Ye Zhang
Assistant Professor-in-Residence, Psychiatry and Biobehavioral Sciences, University of California Los Angeles
yezhang@ucla.edu
Dr. Zhang's research is focused on glia biology in health and disease.
Affiliations
Member, Cell & Developmental Biology GPB Home Area, Molecular, Cellular & Integrative Physiology GPB Home Area, Neuroscience GPB Home Area
Biography:
Dr. Zhang is an assistant professor in the Department of Psychiatry and Biobehavioral Sciences, the Intellectual and Developmental Disabilities Research Center and the Semel Institute for Neuroscience and Human Behavior. Dr. Zhang received her B.S. in Biological Sciences from Tsinghua University in China, earned her Ph.D. in Neuroscience from the University of California San Francisco under the mentorship of Dr. Yuh Nung Jan and received postdoctoral training in the laboratory of Dr. Ben Barres at Stanford University. Dr. Zhang is a recipient of the Pathway to Independence Career Transition Award (K99/R00) from NIH, the Idun and Walter Berry Postdoctoral Fellowship, and the Genentech Graduate Fellowship. At UCLA Dr. Zhang leads efforts in studying glia development and the roles of glia in neurological and psychiatric disorders including autism, brain tumor, and neurodegenerative disorders.
Publications
A selected list of publications:
- Krawczyk MC, Haney JR, Caneda C, Khankan RR, Reyes SD, Chang JW, Morselli M, Vinters HV, Wang AC, Cobos I, Gandal MJ, Bergsneider M, Kim W, Liau LM, Yong WH, Jalali A, Deneen B, Grant GA, Mathern GW, Fallah A, and Zhang Y. Human Astrocytes Exhibit Tumor Microenvironment-, Age-, and Sex-Related Transcriptomic Signatures Journal of Neuroscience, 2022; .
- Lin Pan, Amelia Trimarco, Alice J. Zhang, Ko Fujimori, Yoshihiro Urade, Lu O. Sun, Carla Taveggia, Ye Zhang Oligodendrocyte-lineage cell exocytosis and L-type prostaglandin D synthase promote oligodendrocyte development and myelination BioRxiv, 2022; .
- D. Sapkota, M.S.J. Kater, K. Sakers, K.R. Nygaard1, Y. Liu, A.M. Lake, R. Khazanchi, R.R. Khankan, A.B. Smit, S.E. Maloney, M.H.G. Verheijen, Y. Zhang, & J.D. Dougherty Activity dependent translation in astrocytes dynamically alters the proteome of the perisynaptic astrocyte process BioRxiv, 2021; .
- Kun Leng, Brendan Rooney, Hyosung Kim, Wenlong Xia, Mark Koontz, Mitchell Krawczyk, Ye Zhang, Erik M. Ullian, Stephen P.J. Fancy, Matthew S. Schrag, Ethan S. Lippmann, Martin Kampmann CRISPRi screens in human astrocytes elucidate regulators of distinct inflammatory reactive states BioRxiv, 2021; .
- Li J, Pan L, Godoy MI, Pembroke WG, Rexach JE, Condro MC, Alvarado AG, Harteni M, Chen YW, Stiles L, Chen AY, Wanner IB, Yang X, Goldman SA, Geschwind DH, Kornblum HI, and Zhang Y Conservation and divergence of vulnerability and responses to stressors between human and mouse astrocytes Nature Communications, 2021; .
- Jiwen Li*, Rana R. Khankan*, Christine Caneda, Marlesa I. Godoy, Michael S. Haney, Mitchell C. Krawczyk, Michael C. Bassik, Steven A. Sloan, Ye Zhang Astrocyte‐to‐astrocyte contact and a positive feedback loop of growth factor signaling regulate astrocyte maturation Glia, 2019; .
- Li Zizheng, Siddique Ibrar, Hadrović Inesa, Kirupakaran Abbna, Li Jiwen, Zhang Ye, Klärner Frank-Gerrit, Schrader Thomas, Bitan Gal Lysine-selective molecular tweezers are cell penetrant and concentrate in lysosomes Communications biology, 2021; 4(1): 1076.
- Larson Valerie A, Zhang Ye, Bergles Dwight E Electrophysiological properties of NG2(+) cells: Matching physiological studies with gene expression profiles Brain research, 2016; 1638(Pt B): 138-60.
- Zhang Ye*, Sloan Steven A*, Clarke Laura E, Caneda Christine, Plaza Colton A, Blumenthal Paul D, Vogel Hannes, Steinberg Gary K, Edwards Michael S B, Li Gordon, Duncan John A, Cheshier Samuel H, Shuer Lawrence M, Chang Edward F, Grant Gerald A, Gephart Melanie G Hayden, Barres Ben A Purification and Characterization of Progenitor and Mature Human Astrocytes Reveals Transcriptional and Functional Differences with Mouse Neuron, 2016; 89(1): 37-53.
- Dong Xiaomin, Chen Kenian, Cuevas-Diaz Duran Raquel, You Yanan, Sloan Steven A, Zhang Ye, Zong Shan, Cao Qilin, Barres Ben A, Wu Jia Qian Comprehensive Identification of Long Non-coding RNAs in Purified Cell Types from the Brain Reveals Functional LncRNA in OPC Fate Determination PLoS genetics, 2015; 11(12): e1005669.
- Darmanis Spyros, Sloan Steven A, Zhang Ye, Enge Martin, Caneda Christine, Shuer Lawrence M, Hayden Gephart Melanie G, Barres Ben A, Quake Stephen R A survey of human brain transcriptome diversity at the single cell level Proceedings of the National Academy of Sciences of the United States of America, 2015; 112(23): 7285-90.
- Yan Qinghong, Weyn-Vanhentenryck Sebastien M, Wu Jie, Sloan Steven A, Zhang Ye, Chen Kenian, Wu Jia Qian, Barres Ben A, Zhang Chaolin Systematic discovery of regulated and conserved alternative exons in the mammalian brain reveals NMD modulating chromatin regulators Proceedings of the National Academy of Sciences of the United States of America, 2015; 112(11): 3445-50.
- Zhang Ye*, Chen Kenian*, Sloan Steven A*, Bennett Mariko L, Scholze Anja R, O’Keeffe Sean, Phatnani Hemali P, Guarnieri Paolo, Caneda Christine, Ruderisch Nadine, Deng Shuyun, Liddelow Shane A, Zhang Chaolin, Daneman Richard, Maniatis Tom, Barres Ben A, Wu Jian Qian An RNA-sequencing transcriptome and splicing database of glia, neurons, and vascular cells of the cerebral cortex The Journal of neuroscience : the official journal of the Society for Neuroscience, 2014; 34(36): 11929-47.
- Zhang Ye, Barres Ben A A smarter mouse with human astrocytes BioEssays : news and reviews in molecular, cellular and developmental biology, 2013; 35(10): 876-80.
- Zhang Ye, Barres Ben A Astrocyte heterogeneity: an underappreciated topic in neurobiology Current opinion in neurobiology, 2010; 20(5): 588-94.
- Zheng Yi*, Wildonger Jill*, Ye Bing, Zhang Ye, Kita Angela, Younger Susan H, Zimmerman Sabina, Jan Lily Yeh, Jan Yuh Nung Dynein is required for polarized dendritic transport and uniform microtubule orientation in axons Nature cell biology, 2008; 10(10): 1172-80.
- Ye Bing*, Zhang Ye*, Song Wei, Younger Susan H, Jan Lily Yeh, Jan Yuh Nung Growing dendrites and axons differ in their reliance on the secretory pathway Cell, 2007; 130(4): 717-29.
- Ye Bing*, Zhang Ye W*, Jan Lily Yeh, Jan Yuh Nung The secretory pathway and neuron polarization The Journal of neuroscience : the official journal of the Society for Neuroscience, 2006; 26(42): 10631-2.
Publications
- Li J*, Godoy M*, Zhang AJ, Diamante G, Ahn IS, Cebrian-Silla A, Alvarez-Buylla A, Yang X, Novitch BG, and Zhang Y. Prdm16 and Vcam1 regulate the postnatal disappearance of radial glia and the ending of cortical neurogenesis. BioRxiv, 2023.
- Krawczyk MC, Pan L, Zhang AJ, Zhang Y. Lymphocyte deficiency alters the transcriptomes of oligodendrocytes, but not astrocytes or microglia.. PloS one, 2023.
- Pan L, Trimarco A, Zhang AJ, Fujimori K, Urade Y, Sun LO, Taveggia C, Zhang Y. Oligodendrocyte-lineage cell exocytosis and L-type prostaglandin D synthase promote oligodendrocyte development and myelination.. eLife, 2023.
- Leng K, Rose IVL, Kim H, Xia W, Romero-Fernandez W, Rooney B, Koontz M, Li E, Ao Y, Wang S, Krawczyk M, Tcw J, Goate A, Zhang Y, Ullian EM, Sofroniew MV, Fancy SPJ, Schrag MS, Lippmann ES, Kampmann M. CRISPRi screens in human iPSC-derived astrocytes elucidate regulators of distinct inflammatory reactive states.. Nature neuroscience, 2022.
- Sapkota D, Kater MSJ, Sakers K, Nygaard KR, Liu Y, Koester SK, Fass SB, Lake AM, Khazanchi R, Khankan RR, Krawczyk MC, Smit AB, Maloney SE, Verheijen MHG, Zhang Y, Dougherty JD. Activity-dependent translation dynamically alters the proteome of the perisynaptic astrocyte process.. Cell reports, 2022.
- Krawczyk MC, Haney JR, Pan L, Caneda C, Khankan RR, Reyes SD, Chang JW, Morselli M, Vinters HV, Wang AC, Cobos I, Gandal MJ, Bergsneider M, Kim W, Liau LM, Yong W, Jalali A, Deneen B, Grant GA, Mathern GW, Fallah A, Zhang Y. Human Astrocytes Exhibit Tumor Microenvironment-, Age-, and Sex-Related Transcriptomic Signatures.. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2022.
- Li Z, Siddique I, Hadrovic I, Kirupakaran A, Li J, Zhang Y, Klärner FG, Schrader T, Bitan G. Lysine-selective molecular tweezers are cell penetrant and concentrate in lysosomes.. Communications biology, 2021.
- Li J, Pan L, Pembroke WG, Rexach JE, Godoy MI, Condro MC, Alvarado AG, Harteni M, Chen YW, Stiles L, Chen AY, Wanner IB, Yang X, Goldman SA, Geschwind DH, Kornblum HI, Zhang Y. Conservation and divergence of vulnerability and responses to stressors between human and mouse astrocytes.. Nature communications, 2021.
- Li J, Khankan RR, Caneda C, Godoy MI, Haney MS, Krawczyk MC, Bassik MC, Sloan SA, Zhang Y. Astrocyte-to-astrocyte contact and a positive feedback loop of growth factor signaling regulate astrocyte maturation.. Glia, 2019.
- Darmanis S, Sloan SA, Croote D, Mignardi M, Chernikova S, Samghababi P, Zhang Y, Neff N, Kowarsky M, Caneda C, Li G, Chang SD, Connolly ID, Li Y, Barres BA, Gephart MH, Quake SR. Single-Cell RNA-Seq Analysis of Infiltrating Neoplastic Cells at the Migrating Front of Human Glioblastoma.. Cell reports, 2017.
- Watanabe M, Buth JE, Vishlaghi N, de la Torre-Ubieta L, Taxidis J, Khakh BS, Coppola G, Pearson CA, Yamauchi K, Gong D, Dai X, Damoiseaux R, Aliyari R, Liebscher S, Schenke-Layland K, Caneda C, Huang EJ, Zhang Y, Cheng G, Geschwind DH, Golshani P, Sun R, Novitch BG. Self-Organized Cerebral Organoids with Human-Specific Features Predict Effective Drugs to Combat Zika Virus Infection.. Cell reports, 2017.
- Dong X, Chen K, Cuevas-Diaz Duran R, You Y, Sloan SA, Zhang Y, Zong S, Cao Q, Barres BA, Wu JQ. Comprehensive Identification of Long Non-coding RNAs in Purified Cell Types from the Brain Reveals Functional LncRNA in OPC Fate Determination.. PLoS genetics, 2015.
- Zhang Y, Sloan SA, Clarke LE, Caneda C, Plaza CA, Blumenthal PD, Vogel H, Steinberg GK, Edwards MS, Li G, Duncan JA, Cheshier SH, Shuer LM, Chang EF, Grant GA, Gephart MG, Barres BA. Purification and Characterization of Progenitor and Mature Human Astrocytes Reveals Transcriptional and Functional Differences with Mouse.. Neuron, 2015.
- Larson VA, Zhang Y, Bergles DE. Electrophysiological properties of NG2(+) cells: Matching physiological studies with gene expression profiles.. Brain research, 2015.
- Darmanis S, Sloan SA, Zhang Y, Enge M, Caneda C, Shuer LM, Hayden Gephart MG, Barres BA, Quake SR. A survey of human brain transcriptome diversity at the single cell level.. Proceedings of the National Academy of Sciences of the United States of America, 2015.
- Yan Q, Weyn-Vanhentenryck SM, Wu J, Sloan SA, Zhang Y, Chen K, Wu JQ, Barres BA, Zhang C. Systematic discovery of regulated and conserved alternative exons in the mammalian brain reveals NMD modulating chromatin regulators.. Proceedings of the National Academy of Sciences of the United States of America, 2015.
- Zhang Y, Chen K, Sloan SA, Bennett ML, Scholze AR, O'Keeffe S, Phatnani HP, Guarnieri P, Caneda C, Ruderisch N, Deng S, Liddelow SA, Zhang C, Daneman R, Maniatis T, Barres BA, Wu JQ. An RNA-sequencing transcriptome and splicing database of glia, neurons, and vascular cells of the cerebral cortex.. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2014.
- Zhang Y, Barres BA. A smarter mouse with human astrocytes.. BioEssays : news and reviews in molecular, cellular and developmental biology, 2013.
- Zhang Y, Barres BA. Astrocyte heterogeneity: an underappreciated topic in neurobiology.. Current opinion in neurobiology, 2010.
- Zheng Y, Wildonger J, Ye B, Zhang Y, Kita A, Younger SH, Zimmerman S, Jan LY, Jan YN. Dynein is required for polarized dendritic transport and uniform microtubule orientation in axons.. Nature cell biology, 2008.
- Ye B, Zhang Y, Song W, Younger SH, Jan LY, Jan YN. Growing dendrites and axons differ in their reliance on the secretory pathway.. Cell, 2007.
- Ye B, Zhang YW, Jan LY, Jan YN. The secretory pathway and neuron polarization.. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2006.