Hong Zhou

Professor, MIMG, University of California Los Angeles

Dr. Zhou is a professor in the Department of Microbiology, Immunology and Molecular Genetics and the founding director of the UCLA Electron Imaging Center for Nanomachines.

Education and Training

Baylor College of MedicinePhD05/1995Biochemistry
University of Science and Technology of ChinaM.S.12/1989Solid-state physics
University of Science and Technology of ChinaB.S.07/1986Physics

Awards and Honors

  • Pew Scholar, The Pew Charitable Trust, 1999.


  1. Stevens A, Cui Y, Shivakoti S, Zhou ZH. Asymmetric reconstruction of the aquareovirus core at near-atomic resolution and mechanism of transcription initiation.. Protein & cell, 2023.
  2. Ito F, Alvarez-Cabrera AL, Liu S, Yang H, Shiriaeva A, Zhou ZH, Chen XS. Structural basis for HIV-1 antagonism of host APOBEC3G via Cullin E3 ligase.. Science advances, 2023.
  3. Hu JJ, Lee JKJ, Liu YT, Yu C, Huang L, Aphasizheva I, Aphasizhev R, Zhou ZH. Discovery, structure, and function of filamentous 3-methylcrotonyl-CoA carboxylase.. Structure (London, England : 1993), 2022.
  4. Zhekova HR, Jiang J, Wang W, Tsirulnikov K, Kayik G, Khan HM, Azimov R, Abuladze N, Kao L, Newman D, Noskov SY, Tieleman DP, Hong Zhou Z, Pushkin A, Kurtz I. CryoEM structures of anion exchanger 1 capture multiple states of inward- and outward-facing conformations.. Communications biology, 2022.
  5. Liu S, Xia X, Zhen J, Li Z, Zhou ZH. Structures and comparison of endogenous 2-oxoglutarate and pyruvate dehydrogenase complexes from bovine kidney.. Cell discovery, 2022.
  6. Xia X, Zhou ZH. Using cryoEM and cryoET to visualize membrane penetration of a non-enveloped virus.. STAR protocols, 2022.
  7. Liu YT, Zhang H, Wang H, Tao CL, Bi GQ, Zhou ZH. Isotropic reconstruction for electron tomography with deep learning.. Nature communications, 2022.
  8. Zhou K, Si Z, Ge P, Tsao J, Luo M, Zhou ZH. Atomic model of vesicular stomatitis virus and mechanism of assembly.. Nature communications, 2022.
  9. Liu X, Clemens DL, Lee BY, Yang X, Zhou ZH, Horwitz MA. Atomic Structure of IglD Demonstrates Its Role as a Component of the Baseplate Complex of the Francisella Type VI Secretion System.. mBio, 2022.
  10. Zhou ZH. New cryoEM Methods for Studying Native Biological Complexes, in situ and in Action.. Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada, 2022.
  11. He Y, Song H, Chan H, Liu B, Wang Y, Sušac L, Zhou ZH, Feigon J. Structure of Tetrahymena telomerase-bound CST with polymerase α-primase.. Nature, 2022.
  12. Xia X, Liu S, Zhou ZH. Structure, dynamics and assembly of the ankyrin complex on human red blood cell membrane.. Nature structural & molecular biology, 2022.
  13. Si Z, Zhou K, Tsao J, Luo M, Zhou ZH. Locations and in situ structure of the polymerase complex inside the virion of vesicular stomatitis virus.. Proceedings of the National Academy of Sciences of the United States of America, 2022.
  14. Liu B, He Y, Wang Y, Song H, Zhou ZH, Feigon J. Structure of active human telomerase with telomere shelterin protein TPP1.. Nature, 2022.
  15. Yang Y, Liu S, Egloff S, Eichhorn CD, Hadjian T, Zhen J, Kiss T, Zhou ZH, Feigon J. Structural basis of RNA conformational switching in the transcriptional regulator 7SK RNP.. Molecular cell, 2022.
  16. Zhang Y, Cui Y, Sun J, Zhou ZH. Multiple conformations of trimeric spikes visualized on a non-enveloped virus.. Nature communications, 2022.
  17. Sharma A, Zhang X, Dejnirattisai W, Dai X, Gong D, Wongwiwat W, Duquerroy S, Rouvinski A, Vaney MC, Guardado-Calvo P, Haouz A, England P, Sun R, Zhou ZH, Mongkolsapaya J, Screaton GR, Rey FA. The epitope arrangement on flavivirus particles contributes to Mab C10's extraordinary neutralization breadth across Zika and dengue viruses.. Cell, 2021.
  18. Xia X, Wu W, Cui Y, Roy P, Zhou ZH. Bluetongue virus capsid protein VP5 perforates membranes at low endosomal pH during viral entry.. Nature microbiology, 2021.
  19. Wang W, Tsirulnikov K, Zhekova HR, Kayik G, Khan HM, Azimov R, Abuladze N, Kao L, Newman D, Noskov SY, Zhou ZH, Pushkin A, Kurtz I. Publisher Correction: Cryo-EM structure of the sodium-driven chloride/bicarbonate exchanger NDCBE.. Nature communications, 2021.
  20. Wang W, Tsirulnikov K, Zhekova HR, Kayik G, Khan HM, Azimov R, Abuladze N, Kao L, Newman D, Noskov SY, Zhou ZH, Pushkin A, Kurtz I. Cryo-EM structure of the sodium-driven chloride/bicarbonate exchanger NDCBE.. Nature communications, 2021.
  21. Li T, Xue W, Zheng Q, Song S, Yang C, Xiong H, Zhang S, Hong M, Zhang Y, Yu H, Zhang Y, Sun H, Huang Y, Deng T, Chi X, Li J, Wang S, Zhou L, Chen T, Wang Y, Cheng T, Zhang T, Yuan Q, Zhao Q, Zhang J, McLellan JS, Zhou ZH, Zhang Z, Li S, Gu Y, Xia N. Cross-neutralizing antibodies bind a SARS-CoV-2 cryptic site and resist circulating variants.. Nature communications, 2021.
  22. Liu YT, Strugatsky D, Liu W, Zhou ZH. Structure of human cytomegalovirus virion reveals host tRNA binding to capsid-associated tegument protein pp150.. Nature communications, 2021.
  23. Ho CM, Jih J, Lai M, Li X, Goldberg DE, Beck JR, Zhou ZH. Native structure of the RhopH complex, a key determinant of malaria parasite nutrient acquisition.. Proceedings of the National Academy of Sciences of the United States of America, 2021.
  24. Cai X, Liu L, Qiu C, Wen C, He Y, Cui Y, Li S, Zhang X, Zhang L, Tian C, Bi L, Zhou ZH, Gong W. Identification and architecture of a putative secretion tube across mycobacterial outer envelope.. Science advances, 2021.
  25. Zhang J, Wang H, Imhof S, Zhou X, Liao S, Atanasov I, Hui WH, Hill KL, Zhou ZH. Author Correction: Structure of the trypanosome paraflagellar rod and insights into non-planar motility of eukaryotic cells.. Cell discovery, 2021.
  26. Zhang J, Wang H, Imhof S, Zhou X, Liao S, Atanasov I, Hui WH, Hill KL, Zhou ZH. Structure of the trypanosome paraflagellar rod and insights into non-planar motility of eukaryotic cells.. Cell discovery, 2021.
  27. Pan M, Alvarez-Cabrera AL, Kang JS, Wang L, Fan C, Zhou ZH. Asymmetric reconstruction of mammalian reovirus reveals interactions among RNA, transcriptional factor µ2 and capsid proteins.. Nature communications, 2021.
  28. He Y, Wang Y, Liu B, Helmling C, Sušac L, Cheng R, Zhou ZH, Feigon J. Structures of telomerase at several steps of telomere repeat synthesis.. Nature, 2021.
  29. Stevens A, Muratore K, Cui Y, Johnson PJ, Zhou ZH. Atomic Structure of the Trichomonas vaginalis Double-Stranded RNA Virus 2.. mBio, 2021.
  30. Terwilliger TC, Sobolev OV, Afonine PV, Adams PD, Ho CM, Li X, Zhou ZH. Protein identification from electron cryomicroscopy maps by automated model building and side-chain matching.. Acta crystallographica. Section D, Structural biology, 2021.
  31. Brader ML, Williams SJ, Banks JM, Hui WH, Zhou ZH, Jin L. Encapsulation state of messenger RNA inside lipid nanoparticles.. Biophysical journal, 2021.
  32. Xu L, Zheng Q, Zhu R, Yin Z, Yu H, Lin Y, Wu Y, He M, Huang Y, Jiang Y, Sun H, Zha Z, Yang H, Huang Q, Zhang D, Chen Z, Ye X, Han J, Yang L, Liu C, Que Y, Fang M, Gu Y, Zhang J, Luo W, Zhou ZH, Li S, Cheng T, Xia N. Cryo-EM structures reveal the molecular basis of receptor-initiated coxsackievirus uncoating.. Cell host & microbe, 2021.
  33. Liu YT, Tao CL, Zhang X, Xia W, Shi DQ, Qi L, Xu C, Sun R, Li XW, Lau PM, Zhou ZH, Bi GQ. Mesophasic organization of GABAA receptors in hippocampal inhibitory synapses.. Nature neuroscience, 2020.
  34. Rahman SK, Kerviel A, Mohl BP, He Y, Zhou ZH, Roy P. A Calcium Sensor Discovered in Bluetongue Virus Nonstructural Protein 2 Is Critical for Virus Replication.. Journal of virology, 2020.
  35. Wang W, Zheng Q, Pan D, Yu H, Fu W, Liu J, He M, Zhu R, Cai Y, Huang Y, Zha Z, Chen Z, Ye X, Han J, Que Y, Wu T, Zhang J, Li S, Zhu H, Zhou ZH, Cheng T, Xia N. Near-atomic cryo-electron microscopy structures of varicella-zoster virus capsids.. Nature microbiology, 2020.
  36. Wang B, Thurmond S, Zhou K, Sánchez-Aparicio MT, Fang J, Lu J, Gao L, Ren W, Cui Y, Veit EC, Hong H, Evans MJ, O'Leary SE, García-Sastre A, Zhou ZH, Hai R, Song J. Structural basis for STAT2 suppression by flavivirus NS5.. Nature structural & molecular biology, 2020.
  37. Liu W, Cui Y, Wang C, Li Z, Gong D, Dai X, Bi GQ, Sun R, Zhou ZH. Structures of capsid and capsid-associated tegument complex inside the Epstein-Barr virus.. Nature microbiology, 2020.
  38. Draganova EB, Zhang J, Zhou ZH, Heldwein EE. Structural basis for capsid recruitment and coat formation during HSV-1 nuclear egress.. eLife, 2020.
  39. Zhou K, Liu S, Hardenbrook NJ, Cui Y, Krantz BA, Zhou ZH. Atomic Structures of Anthrax Prechannel Bound with Full-Length Lethal and Edema Factors.. Structure (London, England : 1993), 2020.
  40. Beren C, Cui Y, Chakravarty A, Yang X, Rao ALN, Knobler CM, Zhou ZH, Gelbart WM. Genome organization and interaction with capsid protein in a multipartite RNA virus.. Proceedings of the National Academy of Sciences of the United States of America, 2020.
  41. Das S, Ge P, Oztug Durer ZA, Grintsevich EE, Zhou ZH, Reisler E. D-loop Dynamics and Near-Atomic-Resolution Cryo-EM Structure of Phalloidin-Bound F-Actin.. Structure (London, England : 1993), 2020.
  42. Ge P, Scholl D, Prokhorov NS, Avaylon J, Shneider MM, Browning C, Buth SA, Plattner M, Chakraborty U, Ding K, Leiman PG, Miller JF, Zhou ZH. Action of a minimal contractile bactericidal nanomachine.. Nature, 2020.
  43. Glynn C, Sawaya MR, Ge P, Gallagher-Jones M, Short CW, Bowman R, Apostol M, Zhou ZH, Eisenberg DS, Rodriguez JA. Cryo-EM structure of a human prion fibril with a hydrophobic, protease-resistant core.. Nature structural & molecular biology, 2020.
  44. Bucholc K, Aik WS, Yang XC, Wang K, Zhou ZH, Dadlez M, Marzluff WF, Tong L, Dominski Z. Composition and processing activity of a semi-recombinant holo U7 snRNP.. Nucleic acids research, 2020.
  45. Hardenbrook NJ, Liu S, Zhou K, Ghosal K, Zhou ZH, Krantz BA. Atomic structures of anthrax toxin protective antigen channels bound to partially unfolded lethal and edema factors.. Nature communications, 2020.
  46. He M, Xu L, Zheng Q, Zhu R, Yin Z, Zha Z, Lin Y, Yang L, Huang Y, Ye X, Li S, Hou W, Wu Y, Han J, Liu D, Li Z, Chen Z, Yu H, Que Y, Wang Y, Yan X, Zhang J, Gu Y, Zhou ZH, Cheng T, Li S, Xia N. Identification of Antibodies with Non-overlapping Neutralization Sites that Target Coxsackievirus A16.. Cell host & microbe, 2020.
  47. Chen X, Cui Y, Best RB, Wang H, Zhou ZH, Yang W, Gellert M. Cutting antiparallel DNA strands in a single active site.. Nature structural & molecular biology, 2020.
  48. Chen X, Cui Y, Wang H, Zhou ZH, Gellert M, Yang W. How mouse RAG recombinase avoids DNA transposition.. Nature structural & molecular biology, 2020.
  49. Zhang Y, Liu W, Li Z, Kumar V, Alvarez-Cabrera AL, Leibovitch EC, Cui Y, Mei Y, Bi GQ, Jacobson S, Zhou ZH. Atomic structure of the human herpesvirus 6B capsid and capsid-associated tegument complexes.. Nature communications, 2019.
  50. Ho CM, Li X, Lai M, Terwilliger TC, Beck JR, Wohlschlegel J, Goldberg DE, Fitzpatrick AWP, Zhou ZH. Bottom-up structural proteomics: cryoEM of protein complexes enriched from the cellular milieu.. Nature methods, 2019.
  51. Imhof S, Zhang J, Wang H, Bui KH, Nguyen H, Atanasov I, Hui WH, Yang SK, Zhou ZH, Hill KL. Cryo electron tomography with volta phase plate reveals novel structural foundations of the 96-nm axonemal repeat in the pathogen Trypanosoma brucei.. eLife, 2019.
  52. Cui Y, Zhang Y, Zhou K, Sun J, Zhou ZH. Conservative transcription in three steps visualized in a double-stranded RNA virus.. Nature structural & molecular biology, 2019.
  53. Yang X, Clemens DL, Lee BY, Cui Y, Zhou ZH, Horwitz MA. Atomic Structure of the Francisella T6SS Central Spike Reveals a Unique α-Helical Lid and a Putative Cargo.. Structure (London, England : 1993), 2019.
  54. Li X, Liu S, Zhang L, Issaian A, Hill RC, Espinosa S, Shi S, Cui Y, Kappel K, Das R, Hansen KC, Zhou ZH, Zhao R. A unified mechanism for intron and exon definition and back-splicing.. Nature, 2019.
  55. Wongpalee SP, Liu S, Gallego-Bartolomé J, Leitner A, Aebersold R, Liu W, Yen L, Nohales MA, Kuo PH, Vashisht AA, Wohlschlegel JA, Feng S, Kay SA, Zhou ZH, Jacobsen SE. CryoEM structures of Arabidopsis DDR complexes involved in RNA-directed DNA methylation.. Nature communications, 2019.
  56. Gong D, Dai X, Jih J, Liu YT, Bi GQ, Sun R, Zhou ZH. DNA-Packing Portal and Capsid-Associated Tegument Complexes in the Tumor Herpesvirus KSHV.. Cell, 2019.
  57. He Y, Shivakoti S, Ding K, Cui Y, Roy P, Zhou ZH. In situ structures of RNA-dependent RNA polymerase inside bluetongue virus before and after uncoating.. Proceedings of the National Academy of Sciences of the United States of America, 2019.
  58. Olsen RW, Lindemeyer AK, Wallner M, Li X, Huynh KW, Zhou ZH. Cryo-electron microscopy reveals informative details of GABAA receptor structural pharmacology: implications for drug discovery.. Annals of translational medicine, 2019.
  59. Liu YT, Jih J, Dai X, Bi GQ, Zhou ZH. Cryo-EM structures of herpes simplex virus type 1 portal vertex and packaged genome.. Nature, 2019.
  60. Ding K, Celma CC, Zhang X, Chang T, Shen W, Atanasov I, Roy P, Zhou ZH. In situ structures of rotavirus polymerase in action and mechanism of mRNA transcription and release.. Nature communications, 2019.
  61. Wang K, Preisler SS, Zhang L, Cui Y, Missel JW, Grønberg C, Gotfryd K, Lindahl E, Andersson M, Calloe K, Egea PF, Klaerke DA, Pusch M, Pedersen PA, Zhou ZH, Gourdon P. Structure of the human ClC-1 chloride channel.. PLoS biology, 2019.
  62. Liu YT, Tao CL, Lau PM, Zhou ZH, Bi GQ. Postsynaptic protein organization revealed by electron microscopy.. Current opinion in structural biology, 2019.
  63. Cui Y, Zhou K, Strugatsky D, Wen Y, Sachs G, Zhou ZH, Munson K. pH-dependent gating mechanism of the Helicobacter pylori urea channel revealed by cryo-EM.. Science advances, 2019.
  64. Liu W, Dai X, Jih J, Chan K, Trang P, Yu X, Balogun R, Mei Y, Liu F, Zhou ZH. Atomic structures and deletion mutant reveal different capsid-binding patterns and functional significance of tegument protein pp150 in murine and human cytomegaloviruses with implications for therapeutic development.. PLoS pathogens, 2019.
  65. Kerviel A, Ge P, Lai M, Jih J, Boyce M, Zhang X, Zhou ZH, Roy P. Atomic structure of the translation regulatory protein NS1 of bluetongue virus.. Nature microbiology, 2019.
  66. Gao Y, Cui Y, Fox T, Lin S, Wang H, de Val N, Zhou ZH, Yang W. Structures and operating principles of the replisome.. Science (New York, N.Y.), 2019.
  67. Si Z, Zhang J, Shivakoti S, Atanasov I, Tao CL, Hui WH, Zhou K, Yu X, Li W, Luo M, Bi GQ, Zhou ZH. Different functional states of fusion protein gB revealed on human cytomegalovirus by cryo electron tomography with Volta phase plate.. PLoS pathogens, 2018.
  68. Zheng Q, Zhu R, Xu L, He M, Yan X, Liu D, Yin Z, Wu Y, Li Y, Yang L, Hou W, Li S, Li Z, Chen Z, Li Z, Yu H, Gu Y, Zhang J, Baker TS, Zhou ZH, Graham BS, Cheng T, Li S, Xia N. Atomic structures of enterovirus D68 in complex with two monoclonal antibodies define distinct mechanisms of viral neutralization.. Nature microbiology, 2018.
  69. Kappel K, Liu S, Larsen KP, Skiniotis G, Puglisi EV, Puglisi JD, Zhou ZH, Zhao R, Das R. De novo computational RNA modeling into cryo-EM maps of large ribonucleoprotein complexes.. Nature methods, 2018.
  70. Ding K, Nguyen L, Zhou ZH. In Situ Structures of the Polymerase Complex and RNA Genome Show How Aquareovirus Transcription Machineries Respond to Uncoating.. Journal of virology, 2018.
  71. Hughes TET, Pumroy RA, Yazici AT, Kasimova MA, Fluck EC, Huynh KW, Samanta A, Molugu SK, Zhou ZH, Carnevale V, Rohacs T, Moiseenkova-Bell VY. Structural insights on TRPV5 gating by endogenous modulators.. Nature communications, 2018.
  72. Zhu R, Xu L, Zheng Q, Cui Y, Li S, He M, Yin Z, Liu D, Li S, Li Z, Chen Z, Yu H, Que Y, Liu C, Kong Z, Zhang J, Baker TS, Yan X, Hong Zhou Z, Cheng T, Xia N. Discovery and structural characterization of a therapeutic antibody against coxsackievirus A10.. Science advances, 2018.
  73. Li B, Ge P, Murray KA, Sheth P, Zhang M, Nair G, Sawaya MR, Shin WS, Boyer DR, Ye S, Eisenberg DS, Zhou ZH, Jiang L. Cryo-EM of full-length α-synuclein reveals fibril polymorphs with a common structural kernel.. Nature communications, 2018.
  74. Ho CM, Beck JR, Lai M, Cui Y, Goldberg DE, Egea PF, Zhou ZH. Malaria parasite translocon structure and mechanism of effector export.. Nature, 2018.
  75. Liu S, Xu L, Guan F, Liu YT, Cui Y, Zhang Q, Zheng X, Bi GQ, Zhou ZH, Zhang X, Ye S. Cryo-EM structure of the human α5β3 GABAA receptor.. Cell research, 2018.
  76. Yu I, Nguyen L, Avaylon J, Wang K, Lai M, Zhou ZH. Building atomic models based on near atomic resolution cryoEM maps with existing tools.. Journal of structural biology, 2018.
  77. Tao CL, Liu YT, Zhou ZH, Lau PM, Bi GQ. Accumulation of Dense Core Vesicles in Hippocampal Synapses Following Chronic Inactivity.. Frontiers in neuroanatomy, 2018.
  78. Jiang J, Wang Y, Sušac L, Chan H, Basu R, Zhou ZH, Feigon J. Structure of Telomerase with Telomeric DNA.. Cell, 2018.
  79. Jiang J, Baiesc FL, Hiromasa Y, Yu X, Hui WH, Dai X, Roche TE, Zhou ZH. Atomic Structure of the E2 Inner Core of Human Pyruvate Dehydrogenase Complex.. Biochemistry, 2018.
  80. Li X, Liu S, Jiang J, Zhang L, Espinosa S, Hill RC, Hansen KC, Zhou ZH, Zhao R. Author Correction: CryoEM structure of Saccharomyces cerevisiae U1 snRNP offers insight into alternative splicing.. Nature communications, 2018.
  81. Kim MS, Chuenchor W, Chen X, Cui Y, Zhang X, Zhou ZH, Gellert M, Yang W. Cracking the DNA Code for V(D)J Recombination.. Molecular cell, 2018.
  82. Dai X, Zhou ZH. Structure of the herpes simplex virus 1 capsid with associated tegument protein complexes.. Science (New York, N.Y.), 2018.
  83. Ding K, Zhang X, Mrazek J, Kickhoefer VA, Lai M, Ng HL, Yang OO, Rome LH, Zhou ZH. Solution Structures of Engineered Vault Particles.. Structure (London, England : 1993), 2018.
  84. Guenther EL, Ge P, Trinh H, Sawaya MR, Cascio D, Boyer DR, Gonen T, Zhou ZH, Eisenberg DS. Atomic-level evidence for packing and positional amyloid polymorphism by segment from TDP-43 RRM2.. Nature structural & molecular biology, 2018.
  85. Huynh KW, Jiang J, Abuladze N, Tsirulnikov K, Kao L, Shao X, Newman D, Azimov R, Pushkin A, Zhou ZH, Kurtz I. CryoEM structure of the human SLC4A4 sodium-coupled acid-base transporter NBCe1.. Nature communications, 2018.
  86. Su Z, Wu C, Shi L, Luthra P, Pintilie GD, Johnson B, Porter JR, Ge P, Chen M, Liu G, Frederick TE, Binning JM, Bowman GR, Zhou ZH, Basler CF, Gross ML, Leung DW, Chiu W, Amarasinghe GK. Electron Cryo-microscopy Structure of Ebola Virus Nucleoprotein Reveals a Mechanism for Nucleocapsid-like Assembly.. Cell, 2018.
  87. Tian T, Li X, Liu Y, Wang C, Liu X, Bi G, Zhang X, Yao X, Zhou ZH, Zang J. Molecular basis for CENP-N recognition of CENP-A nucleosome on the human kinetochore.. Cell research, 2018.
  88. Dai X, Gong D, Lim H, Jih J, Wu TT, Sun R, Zhou ZH. Structure and mutagenesis reveal essential capsid protein interactions for KSHV replication.. Nature, 2018.
  89. Park K, Kuo Y, Shvadchak V, Ingargiola A, Dai X, Hsiung L, Kim W, Zhou H, Zou P, Levine AJ, Li J, Weiss S. Membrane insertion of-and membrane potential sensing by-semiconductor voltage nanosensors: Feasibility demonstration.. Science advances, 2018.
  90. Tao CL, Liu YT, Sun R, Zhang B, Qi L, Shivakoti S, Tian CL, Zhang P, Lau PM, Zhou ZH, Bi GQ. Differentiation and Characterization of Excitatory and Inhibitory Synapses by Cryo-electron Tomography and Correlative Microscopy.. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2018.
  91. Hughes TET, Lodowski DT, Huynh KW, Yazici A, Del Rosario J, Kapoor A, Basak S, Samanta A, Han X, Chakrapani S, Zhou ZH, Filizola M, Rohacs T, Han S, Moiseenkova-Bell VY. Structural basis of TRPV5 channel inhibition by econazole revealed by cryo-EM.. Nature structural & molecular biology, 2018.
  92. Grintsevich EE, Ge P, Sawaya MR, Yesilyurt HG, Terman JR, Zhou ZH, Reisler E. Catastrophic disassembly of actin filaments via Mical-mediated oxidation.. Nature communications, 2017.
  93. Dai X, Wu L, Sun R, Zhou ZH. Atomic Structures of Minor Proteins VI and VII in Human Adenovirus.. Journal of virology, 2017.
  94. Liu S, Li X, Zhang L, Jiang J, Hill RC, Cui Y, Hansen KC, Zhou ZH, Zhao R. Structure of the yeast spliceosomal postcatalytic P complex.. Science (New York, N.Y.), 2017.
  95. Li X, Liu S, Jiang J, Zhang L, Espinosa S, Hill RC, Hansen KC, Zhou ZH, Zhao R. CryoEM structure of Saccharomyces cerevisiae U1 snRNP offers insight into alternative splicing.. Nature communications, 2017.
  96. Liu YT, Jiang J, Bohannon KP, Dai X, Gant Luxton GW, Hui WH, Bi GQ, Smith GA, Zhou ZH. A pUL25 dimer interfaces the pseudorabies virus capsid and tegument.. The Journal of general virology, 2017.
  97. Sun Y, Wollenberg AL, O'Shea TM, Cui Y, Zhou ZH, Sofroniew MV, Deming TJ. Conformation-Directed Formation of Self-Healing Diblock Copolypeptide Hydrogels via Polyion Complexation.. Journal of the American Chemical Society, 2017.
  98. Wong JJW, Young TA, Zhang J, Liu S, Leser GP, Komives EA, Lamb RA, Zhou ZH, Salafsky J, Jardetzky TS. Monomeric ephrinB2 binding induces allosteric changes in Nipah virus G that precede its full activation.. Nature communications, 2017.
  99. Sathiyamoorthy K, Jiang J, Möhl BS, Chen J, Zhou ZH, Longnecker R, Jardetzky TS. Inhibition of EBV-mediated membrane fusion by anti-gHgL antibodies.. Proceedings of the National Academy of Sciences of the United States of America, 2017.
  100. Xu L, Zheng Q, Li S, He M, Wu Y, Li Y, Zhu R, Yu H, Hong Q, Jiang J, Li Z, Li S, Zhao H, Yang L, Hou W, Wang W, Ye X, Zhang J, Baker TS, Cheng T, Zhou ZH, Yan X, Xia N. Atomic structures of Coxsackievirus A6 and its complex with a neutralizing antibody.. Nature communications, 2017.
  101. Alewijnse B, Ashton AW, Chambers MG, Chen S, Cheng A, Ebrahim M, Eng ET, Hagen WJH, Koster AJ, López CS, Lukoyanova N, Ortega J, Renault L, Reyntjens S, Rice WJ, Scapin G, Schrijver R, Siebert A, Stagg SM, Grum-Tokars V, Wright ER, Wu S, Yu Z, Zhou ZH, Carragher B, Potter CS. Best practices for managing large CryoEM facilities.. Journal of structural biology, 2017.
  102. Yu X, Jih J, Jiang J, Zhou ZH. Atomic structure of the human cytomegalovirus capsid with its securing tegument layer of pp150.. Science (New York, N.Y.), 2017.
  103. Dai X, Li Z, Lai M, Shu S, Du Y, Zhou ZH, Sun R. In situ structures of the genome and genome-delivery apparatus in a single-stranded RNA virus.. Nature, 2016.
  104. Poweleit N, Ge P, Nguyen HH, Loo RR, Gunsalus RP, Zhou ZH. CryoEM structure of the Methanospirillum hungatei archaellum reveals structural features distinct from the bacterial flagellum and type IV pilus.. Nature microbiology, 2016.
  105. Zhang X, Lai M, Chang W, Yu I, Ding K, Mrazek J, Ng HL, Yang OO, Maslov DA, Zhou ZH. Structures and stabilization of kinetoplastid-specific split rRNAs revealed by comparing leishmanial and human ribosomes.. Nature communications, 2016.
  106. Mayle KM, Dern KR, Wong VK, Chen KY, Sung S, Ding K, Rodriguez AR, Knowles S, Taylor Z, Zhou ZH, Grundfest WS, Wu AM, Deming TJ, Kamei DT. Engineering A11 Minibody-Conjugated, Polypeptide-Based Gold Nanoshells for Prostate Stem Cell Antigen (PSCA)-Targeted Photothermal Therapy.. SLAS technology, 2016.
  107. Lee G, Chakraborty U, Gebhart D, Govoni GR, Zhou ZH, Scholl D. F-Type Bacteriocins of Listeria monocytogenes: a New Class of Phage Tail-Like Structures Reveals Broad Parallel Coevolution between Tailed Bacteriophages and High-Molecular-Weight Bacteriocins.. Journal of bacteriology, 2016.
  108. Mayle KM, Dern KR, Wong VK, Sung S, Ding K, Rodriguez AR, Taylor Z, Zhou ZH, Grundfest WS, Deming TJ, Kamei DT. Polypeptide-Based Gold Nanoshells for Photothermal Therapy.. SLAS technology, 2016.
  109. Huber RC, Ferreira AS, Aguirre JC, Kilbride D, Toso DB, Mayoral K, Zhou ZH, Kopidakis N, Rubin Y, Schwartz BJ, Mason TG, Tolbert SH. Structure and Conductivity of Semiconducting Polymer Hydrogels.. The journal of physical chemistry. B, 2016.
  110. Toso DB, Javed MM, Czornyj E, Gunsalus RP, Zhou ZH. Discovery and Characterization of Iron Sulfide and Polyphosphate Bodies Coexisting in Archaeoglobus fulgidus Cells.. Archaea (Vancouver, B.C.), 2016.
  111. Huynh KW, Cohen MR, Jiang J, Samanta A, Lodowski DT, Zhou ZH, Moiseenkova-Bell VY. Structure of the full-length TRPV2 channel by cryo-EM.. Nature communications, 2016.
  112. Gunsalus RP, Cook LE, Crable B, Rohlin L, McDonald E, Mouttaki H, Sieber JR, Poweleit N, Zhou H, Lapidus AL, Daligault HE, Land M, Gilna P, Ivanova N, Kyrpides N, Culley DE, McInerney MJ. Complete genome sequence of Methanospirillum hungatei type strain JF1.. Standards in genomic sciences, 2016.
  113. Xu K, Chan YP, Bradel-Tretheway B, Akyol-Ataman Z, Zhu Y, Dutta S, Yan L, Feng Y, Wang LF, Skiniotis G, Lee B, Zhou ZH, Broder CC, Aguilar HC, Nikolov DB. Crystal Structure of the Pre-fusion Nipah Virus Fusion Glycoprotein Reveals a Novel Hexamer-of-Trimers Assembly.. PLoS pathogens, 2015.
  114. Zhang X, Patel A, Celma CC, Yu X, Roy P, Zhou ZH. Atomic model of a nonenveloped virus reveals pH sensors for a coordinated process of cell entry.. Nature structural & molecular biology, 2015.
  115. Bor B, Poweleit N, Bois JS, Cen L, Bedree JK, Zhou ZH, Gunsalus RP, Lux R, McLean JS, He X, Shi W. Phenotypic and Physiological Characterization of the Epibiotic Interaction Between TM7x and Its Basibiont Actinomyces.. Microbial ecology, 2015.
  116. Jurado AR, Huang CS, Zhang X, Zhou ZH, Tong L. Structure and substrate selectivity of the 750-kDa α6β6 holoenzyme of geranyl-CoA carboxylase.. Nature communications, 2015.
  117. Volland S, Hughes LC, Kong C, Burgess BL, Linberg KA, Luna G, Zhou ZH, Fisher SK, Williams DS. Three-dimensional organization of nascent rod outer segment disk membranes.. Proceedings of the National Academy of Sciences of the United States of America, 2015.
  118. Zhang X, Ding K, Yu X, Chang W, Sun J, Zhou ZH. In situ structures of the segmented genome and RNA polymerase complex inside a dsRNA virus.. Nature, 2015.
  119. Jiang J, Chan H, Cash DD, Miracco EJ, Ogorzalek Loo RR, Upton HE, Cascio D, O'Brien Johnson R, Collins K, Loo JA, Zhou ZH, Feigon J. Structure of Tetrahymena telomerase reveals previously unknown subunits, functions, and interactions.. Science (New York, N.Y.), 2015.
  120. Yu X, Jiang J, Sun J, Zhou ZH. A putative ATPase mediates RNA transcription and capping in a dsRNA virus.. eLife, 2015.
  121. Kaweeteerawat C, Chang CH, Roy KR, Liu R, Li R, Toso D, Fischer H, Ivask A, Ji Z, Zink JI, Zhou ZH, Chanfreau GF, Telesca D, Cohen Y, Holden PA, Nel AE, Godwin HA. Cu Nanoparticles Have Different Impacts in Escherichia coli and Lactobacillus brevis than Their Microsized and Ionic Analogues.. ACS nano, 2015.
  122. Huber RC, Ferreira AS, Thompson R, Kilbride D, Knutson NS, Devi LS, Toso DB, Challa JR, Zhou ZH, Rubin Y, Schwartz BJ, Tolbert SH. POLARON DYNAMICS. Long-lived photoinduced polaron formation in conjugated polyelectrolyte-fullerene assemblies.. Science (New York, N.Y.), 2015.
  123. Zhou ZH, Chiou J. Protein chainmail variants in dsDNA viruses.. AIMS biophysics, 2015.
  124. AhYoung AP, Jiang J, Zhang J, Khoi Dang X, Loo JA, Zhou ZH, Egea PF. Conserved SMP domains of the ERMES complex bind phospholipids and mediate tether assembly.. Proceedings of the National Academy of Sciences of the United States of America, 2015.
  125. Ge P, Scholl D, Leiman PG, Yu X, Miller JF, Zhou ZH. Atomic structures of a bactericidal contractile nanotube in its pre- and postcontraction states.. Nature structural & molecular biology, 2015.
  126. Jiang J, Pentelute BL, Collier RJ, Zhou ZH. Atomic structure of anthrax protective antigen pore elucidates toxin translocation.. Nature, 2015.
  127. Clemens DL, Ge P, Lee BY, Horwitz MA, Zhou ZH. Atomic structure of T6SS reveals interlaced array essential to function.. Cell, 2015.
  128. Dai X, Gong D, Xiao Y, Wu TT, Sun R, Zhou ZH. CryoEM and mutagenesis reveal that the smallest capsid protein cements and stabilizes Kaposi's sarcoma-associated herpesvirus capsid.. Proceedings of the National Academy of Sciences of the United States of America, 2015.
  129. Dejnirattisai W, Wongwiwat W, Supasa S, Zhang X, Dai X, Rouvinski A, Jumnainsong A, Edwards C, Quyen NTH, Duangchinda T, Grimes JM, Tsai WY, Lai CY, Wang WK, Malasit P, Farrar J, Simmons CP, Zhou ZH, Rey FA, Mongkolsapaya J, Screaton GR. A new class of highly potent, broadly neutralizing antibodies isolated from viremic patients infected with dengue virus.. Nature immunology, 2014.
  130. Ren S, Lu G, Ota A, Zhou ZH, Vondriska TM, Lane TF, Wang Y. IRE1 phosphatase PP2Ce regulates adaptive ER stress response in the postpartum mammary gland.. PloS one, 2014.
  131. Ge P, Durer ZA, Kudryashov D, Zhou ZH, Reisler E. Cryo-EM reveals different coronin binding modes for ADP- and ADP-BeFx actin filaments.. Nature structural & molecular biology, 2014.
  132. Mrazek J, Toso D, Ryazantsev S, Zhang X, Zhou ZH, Fernandez BC, Kickhoefer VA, Rome LH. Polyribosomes are molecular 3D nanoprinters that orchestrate the assembly of vault particles.. ACS nano, 2014.
  133. Zhou ZH, Hui WH, Shah S, Jih J, O'Connor CM, Sherman MB, Kedes DH, Schein S. Four levels of hierarchical organization, including noncovalent chainmail, brace the mature tumor herpesvirus capsid against pressurization.. Structure (London, England : 1993), 2014.
  134. Sathiyamoorthy K, Jiang J, Hu YX, Rowe CL, Möhl BS, Chen J, Jiang W, Mellins ED, Longnecker R, Zhou ZH, Jardetzky TS. Assembly and architecture of the EBV B cell entry triggering complex.. PLoS pathogens, 2014.
  135. Dai X, Gong D, Wu TT, Sun R, Zhou ZH. Organization of capsid-associated tegument components in Kaposi's sarcoma-associated herpesvirus.. Journal of virology, 2014.
  136. Dai X, Zhou ZH. Purification of Herpesvirus Virions and Capsids.. Bio-protocol, 2014.
  137. Buehler DC, Marsden MD, Shen S, Toso DB, Wu X, Loo JA, Zhou ZH, Kickhoefer VA, Wender PA, Zack JA, Rome LH. Bioengineered vaults: self-assembling protein shell-lipophilic core nanoparticles for drug delivery.. ACS nano, 2014.
  138. Zhou ZH. Structures of viral membrane proteins by high-resolution cryoEM.. Current opinion in virology, 2014.
  139. Yan X, Cardone G, Zhang X, Zhou ZH, Baker TS. Single particle analysis integrated with microscopy: a high-throughput approach for reconstructing icosahedral particles.. Journal of structural biology, 2014.
  140. Yang K, Wills E, Lim HY, Zhou ZH, Baines JD. Association of herpes simplex virus pUL31 with capsid vertices and components of the capsid vertex-specific complex.. Journal of virology, 2014.
  141. Gurel PS, Ge P, Grintsevich EE, Shu R, Blanchoin L, Zhou ZH, Reisler E, Higgs HN. INF2-mediated severing through actin filament encirclement and disruption.. Current biology : CB, 2014.
  142. Ge P, Zhou ZH. Chaperone fusion proteins aid entropy-driven maturation of class II viral fusion proteins.. Trends in microbiology, 2013.
  143. Zhang X, Guo H, Jin L, Czornyj E, Hodes A, Hui WH, Nieh AW, Miller JF, Zhou ZH. A new topology of the HK97-like fold revealed in Bordetella bacteriophage by cryoEM at 3.5 A resolution.. eLife, 2013.
  144. Yu X, Jin L, Jih J, Shih C, Zhou ZH. 3.5Å cryoEM structure of hepatitis B virus core assembled from full-length core protein.. PloS one, 2013.
  145. Hui WH, Tang Q, Liu H, Atanasov I, Liu F, Zhu H, Zhou ZH. Protein interactions in the murine cytomegalovirus capsid revealed by cryoEM.. Protein & cell, 2013.
  146. Dai X, Yu X, Gong H, Jiang X, Abenes G, Liu H, Shivakoti S, Britt WJ, Zhu H, Liu F, Zhou ZH. The smallest capsid protein mediates binding of the essential tegument protein pp150 to stabilize DNA-containing capsids in human cytomegalovirus.. PLoS pathogens, 2013.
  147. Hong K, Upton H, Miracco EJ, Jiang J, Zhou ZH, Feigon J, Collins K. Tetrahymena telomerase holoenzyme assembly, activation, and inhibition by domains of the p50 central hub.. Molecular and cellular biology, 2013.
  148. Lu G, Ota A, Ren S, Franklin S, Rau CD, Ping P, Lane TF, Zhou ZH, Reue K, Lusis AJ, Vondriska T, Wang Y. PPM1l encodes an inositol requiring-protein 1 (IRE1) specific phosphatase that regulates the functional outcome of the ER stress response.. Molecular metabolism, 2013.
  149. Jiang J, Miracco EJ, Hong K, Eckert B, Chan H, Cash DD, Min B, Zhou ZH, Collins K, Feigon J. The architecture of Tetrahymena telomerase holoenzyme.. Nature, 2013.
  150. Jiang J, Magilnick N, Tsirulnikov K, Abuladze N, Atanasov I, Ge P, Narla M, Pushkin A, Zhou ZH, Kurtz I. Single particle electron microscopy analysis of the bovine anion exchanger 1 reveals a flexible linker connecting the cytoplasmic and membrane domains.. PloS one, 2013.
  151. Zhang X, Ge P, Yu X, Brannan JM, Bi G, Zhang Q, Schein S, Zhou ZH. Cryo-EM structure of the mature dengue virus at 3.5-Å resolution.. Nature structural & molecular biology, 2012.
  152. Jiang ZK, Koh SB, Sato M, Atanasov IC, Johnson M, Zhou ZH, Deming TJ, Wu L. Engineering polypeptide coatings to augment gene transduction and in vivo stability of adenoviruses.. Journal of controlled release : official journal of the Controlled Release Society, 2012.
  153. Xiao Q, Sohn H, Chen Z, Toso D, Mechlenburg M, Zhou ZH, Poirier E, Dailly A, Wang H, Wu Z, Cai M, Lu Y. Mesoporous metal and metal alloy particles synthesized by aerosol-assisted confined growth of nanocrystals.. Angewandte Chemie (International ed. in English), 2012.
  154. Zhou ZH. Seeing engineered loops in a gene delivery vehicle by cryoEM.. Structure (London, England : 1993), 2012.
  155. Zhang X, Guo H, Jin L, Xu M, Miller JF, Zhou ZH. Atomic Structure of Bordetella Bacteriophage Reveals a Jellyroll Fold in CementProtein and a Topologically Distinct HK97-like Fold in Major Capsid Protein.. Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada, 2012.
  156. Luo J, Obmolova G, Malia TJ, Wu SJ, Duffy KE, Marion JD, Bell JK, Ge P, Zhou ZH, Teplyakov A, Zhao Y, Lamb RJ, Jordan JL, San Mateo LR, Sweet RW, Gilliland GL. Lateral clustering of TLR3:dsRNA signaling units revealed by TLR3ecd:3Fabs quaternary structure.. Journal of molecular biology, 2012.
  157. Hughes LC, Ralston KS, Hill KL, Zhou ZH. Three-dimensional structure of the Trypanosome flagellum suggests that the paraflagellar rod functions as a biomechanical spring.. PloS one, 2012.
  158. Gopal A, Zhou ZH, Knobler CM, Gelbart WM. Visualizing large RNA molecules in solution.. RNA (New York, N.Y.), 2011.
  159. Huang CS, Ge P, Zhou ZH, Tong L. An unanticipated architecture of the 750-kDa α6β6 holoenzyme of 3-methylcrotonyl-CoA carboxylase.. Nature, 2011.
  160. Toso DB, Henstra AM, Gunsalus RP, Zhou ZH. Structural, mass and elemental analyses of storage granules in methanogenic archaeal cells.. Environmental microbiology, 2011.
  161. Zhang X, Zhou ZH. Limiting factors in atomic resolution cryo electron microscopy: no simple tricks.. Journal of structural biology, 2011.
  162. Ge P, Zhou ZH. Hydrogen-bonding networks and RNA bases revealed by cryo electron microscopy suggest a triggering mechanism for calcium switches.. Proceedings of the National Academy of Sciences of the United States of America, 2011.
  163. Yu X, Ge P, Jiang J, Atanasov I, Zhou ZH. Atomic model of CPV reveals the mechanism used by this single-shelled virus to economically carry out functions conserved in multishelled reoviruses.. Structure (London, England : 1993), 2011.
  164. Buehler DC, Toso DB, Kickhoefer VA, Zhou ZH, Rome LH. Vaults engineered for hydrophobic drug delivery.. Small (Weinheim an der Bergstrasse, Germany), 2011.
  165. Yang Z, Hu W, Chen K, Wang J, Lux R, Zhou ZH, Shi W. Alanine 32 in PilA is important for PilA stability and type IV pili function in Myxococcus xanthus.. Microbiology (Reading, England), 2011.
  166. Chen J, Sun J, Atanasov I, Ryazantsev S, Zhou ZH. Electron tomography reveals polyhedrin binding and existence of both empty and full cytoplasmic polyhedrosis virus particles inside infectious polyhedra.. Journal of virology, 2011.
  167. Yu X, Shah S, Lee M, Dai W, Lo P, Britt W, Zhu H, Liu F, Zhou ZH. Biochemical and structural characterization of the capsid-bound tegument proteins of human cytomegalovirus.. Journal of structural biology, 2011.
  168. Zhou ZH. Atomic resolution cryo electron microscopy of macromolecular complexes.. Advances in protein chemistry and structural biology, 2011.
  169. Green TJ, Rowse M, Tsao J, Kang J, Ge P, Zhou ZH, Luo M. Access to RNA encapsidated in the nucleocapsid of vesicular stomatitis virus.. Journal of virology, 2010.
  170. Liu H, Wu L, Zhou ZH. Model of the trimeric fiber and its interactions with the pentameric penton base of human adenovirus by cryo-electron microscopy.. Journal of molecular biology, 2010.
  171. Gangalum RK, Atanasov IC, Zhou ZH, Bhat SP. AlphaB-crystallin is found in detergent-resistant membrane microdomains and is secreted via exosomes from human retinal pigment epithelial cells.. The Journal of biological chemistry, 2010.
  172. Liu J, Howell JK, Bradley SD, Zheng Y, Zhou ZH, Norris SJ. Cellular architecture of Treponema pallidum: novel flagellum, periplasmic cone, and cell envelope as revealed by cryo electron tomography.. Journal of molecular biology, 2010.
  173. Liu H, Jin L, Koh SB, Atanasov I, Schein S, Wu L, Zhou ZH. Atomic structure of human adenovirus by cryo-EM reveals interactions among protein networks.. Science (New York, N.Y.), 2010.
  174. Huang CS, Sadre-Bazzaz K, Shen Y, Deng B, Zhou ZH, Tong L. Crystal structure of the alpha(6)beta(6) holoenzyme of propionyl-coenzyme A carboxylase.. Nature, 2010.
  175. Faller M, Toso D, Matsunaga M, Atanasov I, Senturia R, Chen Y, Zhou ZH, Guo F. DGCR8 recognizes primary transcripts of microRNAs through highly cooperative binding and formation of higher-order structures.. RNA (New York, N.Y.), 2010.
  176. Zhang X, Zhang X, Zhou ZH. Low cost, high performance GPU computing solution for atomic resolution cryoEM single-particle reconstruction.. Journal of structural biology, 2010.
  177. Zhang X, Jin L, Fang Q, Hui WH, Zhou ZH. 3.3 A cryo-EM structure of a nonenveloped virus reveals a priming mechanism for cell entry.. Cell, 2010.
  178. Zhang X, Boyce M, Bhattacharya B, Zhang X, Schein S, Roy P, Zhou ZH. Bluetongue virus coat protein VP2 contains sialic acid-binding domains, and VP5 resembles enveloped virus fusion proteins.. Proceedings of the National Academy of Sciences of the United States of America, 2010.
  179. Dai W, Hodes A, Hui WH, Gingery M, Miller JF, Zhou ZH. Three-dimensional structure of tropism-switching Bordetella bacteriophage.. Proceedings of the National Academy of Sciences of the United States of America, 2010.
  180. Liu S, He J, Shih C, Li K, Dai A, Zhou ZH, Zhang J. Structural comparisons of hepatitis B core antigen particles with different C-terminal lengths.. Virus research, 2010.
  181. Ge P, Tsao J, Schein S, Green TJ, Luo M, Zhou ZH. Cryo-EM model of the bullet-shaped vesicular stomatitis virus.. Science (New York, N.Y.), 2010.
  182. Zhu J, Cheng L, Fang Q, Zhou ZH, Honig B. Building and refining protein models within cryo-electron microscopy density maps based on homology modeling and multiscale structure refinement.. Journal of molecular biology, 2010.
  183. Peng L, Ryazantsev S, Sun R, Zhou ZH. Three-dimensional visualization of gammaherpesvirus life cycle in host cells by electron tomography.. Structure (London, England : 1993), 2010.
  184. Leong PA, Yu X, Zhou ZH, Jensen GJ. Correcting for the ewald sphere in high-resolution single-particle reconstructions.. Methods in enzymology, 2010.
  185. Cheng L, Zhu J, Hui WH, Zhang X, Honig B, Fang Q, Zhou ZH. Backbone model of an aquareovirus virion by cryo-electron microscopy and bioinformatics.. Journal of molecular biology, 2009.
  186. Yan M, Du J, Gu Z, Liang M, Hu Y, Zhang W, Priceman S, Wu L, Zhou ZH, Liu Z, Segura T, Tang Y, Lu Y. A novel intracellular protein delivery platform based on single-protein nanocapsules.. Nature nanotechnology, 2009.
  187. Guo H, Wang L, Peng L, Zhou ZH, Deng H. Open reading frame 33 of a gammaherpesvirus encodes a tegument protein essential for virion morphogenesis and egress.. Journal of virology, 2009.
  188. Li F, Ge P, Hui WH, Atanasov I, Rogers K, Guo Q, Osato D, Falick AM, Zhou ZH, Simpson L. Structure of the core editing complex (L-complex) involved in uridine insertion/deletion RNA editing in trypanosomatid mitochondria.. Proceedings of the National Academy of Sciences of the United States of America, 2009.
  189. Nayak DP, Balogun RA, Yamada H, Zhou ZH, Barman S. Influenza virus morphogenesis and budding.. Virus research, 2009.
  190. Song C, Jiang H, Mancuso A, Amirbekian B, Peng L, Sun R, Shah SS, Zhou ZH, Ishikawa T, Miao J. Quantitative imaging of single, unstained viruses with coherent x rays.. Physical review letters, 2008.
  191. Jiang J, Zhang X, Chen Y, Wu Y, Zhou ZH, Chang Z, Sui SF. Activation of DegP chaperone-protease via formation of large cage-like oligomers upon binding to substrate proteins.. Proceedings of the National Academy of Sciences of the United States of America, 2008.
  192. Cheng L, Fang Q, Shah S, Atanasov IC, Zhou ZH. Subnanometer-resolution structures of the grass carp reovirus core and virion.. Journal of molecular biology, 2008.
  193. Yu X, Jin L, Zhou ZH. 3.88 A structure of cytoplasmic polyhedrosis virus by cryo-electron microscopy.. Nature, 2008.
  194. Zhou ZH. Towards atomic resolution structural determination by single-particle cryo-electron microscopy.. Current opinion in structural biology, 2008.
  195. Yu X, Hiromasa Y, Tsen H, Stoops JK, Roche TE, Zhou ZH. Structures of the human pyruvate dehydrogenase complex cores: a highly conserved catalytic center with flexible N-terminal domains.. Structure (London, England : 1993), 2008.
  196. Dai W, Jia Q, Bortz E, Shah S, Liu J, Atanasov I, Li X, Taylor KA, Sun R, Zhou ZH. Unique structures in a tumor herpesvirus revealed by cryo-electron tomography and microscopy.. Journal of structural biology, 2007.
  197. Deng B, O'Connor CM, Kedes DH, Zhou ZH. Cryo-electron tomography of Kaposi's sarcoma-associated herpesvirus capsids reveals dynamic scaffolding structures essential to capsid assembly and maturation.. Journal of structural biology, 2007.
  198. Liu H, Cheng L, Zeng S, Cai C, Zhou ZH, Yang Q. Symmetry-adapted spherical harmonics method for high-resolution 3D single-particle reconstructions.. Journal of structural biology, 2007.
  199. Bortz E, Wang L, Jia Q, Wu TT, Whitelegge JP, Deng H, Zhou ZH, Sun R. Murine gammaherpesvirus 68 ORF52 encodes a tegument protein required for virion morphogenesis in the cytoplasm.. Journal of virology, 2007.
  200. Yu X, Qiao M, Atanasov I, Hu Z, Kato T, Liang TJ, Zhou ZH. Cryo-electron microscopy and three-dimensional reconstructions of hepatitis C virus particles.. Virology, 2007.
  201. Cheng L, Chen S, Zhou ZH, Zhang J. Structure comparisons of Aedes albopictus densovirus with other parvoviruses.. Science in China. Series C, Life sciences, 2007.
  202. Deng B, O'Connor CM, Kedes DH, Zhou ZH. Direct visualization of the putative portal in the Kaposi's sarcoma-associated herpesvirus capsid by cryoelectron tomography.. Journal of virology, 2007.
  203. Liu F, Zhou ZH. Comparative virion structures of human herpesviruses. Human Herpesviruses: Biology, Therapy, and Immunoprophylaxis, 2007.
  204. Cong Y, Jiang W, Birmanns S, Zhou ZH, Chiu W, Wriggers W. Fast rotational matching of single-particle images.. Journal of structural biology, 2005.
  205. Yu X, Trang P, Shah S, Atanasov I, Kim YH, Bai Y, Zhou ZH, Liu F. Dissecting human cytomegalovirus gene function and capsid maturation by ribozyme targeting and electron cryomicroscopy.. Proceedings of the National Academy of Sciences of the United States of America, 2005.
  206. Yu X, Shah S, Atanasov I, Lo P, Liu F, Britt WJ, Zhou ZH. Three-dimensional localization of the smallest capsid protein in the human cytomegalovirus capsid.. Journal of virology, 2005.
  207. Qiao M, Ashok M, Bernard KA, Palacios G, Zhou ZH, Lipkin WI, Liang TJ. Induction of sterilizing immunity against West Nile Virus (WNV), by immunization with WNV-like particles produced in insect cells.. The Journal of infectious diseases, 2004.
  208. Booth CR, Jiang W, Baker ML, Zhou ZH, Ludtke SJ, Chiu W. A 9 angstroms single particle reconstruction from CCD captured images on a 200 kV electron cryomicroscope.. Journal of structural biology, 2004.
  209. Cheng L, Chen S, Brannan JM, Jakana J, Zhang Q, Zhou ZH, Zhang J. Three-dimensional structure determination of capsid of Aedes albopictus C6/36 cell densovirus.. Science in China. Series C, Life sciences, 2004.
  210. Chen S, Cheng L, Zhang Q, Lin W, Lu X, Brannan J, Zhou ZH, Zhang J. Genetic, biochemical, and structural characterization of a new densovirus isolated from a chronically infected Aedes albopictus C6/36 cell line.. Virology, 2004.
  211. Bortz E, Whitelegge JP, Jia Q, Zhou ZH, Stewart JP, Wu TT, Sun R. Identification of proteins associated with murine gammaherpesvirus 68 virions.. Journal of virology, 2003.
  212. Yu XK, O'Connor CM, Atanasov I, Damania B, Kedes DH, Zhou ZH. Three-dimensional structures of the A, B, and C capsids of rhesus monkey rhadinovirus: insights into gammaherpesvirus capsid assembly, maturation, and DNA packaging.. Journal of virology, 2003.
  213. Dai W, Liang Y, Zhou ZH. Web portal to an image database for high-resolution three-dimensional reconstruction.. Journal of structural biology, 2003.
  214. Baker ML, Jiang W, Bowman BR, Zhou ZH, Quiocho FA, Rixon FJ, Chiu W. Architecture of the herpes simplex virus major capsid protein derived from structural bioinformatics.. Journal of molecular biology, 2003.
  215. Kong Y, Ming D, Wu Y, Stoops JK, Zhou ZH, Ma J. Conformational flexibility of pyruvate dehydrogenase complexes: a computational analysis by quantized elastic deformational model.. Journal of molecular biology, 2003.
  216. Zhou ZH, Zhang H, Jakana J, Lu XY, Zhang JQ. Cytoplasmic polyhedrosis virus structure at 8 A by electron cryomicroscopy: structural basis of capsid stability and mRNA processing regulation.. Structure (London, England : 1993), 2003.
  217. Gu Y, Zhou ZH, McCarthy DB, Reed LJ, Stoops JK. 3D electron microscopy reveals the variable deposition and protein dynamics of the peripheral pyruvate dehydrogenase component about the core.. Proceedings of the National Academy of Sciences of the United States of America, 2003.
  218. Lo P, Yu X, Atanasov I, Chandran B, Zhou ZH. Three-dimensional localization of pORF65 in Kaposi's sarcoma-associated herpesvirus capsid.. Journal of virology, 2003.
  219. Lu BY, Atanasov I, Zhou ZH, Chang JY. Reversible aggregation of mouse prion protein derivatives with PrPSC-like structural properties.. Journal of protein chemistry, 2003.
  220. Zhou ZH, Chiu W. Determination of icosahedral virus structures by electron cryomicroscopy at subnanometer resolution.. Advances in protein chemistry, 2003.
  221. Xia Q, Jakana J, Zhang JQ, Zhou ZH. Structural comparisons of empty and full cytoplasmic polyhedrosis virus. Protein-RNA interactions and implications for endogenous RNA transcription mechanism.. The Journal of biological chemistry, 2002.
  222. Zhang H, Yu XK, Lu XY, Zhang JQ, Zhou ZH. Molecular interactions and viral stability revealed by structural analyses of chemically treated cypovirus capsids.. Virology, 2002.
  223. Chiu W, Baker ML, Jiang W, Zhou ZH. Deriving folds of macromolecular complexes through electron cryomicroscopy and bioinformatics approaches.. Current opinion in structural biology, 2002.
  224. Liang Y, Ke EY, Zhou ZH. IMIRS: a high-resolution 3D reconstruction package integrated with a relational image database.. Journal of structural biology, 2002.
  225. Zhou ZH, McCarthy DB, O'Connor CM, Reed LJ, Stoops JK. The remarkable structural and functional organization of the eukaryotic pyruvate dehydrogenase complexes.. Proceedings of the National Academy of Sciences of the United States of America, 2001.
  226. Chen DH, Jakana J, McNab D, Mitchell J, Zhou ZH, Dougherty M, Chiu W, Rixon FJ. The pattern of tegument-capsid interaction in the herpes simplex virus type 1 virion is not influenced by the small hexon-associated protein VP26.. Journal of virology, 2001.
  227. Zhou ZH, Baker ML, Jiang W, Dougherty M, Jakana J, Dong G, Lu G, Chiu W. Electron cryomicroscopy and bioinformatics suggest protein fold models for rice dwarf virus.. Nature structural biology, 2001.
  228. He J, Schmid MF, Zhou ZH, Rixon F, Chiu W. Finding and using local symmetry in identifying lower domain movements in hexon subunits of the herpes simplex virus type 1 B capsid.. Journal of molecular biology, 2001.
  229. Zhou ZH, Liao W, Cheng RH, Lawson JE, McCarthy DB, Reed LJ, Stoops JK. Direct evidence for the size and conformational variability of the pyruvate dehydrogenase complex revealed by three-dimensional electron microscopy. The "breathing" core and its functional relationship to protein dynamics.. The Journal of biological chemistry, 2001.
  230. Wu L, Lo P, Yu X, Stoops JK, Forghani B, Zhou ZH. Three-dimensional structure of the human herpesvirus 8 capsid.. Journal of virology, 2000.
  231. Zhou ZH, Dougherty M, Jakana J, He J, Rixon FJ, Chiu W. Seeing the herpesvirus capsid at 8.5 A.. Science (New York, N.Y.), 2000.
  232. Saad A, Zhou ZH, Jakana J, Chiu W, Rixon FJ. Roles of triplex and scaffolding proteins in herpes simplex virus type 1 capsid formation suggested by structures of recombinant particles.. Journal of virology, 1999.
  233. Chen DH, Jiang H, Lee M, Liu F, Zhou ZH. Three-dimensional visualization of tegument/capsid interactions in the intact human cytomegalovirus.. Virology, 1999.
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  236. Lu G, Zhou ZH, Baker ML, Jakana J, Cai D, Wei X, Chen S, Gu X, Chiu W. Structure of double-shelled rice dwarf virus.. Journal of virology, 1998.
  237. Zhou ZH, Macnab SJ, Jakana J, Scott LR, Chiu W, Rixon FJ. Identification of the sites of interaction between the scaffold and outer shell in herpes simplex virus-1 capsids by difference electron imaging.. Proceedings of the National Academy of Sciences of the United States of America, 1998.
  238. Zhou ZH, Chiu W, Haskell K, Spears H, Jakana J, Rixon FJ, Scott LR. Refinement of herpesvirus B-capsid structure on parallel supercomputers.. Biophysical journal, 1998.
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  242. Zhou ZH, Prasad BV, Jakana J, Rixon FJ, Chiu W. Protein subunit structures in the herpes simplex virus A-capsid determined from 400 kV spot-scan electron cryomicroscopy.. Journal of molecular biology, 1994.
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