Tzung Hsiai

Professor-in-Residence, Medicine, University of California Los Angeles

Tzung Hsiai, Ph.D., previously held the Maud Cady Guthman Chair in Cardiology (7/1/2018 - 6/30/2023).


  1. Li YR, Zhou Y, Yu J, Zhu Y, Lee D, Zhu E, Li Z, Kim YJ, Zhou K, Fang Y, Lyu Z, Chen Y, Tian Y, Huang J, Cen X, Husman T, Cho JM, Hsiai T, Zhou JJ, Wang P, Puliafito BR, Larson SM, Yang L. Engineering Allorejection-Resistant CAR-NKT Cells from Hematopoietic Stem Cells for Off-The-Shelf Cancer Immunotherapy.. Molecular therapy : the journal of the American Society of Gene Therapy, 2024.
  2. Qi Y, Chang SS, Wang Y, Chen C, Baek KI, Hsiai T, Roper M. Hemodynamic regulation allows stable growth of microvascular networks.. Proceedings of the National Academy of Sciences of the United States of America, 2024.
  3. Hasani-Sadrabadi MM, Majedi FS, Zarubova J, Thauland TJ, Arumugaswami V, Hsiai TK, Bouchard LS, Butte MJ, Li S. Harnessing Biomaterials to Amplify Immunity in Aged Mice through T Memory Stem Cells.. ACS nano, 2024.
  4. Cavallero S, Roustaei M, Satta S, Cho JM, Phan H, Baek KI, Blázquez-Medela AM, Gonzalez-Ramos S, Vu K, Park SK, Yokota T, Sumner J, Mack JJ, Sigmund CD, Reddy ST, Li R, Hsiai TK. Exercise mitigates flow recirculation and activates metabolic transducer SCD1 to catalyze vascular protective metabolites.. Science advances, 2024.
  5. Xu C, Song Y, Sempionatto JR, Solomon SA, Yu Y, Nyein HYY, Tay RY, Li J, Heng W, Min J, Lao A, Hsiai TK, Sumner JA, Gao W. A physicochemical-sensing electronic skin for stress response monitoring.. Nature electronics, 2024.
  6. Chang C, Gupta R, Sedighian F, Louie A, Gonzalez DM, Le C, Cho JM, Park SK, Castellanos J, Ting TW, Dong TS, Arias-Jayo N, Lagishetty V, Navab M, Reddy S, Sioutas C, Hsiai T, Jacobs JP, Araujo JA. Subchronic inhalation exposure to ultrafine particulate matter alters the intestinal microbiome in various mouse models.. Environmental research, 2024.
  7. Chen J, Wang S, Wang K, Abiri P, Huang ZY, Yin J, Jabalera AM, Arianpour B, Roustaei M, Zhu E, Zhao P, Cavallero S, Duarte-Vogel S, Stark E, Luo Y, Benharash P, Tai YC, Cui Q, Hsiai TK. Machine learning-directed electrical impedance tomography to predict metabolically vulnerable plaques.. Bioengineering & translational medicine, 2023.
  8. Wang S, Cui Q, Abiri P, Roustaei M, Zhu E, Li YR, Wang K, Duarte S, Yang L, Ebrahimi R, Bersohn M, Chen J, Hsiai TK. A self-assembled implantable microtubular pacemaker for wireless cardiac electrotherapy.. Science advances, 2023.
  9. Gonzalez-Ramos S, Wang J, Cho JM, Zhu E, Park SK, In JG, Reddy ST, Castillo EF, Campen MJ, Hsiai TK. Integrating 4-D light-sheet fluorescence microscopy and genetic zebrafish system to investigate ambient pollutants-mediated toxicity.. The Science of the total environment, 2023.
  10. Satta S, Rockwood SJ, Wang K, Wang S, Mozneb M, Arzt M, Hsiai TK, Sharma A. Microfluidic Organ-Chips and Stem Cell Models in the Fight Against COVID-19.. Circulation research, 2023.
  11. Cavallero S, Roustaei M, Satta S, Cho JM, Phan H, Baek KI, Blázquez-Medela AM, Gonzalez-Ramos S, Vu K, Park SK, Yokota T, Sumner JA, Mack JJ, Sigmund CD, Reddy ST, Li R, Hsiai TK. Exercise Mitigates Flow Recirculation and Activates Mechanosensitive Transcriptome to Uncover Endothelial SCD1-Catalyzed Anti-Inflammatory Metabolites.. bioRxiv : the preprint server for biology, 2023.
  12. Shahabipour F, Satta S, Mahmoodi M, Sun A, de Barros NR, Li S, Hsiai T, Ashammakhi N. Engineering organ-on-a-chip systems to model viral infections.. Biofabrication, 2023.
  13. Wang Z, Hsiai TK, Gao L. Augmented light field tomography through parallel spectral encoding.. Optica, 2023.
  14. Lin L, Tong X, Cavallero S, Zhang Y, Na S, Cao R, Hsiai TK, Wang LV. Non-invasive photoacoustic computed tomography of rat heart anatomy and function.. Light, science & applications, 2023.
  15. Cho JM, Poon MLS, Zhu E, Wang J, Butcher JT, Hsiai T. Quantitative 4D imaging of biomechanical regulation of ventricular growth and maturation.. Current opinion in biomedical engineering, 2022.
  16. Brown AL, Gerosa FM, Wang J, Hsiai T, Marsden AL. Recent advances in quantifying the mechanobiology of cardiac development via computational modeling.. Current opinion in biomedical engineering, 2022.
  17. Ding X, An Q, Zhao W, Song Y, Tang X, Wang J, Chang CC, Zhao G, Hsiai T, Fan G, Fan Y, Li S. Distinct patterns of responses in endothelial cells and smooth muscle cells following vascular injury.. JCI insight, 2022.
  18. Wang M, Yang Y, Min J, Song Y, Tu J, Mukasa D, Ye C, Xu C, Heflin N, McCune JS, Hsiai TK, Li Z, Gao W. A wearable electrochemical biosensor for the monitoring of metabolites and nutrients.. Nature biomedical engineering, 2022.
  19. Wu D, Yao B, Wu S, Hingorani H, Cui Q, Hua M, Frenkel I, Du Y, Hsiai TK, He X. Room-Temperature Annealing-Free Gold Printing via Anion-Assisted Photochemical Deposition.. Advanced materials (Deerfield Beach, Fla.), 2022.
  20. Satta S, Shahabipour F, Gao W, Lentz SR, Perlman S, Ashammakhi N, Hsiai T. Engineering viral genomics and nano-liposomes in microfluidic platforms for patient-specific analysis of SARS-CoV-2 variants.. Theranostics, 2022.
  21. Baek KI, Chang SS, Chang CC, Roustaei M, Ding Y, Wang Y, Chen J, O'Donnell R, Chen H, Ashby JW, Xu X, Mack JJ, Cavallero S, Roper M, Hsiai TK. Vascular Injury in the Zebrafish Tail Modulates Blood Flow and Peak Wall Shear Stress to Restore Embryonic Circular Network.. Frontiers in cardiovascular medicine, 2022.
  22. Satta S, Meng Z, Hernandez R, Cavallero S, Zhou T, Hsiai TK, Zhou C. An engineered nano-liposome-human ACE2 decoy neutralizes SARS-CoV-2 Spike protein-induced inflammation in both murine and human macrophages.. Theranostics, 2022.
  23. Roustaei M, In Baek K, Wang Z, Cavallero S, Satta S, Lai A, O'Donnell R, Vedula V, Ding Y, Marsden AL, Hsiai TK. Computational simulations of the 4D micro-circulatory network in zebrafish tail amputation and regeneration.. Journal of the Royal Society, Interface, 2022.
  24. Luo Y, Huang D, Huang ZY, Hsiai TK, Tai YC. An Ex Vivo Study of Outward Electrical Impedance Tomography (OEIT) for Intravascular Imaging.. IEEE transactions on bio-medical engineering, 2022.
  25. Sanna V, Satta S, Hsiai T, Sechi M. Development of targeted nanoparticles loaded with antiviral drugs for SARS-CoV-2 inhibition.. European journal of medicinal chemistry, 2022.
  26. Satta S, Lai A, Cavallero S, Williamson C, Chen J, Blázquez-Medela AM, Roustaei M, Dillon BJ, Ashammakhi N, Carlo DD, Li Z, Sun R, Hsiai TK. Rapid Detection and Inhibition of SARS-CoV-2-Spike Mutation-Mediated Microthrombosis.. Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2021.
  27. Cavallero S, Blázquez-Medela AM, Satta S, Hsiai TK. Endothelial mechanotransduction in cardiovascular development and regeneration: emerging approaches and animal models.. Current topics in membranes, 2021.
  28. Chang CC, Huang ZY, Shih SF, Luo Y, Ko A, Cui Q, Sumner J, Cavallero S, Das S, Gao W, Sinsheimer J, Bui A, Jacobs JP, Pajukanta P, Wu H, Tai YC, Li Z, Hsiai TK. Electrical impedance tomography for non-invasive identification of fatty liver infiltrate in overweight individuals.. Scientific reports, 2021.
  29. Fang Y, Zou Y, Xu J, Chen G, Zhou Y, Deng W, Zhao X, Roustaei M, Hsiai TK, Chen J. Ambulatory Cardiovascular Monitoring Via a Machine-Learning-Assisted Textile Triboelectric Sensor.. Advanced materials (Deerfield Beach, Fla.), 2021.
  30. Perley A, Roustaei M, Aguilar-Rivera M, Kunkel DC, Hsiai TK, Coleman TP, Abiri P. Miniaturized wireless gastric pacing via inductive power transfer with non-invasive monitoring using cutaneous Electrogastrography.. Bioelectronic medicine, 2021.
  31. Wang Z, Ding Y, Satta S, Roustaei M, Fei P, Hsiai TK. A hybrid of light-field and light-sheet imaging to study myocardial function and intracardiac blood flow during zebrafish development.. PLoS computational biology, 2021.
  32. Cleveland S, Reed K, Thomas JL, Ajijola OA, Ebrahimi R, Hsiai T, Lazarov A, Montoya AK, Neria Y, Shimbo D, Wolitzky-Taylor K, Sumner JA. Key dimensions of post-traumatic stress disorder and endothelial dysfunction: a protocol for a mechanism-focused cohort study.. BMJ open, 2021.
  33. Lai A, Chang ML, O'Donnell RP, Zhou C, Sumner JA, Hsiai TK. Association of COVID-19 transmission with high levels of ambient pollutants: Initiation and impact of the inflammatory response on cardiopulmonary disease.. The Science of the total environment, 2021.
  34. Wang Z, Zhu L, Zhang H, Li G, Yi C, Li Y, Yang Y, Ding Y, Zhen M, Gao S, Hsiai TK, Fei P. Real-time volumetric reconstruction of biological dynamics with light-field microscopy and deep learning.. Nature methods, 2021.
  35. Abiri P, Duarte-Vogel S, Chou TC, Abiri A, Gudapati V, Yousefi A, Roustaei M, Chang CC, Cui Q, Hsu JJ, Bersohn M, Markovic D, Chen J, Tai YC, Hsiai TK. In Vivo Intravascular Pacing Using a Wireless Microscale Stimulator.. Annals of biomedical engineering, 2021.
  36. Meng Z, Hernandez R, Liu J, Gwag T, Lu W, Hsiai TK, Kaul M, Zhou T, Zhou C. HIV Protein Tat Induces Macrophage Dysfunction and Atherosclerosis Development in Low-Density Lipoprotein Receptor-Deficient Mice.. Cardiovascular drugs and therapy, 2021.
  37. Nguyen NB, Fernandez GE, Ding Y, Hsiai T, Ardehali R. In Vivo Clonal Analysis of Cardiomyocytes.. Methods in molecular biology (Clifton, N.J.), 2021.
  38. Li R, Adami A, Chang CC, Tseng CH, Hsiai TK, Rossiter HB. Serum Acylglycerols Inversely Associate with Muscle Oxidative Capacity in Severe COPD.. Medicine and science in sports and exercise, 2021.
  39. Chang CC, Chu A, Meyer S, Ding Y, Sun MM, Abiri P, Baek KI, Gudapati V, Ding X, Guihard P, Bostrom KI, Li S, Gordon LK, Zheng JJ, Hsiai TK. Three-dimensional Imaging Coupled with Topological Quantification Uncovers Retinal Vascular Plexuses Undergoing Obliteration.. Theranostics, 2021.
  40. Ding Y, Gudapati V, Lin R, Fei Y, Packard RRS, Song S, Chang CC, Baek KI, Wang Z, Roustaei M, Kuang D, Kuo CJ, Hsiai TK. Saak Transform-Based Machine Learning for Light-Sheet Imaging of Cardiac Trabeculation.. IEEE transactions on bio-medical engineering, 2020.
  41. Abiri P, Yousefi A, Abiri A, Gudapati V, Ding Y, Nguyen KL, Abiri A, Markovic D, Tai YC, Hsiai TK. A Multi-Dimensional Analysis of a Novel Approach for Wireless Stimulation.. IEEE transactions on bio-medical engineering, 2020.
  42. Baek KI, Qian Y, Chang CC, O'Donnell R, Soleimanian E, Sioutas C, Li R, Hsiai TK. An Embryonic Zebrafish Model to Screen Disruption of Gut-Vascular Barrier upon Exposure to Ambient Ultrafine Particles.. Toxics, 2020.
  43. Kaneko N, Satta S, Komuro Y, Muthukrishnan SD, Kakarla V, Guo L, An J, Elahi F, Kornblum HI, Liebeskind DS, Hsiai T, Hinman JD. Flow-Mediated Susceptibility and Molecular Response of Cerebral Endothelia to SARS-CoV-2 Infection.. Stroke, 2020.
  44. Yokota T, Li J, Huang J, Xiong Z, Zhang Q, Chan T, Ding Y, Rau C, Sung K, Ren S, Kulkarni R, Hsiai T, Xiao X, Touma M, Minamisawa S, Wang Y. p38 Mitogen-activated protein kinase regulates chamber-specific perinatal growth in heart.. The Journal of clinical investigation, 2020.
  45. Ma X, Zhu P, Ding Y, Zhang H, Qiu Q, Dvornikov AV, Wang Z, Kim M, Wang Y, Lowerison M, Yu Y, Norton N, Herrmann J, Ekker SC, Hsiai TK, Lin X, Xu X. Retinoid X receptor alpha is a spatiotemporally predominant therapeutic target for anthracycline-induced cardiotoxicity.. Science advances, 2020.
  46. Abiri P, Abiri A, Gudapati V, Chang CC, Roustaei M, Bourenane H, Anwar U, Markovic D, Hsiai TK. Wireless Pacing Using an Asynchronous Three-Tiered Inductive Power Transfer System.. Annals of biomedical engineering, 2020.
  47. Feng J, Cavallero S, Hsiai T, Li R. Impact of air pollution on intestinal redox lipidome and microbiome.. Free radical biology & medicine, 2020.
  48. Yang Y, Song Y, Bo X, Min J, Pak OS, Zhu L, Wang M, Tu J, Kogan A, Zhang H, Hsiai TK, Li Z, Gao W. A laser-engraved wearable sensor for sensitive detection of uric acid and tyrosine in sweat.. Nature biotechnology, 2019.
  49. Ding Y, Dvornikov AV, Ma X, Zhang H, Wang Y, Lowerison M, Packard RR, Wang L, Chen J, Zhang Y, Hsiai T, Lin X, Xu X. Haploinsufficiency of mechanistic target of rapamycin ameliorates bag3 cardiomyopathy in adult zebrafish.. Disease models & mechanisms, 2019.
  50. Li R, Baek KI, Chang CC, Zhou B, Hsiai TK. Mechanosensitive Pathways Involved in Cardiovascular Development and Homeostasis in Zebrafish.. Journal of vascular research, 2019.
  51. Chen J, Ding Y, Chen M, Gau J, Jen N, Nahal C, Tu S, Chen C, Zhou S, Chang CC, Lyu J, Xu X, Hsiai TK, Packard RRS. Displacement analysis of myocardial mechanical deformation (DIAMOND) reveals segmental susceptibility to doxorubicin-induced injury and regeneration.. JCI insight, 2019.
  52. Hsu JJ, Vedula V, Baek KI, Chen C, Chen J, Chou MI, Lam J, Subhedar S, Wang J, Ding Y, Chang CC, Lee J, Demer LL, Tintut Y, Marsden AL, Hsiai TK. Contractile and hemodynamic forces coordinate Notch1b-mediated outflow tract valve formation.. JCI insight, 2019.
  53. Shigeta A, Huang V, Zuo J, Besada R, Nakashima Y, Lu Y, Ding Y, Pellegrini M, Kulkarni RP, Hsiai T, Deb A, Zhou B, Nakano H, Nakano A. Endocardially Derived Macrophages Are Essential for Valvular Remodeling.. Developmental cell, 2019.
  54. Vedula V, Lee J, Xu H, Jay Kuo CC, Hsiai TK, Marsden AL. Correction: A method to quantify mechanobiologic forces during zebrafish cardiac development using 4-D light sheet imaging and computational modeling.. PLoS computational biology, 2018.
  55. Ding Y, Bailey Z, Messerschmidt V, Nie J, Bryant R, Rugonyi S, Fei P, Lee J, Hsiai TK. Light-sheet Fluorescence Microscopy for the Study of the Murine Heart.. Journal of visualized experiments : JoVE, 2018.
  56. Ding Y, Ma J, Langenbacher AD, Baek KI, Lee J, Chang CC, Hsu JJ, Kulkarni RP, Belperio J, Shi W, Ranjbarvaziri S, Ardehali R, Tintut Y, Demer LL, Chen JN, Fei P, Packard RRS, Hsiai TK. Multiscale light-sheet for rapid imaging of cardiopulmonary system.. JCI insight, 2018.
  57. Abiri A, Ding Y, Abiri P, Packard RRS, Vedula V, Marsden A, Kuo CJ, Hsiai TK. Simulating Developmental Cardiac Morphology in Virtual Reality Using a Deformable Image Registration Approach.. Annals of biomedical engineering, 2018.
  58. Messerschmidt V, Bailey Z, Baek KI, Bryant R, Li R, Hsiai TK, Lee J. Light-sheet Fluorescence Microscopy to Capture 4-Dimensional Images of the Effects of Modulating Shear Stress on the Developing Zebrafish Heart.. Journal of visualized experiments : JoVE, 2018.
  59. Lee J, Vedula V, Baek KI, Chen J, Hsu JJ, Ding Y, Chang CC, Kang H, Small A, Fei P, Chuong CM, Li R, Demer L, Packard RRS, Marsden AL, Hsiai TK. Spatial and temporal variations in hemodynamic forces initiate cardiac trabeculation.. JCI insight, 2018.
  60. Baek KI, Ding Y, Chang CC, Chang M, Sevag Packard RR, Hsu JJ, Fei P, Hsiai TK. Advanced microscopy to elucidate cardiovascular injury and regeneration: 4D light-sheet imaging.. Progress in biophysics and molecular biology, 2018.
  61. Ding Y, Lee J, Hsu JJ, Chang CC, Baek KI, Ranjbarvaziri S, Ardehali R, Packard RRS, Hsiai TK. Light-Sheet Imaging to Elucidate Cardiovascular Injury and Repair.. Current cardiology reports, 2018.
  62. Sereti KI, Nguyen NB, Kamran P, Zhao P, Ranjbarvaziri S, Park S, Sabri S, Engel JL, Sung K, Kulkarni RP, Ding Y, Hsiai TK, Plath K, Ernst J, Sahoo D, Mikkola HKA, Iruela-Arispe ML, Ardehali R. Analysis of cardiomyocyte clonal expansion during mouse heart development and injury.. Nature communications, 2018.
  63. Hsu JJ, Lu J, Umar S, Lee JT, Kulkarni RP, Ding Y, Chang CC, Hsiai TK, Hokugo A, Gkouveris I, Tetradis S, Nishimura I, Demer LL, Tintut Y. Effects of teriparatide on morphology of aortic calcification in aged hyperlipidemic mice.. American journal of physiology. Heart and circulatory physiology, 2018.
  64. Luo Y, Abiri P, Zhang S, Chang CC, Kaboodrangi AH, Li R, Sahib AK, Bui A, Kumar R, Woo M, Li Z, Packard RRS, Tai YC, Hsiai TK. Non-Invasive Electrical Impedance Tomography for Multi-Scale Detection of Liver Fat Content.. Theranostics, 2018.
  65. Lenning M, Fortunato J, Le T, Clark I, Sherpa A, Yi S, Hofsteen P, Thamilarasu G, Yang J, Xu X, Han HD, Hsiai TK, Cao H. Real-Time Monitoring and Analysis of Zebrafish Electrocardiogram with Anomaly Detection.. Sensors (Basel, Switzerland), 2017.
  66. Chang SS, Tu S, Baek KI, Pietersen A, Liu YH, Savage VM, Hwang SL, Hsiai TK, Roper M. Optimal occlusion uniformly partitions red blood cells fluxes within a microvascular network.. PLoS computational biology, 2017.
  67. Baek KI, Packard RRS, Hsu JJ, Saffari A, Ma Z, Luu AP, Pietersen A, Yen H, Ren B, Ding Y, Sioutas C, Li R, Hsiai TK. Ultrafine Particle Exposure Reveals the Importance of FOXO1/Notch Activation Complex for Vascular Regeneration.. Antioxidants & redox signaling, 2017.
  68. Ding Y, Abiri A, Abiri P, Li S, Chang CC, Baek KI, Hsu JJ, Sideris E, Li Y, Lee J, Segura T, Nguyen TP, Bui A, Sevag Packard RR, Fei P, Hsiai TK. Integrating light-sheet imaging with virtual reality to recapitulate developmental cardiac mechanics.. JCI insight, 2017.
  69. Vedula V, Lee J, Xu H, Kuo CJ, Hsiai TK, Marsden AL. A method to quantify mechanobiologic forces during zebrafish cardiac development using 4-D light sheet imaging and computational modeling.. PLoS computational biology, 2017.
  70. Baek KI, Li R, Jen N, Choi H, Kaboodrangi A, Ping P, Liem D, Beebe T, Hsiai TK. Flow-Responsive Vascular Endothelial Growth Factor Receptor-Protein Kinase C Isoform Epsilon Signaling Mediates Glycolytic Metabolites for Vascular Repair.. Antioxidants & redox signaling, 2017.
  71. Packard RRS, Baek KI, Beebe T, Jen N, Ding Y, Shi F, Fei P, Kang BJ, Chen PH, Gau J, Chen M, Tang JY, Shih YH, Ding Y, Li D, Xu X, Hsiai TK. Automated Segmentation of Light-Sheet Fluorescent Imaging to Characterize Experimental Doxorubicin-Induced Cardiac Injury and Repair.. Scientific reports, 2017.
  72. Abiri P, Abiri A, Packard RRS, Ding Y, Yousefi A, Ma J, Bersohn M, Nguyen KL, Markovic D, Moloudi S, Hsiai TK. Inductively powered wireless pacing via a miniature pacemaker and remote stimulation control system.. Scientific reports, 2017.
  73. Packard RRS, Luo Y, Abiri P, Jen N, Aksoy O, Suh WM, Tai YC, Hsiai TK. 3-D Electrochemical Impedance Spectroscopy Mapping of Arteries to Detect Metabolically Active but Angiographically Invisible Atherosclerotic Lesions.. Theranostics, 2017.
  74. Lee J, Chou TC, Kang D, Kang H, Chen J, Baek KI, Wang W, Ding Y, Carlo DD, Tai YC, Hsiai TK. A Rapid Capillary-Pressure Driven Micro-Channel to Demonstrate Newtonian Fluid Behavior of Zebrafish Blood at High Shear Rates.. Scientific reports, 2017.
  75. Demer LL, Tintut Y, Nguyen KL, Hsiai T, Lee JT. Rigor and Reproducibility in Analysis of Vascular Calcification.. Circulation research, 2017.
  76. Li R, Yang J, Saffari A, Jacobs J, Baek KI, Hough G, Larauche MH, Ma J, Jen N, Moussaoui N, Zhou B, Kang H, Reddy S, Henning SM, Campen MJ, Pisegna J, Li Z, Fogelman AM, Sioutas C, Navab M, Hsiai TK. Ambient Ultrafine Particle Ingestion Alters Gut Microbiota in Association with Increased Atherogenic Lipid Metabolites.. Scientific reports, 2017.
  77. Ding Y, Lee J, Ma J, Sung K, Yokota T, Singh N, Dooraghi M, Abiri P, Wang Y, Kulkarni RP, Nakano A, Nguyen TP, Fei P, Hsiai TK. Light-sheet fluorescence imaging to localize cardiac lineage and protein distribution.. Scientific reports, 2017.
  78. Sideris E, Griffin DR, Ding Y, Li S, Weaver WM, Di Carlo D, Hsiai T, Segura T. Particle Hydrogels Based on Hyaluronic Acid Building Blocks.. ACS biomaterials science & engineering, 2016.
  79. Sung K, Ding Y, Ma J, Chen H, Huang V, Cheng M, Yang CF, Kim JT, Eguchi D, Di Carlo D, Hsiai TK, Nakano A, Kulkarni RP. Simplified three-dimensional tissue clearing and incorporation of colorimetric phenotyping.. Scientific reports, 2016.
  80. Lee J, Fei P, Sevag Packard RR, Kang H, Xu H, Baek KI, Jen N, Chen J, Yen H, Kuo CC, Chi NC, Ho CM, Li R, Hsiai TK. 4-Dimensional light-sheet microscopy to elucidate shear stress modulation of cardiac trabeculation.. The Journal of clinical investigation, 2016.
  81. Ma J, Luo Y, Sevag Packard RR, Ma T, Ding Y, Abiri P, Tai YC, Zhou Q, Shung KK, Li R, Hsiai T. Ultrasonic Transducer-Guided Electrochemical Impedance Spectroscopy to Assess Lipid-Laden Plaques.. Sensors and actuators. B, Chemical, 2016.
  82. Lee J, Fei P, Packard RR, Kang H, Xu H, Baek KI, Jen N, Chen J, Yen H, Kuo CC, Chi NC, Ho CM, Li R, Hsiai TK. 4-Dimensional light-sheet microscopy to elucidate shear stress modulation of cardiac trabeculation.. The Journal of clinical investigation, 2016.
  83. Fei P, Lee J, Packard RR, Sereti KI, Xu H, Ma J, Ding Y, Kang H, Chen H, Sung K, Kulkarni R, Ardehali R, Kuo CC, Xu X, Ho CM, Hsiai TK. Cardiac Light-Sheet Fluorescent Microscopy for Multi-Scale and Rapid Imaging of Architecture and Function.. Scientific reports, 2016.
  84. Packard RR, Zhang X, Luo Y, Ma T, Jen N, Ma J, Demer LL, Zhou Q, Sayre JW, Li R, Tai YC, Hsiai TK. Two-Point Stretchable Electrode Array for Endoluminal Electrochemical Impedance Spectroscopy Measurements of Lipid-Laden Atherosclerotic Plaques.. Annals of biomedical engineering, 2016.
  85. Guan Z, Lee J, Jiang H, Dong S, Jen N, Hsiai T, Ho CM, Fei P. Compact plane illumination plugin device to enable light sheet fluorescence imaging of multi-cellular organisms on an inverted wide-field microscope.. Biomedical optics express, 2015.
  86. Lee J, Packard RR, Hsiai TK. Blood flow modulation of vascular dynamics.. Current opinion in lipidology, 2015.
  87. Ma T, Zhou B, Hsiai TK, Shung KK. A Review of Intravascular Ultrasound-based Multimodal Intravascular Imaging: The Synergistic Approach to Characterizing Vulnerable Plaques.. Ultrasonic imaging, 2015.
  88. Fei C, Ma J, Chiu CT, Williams JA, Fong W, Chen Z, Zhu B, Xiong R, Shi J, Hsiai TK, Shung KK, Zhou Q. Design of matching layers for high-frequency ultrasonic transducers.. Applied physics letters, 2015.
  89. Li R, Jen N, Wu L, Lee J, Fang K, Quigley K, Lee K, Wang S, Zhou B, Vergnes L, Chen YR, Li Z, Reue K, Ann DK, Hsiai TK. Disturbed Flow Induces Autophagy, but Impairs Autophagic Flux to Perturb Mitochondrial Homeostasis.. Antioxidants & redox signaling, 2015.
  90. Yang H, Fang L, Zhan R, Hegarty JM, Ren J, Hsiai TK, Gleeson JG, Miller YI, Trejo J, Chi NC. Polo-like kinase 2 regulates angiogenic sprouting and blood vessel development.. Developmental biology, 2015.
  91. Cao H, Kang BJ, Lee CA, Shung KK, Hsiai TK. Electrical and Mechanical Strategies to Enable Cardiac Repair and Regeneration.. IEEE reviews in biomedical engineering, 2015.
  92. Zhang X, Beebe T, Jen N, Lee CA, Tai Y, Hsiai TK. Flexible and waterproof micro-sensors to uncover zebrafish circadian rhythms: The next generation of cardiac monitoring for drug screening.. Biosensors & bioelectronics, 2015.
  93. Zhao Y, Cao H, Beebe T, Zhang H, Zhang X, Chang H, Scremin O, Lien CL, Tai YC, Hsiai TK. Dry-contact microelectrode membranes for wireless detection of electrical phenotypes in neonatal mouse hearts.. Biomedical microdevices, 2015.
  94. Lee J, Cao H, Kang BJ, Jen N, Yu F, Lee CA, Fei P, Park J, Bohlool S, Lash-Rosenberg L, Shung KK, Hsiai TK. Hemodynamics and ventricular function in a zebrafish model of injury and repair.. Zebrafish, 2014.
  95. Li R, Navab K, Hough G, Daher N, Zhang M, Mittelstein D, Lee K, Pakbin P, Saffari A, Bhetraratana M, Sulaiman D, Beebe T, Wu L, Jen N, Wine E, Tseng CH, Araujo JA, Fogelman A, Sioutas C, Navab M, Hsiai TK. Effect of exposure to atmospheric ultrafine particles on production of free fatty acids and lipid metabolites in the mouse small intestine.. Environmental health perspectives, 2014.
  96. Li R, Beebe T, Jen N, Yu F, Takabe W, Harrison M, Cao H, Lee J, Yang H, Han P, Wang K, Shimizu H, Chen J, Lien CL, Chi NC, Hsiai TK. Shear stress-activated Wnt-angiopoietin-2 signaling recapitulates vascular repair in zebrafish embryos.. Arteriosclerosis, thrombosis, and vascular biology, 2014.
  97. Cao H, Yu F, Zhao Y, Zhang X, Tai J, Lee J, Darehzereshki A, Bersohn M, Lien CL, Chi NC, Tai YC, Hsiai TK. Wearable multi-channel microelectrode membranes for elucidating electrophysiological phenotypes of injured myocardium.. Integrative biology : quantitative biosciences from nano to macro, 2014.
  98. Hsiai T, Li S, Bursac N. Introduction to the special issue on tissue engineering and regenerative medicine.. Annals of biomedical engineering, 2014.
  99. Dickover M, Hegarty JM, Ly K, Lopez D, Yang H, Zhang R, Tedeschi N, Hsiai TK, Chi NC. The atypical Rho GTPase, RhoU, regulates cell-adhesion molecules during cardiac morphogenesis.. Developmental biology, 2014.
  100. Cao H, Yu F, Zhao Y, Scianmarello N, Lee J, Dai W, Jen N, Beebe T, Li R, Ebrahimi R, Chang DS, Mody FV, Pacella J, Tai YC, Hsiai T. Stretchable electrochemical impedance sensors for intravascular detection of lipid-rich lesions in New Zealand White rabbits.. Biosensors & bioelectronics, 2013.
  101. Lee J, Moghadam ME, Kung E, Cao H, Beebe T, Miller Y, Roman BL, Lien CL, Chi NC, Marsden AL, Hsiai TK. Moving domain computational fluid dynamics to interface with an embryonic model of cardiac morphogenesis.. PloS one, 2013.
  102. Du Y, Navab M, Shen M, Hill J, Pakbin P, Sioutas C, Hsiai TK, Li R. Ambient ultrafine particles reduce endothelial nitric oxide production via S-glutathionylation of eNOS.. Biochemical and biophysical research communications, 2013.
  103. Li R, Navab M, Pakbin P, Ning Z, Navab K, Hough G, Morgan TE, Finch CE, Araujo JA, Fogelman AM, Sioutas C, Hsiai T. Ambient ultrafine particles alter lipid metabolism and HDL anti-oxidant capacity in LDLR-null mice.. Journal of lipid research, 2013.
  104. Yu F, Lee J, Jen N, Li X, Zhang Q, Tang R, Zhou Q, Kim ES, Hsiai TK. Elevated electrochemical impedance in the endoluminal regions with high shear stress: implication for assessing lipid-rich atherosclerotic lesions.. Biosensors & bioelectronics, 2012.
  105. Li R, Mittelstein D, Kam W, Pakbin P, Du Y, Tintut Y, Navab M, Sioutas C, Hsiai T. Atmospheric ultrafine particles promote vascular calcification via the NF-κB signaling pathway.. American journal of physiology. Cell physiology, 2012.
  106. Jen N, Yu F, Lee J, Wasmund S, Dai X, Chen C, Chawareeyawong P, Yang Y, Li R, Hamdan MH, Hsiai TK. Atrial fibrillation pacing decreases intravascular shear stress in a New Zealand white rabbit model: implications in endothelial function.. Biomechanics and modeling in mechanobiology, 2012.
  107. Yu F, Zhao Y, Gu J, Quigley KL, Chi NC, Tai YC, Hsiai TK. Flexible microelectrode arrays to interface epicardial electrical signals with intracardial calcium transients in zebrafish hearts.. Biomedical microdevices, 2012.
  108. Li R, Mittelstein D, Fang K, Beebe T, Quigley K, Berliner J, Hsiai TK. Angiopoeitin-2 modulates Survivin expression in OxLDL-induced endothelial cell apoptosis.. Biochemical and biophysical research communications, 2011.
  109. Li R, Mittelstein D, Lee J, Fang K, Majumdar R, Tintut Y, Demer LL, Hsiai TK. A dynamic model of calcific nodule destabilization in response to monocyte- and oxidized lipid-induced matrix metalloproteinases.. American journal of physiology. Cell physiology, 2011.
  110. Li R, Jen N, Yu F, Hsiai TK. Assessing mitochondrial redox status by flow cytometric methods: vascular response to fluid shear stress.. Current protocols in cytometry, 2011.
  111. Yu F, Dai X, Beebe T, Hsiai T. Electrochemical impedance spectroscopy to characterize inflammatory atherosclerotic plaques.. Biosensors & bioelectronics, 2011.
  112. Takabe W, Jen N, Ai L, Hamilton R, Wang S, Holmes K, Dharbandi F, Khalsa B, Bressler S, Barr ML, Li R, Hsiai TK. Oscillatory shear stress induces mitochondrial superoxide production: implication of NADPH oxidase and c-Jun NH2-terminal kinase signaling.. Antioxidants & redox signaling, 2011.
  113. Yu F, Ai L, Dai W, Rozengurt N, Yu H, Hsiai TK. MEMS thermal sensors to detect changes in heat transfer in the pre-atherosclerotic regions of fat-fed New Zealand white rabbits.. Annals of biomedical engineering, 2011.
  114. Yu F, Huang J, Adlerz K, Jadvar H, Hamdan MH, Chi N, Chen JN, Hsiai TK. Evolving cardiac conduction phenotypes in developing zebrafish larvae: implications to drug sensitivity.. Zebrafish, 2010.
  115. Masood SO, Wasmund SL, Akoum NW, Egger MJ, Hsiai T, Hamdan MH. The effects of rate and rhythm control on blood pressure and antihypertensive drug usage in patients with atrial fibrillation and hypertension enrolled in the AFFIRM trial.. Journal of cardiovascular electrophysiology, 2010.
  116. Yu F, Li R, Ai L, Edington C, Yu H, Barr M, Kim ES, Hsiai TK. Electrochemical impedance spectroscopy to assess vascular oxidative stress.. Annals of biomedical engineering, 2010.
  117. Ai L, Zhang L, Dai W, Hu C, Shung KK, Hsiai TK. Real-time assessment of flow reversal in an eccentric arterial stenotic model.. Journal of biomechanics, 2010.
  118. Li R, Ning Z, Cui J, Yu F, Sioutas C, Hsiai T. Diesel exhaust particles modulate vascular endothelial cell permeability: implication of ZO-1 expression.. Toxicology letters, 2010.
  119. Li R, Ning Z, Majumdar R, Cui J, Takabe W, Jen N, Sioutas C, Hsiai T. Ultrafine particles from diesel vehicle emissions at different driving cycles induce differential vascular pro-inflammatory responses: implication of chemical components and NF-kappaB signaling.. Particle and fibre toxicology, 2010.
  120. Yu F, Li R, Parks E, Takabe W, Hsiai TK. Electrocardiogram signals to assess zebrafish heart regeneration: implication of long QT intervals.. Annals of biomedical engineering, 2010.
  121. Takabe W, Li R, Ai L, Yu F, Berliner JA, Hsiai TK. Oxidized low-density lipoprotein-activated c-Jun NH2-terminal kinase regulates manganese superoxide dismutase ubiquitination: implication for mitochondrial redox status and apoptosis.. Arteriosclerosis, thrombosis, and vascular biology, 2010.
  122. Li R, Beebe T, Cui J, Rouhanizadeh M, Ai L, Wang P, Gundersen M, Takabe W, Hsiai TK. Pulsatile shear stress increased mitochondrial membrane potential: implication of Mn-SOD.. Biochemical and biophysical research communications, 2009.
  123. Ai L, Yu H, Dai W, Hale SL, Kloner RA, Hsiai TK. Real-time intravascular shear stress in the rabbit abdominal aorta.. IEEE transactions on bio-medical engineering, 2009.
  124. Ai L, Yu H, Takabe W, Paraboschi A, Yu F, Kim ES, Li R, Hsiai TK. Optimization of intravascular shear stress assessment in vivo.. Journal of biomechanics, 2009.
  125. Sun P, Zhang Y, Yu F, Parks E, Lyman A, Wu Q, Ai L, Hu CH, Zhou Q, Shung K, Lien CL, Hsiai TK. Micro-electrocardiograms to study post-ventricular amputation of zebrafish heart.. Annals of biomedical engineering, 2009.
  126. Ai L, Hsiai TK. Spatial mapping of real-time quantitative shear stress with vascular oxidative stress.. Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference, 2009.
  127. Li R, Ning Z, Cui J, Khalsa B, Ai L, Takabe W, Beebe T, Majumdar R, Sioutas C, Hsiai T. Ultrafine particles from diesel engines induce vascular oxidative stress via JNK activation.. Free radical biology & medicine, 2008.
  128. Hsiai TK, Wu JC. Hemodynamic forces regulate embryonic stem cell commitment to vascular progenitors.. Current cardiology reviews, 2008.
  129. Hamilton RT, Asatryan L, Nilsen JT, Isas JM, Gallaher TK, Sawamura T, Hsiai TK. LDL protein nitration: implication for LDL protein unfolding.. Archives of biochemistry and biophysics, 2008.
  130. Ai L, Rouhanizadeh M, Wu JC, Takabe W, Yu H, Alavi M, Li R, Chu Y, Miller J, Heistad DD, Hsiai TK. Shear stress influences spatial variations in vascular Mn-SOD expression: implication for LDL nitration.. American journal of physiology. Cell physiology, 2008.
  131. Hsiai TK. Mechanosignal transduction coupling between endothelial and smooth muscle cells: role of hemodynamic forces.. American journal of physiology. Cell physiology, 2008.
  132. Rouhanizadeh M, Takabe W, Ai L, Yu H, Hsiai T. Monitoring oxidative stress in vascular endothelial cells in response to fluid shear stress: from biochemical analyses to micro- and nanotechnologies.. Methods in enzymology, 2008.
  133. Hsiai T, Berliner JA. Oxidative stress as a regulator of murine atherosclerosis.. Current drug targets, 2007.
  134. Chang GY, Cao F, Krishnan M, Huang M, Li Z, Xie X, Sheikh AY, Hoyt G, Robbins RC, Hsiai T, Schneider MD, Wu JC. Positron emission tomography imaging of conditional gene activation in the heart.. Journal of molecular and cellular cardiology, 2007.
  135. Hsiai TK, Hwang J, Barr ML, Correa A, Hamilton R, Alavi M, Rouhanizadeh M, Cadenas E, Hazen SL. Hemodynamics influences vascular peroxynitrite formation: Implication for low-density lipoprotein apo-B-100 nitration.. Free radical biology & medicine, 2006.
  136. Lin TC, Tintut Y, Lyman A, Mack W, Demer LL, Hsiai TK. Mechanical response of a calcified plaque model to fluid shear force.. Annals of biomedical engineering, 2006.
  137. Hwang J, Rouhanizadeh M, Hamilton RT, Lin TC, Eiserich JP, Hodis HN, Hsiai TK. 17beta-Estradiol reverses shear-stress-mediated low density lipoprotein modifications.. Free radical biology & medicine, 2006.
  138. Hwang J, Hodis HN, Hsiai TK, Asatryan L, Sevanian A. Role of annexin II in estrogen-induced macrophage matrix metalloproteinase-9 activity: the modulating effect of statins.. Atherosclerosis, 2005.
  139. Rouhanizadeh M, Lin TC, Arcas D, Hwang J, Hsiai TK. Spatial variations in shear stress in a 3-D bifurcation model at low Reynolds numbers.. Annals of biomedical engineering, 2005.
  140. DeMaio L, Rouhanizadeh M, Reddy S, Sevanian A, Hwang J, Hsiai TK. Oxidized phospholipids mediate occludin expression and phosphorylation in vascular endothelial cells.. American journal of physiology. Heart and circulatory physiology, 2005.
  141. Rouhanizadeh M, Hwang J, Clempus RE, Marcu L, Lassègue B, Sevanian A, Hsiai TK. Oxidized-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine induces vascular endothelial superoxide production: implication of NADPH oxidase.. Free radical biology & medicine, 2005.
  142. Hsiai TK, Cho SK, Wong PK, Ing MH, Salazar A, Hama S, Navab M, Demer LL, Ho CM. Micro sensors: linking real-time oscillatory shear stress with vascular inflammatory responses.. Annals of biomedical engineering, 2004.
  143. Rouhanizadeh M, Tang T, Li C, DeMaio L, Zhou C, Hsiai T. Detection of oxidized low density lipoproteins by indium oxide nanowires-based field effect transistor.. Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference, 2004.
  144. Soundararajan G, Hsiai TK, DeMaio L, Chang M, Chang S. MEMS shear stress sensors for cardiovascular diagnostics.. Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference, 2004.
  145. Hwang J, Ing MH, Salazar A, Lassègue B, Griendling K, Navab M, Sevanian A, Hsiai TK. Pulsatile versus oscillatory shear stress regulates NADPH oxidase subunit expression: implication for native LDL oxidation.. Circulation research, 2003.
  146. Hsiai TK, Cho SK, Wong PK, Ing M, Salazar A, Sevanian A, Navab M, Demer LL, Ho CM. Monocyte recruitment to endothelial cells in response to oscillatory shear stress.. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2003.
  147. Hsiai TK, Cho SK, Honda HM, Hama S, Navab M, Demer LL, Ho CM. Endothelial cell dynamics under pulsating flows: significance of high versus low shear stress slew rates (d(tau)/dt).. Annals of biomedical engineering, 2002.
  148. Hsiai TK, Cho SK, Reddy S, Hama S, Navab M, Demer LL, Honda HM, Ho CM. Pulsatile flow regulates monocyte adhesion to oxidized lipid-induced endothelial cells.. Arteriosclerosis, thrombosis, and vascular biology, 2001.
  149. Detrano R, Hsiai T, Wang S, Puentes G, Fallavollita J, Shields P, Stanford W, Wolfkiel C, Georgiou D, Budoff M, Reed J. Prognostic value of coronary calcification and angiographic stenoses in patients undergoing coronary angiography.. Journal of the American College of Cardiology, 1996.