta-defensin-1: an antimicrobial peptide of urogenital tissues.. The Journal of clinical investigation, 1998.
Zhang G, Wu H, Shi J, Ganz T, Ross CR, Blecha F. Molecular cloning and tissue expression of porcine beta-defensin-1.. FEBS letters, 1998.
Ganz T, Lehrer RI. Antimicrobial peptides of vertebrates.. Current opinion in immunology, 1998.
Ganz T, Weiss J. Antimicrobial peptides of phagocytes and epithelia.. Seminars in hematology, 1997.
Liu L, Zhao C, Heng HH, Ganz T. The human beta-defensin-1 and alpha-defensins are encoded by adjacent genes: two peptide families with differing disulfide topology share a common ancestry.. Genomics, 1997.
Higazi AA, Lavi E, Bdeir K, Ulrich AM, Jamieson DG, Rader DJ, Usher DC, Kane W, Ganz T, Cines DB. Defensin stimulates the binding of lipoprotein (a) to human vascular endothelial and smooth muscle cells.. Blood, 1997.
Porter EM, van Dam E, Valore EV, Ganz T. Broad-spectrum antimicrobial activity of human intestinal defensin 5.. Infection and immunity, 1997.
Porter EM, Liu L, Oren A, Anton PA, Ganz T. Localization of human intestinal defensin 5 in Paneth cell granules.. Infection and immunity, 1997.
Barnathan ES, Raghunath PN, Tomaszewski JE, Ganz T, Cines DB. Immunohistochemical localization of defensin in human coronary vessels.. The American journal of pathology, 1997.
Panyutich A, Shi J, Boutz PL, Zhao C, Ganz T. Porcine polymorphonuclear leukocytes generate extracellular microbicidal activity by elastase-mediated activation of secreted proprotegrins.. Infection and immunity, 1997.
Soong LB, Ganz T, Ellison A, Caughey GH. Purification and characterization of defensins from cystic fibrosis sputum.. Inflammation research : official journal of the European Histamine Research Society ... [et al.], 1997.
Lohner K, Latal A, Lehrer RI, Ganz T. Differential scanning microcalorimetry indicates that human defensin, HNP-2, interacts specifically with biomembrane mimetic systems.. Biochemistry, 1997.
Ganz T, Lehrer RI. Antimicrobial peptides of leukocytes.. Current opinion in hematology, 1997.
Valore EV, Ganz T. Laboratory production of antimicrobial peptides in native conformation.. Methods in molecular biology (Clifton, N.J.), 1997.
Lehrer RI, Ganz T. Endogenous vertebrate antibiotics. Defensins, protegrins, and other cysteine-rich antimicrobial peptides.. Annals of the New York Academy of Sciences, 1996.
Higazi AA, Ganz T, Kariko K, Cines DB. Defensin modulates tissue-type plasminogen activator and plasminogen binding to fibrin and endothelial cells.. The Journal of biological chemistry, 1996.
Valore EV, Martin E, Harwig SS, Ganz T. Intramolecular inhibition of human defensin HNP-1 by its propiece.. The Journal of clinical investigation, 1996.
Zhao C, Ganz T, Lehrer RI. Structures of genes for two cathelin-associated antimicrobial peptides: prophenin-2 and PR-39.. FEBS letters, 1995.
Martin E, Ganz T, Lehrer RI. Defensins and other endogenous peptide antibiotics of vertebrates.. Journal of leukocyte biology, 1995.
Zhao C, Ganz T, Lehrer RI. The structure of porcine protegrin genes.. FEBS letters, 1995.
Ganz T, Lehrer RI. Defensins.. Pharmacology & therapeutics, 1995.
Liu L, Oren A, Ganz T. Murine 32D c13 cells--a transfectable model of phagocyte granule formation.. Journal of immunological methods, 1995.
Panyutich AV, Hiemstra PS, van Wetering S, Ganz T. Human neutrophil defensin and serpins form complexes and inactivate each other.. American journal of respiratory cell and molecular biology, 1995.
Liu L, Ganz T. The pro region of human neutrophil defensin contains a motif that is essential for normal subcellular sorting.. Blood, 1995.
Panyutich AV, Szold O, Poon PH, Tseng Y, Ganz T. Identification of defensin binding to C1 complement.. FEBS letters, 1994.
Ganz T, Lehrer RI. Defensins.. Current opinion in immunology, 1994.
Couto MA, Liu L, Lehrer RI, Ganz T. Inhibition of intracellular Histoplasma capsulatum replication by murine macrophages that produce human defensin.. Infection and immunity, 1994.
Kagan BL, Ganz T, Lehrer RI. Defensins: a family of antimicrobial and cytotoxic peptides.. Toxicology, 1994.
Ganz T. Biosynthesis of defensins and other antimicrobial peptides.. Ciba Foundation symposium, 1994.
Harwig SS, Ganz T, Lehrer RI. Neutrophil defensins: purification, characterization, and antimicrobial testing.. Methods in enzymology, 1994.
Panyutich AV, Panyutich EA, Krapivin VA, Baturevich EA, Ganz T. Plasma defensin concentrations are elevated in patients with septicemia or bacterial meningitis.. The Journal of laboratory and clinical medicine, 1993.
Ganz T, Liu L, Valore EV, Oren A. Posttranslational processing and targeting of transgenic human defensin in murine granulocyte, macrophage, fibroblast, and pituitary adenoma cell lines.. Blood, 1993.
Linzmeier R, Michaelson D, Liu L, Ganz T. The structure of neutrophil defensin genes.. FEBS letters, 1993.
Linzmeier R, Michaelson D, Liu L, Ganz T. The structure of neutrophil defensin genes.. FEBS letters, 1993.
Panyutich AV, Baturevich EA, Kolesnikova TS, Ganz T. The effect of biotinylation on the antigenic specificity of anti-defensin monoclonal antibodies.. Journal of immunological methods, 1993.
Nygaard SD, Ganz T, Peterson MW. Defensins reduce the barrier integrity of a cultured epithelial monolayer without cytotoxicity.. American journal of respiratory cell and molecular biology, 1993.
Ganz T. Macrophage function.. New horizons (Baltimore, Md.), 1993.
Lehrer RI, Lichtenstein AK, Ganz T. Defensins: antimicrobial and cytotoxic peptides of mammalian cells.. Annual review of immunology, 1993.
Ogata K, Linzer BA, Zuberi RI, Ganz T, Lehrer RI, Catanzaro A. Activity of defensins from human neutrophilic granulocytes against Mycobacterium avium-Mycobacterium intracellulare.. Infection and immunity, 1992.
Michaelson D, Rayner J, Couto M, Ganz T. Cationic defensins arise from charge-neutralized propeptides: a mechanism for avoiding leukocyte autocytotoxicity?. Journal of leukocyte biology, 1992.
Valore EV, Ganz T. Posttranslational processing of defensins in immature human myeloid cells.. Blood, 1992.
Lehrer RI, Ganz T. Defensins: endogenous antibiotic peptides from human leukocytes.. Ciba Foundation symposium, 1992.
Ganz T, Oren A, Lehrer RI. Defensins: microbicidal and cytotoxic peptides of mammalian host defense cells.. Medical microbiology and immunology, 1992.
Sherman MP, Ganz T. Host defense in pulmonary alveoli.. Annual review of physiology, 1992.
Panyutich AV, Voitenok NN, Lehrer RI, Ganz T. An enzyme immunoassay for human defensins.. Journal of immunological methods, 1991.
Panyutich A, Ganz T. Activated alpha 2-macroglobulin is a principal defensin-binding protein.. American journal of respiratory cell and molecular biology, 1991.
Borenstein LA, Ganz T, Sell S, Lehrer RI, Miller JN. Contribution of rabbit leukocyte defensins to the host response in experimental syphilis.. Infection and immunity, 1991.
Lehrer RI, Ganz T, Selsted ME. Defensins: endogenous antibiotic peptides of animal cells.. Cell, 1991.
Lehrer RI, Ganz T. Antimicrobial polypeptides of human neutrophils.. Blood, 1990.
Miyasaki KT, Bodeau AL, Ganz T, Selsted ME, Lehrer RI. In vitro sensitivity of oral, gram-negative, facultative bacteria to the bactericidal activity of human neutrophil defensins.. Infection and immunity, 1990.
Miyasaki KT, Bodeau AL, Selsted ME, Ganz T, Lehrer RI. Killing of oral, gram-negative, facultative bacteria by the rabbit defensin, NP-1.. Oral microbiology and immunology, 1990.
Eisenhauer P, Harwig SS, Szklarek D, Ganz T, Lehrer RI. Polymorphic expression of defensins in neutrophils from outbred rats.. Infection and immunity, 1990.
Saxon A, Shanahan F, Landers C, Ganz T, Targan S. A distinct subset of antineutrophil cytoplasmic antibodies is associated with inflammatory bowel disease.. The Journal of allergy and clinical immunology, 1990.
Burgener R, Wolf M, Ganz T, Baggiolini M. Purification and characterization of a major phosphatidylserine-binding phosphoprotein from human platelets.. The Biochemical journal, 1990.
Kagan BL, Selsted ME, Ganz T, Lehrer RI. Antimicrobial defensin peptides form voltage-dependent ion-permeable channels in planar lipid bilayer membranes.. Proceedings of the National Academy of Sciences of the United States of America, 1990.
Ganz T, Selsted ME, Lehrer RI. Defensins.. European journal of haematology, 1990.
Okrent DG, Lichtenstein AK, Ganz T. Direct cytotoxicity of polymorphonuclear leukocyte granule proteins to human lung-derived cells and endothelial cells.. The American review of respiratory disease, 1990.
Territo MC, Ganz T, Selsted ME, Lehrer R. Monocyte-chemotactic activity of defensins from human neutrophils.. The Journal of clinical investigation, 1989.
Joiner KA, Ganz T, Albert J, Rotrosen D. The opsonizing ligand on Salmonella typhimurium influences incorporation of specific, but not azurophil, granule constituents into neutrophil phagosomes.. The Journal of cell biology, 1989.
Chng HH, Ganz T, Saxon A. The utility of detecting of autoantibodies against neutrophil cytoplasmic components in Wegener's granulomatosis.. Annals of allergy, 1989.
Ganz T, Rayner JR, Valore EV, Tumolo A, Talmadge K, Fuller F. The structure of the rabbit macrophage defensin genes and their organ-specific expression.. Journal of immunology (Baltimore, Md. : 1950), 1989.
Sparkes RS, Kronenberg M, Heinzmann C, Daher KA, Klisak I, Ganz T, Mohandas T. Assignment of defensin gene(s) to human chromosome 8p23.. Genomics, 1989.
Lehrer RI, Barton A, Daher KA, Harwig SS, Ganz T, Selsted ME. Interaction of human defensins with Escherichia coli. Mechanism of bactericidal activity.. The Journal of clinical investigation, 1989.
Eisenhauer PB, Harwig SS, Szklarek D, Ganz T, Selsted ME, Lehrer RI. Purification and antimicrobial properties of three defensins from rat neutrophils.. Infection and immunity, 1989.
Lehrer RI, Szklarek D, Barton A, Ganz T, Hamann KJ, Gleich GJ. Antibacterial properties of eosinophil major basic protein and eosinophil cationic protein.. Journal of immunology (Baltimore, Md. : 1950), 1989.
Daher KA, Lehrer RI, Ganz T, Kronenberg M. Isolation and characterization of human defensin cDNA clones.. Proceedings of the National Academy of Sciences of the United States of America, 1988.
Ganz T, Metcalf JA, Gallin JI, Boxer LA, Lehrer RI. Microbicidal/cytotoxic proteins of neutrophils are deficient in two disorders: Chediak-Higashi syndrome and "specific" granule deficiency.. The Journal of clinical investigation, 1988.
Lehrer RI, Ganz T, Selsted ME, Babior BM, Curnutte JT. Neutrophils and host defense.. Annals of internal medicine, 1988.
Lehrer RI, Ganz T, Szklarek D, Selsted ME. Modulation of the in vitro candidacidal activity of human neutrophil defensins by target cell metabolism and divalent cations.. The Journal of clinical investigation, 1988.
Lichtenstein AK, Ganz T, Selsted ME, Lehrer RI. Synergistic cytolysis mediated by hydrogen peroxide combined with peptide defensins.. Cellular immunology, 1988.
Lichtenstein AK, Ganz T, Nguyen TM, Selsted ME, Lehrer RI. Mechanism of target cytolysis by peptide defensins. Target cell metabolic activities, possibly involving endocytosis, are crucial for expression of cytotoxicity.. Journal of immunology (Baltimore, Md. : 1950), 1988.
Lehrer RI, Barton A, Ganz T. Concurrent assessment of inner and outer membrane permeabilization and bacteriolysis in E. coli by multiple-wavelength spectrophotometry.. Journal of immunological methods, 1988.
Charp PA, Rice WG, Raynor RL, Reimund E, Kinkade JM, Ganz T, Selsted ME, Lehrer RI, Kuo JF. Inhibition of protein kinase C by defensins, antibiotic peptides from human neutrophils.. Biochemical pharmacology, 1988.
Lehrer RI, Ganz T, Selsted ME. Oxygen-independent bactericidal systems. Mechanisms and disorders.. Hematology/oncology clinics of North America, 1988.
Rice WG, Ganz T, Kinkade JM, Selsted ME, Lehrer RI, Parmley RT. Defensin-rich dense granules of human neutrophils.. Blood, 1987.
Greenwald GI, Ganz T. Defensins mediate the microbicidal activity of human neutrophil granule extract against Acinetobacter calcoaceticus.. Infection and immunity, 1987.
Ganz T. Preventive therapy of emphysema: lessons from the elastase model.. The American review of respiratory disease, 1987.
Ganz T. Extracellular release of antimicrobial defensins by human polymorphonuclear leukocytes.. Infection and immunity, 1987.
Lichtenstein A, Ganz T, Selsted ME, Lehrer RI. In vitro tumor cell cytolysis mediated by peptide defensins of human and rabbit granulocytes.. Blood, 1986.
Levitz SM, Selsted ME, Ganz T, Lehrer RI, Diamond RD. In vitro killing of spores and hyphae of Aspergillus fumigatus and Rhizopus oryzae by rabbit neutrophil cationic peptides and bronchoalveolar macrophages.. The Journal of infectious diseases, 1986.
Ganz T, Selsted ME, Lehrer RI. Antimicrobial activity of phagocyte granule proteins.. Seminars in respiratory infections, 1986.
Lehrer RI, Szklarek D, Ganz T, Selsted ME. Synergistic activity of rabbit granulocyte peptides against Candida albicans.. Infection and immunity, 1986.
Ganz T, Selsted ME, Szklarek D, Harwig SS, Daher K, Bainton DF, Lehrer RI. Defensins. Natural peptide antibiotics of human neutrophils.. The Journal of clinical investigation, 1985.
Ganz T, Sherman MP, Selsted ME, Lehrer RI. Newborn rabbit alveolar macrophages are deficient in two microbicidal cationic peptides, MCP-1 and MCP-2.. The American review of respiratory disease, 1985.
Selsted ME, Harwig SS, Ganz T, Schilling JW, Lehrer RI. Primary structures of three human neutrophil defensins.. The Journal of clinical investigation, 1985.
Selsted ME, Szklarek D, Ganz T, Lehrer RI. Activity of rabbit leukocyte peptides against Candida albicans.. Infection and immunity, 1985.
Lehrer RI, Szklarek D, Ganz T, Selsted ME. Correlation of binding of rabbit granulocyte peptides to Candida albicans with candidacidal activity.. Infection and immunity, 1985.
Lehrer RI, Daher K, Ganz T, Selsted ME. Direct inactivation of viruses by MCP-1 and MCP-2, natural peptide antibiotics from rabbit leukocytes.. Journal of virology, 1985.
Andersen RD, Birren BW, Ganz T, Piletz JE, Herschman HR. Molecular cloning of the rat metallothionein 1 (MT-1) mRNA sequence.. DNA (Mary Ann Liebert, Inc.), 1983.

Setting

Tomas Ganz

Interests

Education and Training

Awards and Honors

Publications

A UCLA Collaboration of:

Quick Links

Contact Us