Van Savage

Van Maurice Savage

Professor, Ecology And Evolutionary Biology, University of California Los Angeles

Professor, Computational Medicine, University of California Los Angeles


  1. Bullivant A, Lozano-Huntelman N, Tabibian K, Leung V, Armstrong D, Dudley H, Savage VM, Rodríguez-Verdugo A, Yeh PJ. Evolution Under Thermal Stress Affects Escherichia coli's Resistance to Antibiotics.. bioRxiv : the preprint server for biology, 2024.
  2. Souri M, Kiani Shahvandi M, Chiani M, Moradi Kashkooli F, Farhangi A, Mehrabi MR, Rahmim A, Savage VM, Soltani M. Stimuli-sensitive nano-drug delivery with programmable size changes to enhance accumulation of therapeutic agents in tumors.. Drug delivery, 2023.
  3. Desai-Chowdhry P, Brummer AB, Mallavarapu S, Savage VM. Neuronal branching is increasingly asymmetric near synapses, potentially enabling plasticity while minimizing energy dissipation and conduction time.. Journal of the Royal Society, Interface, 2023.
  4. Desai-Chowdhry P, Brummer AB, Mallavarapu S, Savage VM. Neuronal Branching is Increasingly Asymmetric Near Synapses, Potentially Enabling Plasticity While Minimizing Energy Dissipation and Conduction Time.. bioRxiv : the preprint server for biology, 2023.
  5. Diamant ES, Boyd S, Lozano-Huntelman NA, Enriquez V, Kim AR, Savage VM, Yeh PJ. Meta-analysis of three-stressor combinations on population-level fitness reveal substantial higher-order interactions.. The Science of the total environment, 2022.
  6. Desai-Chowdhry P, Brummer AB, Savage VM. How axon and dendrite branching are guided by time, energy, and spatial constraints.. Scientific reports, 2022.
  7. Mira P, Lozano-Huntelman N, Johnson A, Savage VM, Yeh P. Evolution of antibiotic resistance impacts optimal temperature and growth rate in Escherichia coli and Staphylococcus epidermidis.. Journal of applied microbiology, 2022.
  8. Cruz-Loya M, Tekin E, Kang TM, Cardona N, Lozano-Huntelman N, Rodriguez-Verdugo A, Savage VM, Yeh PJ. Antibiotics Shift the Temperature Response Curve of Escherichia coli Growth.. mSystems, 2021.
  9. Cloyed CS, Grady JM, Savage VM, Uyeda JC, Dell AI. The allometry of locomotion.. Ecology, 2021.
  10. Lozano-Huntelman NA, Zhou A, Tekin E, Cruz-Loya M, Østman B, Boyd S, Savage VM, Yeh P. Hidden suppressive interactions are common in higher-order drug combinations.. iScience, 2021.
  11. Brummer AB, Lymperopoulos P, Shen J, Tekin E, Bentley LP, Buzzard V, Gray A, Oliveras I, Enquist BJ, Savage VM. Branching principles of animal and plant networks identified by combining extensive data, machine learning and modelling.. Journal of the Royal Society, Interface, 2021.
  12. Brummer AB, Hunt D, Savage V. Improving Blood Vessel Tortuosity Measurements via Highly Sampled Numerical Integration of the Frenet-Serret Equations.. IEEE transactions on medical imaging, 2020.
  13. Pettersson S, Savage VM, Jacobi MN. Stability of ecosystems enhanced by species-interaction constraints.. Physical review. E, 2020.
  14. Cao J, Herman AB, West GB, Poe G, Savage VM. Unraveling why we sleep: Quantitative analysis reveals abrupt transition from neural reorganization to repair in early development.. Science advances, 2020.
  15. Borremans B, Gamble A, Prager KC, Helman SK, McClain AM, Cox C, Savage V, Lloyd-Smith JO. Quantifying antibody kinetics and RNA detection during early-phase SARS-CoV-2 infection by time since symptom onset.. eLife, 2020.
  16. Tekin E, Diamant ES, Cruz-Loya M, Enriquez V, Singh N, Savage VM, Yeh PJ. Using a newly introduced framework to measure ecological stressor interactions.. Ecology letters, 2020.
  17. Pettersson S, Savage VM, Nilsson Jacobi M. Predicting collapse of complex ecological systems: quantifying the stability-complexity continuum.. Journal of the Royal Society, Interface, 2020.
  18. Rodríguez-Verdugo A, Lozano-Huntelman N, Cruz-Loya M, Savage V, Yeh P. Compounding Effects of Climate Warming and Antibiotic Resistance.. iScience, 2020.
  19. Durán SM, Martin RE, Díaz S, Maitner BS, Malhi Y, Salinas N, Shenkin A, Silman MR, Wieczynski DJ, Asner GP, Bentley LP, Savage VM, Enquist BJ. Informing trait-based ecology by assessing remotely sensed functional diversity across a broad tropical temperature gradient.. Science advances, 2019.
  20. Savage V, Yeh P. Novelist Cormac McCarthy's tips on how to write a great science paper.. Nature, 2019.
  21. Mordecai EA, Caldwell JM, Grossman MK, Lippi CA, Johnson LR, Neira M, Rohr JR, Ryan SJ, Savage V, Shocket MS, Sippy R, Stewart Ibarra AM, Thomas MB, Villena O. Thermal biology of mosquito-borne disease.. Ecology letters, 2019.
  22. Newberry MG, Savage VM. Self-Similar Processes Follow a Power Law in Discrete Logarithmic Space.. Physical review letters, 2019.
  23. Wieczynski DJ, Boyle B, Buzzard V, Duran SM, Henderson AN, Hulshof CM, Kerkhoff AJ, McCarthy MC, Michaletz ST, Swenson NG, Asner GP, Bentley LP, Enquist BJ, Savage VM. Climate shapes and shifts functional biodiversity in forests worldwide.. Proceedings of the National Academy of Sciences of the United States of America, 2018.
  24. Pruitt JN, Berdahl A, Riehl C, Pinter-Wollman N, Moeller HV, Pringle EG, Aplin LM, Robinson EJH, Grilli J, Yeh P, Savage VM, Price MH, Garland J, Gilby IC, Crofoot MC, Doering GN, Hobson EA. Social tipping points in animal societies.. Proceedings. Biological sciences, 2018.
  25. Tekin E, White C, Kang TM, Singh N, Cruz-Loya M, Damoiseaux R, Savage VM, Yeh PJ. Prevalence and patterns of higher-order drug interactions in Escherichia coli.. NPJ systems biology and applications, 2018.
  26. Cruz-Loya M, Kang TM, Lozano NA, Watanabe R, Tekin E, Damoiseaux R, Savage VM, Yeh PJ. Stressor interaction networks suggest antibiotic resistance co-opted from stress responses to temperature.. The ISME journal, 2018.
  27. Lee L, Savage VM, Yeh PJ. Intermediate Levels of Antibiotics May Increase Diversity of Colony Size Phenotype in Bacteria.. Computational and structural biotechnology journal, 2018.
  28. Chang SS, Tu S, Baek KI, Pietersen A, Liu YH, Savage VM, Hwang SL, Hsiai TK, Roper M. Optimal occlusion uniformly partitions red blood cells fluxes within a microvascular network.. PLoS computational biology, 2017.
  29. Beppler C, Tekin E, White C, Mao Z, Miller JH, Damoiseaux R, Savage VM, Yeh PJ. When more is less: Emergent suppressive interactions in three-drug combinations.. BMC microbiology, 2017.
  30. Mordecai EA, Cohen JM, Evans MV, Gudapati P, Johnson LR, Lippi CA, Miazgowicz K, Murdock CC, Rohr JR, Ryan SJ, Savage V, Shocket MS, Stewart Ibarra A, Thomas MB, Weikel DP. Detecting the impact of temperature on transmission of Zika, dengue, and chikungunya using mechanistic models.. PLoS neglected tropical diseases, 2017.
  31. Brummer AB, Savage VM, Enquist BJ. A general model for metabolic scaling in self-similar asymmetric networks.. PLoS computational biology, 2017.
  32. Beppler C, Tekin E, Mao Z, White C, McDiarmid C, Vargas E, Miller JH, Savage VM, Yeh PJ. Uncovering emergent interactions in three-way combinations of stressors.. Journal of the Royal Society, Interface, 2016.
  33. Tekin E, Hunt D, Newberry MG, Savage VM. Do Vascular Networks Branch Optimally or Randomly across Spatial Scales?. PLoS computational biology, 2016.
  34. Hunt D, Savage VM. Asymmetries arising from the space-filling nature of vascular networks.. Physical review. E, 2016.
  35. Tekin E, Beppler C, White C, Mao Z, Savage VM, Yeh PJ. Enhanced identification of synergistic and antagonistic emergent interactions among three or more drugs.. Journal of the Royal Society, Interface, 2016.
  36. Pawar S, Dell AI, Savage VM, Knies JL. Real versus Artificial Variation in the Thermal Sensitivity of Biological Traits.. The American naturalist, 2016.
  37. Newberry MG, Ennis DB, Savage VM. Testing Foundations of Biological Scaling Theory Using Automated Measurements of Vascular Networks.. PLoS computational biology, 2015.
  38. DeLong JP, Gilbert B, Shurin JB, Savage VM, Barton BT, Clements CF, Dell AI, Greig HS, Harley CD, Kratina P, McCann KS, Tunney TD, Vasseur DA, O'Connor MI. The body size dependence of trophic cascades.. The American naturalist, 2015.
  39. Gilbert B, Tunney TD, McCann KS, DeLong JP, Vasseur DA, Savage V, Shurin JB, Dell AI, Barton BT, Harley CD, Kharouba HM, Kratina P, Blanchard JL, Clements C, Winder M, Greig HS, O'Connor MI. A bioenergetic framework for the temperature dependence of trophic interactions.. Ecology letters, 2014.
  40. Vasseur DA, DeLong JP, Gilbert B, Greig HS, Harley CD, McCann KS, Savage V, Tunney TD, O'Connor MI. Increased temperature variation poses a greater risk to species than climate warming.. Proceedings. Biological sciences, 2014.
  41. Smith DD, Sperry JS, Enquist BJ, Savage VM, McCulloh KA, Bentley LP. Deviation from symmetrically self-similar branching in trees predicts altered hydraulics, mechanics, light interception and metabolic scaling.. The New phytologist, 2013.
  42. Bentley LP, Stegen JC, Savage VM, Smith DD, von Allmen EI, Sperry JS, Reich PB, Enquist BJ. An empirical assessment of tree branching networks and implications for plant allometric scaling models.. Ecology letters, 2013.
  43. Savage VM, Herman AB, West GB, Leu K. Using Fractal Geometry and Universal Growth Curves as Diagnostics for Comparing Tumor Vasculature and Metabolic Rate With Healthy Tissue and for Predicting Responses to Drug Therapies.. Discrete and continuous dynamical systems. Series B, 2013.
  44. Dell AI, Pawar S, Savage VM. Temperature dependence of trophic interactions are driven by asymmetry of species responses and foraging strategy.. The Journal of animal ecology, 2013.
  45. Price CA, Weitz JS, Savage VM, Stegen J, Clarke A, Coomes DA, Dodds PS, Etienne RS, Kerkhoff AJ, McCulloh K, Niklas KJ, Olff H, Swenson NG, Chave J. Testing the metabolic theory of ecology.. Ecology letters, 2012.
  46. Pawar S, Dell AI, Savage VM. Dimensionality of consumer search space drives trophic interaction strengths.. Nature, 2012.
  47. Amarasekare P, Savage V. A framework for elucidating the temperature dependence of fitness.. The American naturalist, 2011.
  48. Herman AB, Savage VM, West GB. A quantitative theory of solid tumor growth, metabolic rate and vascularization.. PloS one, 2011.
  49. Dell AI, Pawar S, Savage VM. Systematic variation in the temperature dependence of physiological and ecological traits.. Proceedings of the National Academy of Sciences of the United States of America, 2011.
  50. Deeds EJ, Savage V, Fontana W. Curvature in metabolic scaling: a reply to MacKay.. Journal of theoretical biology, 2011.
  51. Savage VM, Bentley LP, Enquist BJ, Sperry JS, Smith DD, Reich PB, von Allmen EI. Hydraulic trade-offs and space filling enable better predictions of vascular structure and function in plants.. Proceedings of the National Academy of Sciences of the United States of America, 2010.
  52. Savage VM, Deeds EJ, Fontana W. Sizing up allometric scaling theory.. PLoS computational biology, 2008.
  53. Savage VM, Enquist BJ, West GB. Comment on 'A critical understanding of the fractal model of metabolic scaling'.. The Journal of experimental biology, 2007.
  54. Price CA, Enquist BJ, Savage VM. A general model for allometric covariation in botanical form and function.. Proceedings of the National Academy of Sciences of the United States of America, 2007.
  55. Allen AP, Savage VM. Setting the absolute tempo of biodiversity dynamics.. Ecology letters, 2007.
  56. Savage VM, Webb CT, Norberg J. A general multi-trait-based framework for studying the effects of biodiversity on ecosystem functioning.. Journal of theoretical biology, 2007.
  57. Savage VM, Allen AP, Brown JH, Gillooly JF, Herman AB, Woodruff WH, West GB. Scaling of number, size, and metabolic rate of cells with body size in mammals.. Proceedings of the National Academy of Sciences of the United States of America, 2007.
  58. Savage VM, West GB. A quantitative, theoretical framework for understanding mammalian sleep.. Proceedings of the National Academy of Sciences of the United States of America, 2007.
  59. Allen AP, Gillooly JF, Savage VM, Brown JH. Kinetic effects of temperature on rates of genetic divergence and speciation.. Proceedings of the National Academy of Sciences of the United States of America, 2006.
  60. Savage VM, White EP, Moses ME, Ernest SK, Enquist BJ, Charnov EL. Comment on "The illusion of invariant quantities in life histories".. Science (New York, N.Y.), 2006.
  61. Gillooly JF, Allen AP, Brown JH, Elser JJ, Martinez del Rio C, Savage VM, West GB, Woodruff WH, Woods HA. The metabolic basis of whole-organism RNA and phosphorus content.. Proceedings of the National Academy of Sciences of the United States of America, 2005.
  62. Cohen JE, Jonsson T, Müller CB, Godfray HC, Savage VM. Body sizes of hosts and parasitoids in individual feeding relationships.. Proceedings of the National Academy of Sciences of the United States of America, 2005.
  63. Savage VM. Improved approximations to scaling relationships for species, populations, and ecosystems across latitudinal and elevational gradients.. Journal of theoretical biology, 2004.
  64. Savage VM, Gilloly JF, Brown JH, Charnov EL. Effects of body size and temperature on population growth.. The American naturalist, 2004.
  65. West GB, Savage VM, Gillooly J, Enquist BJ, Woodruff WH, Brown JH. Physiology: Why does metabolic rate scale with body size?. Nature, 2003.
  66. Gillooly JF, Charnov EL, West GB, Savage VM, Brown JH. Effects of size and temperature on developmental time.. Nature, 2002.