Weizhe Hong

Weizhe Hong

Associate Professor, Biological Chemistry, University of California Los Angeles

Associate Professor, Neurobiology, University of California Los Angeles

Affiliations

Member, Bioinformatics GPB Home Area, Gene Regulation GPB Home Area, Molecular, Cellular & Integrative Physiology GPB Home Area, Neuroscience GPB Home Area
 

Research Interests

Social behaviors are exhibited by a wide range of animal species and are of ubiquitous adaptive value; many social behaviors, such as aggression, pair bonding, and mating, are essential for the health, survival, and reproduction of animals. The control of social behavior is of vital importance in social species such as humans; impairment in social function is a prominent feature of several neuropsychiatric disorders, such as autism and schizophrenia. However, despite its importance, many fundamental questions regarding the neural mechanisms underlying social behavior and its disorders still remain unanswered. One central question is how neural circuits, important computing units in the brain, process and integrate information for the decision and execution of specific social behaviors. To address this question, the Hong lab applies a multidisciplinary approach to investigating social behavior, using techniques including but not limited to:

  • Single-cell RNA-seq and bioinformatics to comprehensively identify and characterize diverse neuronal cell types in social behavior circuits and their molecular profiles with single-cell resolution.
  • Optogenetics and chemogenetics to manipulate neuronal circuit activities in different neuronal subtypes in different social behaviors, to determine their causal roles, and to map their functional connections.
  • Fiber photometry, miniscope imaging, and neural computation to map neural network activities during social behaviors and to uncover the encoding of sensory processing and behavioral decisions in neuronal ensembles.
  • Advanced engineering technology and machine learning to make the analysis of social behaviors more efficient, objective, quantitative, and ethologically relevant.

Biography

The Hong Lab employs a multidisciplinary approach to identify the molecular and neural circuit mechanisms underlying normal social behaviors as well as their dysregulations in neuropsychiatric disorders. Social behaviors are essential for the survival and reproduction of animals. The control of social behavior is of particular importance in social species such as humans. Abnormalities in social behaviors are associated with several neuropsychiatric disorders, such as autism spectrum disorders and schizophrenia.  Despite its importance, many fundamental questions regarding social behavior and its disorders still remain unanswered. We aim to understand how social behavior is regulated at the molecular and circuit level and how social behavior and social experience lead to molecular and circuit level changes in the brain.

We study these questions across molecular, circuit, and behavioral levels, by linking genes to circuits to behaviors. To do that, we take a multi-disciplinary approach and utilize a variety of experimental and computational technologies, including but not limited to optogenetics/chemogenetics, in vivo/vitro calcium imaging and electrophysiology, various genetic and molecular biology techniques, systems approaches such as next-generation sequencing and bioinformatics, and engineering and computational approaches such as machine learning and computer vision.

Publications