William Lowry

William Edward Lowry

Professor, Molecular, Cell and Developmental Biology, University of California Los Angeles

Professor, Medicine, University of California Los Angeles


  1. Galvan C, Lowry WE. Yo-yoing stem cells defy dogma to maintain hair colour.. Nature, 2023.
  2. Otero-Garcia M, Mahajani SU, Wakhloo D, Tang W, Xue YQ, Morabito S, Pan J, Oberhauser J, Madira AE, Shakouri T, Deng Y, Allison T, He Z, Lowry WE, Kawaguchi R, Swarup V, Cobos I. Molecular signatures underlying neurofibrillary tangle susceptibility in Alzheimer's disease.. Neuron, 2022.
  3. Mitroi DN, Tian M, Kawaguchi R, Lowry WE, Carmichael ST. Single-nucleus transcriptome analysis reveals disease- and regeneration-associated endothelial cells in white matter vascular dementia.. Journal of cellular and molecular medicine, 2022.
  4. Allison T, Langerman J, Sabri S, Otero-Garcia M, Lund A, Huang J, Wei X, Samarasinghe RA, Polioudakis D, Mody I, Cobos I, Novitch BG, Geschwind DH, Plath K, Lowry WE. Defining the nature of human pluripotent stem cell-derived interneurons via single-cell analysis.. Stem cell reports, 2021.
  5. Johnston RA, Rheinwald JG, vonHoldt BM, Stahler DR, Lowry W, Tung J, Wayne RK. K Locus Effects in Gray Wolves: Experimental Assessment of TLR3 Signaling and the Gene Expression Response to Canine Distemper Virus.. The Journal of heredity, 2021.
  6. Samarasinghe RA, Miranda OA, Buth JE, Mitchell S, Ferando I, Watanabe M, Allison TF, Kurdian A, Fotion NN, Gandal MJ, Golshani P, Plath K, Lowry WE, Parent JM, Mody I, Novitch BG. Identification of neural oscillations and epileptiform changes in human brain organoids.. Nature neuroscience, 2021.
  7. Miranda M, Avila I, Esparza J, Shwartz Y, Hsu YC, Berdeaux R, Lowry WE. Defining a Role for G-Protein Coupled Receptor/cAMP/CRE-Binding Protein Signaling in Hair Follicle Stem Cell Activation.. The Journal of investigative dermatology, 2021.
  8. Llorente IL, Hatanaka EA, Meadow ME, Xie Y, Lowry WE, Carmichael ST. Reliable generation of glial enriched progenitors from human fibroblast-derived iPSCs.. Stem cell research, 2021.
  9. Llorente IL, Xie Y, Mazzitelli JA, Hatanaka EA, Cinkornpumin J, Miller DR, Lin Y, Lowry WE, Carmichael ST. Patient-derived glial enriched progenitors repair functional deficits due to white matter stroke and vascular dementia in rodents.. Science translational medicine, 2021.
  10. Flores A, Choi S, Hsu YC, Lowry WE. Inhibition of pyruvate oxidation as a versatile stimulator of the hair cycle in models of alopecia.. Experimental dermatology, 2021.
  11. Liu X, Flores AA, Situ L, Gu W, Ding H, Christofk HR, Lowry WE, Jung ME. Development of Novel Mitochondrial Pyruvate Carrier Inhibitors to Treat Hair Loss.. Journal of medicinal chemistry, 2021.
  12. Joly JH, Lowry WE, Graham NA. Differential Gene Set Enrichment Analysis: a statistical approach to quantify the relative enrichment of two gene sets.. Bioinformatics (Oxford, England), 2021.
  13. Lowry WE. Its written all over your face: The molecular and physiological consequences of aging skin.. Mechanisms of ageing and development, 2020.
  14. Takahashi R, Grzenda A, Allison TF, Rawnsley J, Balin SJ, Sabri S, Plath K, Lowry WE. Defining Transcriptional Signatures of Human Hair Follicle Cell States.. The Journal of investigative dermatology, 2019.
  15. Polioudakis D, de la Torre-Ubieta L, Langerman J, Elkins AG, Shi X, Stein JL, Vuong CK, Nichterwitz S, Gevorgian M, Opland CK, Lu D, Connell W, Ruzzo EK, Lowe JK, Hadzic T, Hinz FI, Sabri S, Lowry WE, Gerstein MB, Plath K, Geschwind DH. A Single-Cell Transcriptomic Atlas of Human Neocortical Development during Mid-gestation.. Neuron, 2019.
  16. Flores A, Sandoval-Gonzalez S, Takahashi R, Krall A, Sathe L, Wei L, Radu C, Joly JH, Graham NA, Christofk HR, Lowry WE. Author Correction: Increased lactate dehydrogenase activity is dispensable in squamous carcinoma cells of origin.. Nature communications, 2019.
  17. Hazim RA, Karumbayaram S, Jiang M, Dimashkie A, Lopes VS, Li D, Burgess BL, Vijayaraj P, Alva-Ornelas JA, Zack JA, Kohn DB, Gomperts BN, Pyle AD, Lowry WE, Williams DS. Correction to: Differentiation of RPE cells from integration-free iPS cells and their cell biological characterization.. Stem cell research & therapy, 2019.
  18. Flores A, Sandoval-Gonzalez S, Takahashi R, Krall A, Sathe L, Wei L, Radu C, Joly JH, Graham NA, Christofk HR, Lowry WE. Increased lactate dehydrogenase activity is dispensable in squamous carcinoma cells of origin.. Nature communications, 2019.
  19. El Ayachi I, Fatima I, Wend P, Alva-Ornelas JA, Runke S, Kuenzinger WL, Silva J, Silva W, Gray JK, Lehr S, Barch HC, Krutilina RI, White AC, Cardiff R, Yee LD, Yang L, O'Regan RM, Lowry WE, Seagroves TN, Seewaldt V, Krum SA, Miranda-Carboni GA. The WNT10B Network Is Associated with Survival and Metastases in Chemoresistant Triple-Negative Breast Cancer.. Cancer research, 2018.
  20. Sullivan WJ, Mullen PJ, Schmid EW, Flores A, Momcilovic M, Sharpley MS, Jelinek D, Whiteley AE, Maxwell MB, Wilde BR, Banerjee U, Coller HA, Shackelford DB, Braas D, Ayer DE, de Aguiar Vallim TQ, Lowry WE, Christofk HR. Extracellular Matrix Remodeling Regulates Glucose Metabolism through TXNIP Destabilization.. Cell, 2018.
  21. Raman AT, Pohodich AE, Wan YW, Yalamanchili HK, Lowry WE, Zoghbi HY, Liu Z. Apparent bias toward long gene misregulation in MeCP2 syndromes disappears after controlling for baseline variations.. Nature communications, 2018.
  22. Miranda MM, Lowry WE. Hip to the Game: YAP/TAZ is required for nonmelanoma skin cancers.. The EMBO journal, 2018.
  23. Jelinek D, Flores A, Uebelhoer M, Pasque V, Plath K, Iruela-Arispe ML, Christofk HR, Lowry WE, Coller HA. Mapping Metabolism: Monitoring Lactate Dehydrogenase Activity Directly in Tissue.. Journal of visualized experiments : JoVE, 2018.
  24. Ohashi M, Korsakova E, Allen D, Lee P, Fu K, Vargas BS, Cinkornpumin J, Salas C, Park JC, Germanguz I, Langerman J, Chronis C, Kuoy E, Tran S, Xiao X, Pellegrini M, Plath K, Lowry WE. Loss of MECP2 Leads to Activation of P53 and Neuronal Senescence.. Stem cell reports, 2018.
  25. Allison TF, Lowry WE. Publisher Correction: Stem cells: The reprogramming method matters.. Nature biomedical engineering, 2018.
  26. Cinkornpumin J, Roos M, Nguyen L, Liu X, Gaeta X, Lin S, Chan DN, Liu A, Gregory RI, Jung M, Chute J, Zhu H, Lowry WE. A small molecule screen to identify regulators of let-7 targets.. Scientific reports, 2017.
  27. Miranda M, Christofk H, Jones DL, Lowry WE. Topical Inhibition of the Electron Transport Chain Can Stimulate the Hair Cycle.. The Journal of investigative dermatology, 2017.
  28. Moon H, Donahue LR, Choi E, Scumpia PO, Lowry WE, Grenier JK, Zhu J, White AC. Melanocyte Stem Cell Activation and Translocation Initiate Cutaneous Melanoma in Response to UV Exposure.. Cell stem cell, 2017.
  29. Hazim RA, Karumbayaram S, Jiang M, Dimashkie A, Lopes VS, Li D, Burgess BL, Vijayaraj P, Alva-Ornelas JA, Zack JA, Kohn DB, Gomperts BN, Pyle AD, Lowry WE, Williams DS. Differentiation of RPE cells from integration-free iPS cells and their cell biological characterization.. Stem cell research & therapy, 2017.
  30. Allison TF, Lowry WE. The reprogramming method matters.. Nature biomedical engineering, 2017.
  31. Xie Y, Lowry WE. Manipulation of neural progenitor fate through the oxygen sensing pathway.. Methods (San Diego, Calif.), 2017.
  32. Schell JC, Wisidagama DR, Bensard C, Zhao H, Wei P, Tanner J, Flores A, Mohlman J, Sorensen LK, Earl CS, Olson KA, Miao R, Waller TC, Delker D, Kanth P, Jiang L, DeBerardinis RJ, Bronner MP, Li DY, Cox JE, Christofk HR, Lowry WE, Thummel CS, Rutter J. Control of intestinal stem cell function and proliferation by mitochondrial pyruvate metabolism.. Nature cell biology, 2017.
  33. Flores A, Schell J, Krall AS, Jelinek D, Miranda M, Grigorian M, Braas D, White AC, Zhou JL, Graham NA, Graeber T, Seth P, Evseenko D, Coller HA, Rutter J, Christofk HR, Lowry WE. Lactate dehydrogenase activity drives hair follicle stem cell activation.. Nature cell biology, 2017.
  34. Gaeta X, Le L, Lin Y, Xie Y, Lowry WE. Defining Transcriptional Regulatory Mechanisms for Primary let-7 miRNAs.. PloS one, 2017.
  35. Patel S, Bonora G, Sahakyan A, Kim R, Chronis C, Langerman J, Fitz-Gibbon S, Rubbi L, Skelton RJP, Ardehali R, Pellegrini M, Lowry WE, Clark AT, Plath K. Human Embryonic Stem Cells Do Not Change Their X Inactivation Status during Differentiation.. Cell reports, 2016.
  36. Nih LR, Moshayedi P, Llorente IL, Berg AR, Cinkornpumin J, Lowry WE, Segura T, Carmichael ST. Engineered HA hydrogel for stem cell transplantation in the brain: Biocompatibility data using a design of experiment approach.. Data in brief, 2016.
  37. Germanguz I, Lowry WE. RNA editing as an activator of self-renewal in cancer.. Stem cell investigation, 2016.
  38. Gu W, Gaeta X, Sahakyan A, Chan AB, Hong CS, Kim R, Braas D, Plath K, Lowry WE, Christofk HR. Glycolytic Metabolism Plays a Functional Role in Regulating Human Pluripotent Stem Cell State.. Cell stem cell, 2016.
  39. Moshayedi P, Nih LR, Llorente IL, Berg AR, Cinkornpumin J, Lowry WE, Segura T, Carmichael ST. Systematic optimization of an engineered hydrogel allows for selective control of human neural stem cell survival and differentiation after transplantation in the stroke brain.. Biomaterials, 2016.
  40. Flores A, Grant W, White AC, Scumpia P, Takahashi R, Lowry WE. Tumor suppressor identity can contribute to heterogeneity of phenotype in hair follicle stem cell-induced squamous cell carcinoma.. Experimental dermatology, 2016.
  41. Lowry WE, Flores A, White AC. Exploiting Mouse Models to Study Ras-Induced Cutaneous Squamous Cell Carcinoma.. The Journal of investigative dermatology, 2016.
  42. White A, Flores A, Ong J, Lowry WE. Hmga2 is dispensable for cutaneous squamous cell carcinoma.. Experimental dermatology, 2016.
  43. Germanguz I, Listgarten J, Cinkornpumin J, Solomon A, Gaeta X, Lowry WE. Identifying gene expression modules that define human cell fates.. Stem cell research, 2016.
  44. Berent-Maoz B, Montecino-Rodriguez E, Fice M, Casero D, Seet CS, Crooks GM, Lowry W, Dorshkind K. The expansion of thymopoiesis in neonatal mice is dependent on expression of high mobility group a 2 protein (Hmga2).. PloS one, 2015.
  45. Lam J, Lowry WE, Carmichael ST, Segura T. Delivery of iPS-NPCs to the Stroke Cavity within a Hyaluronic Acid Matrix Promotes the Differentiation of Transplanted Cells.. Advanced functional materials, 2014.
  46. Lam J, Carmichael ST, Lowry WE, Segura T. Hydrogel design of experiments methodology to optimize hydrogel for iPSC-NPC culture.. Advanced healthcare materials, 2014.
  47. Xie Y, Zhang J, Lin Y, Gaeta X, Meng X, Wisidagama DR, Cinkornpumin J, Koehler CM, Malone CS, Teitell MA, Lowry WE. Defining the role of oxygen tension in human neural progenitor fate.. Stem cell reports, 2014.
  48. Patterson M, Gaeta X, Loo K, Edwards M, Smale S, Cinkornpumin J, Xie Y, Listgarten J, Azghadi S, Douglass SM, Pellegrini M, Lowry WE. let-7 miRNAs can act through notch to regulate human gliogenesis.. Stem cell reports, 2014.
  49. White AC, Lowry WE. Refining the role for adult stem cells as cancer cells of origin.. Trends in cell biology, 2014.
  50. White AC, Khuu JK, Dang CY, Hu J, Tran KV, Liu A, Gomez S, Zhang Z, Yi R, Scumpia P, Grigorian M, Lowry WE. Stem cell quiescence acts as a tumour suppressor in squamous tumours.. Nature cell biology, 2013.
  51. Awe JP, Lee PC, Ramathal C, Vega-Crespo A, Durruthy-Durruthy J, Cooper A, Karumbayaram S, Lowry WE, Clark AT, Zack JA, Sebastiano V, Kohn DB, Pyle AD, Martin MG, Lipshutz GS, Phelps PE, Pera RA, Byrne JA. Generation and characterization of transgene-free human induced pluripotent stem cells and conversion to putative clinical-grade status.. Stem cell research & therapy, 2013.
  52. Lowry WE. -Oh no! hiPSCs misplace their 5hmCs.. Cell stem cell, 2013.
  53. Kartikasari AE, Zhou JX, Kanji MS, Chan DN, Sinha A, Grapin-Botton A, Magnuson MA, Lowry WE, Bhushan A. The histone demethylase Jmjd3 sequentially associates with the transcription factors Tbx3 and Eomes to drive endoderm differentiation.. The EMBO journal, 2013.
  54. Lee P, Martin NT, Nakamura K, Azghadi S, Amiri M, Ben-David U, Perlman S, Gatti RA, Hu H, Lowry WE. SMRT compounds abrogate cellular phenotypes of ataxia telangiectasia in neural derivatives of patient-specific hiPSCs.. Nature communications, 2013.
  55. Palomares K, Vigant F, Van Handel B, Pernet O, Chikere K, Hong P, Sherman SP, Patterson M, An DS, Lowry WE, Mikkola HK, Morizono K, Pyle AD, Lee B. Nipah virus envelope-pseudotyped lentiviruses efficiently target ephrinB2-positive stem cell populations in vitro and bypass the liver sink when administered in vivo.. Journal of virology, 2012.
  56. Chan DN, Azghadi SF, Feng J, Lowry WE. PTK7 marks the first human developmental EMT in vitro.. PloS one, 2012.
  57. Lowry WE. Does transcription factor induced pluripotency accurately mimic embryo derived pluripotency?. Current opinion in genetics & development, 2012.
  58. Li JY, Patterson M, Mikkola HK, Lowry WE, Kurdistani SK. Dynamic distribution of linker histone H1.5 in cellular differentiation.. PLoS genetics, 2012.
  59. Karumbayaram S, Lee P, Azghadi SF, Cooper AR, Patterson M, Kohn DB, Pyle A, Clark A, Byrne J, Zack JA, Plath K, Lowry WE. From skin biopsy to neurons through a pluripotent intermediate under Good Manufacturing Practice protocols.. Stem cells translational medicine, 2011.
  60. White AC, Lowry WE. Exploiting the origins of Ras mediated squamous cell carcinoma to develop novel therapeutic interventions.. Small GTPases, 2011.
  61. Zhang J, Tokatlian T, Zhong J, Ng QK, Patterson M, Lowry WE, Carmichael ST, Segura T. Physically associated synthetic hydrogels with long-term covalent stabilization for cell culture and stem cell transplantation.. Advanced materials (Deerfield Beach, Fla.), 2011.
  62. Patterson M, Chan DN, Ha I, Case D, Cui Y, Van Handel B, Mikkola HK, Lowry WE. Defining the nature of human pluripotent stem cell progeny.. Cell research, 2011.
  63. Lowry WE. E-cadherin, a new mixer in the Yamanaka cocktail.. EMBO reports, 2011.
  64. White AC, Tran K, Khuu J, Dang C, Cui Y, Binder SW, Lowry WE. Defining the origins of Ras/p53-mediated squamous cell carcinoma.. Proceedings of the National Academy of Sciences of the United States of America, 2011.
  65. Plath K, Lowry WE. Progress in understanding reprogramming to the induced pluripotent state.. Nature reviews. Genetics, 2011.
  66. Mayshar Y, Ben-David U, Lavon N, Biancotti JC, Yakir B, Clark AT, Plath K, Lowry WE, Benvenisty N. Identification and classification of chromosomal aberrations in human induced pluripotent stem cells.. Cell stem cell, 2010.
  67. Tchieu J, Kuoy E, Chin MH, Trinh H, Patterson M, Sherman SP, Aimiuwu O, Lindgren A, Hakimian S, Zack JA, Clark AT, Pyle AD, Lowry WE, Plath K. Female human iPSCs retain an inactive X chromosome.. Cell stem cell, 2010.
  68. Chin MH, Pellegrini M, Plath K, Lowry WE. Molecular analyses of human induced pluripotent stem cells and embryonic stem cells.. Cell stem cell, 2010.
  69. Lowry WE, Quan WL. Roadblocks en route to the clinical application of induced pluripotent stem cells.. Journal of cell science, 2010.
  70. Lee R, Chang SY, Trinh H, Tu Y, White AC, Davies BS, Bergo MO, Fong LG, Lowry WE, Young SG. Genetic studies on the functional relevance of the protein prenyltransferases in skin keratinocytes.. Human molecular genetics, 2010.
  71. Chin MH, Mason MJ, Xie W, Volinia S, Singer M, Peterson C, Ambartsumyan G, Aimiuwu O, Richter L, Zhang J, Khvorostov I, Ott V, Grunstein M, Lavon N, Benvenisty N, Croce CM, Clark AT, Baxter T, Pyle AD, Teitell MA, Pelegrini M, Plath K, Lowry WE. Induced pluripotent stem cells and embryonic stem cells are distinguished by gene expression signatures.. Cell stem cell, 2009.
  72. Park TS, Galic Z, Conway AE, Lindgren A, van Handel BJ, Magnusson M, Richter L, Teitell MA, Mikkola HK, Lowry WE, Plath K, Clark AT. Derivation of primordial germ cells from human embryonic and induced pluripotent stem cells is significantly improved by coculture with human fetal gonadal cells.. Stem cells (Dayton, Ohio), 2009.
  73. Karumbayaram S, Novitch BG, Patterson M, Umbach JA, Richter L, Lindgren A, Conway AE, Clark AT, Goldman SA, Plath K, Wiedau-Pazos M, Kornblum HI, Lowry WE. Directed differentiation of human-induced pluripotent stem cells generates active motor neurons.. Stem cells (Dayton, Ohio), 2009.
  74. Lowry WE, Plath K. The many ways to make an iPS cell.. Nature biotechnology, 2008.
  75. Wu H, Kim KJ, Mehta K, Paxia S, Sundstrom A, Anantharaman T, Kuraishy AI, Doan T, Ghosh J, Pyle AD, Clark A, Lowry W, Fan G, Baxter T, Mishra B, Sun Y, Teitell MA. Copy number variant analysis of human embryonic stem cells.. Stem cells (Dayton, Ohio), 2008.
  76. Lowry WE, Richter L, Yachechko R, Pyle AD, Tchieu J, Sridharan R, Clark AT, Plath K. Generation of human induced pluripotent stem cells from dermal fibroblasts.. Proceedings of the National Academy of Sciences of the United States of America, 2008.
  77. Lowry WE, Richter L. Signaling in adult stem cells.. Frontiers in bioscience : a journal and virtual library, 2007.
  78. Blanpain C, Lowry WE, Pasolli HA, Fuchs E. Canonical notch signaling functions as a commitment switch in the epidermal lineage.. Genes & development, 2006.
  79. Lowry WE, Blanpain C, Nowak JA, Guasch G, Lewis L, Fuchs E. Defining the impact of beta-catenin/Tcf transactivation on epithelial stem cells.. Genes & development, 2005.
  80. Blanpain C, Lowry WE, Geoghegan A, Polak L, Fuchs E. Self-renewal, multipotency, and the existence of two cell populations within an epithelial stem cell niche.. Cell, 2004.
  81. Tumbar T, Guasch G, Greco V, Blanpain C, Lowry WE, Rendl M, Fuchs E. Defining the epithelial stem cell niche in skin.. Science (New York, N.Y.), 2003.
  82. Lowry WE, Huang XY. G Protein beta gamma subunits act on the catalytic domain to stimulate Bruton's agammaglobulinemia tyrosine kinase.. The Journal of biological chemistry, 2001.
  83. Lowry WE, Follender AB. Interfascicular neurolysis in the severe carpal tunnel syndrome. A prospective, randomized, double-blind, controlled study.. Clinical orthopaedics and related research, 1988.
  84. Lowry WE, Cord SA. Traumatic avascular necrosis of the capitate bone-case report.. The Journal of hand surgery, 1981.